Ali Moshfegh

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Articles

Article: IMMUNITY. 2023;56(5):979-997.e11

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation.

Gatsiou A; Tual-Chalot S; Napoli M; Ortega-Gomez A; Regen T; Badolia R; Cesarini V; Garcia-Gonzalez C; Chevre R; Ciliberti G; Silvestre-Roig C; Martini M; Hoffmann J; Hamouche R; Visker JR; Diakos N; Wietelmann A; Silvestris DA; Georgiopoulos G; Moshfegh A; Schneider A; Chen W; Guenther S; Backs J; Kwak S; Selzman CH; Stamatelopoulos K; Rose-John S; Trautwein C; Spyridopoulos I; Braun T; Waisman A; Gallo A; Drakos SG; Dimmeler S; Sperandio M; Soehnlein O; Stellos K
Article: PHARMACEUTICS. 2023;15(4):1148

A Small Molecule Targeting the Intracellular Tyrosine Kinase Domain of ROR1 (KAN0441571C) Induced Significant Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells.

Ghaderi A; Okhovat M-A; Lehto J; De Petris L; Manouchehri Doulabi E; Kokhaei P; Zhong W; Rassidakis GZ; Drakos E; Moshfegh A; Schultz J; Olin T; Österborg A; Mellstedt H; Hojjat-Farsangi M
Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:75-99

Targeting the Receptor Tyrosine Kinase ROR1 by Small Molecules.

Hojjat-Farsangi M; Moshfegh A; Schultz J; Norin M; Olin T; Österborg A; Mellstedt H
Article: BIOMEDICINES. 2020;8(6):E170-170

ROR1 Is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells.

Ghaderi A; Daneshmanesh AH; Moshfegh A; Kokhaei P; Vågberg J; Schultz J; Olin T; Harrysson S; Smedby KE; Drakos E; Rassidakis GZ; Österborg A; Hojjat-Farsangi M; Mellstedt H
Article: LEUKEMIA. 2018;32(10):2291-2295

First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells.

Hojjat-Farsangi M; Daneshmanesh AH; Khan AS; Shetye J; Mozaffari F; Kharaziha P; Rathje L-S; Kokhaei P; Hansson L; Vågberg J; Byström S; Olsson E; Löfberg C; Norström C; Schultz J; Norin M; Olin T; Österborg A; Mellstedt H; Moshfegh A
Article: PLOS ONE. 2018;13(6):e0198038

A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib.

Daneshmanesh AH; Hojjat-Farsangi M; Ghaderi A; Moshfegh A; Hansson L; Schultz J; Vågberg J; Byström S; Olsson E; Olin T; Österborg A; Mellstedt H
Article: PLOS ONE. 2018;13(2):e0192839

Autologous T cells expressing the oncogenic transcription factor KLF6-SV1 prevent apoptosis of chronic lymphocytic leukemia cells.

Kokhaei P; Hojjat-Farsangi M; Mozaffari F; Moshfegh A; Pak F; Rashidy-Pour A; Palma M; Hansson L; Österborg A; Mellstedt H
Article: BMC NEPHROLOGY. 2017;18(1):161

Vitamin D receptor activation reduces inflammatory cytokines and plasma MicroRNAs in moderate chronic kidney disease - a randomized trial.

Mansouri L; Lundwall K; Moshfegh A; Jacobson SH; Lundahl J; Spaak J
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2017;31(1):4-12

Mono-epoxy-tocotrienol-α enhances wound healing in diabetic mice and stimulates in vitro angiogenesis and cell migration.

Xu C; Bentinger M; Savu O; Moshfegh A; Sunkari V; Dallner G; Swiezewska E; Catrina S-B; Brismar K; Tekle M
Article: PLOS ONE. 2017;12(11):e0187294

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway.

El-Serafi I; Terelius Y; Abedi-Valugerdi M; Naughton S; Saghafian M; Moshfegh A; Mattsson J; Potácová Z; Hassan M
Article: ONCOLOGY LETTERS. 2016;12(4):2782-2788

Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions.

Högfeldt T; Jaing C; Loughlin KM; Thissen J; Gardner S; Bahnassy AA; Gharizadeh B; Lundahl J; Österborg A; Porwit A; Zekri A-RN; Khaled HM; Mellstedt H; Moshfegh A
Article: TUMOR BIOLOGY. 2016;37(9):11947-11957

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.

Khan AS; Hojjat-Farsangi M; Daneshmanesh AH; Hansson L; Kokhaei P; Österborg A; Mellstedt H; Moshfegh A
Article: PHARMACOGENOMICS JOURNAL. 2015;15(5):405-413

Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies.

El-Serafi I; Fares M; Abedi-Valugerdi M; Afsharian P; Moshfegh A; Terelius Y; Potácová Z; Hassan M
Article: PLOS ONE. 2015;10(11):e0142310

Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia.

Hojjat-Farsangi M; Jeddi-Tehrani M; Daneshmanesh AH; Mozaffari F; Moshfegh A; Hansson L; Razavi SM; Sharifian RA; Rabbani H; Österborg A; Mellstedt H; Shokri F
Article: PLOS ONE. 2015;10(11):e0141979

Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation.

El-Serafi I; Afsharian P; Moshfegh A; Hassan M; Terelius Y
Article: LEUKEMIA & LYMPHOMA. 2014;55(5):1158-1165

Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas.

Högfeldt T; Johnsson P; Grandér D; Bahnassy AA; Porwit A; Eid S; Österborg A; Zekri A-RN; Lundahl J; Khaled MH; Mellstedt H; Moshfegh A
Article: PLOS ONE. 2014;9(1):e86619

Cyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation.

El-Serafi I; Abedi-Valugerdi M; Potácová Z; Afsharian P; Mattsson J; Moshfegh A; Hassan M
Article: LEUKEMIA & LYMPHOMA. 2013;54(5):996-1003

Patients with activated B-cell like diffuse large B-cell lymphoma in high and low infectious disease areas have different inflammatory gene signatures.

Högfeldt T; Bahnassy AA; Kwiecinska A; Osterborg A; Tamm KP; Porwit A; Zekri A-RN; Lundahl J; Khaled HM; Mellstedt H; Moshfegh A
Article: BONE MARROW TRANSPLANTATION. 2013;48(2):284-293

Early-phase GVHD gene expression profile in target versus non-target tissues: kidney, a possible target?

Sadeghi B; Al-Chaqmaqchi H; Al-Hashmi S; Brodin D; Hassan Z; Abedi-Valugerdi M; Moshfegh A; Hassan M
Article: CELL DEATH & DISEASE. 2013;4(1):e454

Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412.

Ståhl S; Kaminskyy VO; Efazat G; Hyrslova Vaculova A; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B
Article: PLOS ONE. 2013;8(4):e60367

The role of programmed cell death ligand-1 (PD-L1/CD274) in the development of graft versus host disease.

Al-Chaqmaqchi H; Sadeghi B; Abedi-Valugerdi M; Al-Hashmi S; Fares M; Kuiper R; Lundahl J; Hassan M; Moshfegh A
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2013;62(1):51-63

T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile.

Kiaii S; Kokhaei P; Mozaffari F; Rossmann E; Pak F; Moshfegh A; Palma M; Hansson L; Mashayekhi K; Hojjat-Farsangi M; Österborg A; Choudhury A; Mellstedt H
Article: PLOS ONE. 2013;8(10):e78339

The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells.

Hojjat-Farsangi M; Khan AS; Daneshmanesh AH; Moshfegh A; Sandin A; Mansouri L; Palma M; Lundin J; Österborg A; Mellstedt H
Article: PLOS ONE. 2013;8(8):e73141

Leukocyte proliferation and immune modulator production in patients with chronic kidney disease.

Mansouri L; Paulsson JM; Moshfegh A; Jacobson SH; Lundahl J
Article: PLOS ONE. 2013;8(7):e68937

Activation of Wnt/β-catenin pathway in monocytes derived from chronic kidney disease patients.

Al-Chaqmaqchi HAM; Moshfegh A; Dadfar E; Paulsson J; Hassan M; Jacobson SH; Lundahl J
Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(29):3633-3639

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer.

Lehmann S; Bykov VJN; Ali D; Andrén O; Cherif H; Tidefelt U; Uggla B; Yachnin J; Juliusson G; Moshfegh A; Paul C; Wiman KG; Andersson P-O
Article: BRITISH JOURNAL OF CANCER. 2012;107(8):1361-1373

miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence.

Salim H; Akbar NS; Zong D; Vaculova AH; Lewensohn R; Moshfegh A; Viktorsson K; Zhivotovsky B
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;168(1):105-112

In-vivo extravasation induces the expression of interleukin 1 receptor type 1 in human neutrophils.

Paulsson JM; Moshfegh A; Dadfar E; Held C; Jacobson SH; Lundahl J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):156-161

The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells.

Karim H; Hashemi J; Larsson C; Moshfegh A; Fotoohi AK; Albertioni F
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2011;26(7):2195-2201

Expression of neutrophil SOD2 is reduced after lipopolysaccharide stimulation: a potential cause of neutrophil dysfunction in chronic kidney disease.

Olsson J; Jacobson TAS; Paulsson JM; Dadfar E; Moshfegh A; Jacobson SH; Lundahl J
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(4):1075-1081

Gene expression analysis using long-term preserved formalin-fixed and paraffin-embedded tissue of non-small cell lung cancer.

Jacobson TAS; Lundahl J; Mellstedt H; Moshfegh A
Article: ONCOGENE. 2010;29(9):1329-1338

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.

Lambert JMR; Moshfegh A; Hainaut P; Wiman KG; Bykov VJN
Article: BIOCHEMICAL PHARMACOLOGY. 2009;77(8):1410-1417

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.

Fotoohi AK; Assaraf YG; Moshfegh A; Hashemi J; Jansen G; Peters GJ; Larsson C; Albertioni F
Article: BLOOD PURIFICATION. 2009;28(1):47-52

Monocyte and neutrophil chemotactic activity at the site of interstitial inflammation in patients on high-flux hemodialysis or hemodiafiltration.

Olsson J; Paulsson J; Dadfar E; Lundahl J; Moshfegh A; Jacobson SH
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2007;18(8):643-651

The stress of birth enhances in vitro spontaneous and IL-8-induced neutrophil chemotaxis in the human newborn.

Yektaei-Karin E; Moshfegh A; Lundahl J; Berggren V; Hansson L-O; Marchini G
Article: CLINICAL CANCER RESEARCH. 2007;13(5):1503-1510

Long-term idiotype vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients.

Hansson L; Abdalla AO; Moshfegh A; Choudhury A; Rabbani H; Nilsson B; Osterborg A; Mellstedt H
Article: KIDNEY INTERNATIONAL. 2007;71(6):582-588

Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration.

Olsson J; Dadfar E; Paulsson J; Lundahl J; Moshfegh A; Jacobson SH
Article: BIOCHEMICAL PHARMACOLOGY. 2006;72(7):816-823

Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.

Fotoohi AK; Wrabel A; Moshfegh A; Peterson C; Albertioni F
Article: PEDIATRIC RESEARCH. 2005;58(1):138-142

Neonatal eosinophils possess efficient Eotaxin/IL-5- and N-formyl-methionyl-leucyl-phenylalanine-induced transmigration in vitro.

Moshfegh A; Lothian C; Halldén G; Marchini G; Lagercrantz H; Lundahl J
Article: LEUKEMIA. 2004;18(11):1810-1815

Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL.

Kokhaei P; Choudhury A; Mahdian R; Lundin J; Moshfegh A; Osterborg A; Mellstedt H
Article: EUROPEAN RESPIRATORY JOURNAL. 2003;21(4):646-651

Lung accumulations of eosinophil granulocytes after exposure to cornstarch glove powder.

Grunewald J; Eklund A; Katchar K; Moshfegh A; Lidén C; Lundgren L; Skare L; Tornling G
Article: ALLERGY. 2002;57(12):1200-1204

Increased eosinophil transmigration after nasal allergen challenge in children with allergic asthma and rhinitis.

Lönnkvist K; Moshfegh A; Pedroletti C; Hedlin G; Halldén G; Lundahl J
Article: NEPHRON. 2002;91(4):659-665

Impact of hemodialysis membrane and permeability on neutrophil transmigration in vitro.

Moshfegh A; Jacobson SH; Halldén G; Thylén P; Lundahl J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;56(2):161-167

Distinct phenotypic adhesion molecule expression on human cord blood progenitors during early Eosinophilic commitment: upregulation of beta(7) integrins.

Lundahl J; Sehmi R; Moshfegh A; Hayes L; Howie K; Upham J; Denburg JA
Article: INFLAMMATION. 2001;25(6):399-404

Increased expression of CD25 and HLA-DR on lymphocytes recruited into the peritoneal cavity in non-infected CAPD patients.

Brauner A; Hylander B; Jacobson SH; Moshfegh A; Lundahl J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1999;50(3):262-269

Methods for simultaneous quantitative analysis of eosinophil and neutrophil adhesion and transmigration.

Moshfegh A; Halldé n G; Lundahl J
Article: INFLAMMATION. 1998;22(2):123-135

Eotaxin increases the expression of CD11b/CD18 and adhesion properties in IL5, but not fMLP-prestimulated human peripheral blood eosinophils.

Lundahl J; Moshfegh A; Grönneberg R; Halldén G
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Meeting abstract: ANNALS OF ONCOLOGY. 2016;27:vi530

First generation of a small chemical molecule ROR1 RTK tyrosine kinase inhibitor

Mellstedt H; Hojjat-Farsangi M; Daneshmanesh AH; Moshfegh A; Bystrom S; Norin M; Olin T; Schultz J; Vagberg J; Osterborg A
Meeting abstract: BLOOD. 2015;126(23):2912

First-in-Class ROR1 Small Molecule Inhibitor (KAN0439834) Downregulated Wnt-Canonical and Non-Canonical Signaling Pathways and Induced Apoptosis of CLL Cells

Hojjat-Farsangi M; Moshfegh A; Daneshmanesh AH; Vagberg J; Styrbjorn B; Schultz J; Olsson E; Lofberg C; Norstrom C; Norin M; Olin T; Osterborg A; Mellstedt H
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2015;169(3):455-458

The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies.

Daneshmanesh AH; Hojjat-Farsangi M; Moshfegh A; Khan AS; Mikaelsson E; Österborg A; Mellstedt H
Review: SEMINARS IN CANCER BIOLOGY. 2014;29:21-31

The receptor tyrosine kinase ROR1--an oncofetal antigen for targeted cancer therapy.

Hojjat-Farsangi M; Moshfegh A; Daneshmanesh AH; Khan AS; Mikaelsson E; Osterborg A; Mellstedt H
Meeting abstract: CANCER RESEARCH. 2014;74(19):4770

Anti-ROR1 monoclonal antibodies induce apoptosis in pancreatic cancer cells via the PI3-kinase/AKT/mTOR pathway

Daneshmanesh AH; Hojjat-Farsangi M; Moshfegh A; Mikaelsson E; Khan AS; Osterborg A; Mellstedt H
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2014;32(15):e13561

A new class of compound for pancreatic carcinoma targeting the tyrosine kinase receptor (TKR) ROR1.

Mellstedt H; Daneshmanesh AH; Moshfegh A; Farsangl MH; Khan S; Mlkaelsson E; Vagberg J; Systrom S; Schultz J; Olin T; Ostorborg A
Meeting abstract: BLOOD. 2012;120(21):4583

Dishevelled Proteins of Wnt Signaling Pathways Are Highly Expressed in Chronic Lymphocytic Leukemia

Khan AS; Sandin A; Osterborg A; Hojjat-Farsangi M; Mellstedt H; Moshfegh A
Meeting abstract: BLOOD. 2012;120(21):1769

Monoclonal Antibody Against ROR1 in Chronic Lymphocytic Leukemia Cells Induced Apoptosis Via PI3-Kinase/AKT/CREB Pathway

Daneshmanesh AH; Hojjat-Farsangi M; Sandin A; Khan AS; Moshfegh A; Jeddi-Tehrani M; Osterborg A; Mellstedt H
Meeting abstract: CANCER RESEARCH. 2012;72:3027

Dishevelled proteins are highly upregulated in chronic lymphocytic leukemia

Khan AS; Osterborg A; Moshfegh A; Mellstedt H
Meeting abstract: CANCER RESEARCH. 2011;71:5011

Difference in expression of STAT3 and STAT5b in Swedish and Egyptian patients with activated b-cell subtype of diffuse large b-cell lymphoma

Jacobson T; Bahnassy AA; Lundahl J; Tamm KP; Porwit A; Zekri A-RN; Khaled HM; Mellstedt H; Moshfegh A
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2010;11(2):100-101

NEUTROPHIL IL-1R AND CHEMOKINE EXPRESSION FOLLOWING IN VIVO EXTRAVASATION IN PATIENTS WITH CORONARY ARTERY DISEASE

Paulsson J; Moshfegh A; Dadfar E; Bygden-Nylander A; Held C; Jacobson S; Lundahl J
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):134

Global gene analysis reveals ephrin B3 as a potential radio sensitizing target in non small cell lung cancer cells

Stahl S; Vaculova A; Kaminskyy V; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B

Employments

Senior Research Specialist, Department of Oncology-Pathology, Karolinska Institutet, 2022-

Degrees and Education

Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2002
Licentiate Degree, DEPT OF LABORATORY MEDICINE, Karolinska Institutet, 1999

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