Antonio Checa Gómez

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About me

Analytical chemist with over a decade of LC-MS based small metabolomics experience a focus on biomedical projects and analysis of large clinical cohorts.

At the Small Molecule Mass Spectrometry core facility, we bring to the table over a decade of experience in LC-MS based small metabolomics. Our expertise particularly focuses in biomedical projects, from basic research pre-clinical cell models to the analysis of extensive clinical cohorts.

Our core facility is dedicated to the development and application of liquid chromatography-mass spectrometry methods for small molecule analysis within a biomedical context. However, our support extends beyond mere analytical assistance. We also provide expert guidance in experimental design and data interpretation for metabolomic studies.

Research

Mass Spectrometry

Metabolomics

Immune mediated diseases

Sphingolipids

Articles

Article: ELIFE. 2022;11:e78861

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis.

Kuo A; Checa A; Niaudet C; Jung B; Fu Z; Wheelock CE; Singh SA; Aikawa M; Smith LE; Proia RL; Hla T
Article: EBIOMEDICINE. 2022;83:104236

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

Sevelsted A; Gürdeniz G; Rago D; Pedersen C-ET; Lasky-Su JA; Checa A; Zhang P; Wheelock CE; Normann SS; Kristensen DM; Rasmussen MA; Schullehner J; Sdougkou K; Martin JW; Stokholm J; Bønnelykke K; Bisgaard H; Chawes B
Article: SCIENTIFIC REPORTS. 2022;12(1):6317

Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767).

Koutsouveli V; Balgoma D; Checa A; Hedeland M; Riesgo A; Cárdenas P
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2021;77(20):2494-2513

Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease.

Akawi N; Checa A; Antonopoulos AS; Akoumianakis I; Daskalaki E; Kotanidis CP; Kondo H; Lee K; Yesilyurt D; Badi I; Polkinghorne M; Akbar N; Lundgren J; Chuaiphichai S; Choudhury R; Neubauer S; Channon KM; Torekov SS; Wheelock CE; Antoniades C
Article: JOURNAL OF HEPATOLOGY. 2020;73(4):817-828

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis.

López-Vicario C; Checa A; Urdangarin A; Aguilar F; Alcaraz-Quiles J; Caraceni P; Amorós A; Pavesi M; Gómez-Cabrero D; Trebicka J; Oettl K; Moreau R; Planell N; Arroyo V; Wheelock CE; Clària J
Article: NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2020;98:33-40

"Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury".

Heredia Martinez A; Rosa Diez G; Ferraris V; Coccia PA; Ferraris JR; Checa A; Wheelock CE; Lundberg JO; Weitzberg E; Carlström M; Krmar RT
Article: CELL METABOLISM. 2020;31(2):375-390.e11

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue.

Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Rydén M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2019;317(3):F529-F539

Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients.

Mortensen LA; Bistrup C; Stubbe J; Carlström M; Checa A; Wheelock CE; Palarasah Y; Bladbjerg EM; Thiesson HC; Jensen BL
Article: NATURE COMMUNICATIONS. 2019;10(1):3081

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes.

Carlström KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.

Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Rönnelid J; Oke V; Grosso G; Kvarnström M; Larsson A; Wheelock CE; Syvänen A-C; Rönnblom L; Kultima K; Persson H; Gräslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:636

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.

Bergqvist F; Ossipova E; Idborg H; Raouf J; Checa A; Englund K; Englund P; Khoonsari PE; Kultima K; Wheelock CE; Larsson K; Korotkova M; Jakobsson P-J
Article: ANALYTICA CHIMICA ACTA. 2018;1037:338-350

The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability.

Daskalaki E; Pillon NJ; Krook A; Wheelock CE; Checa A
Article: RESPIRATORY RESEARCH. 2018;19(1):236

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study.

Sjödin MOD; Checa A; Yang M; Dahlén S-E; Wheelock ÅM; Eklund A; Grunewald J; Wheelock CE
Article: CIRCULATION. 2018;138(16):1693-1705

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.

Laguna-Fernandez A; Checa A; Carracedo M; Artiach G; Petri MH; Baumgartner R; Forteza MJ; Jiang X; Andonova T; Walker ME; Dalli J; Arnardottir H; Gisterå A; Thul S; Wheelock CE; Paulsson-Berne G; Ketelhuth DFJ; Hansson GK; Bäck M
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):388-398

Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy.

Mahdi A; Kövamees O; Checa A; Wheelock CE; von Heijne M; Alvarsson M; Pernow J
Article: PEDIATRIC NEPHROLOGY. 2018;33(4):639-649

Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children.

Al-Mashhadi A; Checa A; Wåhlin N; Neveus T; Fossum M; Wheelock CE; Karanikas B; Stenberg A; Persson AEG; Carlstrom M
Article: JOURNAL OF PROTEOME RESEARCH. 2018;17(2):870-878

Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics.

Kamleh MA; McLeod O; Checa A; Baldassarre D; Veglia F; Gertow K; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Silveira A; Örvik J; Hamsten A; Wheelock CE
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2018;103(2):710-721

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.

Petrus P; Bialesova L; Checa A; Kerr A; Naz S; Bäckdahl J; Gracia A; Toft S; Dahlman-Wright K; Hedén P; Dahlman I; Wheelock CE; Arner P; Mejhert N; Gao H; Rydén M
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2275-2288

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA; Heckert A; Ulmer CZ; Jones CM; Koelmel JP; Abdullah L; Ahonen L; Alnouti Y; Armando AM; Asara JM; Bamba T; Barr JR; Bergquist J; Borchers CH; Brandsma J; Breitkopf SB; Cajka T; Cazenave-Gassiot A; Checa A; Cinel MA; Colas RA; Cremers S; Dennis EA; Evans JE; Fauland A; Fiehn O; Gardner MS; Garrett TJ; Gotlinger KH; Han J; Huang Y; Neo AH; Hyötyläinen T; Izumi Y; Jiang H; Jiang H; Jiang J; Kachman M; Kiyonami R; Klavins K; Klose C; Köfeler HC; Kolmert J; Koal T; Koster G; Kuklenyik Z; Kurland IJ; Leadley M; Lin K; Maddipati KR; McDougall D; Meikle PJ; Mellett NA; Monnin C; Moseley MA; Nandakumar R; Oresic M; Patterson R; Peake D; Pierce JS; Post M; Postle AD; Pugh R; Qiu Y; Quehenberger O; Ramrup P; Rees J; Rembiesa B; Reynaud D; Roth MR; Sales S; Schuhmann K; Schwartzman ML; Serhan CN; Shevchenko A; Somerville SE; St John-Williams L; Surma MA; Takeda H; Thakare R; Thompson JW; Torta F; Triebl A; Trötzmüller M; Ubhayasekera SJK; Vuckovic D; Weir JM; Welti R; Wenk MR; Wheelock CE; Yao L; Yuan M; Zhao XH; Zhou S
Article: LUPUS. 2017;26(10):1023-1033

Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.

Checa A; Idborg H; Zandian A; Sar DG; Surowiec I; Trygg J; Svenungsson E; Jakobsson P-J; Nilsson P; Gunnarsson I; Wheelock CE
Article: REDOX BIOLOGY. 2017;11:205-212

New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia.

González-Peña D; Checa A; de Ancos B; Wheelock CE; Sánchez-Moreno C
Article: EUROPEAN RESPIRATORY JOURNAL. 2017;49(3):1601740

Metabolomics analysis identifies different metabotypes of asthma severity.

Reinke SN; Gallart-Ayala H; Gómez C; Checa A; Fauland A; Naz S; Kamleh MA; Djukanović R; Hinks TSC; Wheelock CE
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(11):3952-3958

Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus.

Kövamees O; Shemyakin A; Checa A; Wheelock CE; Lundberg JO; Östenson C-G; Pernow J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;99:87-98

Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.

Hezel M; Peleli M; Liu M; Zollbrecht C; Jensen BL; Checa A; Giulietti A; Wheelock CE; Lundberg JO; Weitzberg E; Carlström M
Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.

Paquin-Proulx D; Gibbs A; Bächle SM; Checa A; Introini A; Leeansyah E; Wheelock CE; Nixon DF; Broliden K; Tjernlund A; Moll M; Sandberg JK
Article: NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2016;58:1-9

Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.

Carlström M; Cananau C; Checa A; Wide K; Sartz L; Svensson A; Wheelock CE; Westphal S; Békássy Z; Bárány P; Lundberg JO; Hansson S; Weitzberg E; Krmar RT
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(7):e003868

Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.

Yang T; Zollbrecht C; Winerdal ME; Zhuge Z; Zhang X-M; Terrando N; Checa A; Sällström J; Wheelock CE; Winqvist O; Harris RA; Larsson E; Persson AEG; Fredholm BB; Carlström M
Article: JOURNAL OF THE INSTITUTE OF BREWING. 2016;122(3):430-436

Ultra-high-performance liquid chromatography-high-resolution mass spectrometry based metabolomics as a strategy for beer characterization

Gallart-Ayala H; Anas Kamleh M; Hernandez-Cassou S; Saurina J; Checa A
Article: JOURNAL OF CHROMATOGRAPHY A. 2016;1433:90-97

Told through the wine: A liquid chromatography-mass spectrometry interplatform comparison reveals the influence of the global approach on the final annotated metabolites in non-targeted metabolomics.

Díaz R; Gallart-Ayala H; Sancho JV; Nuñez O; Zamora T; Martins CPB; Hernández F; Hernández-Cassou S; Saurina J; Checa A
Article: SCIENTIFIC REPORTS. 2015;5:15740

Lipid mediator profile in vernix caseosa reflects skin barrier development.

Checa A; Holm T; Sjödin MOD; Reinke SN; Alm J; Scheynius A; Wheelock CE
Article: MULTIPLE SCLEROSIS JOURNAL. 2015;21(10):1271-1279

Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis.

Checa A; Khademi M; Sar DG; Haeggström JZ; Lundberg JO; Piehl F; Olsson T; Wheelock CE
Article: REDOX BIOLOGY. 2015;5:234-242

Effects of long-term dietary nitrate supplementation in mice.

Hezel MP; Liu M; Schiffer TA; Larsen FJ; Checa A; Wheelock CE; Carlström M; Lundberg JO; Weitzberg E
Article: ANALYTICA CHIMICA ACTA. 2015;885:1-16

Lipidomic data analysis: tutorial, practical guidelines and applications.

Checa A; Bedia C; Jaumot J
Article: SCIENTIFIC REPORTS. 2015;5:12017

Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment.

Checa A; Xu N; Sar DG; Haeggström JZ; Ståhle M; Wheelock CE
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2014;99(4):843-850

Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans.

Larsen FJ; Schiffer TA; Ekblom B; Mattsson MP; Checa A; Wheelock CE; Nyström T; Lundberg JO; Weitzberg E
Article: FOOD CHEMISTRY. 2012;135(3):1425-1431

Classification and characterisation of Spanish red wines according to their appellation of origin based on chromatographic profiles and chemometric data analysis.

Serrano-Lourido D; Saurina J; Hernández-Cassou S; Checa A
Article: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2012;60(34):8340-8349

Determination of polyphenols in Spanish wines by capillary zone electrophoresis. Application to wine characterization by using chemometrics.

Franquet-Griell H; Checa A; Núñez O; Saurina J; Hernández-Cassou S; Puignou L
Article: ANALYTICA CHIMICA ACTA. 2012;722:34-42

Combination of chromatographic and chemometric methods to study the interactions between DNA strands.

Ruiz-Castelar S; Checa A; Gargallo R; Jaumot J
Article: JOURNAL OF SEPARATION SCIENCE. 2011;34(5):527-535

Determination of polyphenols in wines by liquid chromatography with UV spectrophotometric detection.

Aznar O; Checa A; Oliver R; Hernández-Cassou S; Saurina J
Article: ANALYTICA CHIMICA ACTA. 2008;616(1):85-94

Reversed-phase liquid chromatographic method with spectrophotometric detection for the determination of antiretroviral drugs.

Checa A; Oliver R; Hernández-Cassou S; Saurina J
Article: ANALYTICA CHIMICA ACTA. 2007;592(2):173-180

Flow-injection determination of zidovudine in plasma samples using multivariate curve resolution.

Checa A; Oliver R; Hernández-Cassou S; Saurina J
Article: ANALYTICA CHIMICA ACTA. 2006;572(1):155-164

Flow-injection spectrophotometric determination of reverse transcriptase inhibitors used for acquired immuno deficiency syndrome (AIDS) treatment: focus on strategies for dealing with the background components.

Checa A; Oliver R; Saurina J; Hernández-Cassou S
Article: ANALYTICA CHIMICA ACTA. 2005;554(1-2):177-183

Fast determination of pK_a values of reverse transcriptase inhibitor drugs for AIDS treatment by using pH-gradient flow-injection analysis and multivariate curve resolution

Checa A; Soto VG; Hernández-Cassou S; Saurina J
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Published conference paper: SCIENCE OF THE TOTAL ENVIRONMENT. 2018;644:1101-1109

Effect of psychiatric drugs on Daphnia magna oxylipin profiles.

Garreta-Lara E; Checa A; Fuchs D; Tauler R; Lacorte S; Wheelock CE; Barata C
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Erhardt S; Wheelock CE
Book chapter: DATA ANALYSIS FOR OMIC SCIENCES: METHODS AND APPLICATIONS: COMPREHENSIVE ANALYTICAL CHEMISTRY. 2018;p. 613-641

Data Analysis in Transcriptomics and Metabolomics Clinical Applications

Gallart-Ayala H; Fernández-Navarro J; Checa A
Review: MOLECULAR NUTRITION & FOOD RESEARCH. 2013;57(8):1359-1377

Quantitative metabolic profiling of lipid mediators.

Balgoma D; Checa A; Sar DG; Snowden S; Wheelock CE
Book chapter: FOOD PROTECTED DESIGNATION OF ORIGIN - METHODOLOGIES AND APPLICATIONS: COMPREHENSIVE ANALYTICAL CHEMISTRY. 2013;p. 123-143

Metabolomics and PDO

Checa A; Saurina J
Review: ANALYTICA CHIMICA ACTA. 2009;647(1):1-13

Determination of HIV drugs in biological matrices: a review.

Checa A; Oliver R; Hernández-Cassou S; Saurina J

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