I work at the interface between laboratory and clinic, in collaboration with the pharmaceutical industry, to streamline the use of human tissue-based models of disease in pre-clinical drug screening.
The goal of my research is to devise patient-derived cell assays in inflammatory bowel disease. Using highly selective and potent protein inhibitors provided by the SGC Open-Source Target Discovery Partnership, in conjunction with deep molecular patient characterization, we aim at identifying novel therapeutic targets and biomarkers. We believe that our approach will contribute to fulfill the promise of personalized medicine and accelerate early drug discovery through open access research.
2018-present Project leader, SGC at Karolinska Institutet
Human tissue assays, patient-derived cell assays for target identification in inflammatory bowel disease
2013-2017 Postdoc, Karolinska Institutet
Study of the early immunologic events surrounding human reproduction and HIV-1 transmission to the female genital mucosa in human tissue explants
2010-2013 Doctoral student, National Institutes of Health (NIH)
Study of the pathogenesis of HIV-1 infection in lymphoid and mucosal human tissue explants for mechanistic and drug efficacy analysis
2010-2013 Ph.D. in Molecular Medicine - University of Milan, Milan, Italy
Pre-doctoral Visiting Fellow at the National Institutes of Health, Bethesda MD, USA (Graduate Partnership Program)