Andrey Kleshchev

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About me

My scientific name is *Andrei Kleschyov*.
I work on emerging /NO-heme-entity/ signaling pathway.

Articles

Article: REDOX BIOLOGY. 2023;60:102612

Red blood cells from endothelial nitric oxide synthase-deficient mice induce vascular dysfunction involving oxidative stress and endothelial arginase I.

Zhuge Z; McCann Haworth S; Nihlén C; Carvalho LRRA; Heuser SK; Kleschyov AL; Nasiell J; Cortese-Krott MM; Weitzberg E; Lundberg JO; Carlström M
Article: CIRCULATION. 2019;139(23):2654-2663

Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.

Sun C-W; Yang J; Kleschyov AL; Zhuge Z; Carlström M; Pernow J; Wajih N; Isbell TS; Oh J-Y; Cabrales P; Tsai AG; Townes T; Kim-Shapiro DB; Patel RP; Lundberg JO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(1):217-226

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.

Cordero-Herrera I; Kozyra M; Zhuge Z; McCann Haworth S; Moretti C; Peleli M; Caldeira-Dias M; Jahandideh A; Huirong H; Cruz JDC; Kleschyov AL; Montenegro MF; Ingelman-Sundberg M; Weitzberg E; Lundberg JO; Carlstrom M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2017;112:544-552

The NO-heme signaling hypothesis.

Kleschyov AL
Article: JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014;125(4):422-425

Glycyrrhetinic acid reverses the lipopolysaccharide-induced hypocontractility to noradrenaline in rat aorta: implications to septic shock.

Muller B; Aparin PG; Stoclet J-C; Kleschyov AL
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2012;58:265-271

Heparin-polynitroxides: synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants.

Kleschyov AL; Sen' V; Golubev V; Münnemann K; Hinderberger D; Lackner KJ; Weber S; Terekhov M; Schreiber LM; Münzel T
Article: BASIC RESEARCH IN CARDIOLOGY. 2011;106(6):1147-1158

Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.

Kröller-Schön S; Schulz E; Wenzel P; Kleschyov AL; Hortmann M; Torzewski M; Oelze M; Renné T; Daiber A; Münzel T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(3):560-566

α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation.

Schuhmacher S; Foretz M; Knorr M; Jansen T; Hortmann M; Wenzel P; Oelze M; Kleschyov AL; Daiber A; Keaney JF; Wegener G; Lackner K; Münzel T; Viollet B; Schulz E
Article: CHEMPHYSCHEM. 2010;11(17):3656-3663

Spin-labeled heparins as polarizing agents for dynamic nuclear polarization.

Dollmann BC; Kleschyov AL; Sen V; Golubev V; Schreiber LM; Spiess HW; Münnemann K; Hinderberger D
Article: MOLECULAR PHARMACOLOGY. 2009;75(4):886-891

Inactivation of soluble guanylate cyclase by stoichiometric S-nitrosation.

Mayer B; Kleschyov AL; Stessel H; Russwurm M; Münzel T; Koesling D; Schmidt K
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2008;326(3):745-753

Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases.

Li H; Hortmann M; Daiber A; Oelze M; Ostad MA; Schwarz PM; Xu H; Xia N; Kleschyov AL; Mang C; Warnholtz A; Münzel T; Förstermann U
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2008;51(22):2130-2138

Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation.

Jabs A; Göbel S; Wenzel P; Kleschyov AL; Hortmann M; Oelze M; Daiber A; Münzel T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(4):850-857

Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.

Torzewski M; Ochsenhirt V; Kleschyov AL; Oelze M; Daiber A; Li H; Rossmann H; Tsimikas S; Reifenberg K; Cheng F; Lehr H-A; Blankenberg S; Förstermann U; Münzel T; Lackner KJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;42(4):466-473

Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.

Deng S; Kruger A; Kleschyov AL; Kalinowski L; Daiber A; Wojnowski L
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2007;150(4):526-533

Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.

Wenzel P; Hink U; Oelze M; Seeling A; Isse T; Bruns K; Steinhoff L; Brandt M; Kleschyov AL; Schulz E; Lange K; Weiner H; Lehmann J; Lackner KJ; Kawamoto T; Münzel T; Daiber A
Article: NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2006;15(3):241-251

Mechanisms underlying dysfunction of carotid arteries in genetically hyperlipidemic rabbits.

August M; Wingerter O; Oelze M; Wenzel P; Kleschyov AL; Daiber A; Mülsch A; Münzel T; Tsilimingas N
Article: HYPERTENSION. 2006;48(4):677-684

Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.

Oelze M; Daiber A; Brandes RP; Hortmann M; Wenzel P; Hink U; Schulz E; Mollnau H; von Sandersleben A; Kleschyov AL; Mülsch A; Li H; Förstermann U; Münzel T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2006;26(8):1753-1759

NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice.

Oelze M; Warnholtz A; Faulhaber J; Wenzel P; Kleschyov AL; Coldewey M; Hink U; Pongs O; Fleming I; Wassmann S; Meinertz T; Ehmke H; Daiber A; Münzel T
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2006;40(8):1340-1348

Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2.

Kleschyov AL; Strand S; Schmitt S; Gottfried D; Skatchkov M; Sjakste N; Daiber A; Umansky V; Munzel T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(12):2554-2559

Mechanisms of increased vascular superoxide production in an experimental model of idiopathic dilated cardiomyopathy.

Mollnau H; Oelze M; August M; Wendt M; Daiber A; Schulz E; Baldus S; Kleschyov AL; Materne A; Wenzel P; Hink U; Nickenig G; Fleming I; Münzel T
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2005;39(3):381-391

Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.

Wendt MC; Daiber A; Kleschyov AL; Mülsch A; Sydow K; Schulz E; Chen K; Keaney JF; Lassègue B; Walter U; Griendling KK; Münzel T
Article: JOURNAL OF VASCULAR RESEARCH. 2005;42(4):331-336

Role of the adventitia in the cyclic GMP-mediated relaxant effect of N-hydroxy-L-arginine in rat aorta.

Beranova P; Schott C; Chalupsky K; Kleschyov AL; Stoclet J-C; Muller B
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2005;516(3):260-267

Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.

Beranova P; Chalupsky K; Kleschyov AL; Schott C; Boucher J-L; Mansuy D; Munzel T; Muller B; Stoclet J-C
Article: MOLECULAR PHARMACOLOGY. 2004;66(6):1372-1382

Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates.

Daiber A; Oelze M; Coldewey M; Bachschmid M; Wenzel P; Sydow K; Wendt M; Kleschyov AL; Stalleicken D; Ullrich V; Mülsch A; Münzel T
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2004;495(1):67-73

Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.

Sjakste N; Kleschyov AL; Boucher J-L; Baumane L; Dzintare M; Meirena D; Sjakste J; Sydow K; Münzel T; Kalvinsh I
Article: FREE RADICAL RESEARCH. 2004;38(3):259-269

Detection of superoxide and peroxynitrite in model systems and mitochondria by the luminol analogue L-012.

Daiber A; Oelze M; August M; Wendt M; Sydow K; Wieboldt H; Kleschyov AL; Munzel T
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36(1):101-111

Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012.

Daiber A; August M; Baldus S; Wendt M; Oelze M; Sydow K; Kleschyov AL; Munzel T
Article: CIRCULATION RESEARCH. 2003;93(9):e104-e112

Does nitric oxide mediate the vasodilator activity of nitroglycerin?

Kleschyov AL; Oelze M; Daiber A; Huang Y; Mollnau H; Schulz E; Sydow K; Fichtlscherer B; Mülsch A; Münzel T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2003;23(4):615-621

Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells.

Mollnau H; Schulz E; Daiber A; Baldus S; Oelze M; August M; Wendt M; Walter U; Geiger C; Agrawal R; Kleschyov AL; Meinertz T; Münzel T
Article: CIRCULATION RESEARCH. 2002;90(4):E58-E65

Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling.

Mollnau H; Wendt M; Szöcs K; Lassègue B; Schulz E; Oelze M; Li H; Bodenschatz M; August M; Kleschyov AL; Tsilimingas N; Walter U; Förstermann U; Meinertz T; Griendling K; Münzel T
Article: BMC PHARMACOLOGY. 2002;2:3

Low molecular mass dinitrosyl nonheme-iron complexes up-regulate noradrenaline release in the rat tail artery.

Kleschyov AL; Hubert G; Munzel T; Stoclet J-C; Bucher B
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2000;529 Pt 3(Pt 3):735-745

Novel activation of non-selective cationic channels by dinitrosyl iron-thiosulfate in PC12 cells.

Giannone G; Takeda K; Kleschyov AL
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;275(2):672-677

Spin trapping of vascular nitric oxide using colloid Fe(II)-diethyldithiocarbamate.

Kleschyov AL; Mollnau H; Oelze M; Meinertz T; Huang Y; Harrison DG; Munzel T
Article: JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 1999;50(4):535-540

Endothelial no release caused by red wine polyphenols.

Stoclet JC; Kleschyov A; Andriambeloson E; Diebolt M; Andriantsitohaina R
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1999;127(8):1892-1898

Triggering role of nitric oxide in the delayed protective effect of monophosphoryl lipid A in rat heart.

György K; Muller B; Vegh A; Kleschyov AL; Stoclet JC
Article: FEBS LETTERS. 1999;455(1-2):179-182

Dinitrosyl iron complexes with thiol-containing ligands and S-nitroso-D,L-penicillamine as inductors of heat shock protein synthesis in H35 hepatoma cells.

Wiegant FA; Malyshev IY; Kleschyov AL; van Faassen E; Vanin AF
Article: EXPERT OPINION ON INVESTIGATIONAL DRUGS. 1998;7(11):1769-1779

Molecular mechanisms underlying the role of nitric oxide in the cardiovascular system.

Stoclet JC; Troncy E; Muller B; Brua C; Kleschyov AL
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1998;124(4):623-626

Role of adventitial nitric oxide in vascular hyporeactivity induced by lipopolysaccharide in rat aorta.

Kleschyov AL; Muller B; Schott C; Stoclet JC
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1998;123(6):1221-1229

Nitric oxide-related cyclic GMP-independent relaxing effect of N-acetylcysteine in lipopolysaccharide-treated rat aorta.

Muller B; Kleschyov AL; Malblanc S; Stoclet JC
Article: TRENDS IN CARDIOVASCULAR MEDICINE. 1998;8(1):14-19

Nitric Oxide and cGMP in Regulation of Arterial Tone.

Stoclet JC; Andriantsitohaina R; Kleschyov A; Muller B
Article: INFECTION AND IMMUNITY. 1997;65(6):2074-2079

Induction of nitric oxide production by polyosides from the cell walls of Streptococcus mutans OMZ 175, a gram-positive bacterium, in the rat aorta.

Martin V; Kleschyov AL; Klein JP; Beretz A
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1997;120(6):1053-1058

Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta.

Andriambeloson E; Kleschyov AL; Muller B; Beretz A; Stoclet JC; Andriantsitohaina R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1997;1334(1):51-56

Nitric oxide generation from extracellularly applied NG-hydroxy-L-arginine in LPS-activated RAW 264 macrophages.

Vetrovsky P; Kleschyov AL; Entlicher G; Poindron P; Stoclet JC
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1996;119(6):1281-1285

Evidence for N-acetylcysteine-sensitive nitric oxide storage as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta.

Muller B; Kleschyov AL; Stoclet JC
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Editorial comment: BIOANALYSIS. 2013;5(18):2233-2237

Electron paramagnetic resonance in a biomedical laboratory.

Kleschyov AL; Terekhov M
Editorial comment: FUTURE MEDICINAL CHEMISTRY. 2013;5(4):385-388

Heparin-polynitroxide derivatives: a platform for new diagnostic and therapeutic agents in cardiovascular disease?

Kleschyov AL; Sen' VD
Meeting abstract: NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2008;19:30

Inhibition of CD98-associated amino acid transporters by dinitrosyl iron complexes

Kleschyov AL; Rotmann A; Simon A; Habermeier A; Rupp J; Nawrath H; Munzel T; Class EI
Review: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2007;851(1-2):12-20

Electron paramagnetic resonance (EPR) spin trapping of biological nitric oxide.

Kleschyov AL; Wenzel P; Munzel T
Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2002;22(11):1761-1768

Detection of superoxide in vascular tissue.

Münzel T; Afanas'ev IB; Kleschyov AL; Harrison DG
Editorial comment: CIRCULATION. 2002;106(2):170-172

Mechanisms underlying nitroglycerin-induced superoxide production in platelets: some insight, more questions.

Münzel T; Mülsch A; Kleschyov A
Letter: CIRCULATION. 2002;105(25):e196

Heme oxygenase-1-mediated protection: potential role of nonheme iron-nitric oxide complexes.

Kleschyov AL; Wendt M; Munzel T
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2002;962:131-139

Nitric oxide transport and storage in the cardiovascular system.

Muller B; Kleschyov AL; Alencar JL; Vanin A; Stoclet J-C
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2002;359:42-51

Advanced spin trapping of vascular nitric oxide using colloid iron diethyldithiocarbamate.

Kleschyov AL; Münzel T
Corrigendum: JOURNAL OF PHYSIOLOGY-LONDON. 2001;530(3):575

Novel activation of non-selective cationic channels by dinitrosyl iron-thiosulfate in PC12 cells (vol 529, pg 735, 2000)

Giannone G; Takeda K; Kleschyov AL
Published conference paper: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2000;279(6):H2743-H2751

Adventitia-derived nitric oxide in rat aortas exposed to endotoxin: cell origin and functional consequences.

Kleschyov AL; Muller B; Keravis T; Stoeckel ME; Stoclet JC
Review: PHYSIOLOGICAL RESEARCH. 2000;49(1):19-26

Inducible NO synthase activity in blood vessels and heart: new insight into cell origin and consequences.

Muller B; Kleschyov AL; Gyorgy K; Stoclet JC
Published conference paper: CIRCULATION. 1999;100(2):107-112

Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock.

Stoclet JC; Martínez MC; Ohlmann P; Chasserot S; Schott C; Kleschyov AL; Schneider F; Andriantsitohaina R
Published conference paper: EUROPEAN JOURNAL OF PHARMACOLOGY. 1999;375(1-3):139-155

The inducible nitric oxide synthase in vascular and cardiac tissue.

Stoclet JC; Muller B; György K; Andriantsiothaina R; Kleschyov AL
Review: BIOCHEMISTRY-MOSCOW. 1998;63(7):826-832

Overproduction of nitric oxide in pathophysiology of blood vessels.

Stoclet JC; Muller B; Andriantsitohaina R; Kleschyov A
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;418:669-672

Induction of NO production by polyosides from the wall of Streptococcus mutans OMZ175 in the rat aorta.

Martin V; Kleschyov AL; Schöller M; Klein JP; Beretz A

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