I obtained my MPharm, MD and PhD at Uppsala University, Uppsala, Sweden . After positions as Associate Professor and Senior Lecture in Pharmacology at Uppsala University I am since 1992 Professor in Clinical Neuroscience at Karolinska Institutet and Senior Consultant at Theme Aging, Karolinska University Hospital, Stockholm.
I have pioneered in field of cholinergic neurotransmission, nicotinic acetylcholine receptors as well as in the development of amyloid PET imaging, introducing the multi-tracer PET concept , evaluating drug mechanism of action and visualising reactive astrogliosis and tau pathology in patients with Alzheimer´s disease (AD) and dementia disorders. My frontline research findings have been published in leading journals (500+ publications, H-index 79) and I have been PI for more than 15 clinical PET trials and received several prizes and rewards.
I am leading a research team with a major focus on developing early diagnostic biomarkers and new drug targets in AD and other neurodegenerative proteinopathies.
Our research has a translational multimodal molecular imaging approach with the mission of further understanding of the time course and important interactions between different neurodegenerative pathophysiological processes in brain such as deposition of amyloid and tau, neuroinflammation especially reactive astrogliosis and synaptic dysfunction .
We have a great interest in performing longitudinal brain PET studies in presymptomatic carriers of different forms of autosomal dominant AD as well as in Down´s syndrome.
We also want to relate pathological brain imaging and cognitive findings to fluid biomarkers for a further understanding of how early can we detect AD and other related neurodegenerative disorders and what are the implications for new promising treatment strategies.
Furthermore, we have ongoing studies aiming to develop new selective PET tracers for alpha-synuclein, 4R tau, as well as alpha 7 nicotinic acetylcholine receptors, the latter as a synaptic marker.
Academic honours, awards and prizes
2020 Foundation for Research on Alzheimer/ European Grand Prix 2020 , 2017 Nominated by Swedish Research Council to Robert Bosch Stiftung Academia Net outstanding female academics ,2016 the Grand Silver Medal from Karolinska Institutet for outstanding research, 2014 Queen Silvia prize for outstanding Alzheimer research ,2013 Wailet and Eric Forsgren prize for prominent Alzheimer research, 2006 Alois Alzheimer Award , 2004 de Leon Imaging Award in Alzheimer Research (Alz assoc USA), 2002 Life Achievement Award , ADRD conference, 2002 The Swedish Society of Medicine , Inga Sandeborg Alzheimer prize, 2001 Luigi Amaducci award in Alzheimer´s disease, 1995 The Norage Kabi Pharmacia award 1 prize.