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Anne Örtqvist

Affiliated to research

Department and organisational affiliation:

About me

I earned my PhD in 2015 with a thesis named "Early life origins of asthma - genetic and environmental factors in twin and kin" at the Department of Medical Epidemiology and Biostatistics. My studies focused on potential risk factors during the period around pregnancy and subsequent childhood health.

After finishing my PhD studies I pursuied my clinical career as a medical doctor, and currently work as resident in obstetrics and gynecology at Visby Lasarett, Gotland. 

In parallell with clinical work I have continued doing research and I am now a post-doctoral fellow in Olof Stephansson's research group within Reproductive Epidemiology, at the Clinical Epidemiology Division. 

Research description

Current research area

My projects will focus on health care determinants on pregnancy outcome, and more specifically safe deliveries for both mother and child. The projects will look into the association between travel distance from home to the delivery ward and hospital size, in relation to severe maternal and infant morbidity and mortality. 

Description of PhD studies and prior projects:

During the last decades there has been an upsurge of studies investigating how early life events or exposures may affect subsequent health outcomes of the child, such as childhood asthma and lung function. Much focus has been put into the idea of how our future may be programmed already in utero or during our first months in life. By combining data from national health registers such as the National Patient Register, the Prescribed Drug Register and the Medical Birth Register, prospectively collected clinical material and questionnaire data, with twin- and family based designs, the studies included in my thesis aimed to disentangle familial genetic and environmental confounding from causal mechanisms leading to asthma. I have focused on the role of fetal growth and exposure to antibiotics, and the risk of developing asthma/lung function restriction. We have further investigated the potential role of early antibiotic exposure and the risk of developing very early onset inflammatory bowel disease. I have also worked with validation studies of asthma in the Swedish population-based registers.

Selected publications

Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study.

Örtqvist AK, Lundholm C, Halfvarson J, Ludvigsson JF, Almqvist C.

Gut. 2019 Feb;68(2):218-225. doi: 10.1136/gutjnl-2017-314352. Epub 2018 Jan 10. PMID: 29321166

Parental antibiotics and childhood asthma-a population-based study.

Örtqvist AK, Lundholm C, Fang F, Fall T, Almqvist C.

J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1451-1454.e4. doi: 10.1016/j.jaip.2017.03.009. Epub 2017 Apr 29. PMID: 28465011

Fetal Growth and Childhood Lung Function in the Swedish Twin Study on Prediction and Prevention of Asthma.

Örtqvist AK, Ullemar V, Lundholm C, Kuja-Halkola R, Magnusson PKE, Lichtenstein P, Hallberg J, Almqvist C.

Ann Am Thorac Soc. 2017 Jul;14(7):1147-1153. doi: 10.1513/AnnalsATS.201611-908OC. PMID: 28398078

Cohort Profile: Swedish Twin Study on Prediction and Prevention of Asthma (STOPPA).

Almqvist C, Örtqvist AK, Ullemar V, Lundholm C, Lichtenstein P, Magnusson PK.

Twin Res Hum Genet. 2015 Jun;18(3):273-80. doi: 10.1017/thg.2015.17. Epub 2015 Apr 22. PMID: 25900604

Individual maternal and child exposure to antibiotics in hospital - a national population-based validation study.

Almqvist C, Örtqvist AK, Gong T, Wallas A, Ahlén KM, Ye W, Lundholm C.

Acta Paediatr. 2015 Apr;104(4):392-5. doi: 10.1111/apa.12916. Epub 2015 Feb 7. PMID: 25545741 

Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis.

Örtqvist AK, Lundholm C, Kieler H, Ludvigsson JF, Fall T, Ye W, Almqvist C.

BMJ. 2014 Nov 28;349:g6979. doi: 10.1136/bmj.g6979. Erratum in: BMJ. 2014;349:g7395. PMID: 2543293 

Validation of asthma and eczema in population-based Swedish drug and patient registers.

Örtqvist AK, Lundholm C, Wettermark B, Ludvigsson JF, Ye W, Almqvist C.

Pharmacoepidemiol Drug Saf. 2013 Aug;22(8):850-60. doi: 10.1002/pds.3465. Epub 2013 Jun 11. PMID: 23754713

Familial factors do not confound the association between birth weight and childhood asthma.

Ortqvist AK, Lundholm C, Carlström E, Lichtenstein P, Cnattingius S, Almqvist C.

Pediatrics. 2009 Oct;124(4):e737-43. doi: 10.1542/peds.2009-0305. Epub 2009 Sep 28. PMID: 19786434

Teaching portfolio

Since 2016 I am the course organizer and lecturer for the course in Scientific Education at Visby Lasarett, which is a mandatory course for all residents at the hospital. 

Education

  • MD, Karolinska Institutet, 2013
  • PhD, Karolinska Institutet, 2015 
  • Post-doctoral research fellow at Department of Medical Epidemiology and Biostatistics, 2015-2018
  • Licence to practice medicine, 2018
  • Resident in Obstetrics and Gynecology, Visby Lasarett, 2018
  • Post-doctoral research fellow at the Clinical Epidemiology Division, 2018 - current
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