Anna Smed Sörensen
Associate professor (docent) and research group leader at the Immunology and Allergy Unit, Department of Medicine, Solna.
I did my undergraduate studies (MSc) in Biology at Uppsala universitet. I received my PhD in Experimental Medicine from Karolinska Institutet (Center of Infectious Medicine) in 2004 and then did postdoctoral training at Yale University School of Medicine, New Haven, CT, USA and Genentech, Inc., South San Francisco, CA, USA. I returned to Karolinska Institutet in 2010 as assistant professor supported by a Marie Curie/Vinnmer fellowship from Vinnova and a research grant for young investigators from the Swedish Research Council. Since 2014 I am a research group leader at the Department of Medicine Solna. I have received support from Karolinska Institutet including a salary grant as part of the KI career ladder. I currently hold a senior research position funded by the Swedish Heart and Lung Foundation.
The research in my group is focused on dendritic cells, monocytes and macrophages and their role in infection and inflammation of the respiratory system in humans. Specifically, we study lung tissue and lavage samples as well as aspirates from lung draining lymph nodes and blood collected from patients with viral infection or pulmonary sarcoidosis and healthy volunteers undergoing bronchoscopy. We have also developed methods to study immune cells and immune responses in the nasopharynx of patients during acute influenza A virus infection. The samples are carefully characterized using multiparameter flow cytometry and RNA sequencing, and the functional capacity of the cells is assessed in vitro with the overarching goal to understand how early, innate immune responses in the local tissue dictate disease severity and outcome.