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Working in stem cell research lab

Bentolhoda Fereydouni

Postdoctoral researcher

Department and organisational affiliation:

About me

I am a scientist with a broad and deep experiences of several techniques within genomics (Next generation sequencing ), cell culture , histology, staining , microscopy, animal models ( rat, mouse. non-human primates), single cell RNA- seq, flow cytometry ,some bioinformatics . Current focus on clinical data analysis from patients and single cell RNA-seq with 10x chromium.  I am very creative and self-motivated with a great ability to adopt to multicultural environment. I am very hard working with pedagogical skills and excellent team player with the skillful leadership ability. I love running in my spare time, I am a long -distance runner and attending different long distance races.

Research description

My research is focusing on single cell RNA seq for pain behaviour . Pain is the most common problem in the patients with rheumatoid arthritis (RA) and mostly interpreted as a marker of inflammation, the correlation between pain intensity and measure of peripheral inflammation still not complete understood. It is very necessary to understand the mechanism of pain in inflammatory arthritis. It has been reported that macrophages are linked to the development of pain by production of inflammatory mediators. For this purpose, I am going to use single cell RNA (ScRNA) sequencing technology with using novel computational approaches including multiple transcriptomic subpopulations and compare heterogeneous macrophage population between control and RA induced mouse model ( CAIA) for better understanding of pain mechanism in RA patient. ScRNA seq of macrophages from DRGs will also help us to find novel /rare cell types of macrophages that can be targeted in future for drug therapy. 

Education

 

 Dr.rer.nat in Biology at Georg-August-University Goettingen, Goettingen, Germany.

I worked with Common Marmoset monkey as non-human primate model and for the first time introduced the marmoset monkey as a suitable non-human primate model to experimentally study aspects of primate primitive gonad development  and germ cell biology in vivo. In the second part  I aimed at culturing marmoset female germline stem cells from neonatal ovaries. I successfully established ovarian cell cultures for more than 20 passages and keep ongoing for 6 months and developing oocyte-like cells . 

            

Academic honours, awards and prizes

2018   Wilhelm och Martina Lundgrens Vetenskapsfond, “Study of IGF-1R as

 an anti-cancer target in sarcoma.”: 50000 SEK

2017-2018    Johan Janssons Foundation, “The FET oncogenes in sarcomas and

 Interactions with SWI/SNF protein complex”: 70000 SEK

2017-2018    Assar Gabrielssons Foundation, “The FET oncogenes in sarcomas

 and Interactions with SWI/SNF protein complex”: 54500 SEK

2016-2017    Assar Gabrielssons Foundation, “The FET oncogenes in sarcomas

 and Interactions with SWI/SNF protein complex”: 51000 SEK

2016-2017   Johan Janssons Foundation, “The FET oncogenes in sarcomas and

 Interactions with SWI/SNF protein complex”: 51000 SEK

2015           Marie Curie Fellowship as part of the EU-funded project to understand epigenetic regulation in the pathogenesis of common diseases 

2010-2014   DAAD (German Academic Exchange Service) scholarship.

2010             Singapore International Graduate Award (SINGA), NUS. Singapore.

 

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