Alamdar Hussain

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About me

As a researcher with a background in Laboratory Medicine at KI, my expertise lies in lymphocyte signal transduction, particularly in analyzing the structure-function relationship of chimeric genes associated with T cell lymphoma and B cell proximal signal transduction. Prior to this, I delved into genetic disorders, focusing on retinitis pigmentosa.

Currently, my focus has shifted towards protein engineering projects, where I specialize in generating designer chimeric proteins aimed at enhancing immune cell capabilities. I am deeply involved in creating novel constructs with tailored promoters and developing new biological machines to further advance our understanding and manipulation of cellular processes for novel cancer immunotherapy products including CARs, DARs and TCRs.

Articles

Article: CYTOTHERAPY. 2023;25(7):763-772

Challenges in αCD38-chimeric antigen receptor (CAR)-expressing natural killer (NK) cell-based immunotherapy in multiple myeloma: Harnessing the CD38dim phenotype of cytokine-stimulated NK cells as a strategy to prevent fratricide.

Karvouni M; Vidal-Manrique M; Susek KH; Hussain A; Gilljam M; Zhang Y; Gray JD; Lund J; Kaufmann G; Ljunggren H-G; Ji H; Lundqvist A; Wagner AK; Guo W; Alici E
Journal article: CYTOTHERAPY. 2023;25(6):s13-s14

13 Tissue Engineering: GENERATION OF UNIVERSAL CELLULAR GRAFTS UTILIZING SIGNALING-DEFICIENT MEMBRANE-BOUND CD45 ENGAGERS

Hussain A; Mohammad DK; Karvouni M; Hållstrand C; Gilljam M; Wagner AK; Ljunggren H; Alici E
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2023;72(5):1153-1167

Generation of NK cells with chimeric-switch receptors to overcome PD1-mediated inhibition in cancer immunotherapy.

Susek KH; Schwietzer YA; Karvouni M; Gilljam M; Keszei M; Hussain A; Lund J; Kashif M; Lundqvist A; Ljunggren H-G; Nahi H; Wagner AK; Alici E
Article: CURRENT ISSUES IN MOLECULAR BIOLOGY. 2022;44(9):3859-3871

Assessment of T Cell Receptor Complex Expression Kinetics in Natural Killer Cells.

Rasul KH; Hussain A; Reilly H; Karvouni M; Dahlberg CIM; Al-Attar MS; Wagner AK; Alici E; Mohammad DK
Journal article: HEMASPHERE. 2022;6(Suppl):1318-1319

P1435: PRECLINICAL EVALUATION OF ZILOVERTAMAB‐BASED ANTI‐ROR1 CHIMERIC ANTIGEN RECEPTORS IN NK AND T CELLS

Meinke S; Kadri N; Bi S; Bostancioglu B; Markey C; Breitmeyer JB; Hussain A; Krishnan R; Kaufmann GF; Alici E
Journal article: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2021;180:739-752

Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis-New insight and futuristic vision.

Huang XL; Khan MI; Wang J; Ali R; Ali SW; Zahra Q-U; Kazmi A; Lolai A; Huang YL; Hussain A; Bilal M; Li F; Qiu B
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2020;105(2):196-202

Impact of performance status on overall survival in patients with relapsed and/or refractory multiple myeloma: Real-life outcomes of daratumumab treatment.

Afram G; Gran C; Borg Bruchfeld J; Wagner AK; Hussain A; Alici E; Nahi H
Article: GENETICS AND MOLECULAR BIOLOGY. 2019;42(1):40-47

Increased expression levels of Syntaxin 1A and Synaptobrevin 2/Vesicle-Associated Membrane Protein-2 are associated with the progression of bladder cancer.

Raja SA; Abbas S; Shah STA; Tariq A; Bibi N; Yousuf A; Khawaja A; Nawaz M; Mehmood A; Khan MJ; Hussain A
Article: GENETICS AND MOLECULAR BIOLOGY. 2018;41(3):570-577

Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene.

Idrees M; Siddiq AR; Ajmal M; Akram M; Khalid RR; Hussain A; Qamar R; Bokhari H
Article: LANCET INFECTIOUS DISEASES. 2018;18(6):675-683

Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study.

Zignol M; Cabibbe AM; Dean AS; Glaziou P; Alikhanova N; Ama C; Andres S; Barbova A; Borbe-Reyes A; Chin DP; Cirillo DM; Colvin C; Dadu A; Dreyer A; Driesen M; Gilpin C; Hasan R; Hasan Z; Hoffner S; Hussain A; Ismail N; Kamal SMM; Khanzada FM; Kimerling M; Kohl TA; Mansjö M; Miotto P; Mukadi YD; Mvusi L; Niemann S; Omar SV; Rigouts L; Schito M; Sela I; Seyfaddinova M; Skenders G; Skrahina A; Tahseen S; Wells WA; Zhurilo A; Weyer K; Floyd K; Raviglione MC
Article: TOXICOLOGY MECHANISMS AND METHODS. 2018;28(1):62-68

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

Arshad M; Fatmi MQ; Musilek K; Hussain A; Kuca K; Petroianu G; Kalasz H; Nurulain SM
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017;58(9):3481-3487

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus.

Arbab M; Tahir S; Niazi MK; Ishaq M; Hussain A; Siddique PM; Saeed S; Khan WA; Qamar R; Butt AM; Azam M
Article: ENVIRONMENTAL GEOCHEMISTRY AND HEALTH. 2015;37(3):515-527

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility.

Zafar A; Eqani SAMAS; Bostan N; Cincinelli A; Tahir F; Shah STA; Hussain A; Alamdar A; Huang Q; Peng S; Shen H
Article: PLOS ONE. 2015;10(3):e0119806

Homozygosity mapping and targeted sanger sequencing reveal genetic defects underlying inherited retinal disease in families from pakistan.

Maria M; Ajmal M; Azam M; Waheed NK; Siddiqui SN; Mustafa B; Ayub H; Ali L; Ahmad S; Micheal S; Hussain A; Shah STA; Ali SHB; Ahmed W; Khan YM; den Hollander AI; Haer-Wigman L; Collin RWJ; Khan MI; Qamar R; Cremers FPM
Article: ENVIRONMENTAL GEOCHEMISTRY AND HEALTH. 2014;36(3):375-384

Cattle egrets as a biosentinels of persistent organic pollutants exposure.

Khan M; Mohammad A; Ahad K; Katsoyiannis A; Malik SA; Abdullaha M; Rashid A; Fasola M; Hussain A; Bokhari H; Eqani SAMAS
Article: PLOS ONE. 2014;9(6):e100146

Genetic spectrum of autosomal recessive non-syndromic hearing loss in Pakistani families.

Shafique S; Siddiqi S; Schraders M; Oostrik J; Ayub H; Bilal A; Ajmal M; Seco CZ; Strom TM; Mansoor A; Mazhar K; Shah STA; Hussain A; Azam M; Kremer H; Qamar R
Article: MOLECULAR AND CELLULAR BIOLOGY. 2013;33(16):3214-3226

Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.

Mohammad DK; Nore BF; Hussain A; Gustafsson MO; Mohamed AJ; Smith CIE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(10):7338-7350

Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.

Hussain A; Mohammad DK; Gustafsson MO; Uslu M; Hamasy A; Nore BF; Mohamed AJ; Smith CIE
Article: MOLECULAR AND CELLULAR BIOLOGY. 2012;32(13):2440-2453

Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).

Gustafsson MO; Hussain A; Mohammad DK; Mohamed AJ; Nguyen V; Metalnikov P; Colwill K; Pawson T; Smith CIE; Nore BF
Article: PLOS ONE. 2012;7(5):e36804

Ischemia-reperfusion injury and pregnancy initiate time-dependent and robust signs of up-regulation of cardiac progenitor cells.

Genead R; Fischer H; Hussain A; Jaksch M; Andersson AB; Ljung K; Bulatovic I; Franco-Cereceda A; Elsheikh E; Corbascio M; Smith CIE; Sylvén C; Grinnemo K-H
Article: OPHTHALMOLOGY. 2011;118(7):1444-1448

CLRN1 mutations cause nonsyndromic retinitis pigmentosa.

Khan MI; Kersten FFJ; Azam M; Collin RWJ; Hussain A; Shah ST-A; Keunen JEE; Kremer H; Cremers FPM; Qamar R; den Hollander AI
Article: MOLECULAR VISION. 2010;16:774-781

Novel CNGA3 and CNGB3 mutations in two Pakistani families with achromatopsia.

Azam M; Collin RWJ; Shah STA; Shah AA; Khan MI; Hussain A; Sadeque A; Strom TM; Thiadens AAHJ; Roosing S; den Hollander AI; Cremers FPM; Qamar R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(3):892-896

Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein.

Hussain A; Faryal R; Nore BF; Mohamed AJ; Smith CIE
Article: MOLECULAR VISION. 2009;15:2526-2534

A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa.

Azam M; Khan MI; Gal A; Hussain A; Shah STA; Khan MS; Sadeque A; Bokhari H; Collin RWJ; Orth U; van Genderen MM; den Hollander AI; Cremers FPM; Qamar R
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All other publications

Conference publication: CYTOTHERAPY. 2023;25(6):S13-S14

GENERATION OF UNIVERSAL CELLULAR GRAFTS UTILIZING SIGNALING-DEFICIENT MEMBRANE-BOUND CD45 ENGAGERS

Hussain A; Mohammad DK; Karvouni M; Hallstrand C; Gilljam M; Wagner AK; Ljunggren H; Alici E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):348

Optimized genetic modification of primary human NK cells

Wagner AK; Chrobok M; Hussain A; Gilljam M; Dahlberg CIM; Sutlu T; Duru AD; Nahi H; Lundqvist A; Ljunggren H-G; Alici E
Letter: HUMAN MUTATION. 2014;35(1):147-148

Comprehensive registration of DNA sequence variants associated with inherited retinal diseases in Leiden Open Variation Databases.

Cremers FPM; den Dunnen JT; Ajmal M; Hussain A; Preising MN; Daiger SP; Qamar R
Letter: ARCHIVES OF OPHTHALMOLOGY. 2011;129(10):1377-1378

Identification of novel mutations in Pakistani families with autosomal recessive retinitis pigmentosa.

Azam M; Collin RWJ; Malik A; Khan MI; Shah STA; Shah AA; Hussain A; Sadeque A; Arimadyo K; Ajmal M; Azam A; Qureshi N; Bokhari H; Strom TM; Cremers FPM; Qamar R; den Hollander AI
Review: FEBS JOURNAL. 2011;278(12):2001-2010

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.

Hussain A; Yu L; Faryal R; Mohammad DK; Mohamed AJ; Smith CIE

Employments

Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2013

About me

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Degrees and Education

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