Md Abdul Alim
Oct. 2020 -To date: Post-Doctoral Researcher Karolinska Institutet, Sweden
Dec. 2019 - Dec. 2020: Post-Doctoral Researcher, Uppsala University, Sweden
2016 - 2019: PhD in Medical Science, Uppsala University, Sweden
2015 - 2016: Research Assistant, Karolinska Institutet, Sweden
2014 - 2015: PhD preparatory training, UGSBR, Uppsala University, Sweden
2013: Master of Science in Biomedicine, University of Skövde, Sweden
2011: Master of Science in Molecular Biology, University of Skövde, Sweden
2008. Bachelor of Science (Honors) in Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh
Dr. Abdul Alim has appropriate skills in different laborative techniques/concepts, in particular focusing on the neuro-immunology field. He has completed his PhD on “Mechanisms in tendon healing: pain, biomarkers and the role of mast cells”. His publication records on translational medicine research includes both pre-clinical and clinical studies. In a previous study, Dr. Alim used an Achilles tendon injury rat model as well as human patients with tendon pain in collaboration with Uppsala University, Karolinska Institutet and Linköping University. In that project, he demonstrated that neuro-immune responses are vital in the painful healing tendon as compared to painfree tendon. He was able to show that different functional channels including ionotropic-metabotropic glutamate receptors (e.g. NMDA-subtypes, mGluR-subtupes) are expressed by non-neuronal cells (e.g. mast cells), and these receptors are implicated in various pain conditions (e.g. tendon pain) including tendon healing and inflammation.
Currently, Dr. Alim is also interested to investigate the relationship between periodontitis/periodontal pathogens and the chronic inflammatory disease rheumatoid arthritis - to study the interactions between oral microbiome and carcinogenesis including autoimmune diseases, diabetes by connecting mast cells immunology.
Academic honours, awards and prizes
2019: Travel Grant; The 11th Congress of the European Pain Federation, Pain in Europe XI, Valencia, Spain.
2015: Travel Grant; Grand Challenges Symposium, Van Andel Institute, Michigan, USA.
2013: Karolinska Foundation Scholarship; Karolinska Institutet, Stockholm, Sweden
2010: Swedish-Bangladesh Trust Scholarship; The people republic of Bangladesh; Ministry of finance, Dhaka, Bangladesh.
2008: Graduate Scholarship; Department of Biochemistry and Molecular Biology, Rajshahi University, Bangladesh.
-Peer-reviewed original articles
Alim MA, Grujic M, Ackermann PW, Kristiansson P, Blomgran P, Eliasson P, Peterson M, Pejler G. Glutamate Triggers the Expression of Functional Ionotropic and Metabotropic Glutamate Receptors in Mast Cells. Cellular and Molecular Immunology, (Nature publisher), 2020 March, https://doi.org/10.1038/s41423-020-0421-z
Alim MA, Ackermann PW, Eliasson P, Blomgran P, Kristiansson P, Pejler G, Peterson M. Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture. Cell Tissue Res. 2017 Dec; 370(3):451-460; https://link.springer.com/article/10.1007%2Fs00441-017-2684-y
Ahmed AS, Li J2, Abdul AM, Ahmed M, Östenson CG, Salo PT, Hewitt C, Hart DA, Ackermann PW. Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes. PLoS One. 2017 Jan 25;12(1):e0170748. https://doi.org/10.1371/journal.pone.0170748
Abdul Alim M Domeij-Arverud E, Nilsson G, Edman G, Ackermann PW. Achilles tendon rupture healing is enhanced by intermittent pneumatic compression upregulating collagen type I synthesis. Knee Surg Sports Traumatol Arthrosc. 2017 Jul 1. https://link.springer.com/article/10.1007%2Fs00167-017-4621-8
Alim MA, Svedman S., Edman G, Ackermann PW. Procollagen markers in microdialysate can predict patient outcome after Achilles tendon rupture. BMJ Open Sport Exerc Med. 2016; 2(1): e000114. Published online 2016 Jun 10. https://bmjopensem.bmj.com/content/2/1/e000114.info
-Research review articles
Alim MA, Peterson M, Pejler G. Do Mast Cells Have a Role in Tendon Healing and Inflammation? Cells. 2020; 9(5):1134. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290807/
Peer-reviewed books and book chapters
Alim MA, Peterson M, Pejler G. Tendon and Mast Cells. Scholarly Community Encyclopedia, 2020.
Alim MA, Peterson M, Pejler G. Molecular Understanding of Mast cells in Tendon Healing, Pain, and Inflammation. Book Title: Prime Archives in Molecular Biology, 2020; Editor: Song Guo Zheng, Mode of Publication: Digital (Open Access), In-press.
Alim, Abdul. Mechanisms in Tendon Healing: Pain, Biomarkers and the Role of Mast Cells. Uppsala: Acta Universitatis Upsaliensis, 2019. S. 47. URN: urn:nbn:se:uu:diva-394741.