Andrea Del Valle

About me

I am a diligent scientist with experience delivering development projects to GMP manufacturing.  Research Orientation: Nanotechnology research and pharmaceutical drug development for further application in cancer therapy/ metabolic diseases and its translation to the industry.

Research description

--- Original, peer-reviewed papers ---

1. Fernández Moro, C., Geyer, N., Harrizi, S. et al. An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver. Nat Commun 14, 5024 (2023). 

2. Bonilla, K.,  Romero-Oliva, C. S., Arrechea, S., Ortíz, N., Mazariegos, S., Alonzo, M., Orellana-Corrales, G., and del Valle, A.C. Engaging the Guatemala Scientific Diaspora: The power of networking and shared learning, Front. Res. Metr. 

3. del Valle, A. C., Yeh, C.‐K., Huang, Y.‐F., Near Infrared‐Activatable Platinum‐Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance, Adv. Healthcare Mater. 2020, 9, 2000864. (IF = 11.02, Q1) (Selected as a Cover Page) First Author.

4. del Valle, A. C., Su C.-K., Sun Y.-C., Huang Y.-F., NIR-cleavable drug adducts of gold nanostars for overcoming multidrug-resistant tumors, Biomater. Sci. 8 (7), 1934-1950. (IF=6.84, Q1) First Author.

5. Chang Y.-C., del Valle A. C., Yeh, H.-P., He, Y., Huang, Y.-F., Development of photo-activated ROS-responsive nanoplatform as a dual-functional drug carrier in combinational chemo-photodynamic therapy, Front Chem. 2019;6:647. (IF = 4.62, Q2). 

6. Yeh, H.-P., del Valle, A. C., Syu, M.-C., Qian, Y., Chang, Y.-C., Huang, Y.-F., A new photosensitized oxidation-responsive nanoplatform for controlled drug release and photodynamic cancer therapy, ACS Appl. Mater. Interfaces 2018, 10(25) (IF = 10.38, Q1) First Author.

7. Yue, H, del Valle, A. C., Qian, Y., Huang, Y.-F., Near infrared light-mediated enhancement of reactive oxygen species generation through electron transfer from graphene oxide to iron hydroxide/oxide, Nanoscale, 2017,9, 1559-1566. (IF =8.3, Q1).

8. Su, C.-K., Tseng, P.-J., Chiu, H.-T., del Valle, A. C., Huang, Y.-F., Sun Y.-C., Sequential enzymatic derivatization coupled with online microdialysis sampling for simultaneous profiling of mouse tumor extracellular hydrogen peroxide, lactate, and glucose, Analytica Chimica Acta 2016. 956. (IF= 5.99, Q1, 4/74).

9. Su, C.-K., Tseng, P.-J., Lin, M.-H., Chiu, H.-T., del Valle, A. C., Huang Y.-F., Sun Y.-C., Online open-tubular fractionation scheme coupled with push-pull perfusion sampling for profiling extravasation of gold nanoparticles in a mouse tumor model, J. Chromatogr. A, 2015, 1402. (IF= 3.810, Q1, 17 / 119).

10. Lin, K.-C., del Valle, C., Huang, Y.-F. Synthesis of gold@ iron oxide core-shell nanostructures via an electrochemical procedure, ECS Transactions 2014, 64, 77-81. 

 

--- Book Chapters ---

1. Yue, H, del Valle, A. C., Huang, Y.-F., Cell-Specific Aptamers for Targeted Therapy, Book chapter, 1st ed. Springer, 2015. (Editors: Weihong Tan and Xiaohong Fang)

--- Other Comments and Correspondence ---

1. del Valle, A.C. Latino scientists need professional incentives to return home, Correspondence, Nature 613, 437 (2023)

2. del Valle, A.C. Finding my way home, Science, (2023)

--- Preprint and submitted manuscripts ---

1. del Valle A. C., Wua J.-J., Huang Y.-F. Targeting Cellular Membrane Fluidity via GSH Depleting Polyflavonoid-based  Nanoparticles Suppresses Triple-Negative Breast Cancer Growth and Metastasis (submitted to peer review) First Author

2. Wu, J.-J., Chan, K.-M., He, X.-Q., del Valle, A.C., Chiu, H.-C., and Huang, Y.-F. Dopamine-Derived Carbonized Polymer Dots for Effective Anticancer and Anti-metastatic Therapy against Triple-Negative Breast Cancer. (submitted to peer review)

Education

Scientific Development:

- 2023-Present: Post-Doctoral Researcher, Karolinska Institutet, Sweden, KIRI grant postdoctoral fellow for developing nanotherapeutics in the dysfunctional placenta. 

- 2021-2023: Post-Doctoral Studies, Karolinska Institutet, Sweden, studies centered on the invasion growth patterns of cancer liver metastases. 

- 2020-2021: Researcher, National Tsing Hua University, Taiwan (drug development within a Taiwanese national initiative, responsible for wet-lab drug development and data presentation/marketing)

- 2014-2020: Ph.D. studies, Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan. Thesis Topic: “Photo-Responsive Metal-Based Nanoparticles for Treatment of Multidrug-resistant Tumors”

- 2016 - 2018: Professional Certificate in Genetics and Genomics, Stanford University, USA

- 2010 – 2014: B.S. Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan

Extracurricular Activities:

-2022-Present: Secretary of the Swedish Network of Postdoc Association (SNPA), Sweden

-2020-Present: Active Member of Organization for Women in Science for the Developing World (OWSD) Guatemala. Profile

-2022-2023: Chair of Karolinska Institutet Postdoctorate Association (KIPA), Sweden. 

- 2015-2018: Coordinator and Educator, Advanced Level Biology, Hsinchu International School, Taiwan (organizing laboratory visits, science fairs, and early career symposia)

- 2014-2016: Teaching Assistant, Biochemistry, National Tsing Hua University, Taiwan

Academic honours, awards and prizes

2022: KI Innovations Start project. 

2019: Outstanding Student Oral Presentation Award. IADDS-BCRS meeting.

2017: Outstanding oral presentation award, isCEBT meeting, Tohoku University, Sendai, Japan

2015: Outstanding Poster Award, International Symposium on chemical and polyscale technologies. Taipei, Taiwan

2014-2018: National TsingHua University International Ph.D. Student Scholarship

2014: Taiwan’s Government Academic Award

2014: Chapin Forte Award for scientific discoveries, Donovan Werke Pharmaceuticals, Guatemala

2009-2014: Taiwan Scholarship Award