My main interests lie in investigating early risk factors for childhood and adult diseases, that is risk factors in a life course perspective. My academic home is the Department of Medical Epidemiology and Biostatistics where I am an associate professor.
Developmental origins of adult disease
The developmental origins of adult disease states that adaptations to adverse conditions during any critical window of the prenatal development can have detrimental effects on structure, physiology and metabolism of the individual. In a twin setting we are able to investigate aspect of the developmental origins of adult disease on a range of outcomes and investigate whether the found associations are confounded by familial factors.
Maternal smoking during pregnancy
The early adverse effects of maternal smoking during pregnancy, such as sudden infant death, low birth weight and miscarriage are widely known and well-studied. However, the long term effects of maternal smoking during pregnancy are just being investigated. With novel approaches, looking at the association between maternal smoking during pregnancy and adult disease in related individuals of various degrees we can estimate whether familial factors are of importance for these associations.
Assisted reproductive techniques
The growing use of Assisted Reproductive Techniques (ART) is both due to male infertility being now treatable and due to women choosing to delay childbearing, thereby decreasing their chances of conceiving spontaneously. In high income countries ART stands for 1-4% of all conceptions. Sweden is ranked 5th in Europe with almost 3.6% of all conceptions attributed to ART. Further, little is known about the short and long term effects of these procedures on offspring health during their lifespan.
We have collect information on all ART attempts during 2 years from both private and public clinics in Uppsala and Stockholm County (The UppStART study), and prospectively followed up ART children from pre-conception. Follow the link to read more about the UppStART study.
In parallel we are investigating the health and behaviors of IVF twins compared to non-IVF twins in the CATSS study.
Urinary incontinence is often associated with severe implications on daily function, social interactions, sexuality and psychological wellbeing. At present, most research is oriented towards the development of new alleviating treatment options with relatively little attention paid to the etiology of disease and prevention measures. It is essential to find risk factors for urinary incontinence that could be used as sensible predictors and hence be linked to pathophysiological mechanisms.
Current doctoral students
- Sven Sandin
- Gerasimos Tzortsatos
Previous doctoral students
As a researcher within assisted reproductive techniques (ART) I was also intrigued by research articles mentioning the importance of telling IVF children in an early age about their origin. Talking about ART is not as taboo nowadays as it was 10 years back. But how do we talk to our children about ART? The product of my thoughts became a children's book on IVF. Together with a very good friend and illustrator of the book, Camilla McConnell, we produced this lovely book for children aged 2-6 years. For more information contact us at: email@example.com
- 2009 Associate Professor (Docent)
- 2003 PhD in Epidemiology, Karolinska Institutet
- 1998 MSc in Mathematics, Stockholm University