Bengt Samuelsson

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About me

Bengt I. Samuelsson is Professor Emeritus of Medical and Physiological Chemistry and former President of Karolinska Institutet. In 1982, he received the Nobel Prize in Physiology or Medicine together with Sune K. Bergström and John R. Vane for discoveries concerning prostaglandins and related substances.

Articles

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2116559118

Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer.

Shay AE; Nshimiyimana R; Samuelsson B; Petasis NA; Haeggström JZ; Serhan CN
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(15):8573-8583

Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells.

Basavarajappa D; Uebbing S; Kreiss M; Lukic A; Suess B; Steinhilber D; Samuelsson B; Rådmark O
Article: CANCER LETTERS. 2019;444:1-8

Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1.

Lukic A; Wahlund CJE; Gómez C; Brodin D; Samuelsson B; Wheelock CE; Gabrielsson S; Rådmark O
Article: JOURNAL OF IMMUNOLOGY. 2018;200(5):1538-1542

Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279.

Murphy RC; Hammarström S; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(8):1907-1912

Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.

Di Gennaro A; Araújo AC; Busch A; Jin H; Wågsäter D; Vorkapic E; Caidahl K; Eriksson P; Samuelsson B; Maegdefessel L; Haeggström JZ
Article: FASEB JOURNAL. 2017;31(10):4370-4381

GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures.

Lukic A; Larssen P; Fauland A; Samuelsson B; Wheelock CE; Gabrielsson S; Radmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(36):9689-9694

Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.

Stsiapanava A; Samuelsson B; Haeggström JZ
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(8):3167-3176

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.

Pace S; Pergola C; Dehm F; Rossi A; Gerstmeier J; Troisi F; Pein H; Schaible AM; Weinigel C; Rummler S; Northoff H; Laufer S; Maier TJ; Rådmark O; Samuelsson B; Koeberle A; Sautebin L; Werz O
Article: JOURNAL OF LIPID RESEARCH. 2016;57(9):1659-1669

Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.

Lukic A; Ji J; Idborg H; Samuelsson B; Palmberg L; Gabrielsson S; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(4):972-977

A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.

Brock JS; Hamberg M; Balagunaseelan N; Goodman M; Morgenstern R; Strandback E; Samuelsson B; Rinaldo-Matthis A; Haeggström JZ
Article: LAKARTIDNINGEN. 2015;112:DLCZ

[Not Available].

Samuelsson K; Lagercrantz H; Lindahl S; Philipson A; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(31):11371-11376

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.

Basavarajappa D; Wan M; Lukic A; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(11):4227-4232

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.

Stsiapanava A; Olsson U; Wan M; Kleinschmidt T; Rutishauser D; Zubarev RA; Samuelsson B; Rinaldo-Matthis A; Haeggström JZ
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2014;545:179-185

A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.

Rakonjac Ryge M; Tanabe M; Provost P; Persson B; Chen X; Funk CD; Rinaldo-Matthis A; Hofmann B; Steinhilber D; Watanabe T; Samuelsson B; Rådmark O
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(13):10070-10080

Role of basic science in the development of new medicines: examples from the eicosanoid field.

Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):20479-20484

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development.

Haas U; Raschperger E; Hamberg M; Samuelsson B; Tryggvason K; Haeggström JZ
Article: FASEB JOURNAL. 2011;25(4):1417-1427

Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.

Esser J; Gehrmann U; Salvado MD; Wetterholm A; Haeggström JZ; Samuelsson B; Gabrielsson S; Scheynius A; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(49):21093-21097

Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.

Di Gennaro A; Wågsäter D; Mäyränpää MI; Gabrielsen A; Swedenborg J; Hamsten A; Samuelsson B; Eriksson P; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):105-110

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

Rådmark O; Samuelsson B
Article: BIOCHEMICAL JOURNAL. 2009;425(1):265-274

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

Esser J; Rakonjac M; Hofmann B; Fischer L; Provost P; Schneider G; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjörnsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Rådmark O
Article: JOURNAL OF LIPID RESEARCH. 2009;50 Suppl(Suppl):S40-S45

5-Lipoxygenase: mechanisms of regulation.

Rådmark O; Samuelsson B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1789(2):99-108

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

Dincbas-Renqvist V; Pépin G; Rakonjac M; Plante I; Ouellet DL; Hermansson A; Goulet I; Doucet J; Samuelsson B; Rådmark O; Provost P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(1):301-305

Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha.

Hammarberg T; Hamberg M; Wetterholm A; Hansson H; Samuelsson B; Haeggstro M JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19881-19886

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma.

Pergola C; Dodt G; Rossi A; Neunhoeffer E; Lawrenz B; Northoff H; Samuelsson B; Rådmark O; Sautebin L; Werz O
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):162-174

5-lipoxygenase: regulation and possible involvement in atherosclerosis.

Rådmark O; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(35):13150-13155

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.

Rakonjac M; Fischer L; Provost P; Werz O; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(21):8161-8166

Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.

Qiu H; Gabrielsen A; Agardh HE; Wan M; Wetterholm A; Wong C-H; Hedin U; Swedenborg J; Hansson GK; Samuelsson B; Paulsson-Berne G; Haeggström JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1738(1-3):37-47

GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.

Dishart D; Schnur N; Klan N; Werz O; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(37):13164-13169

Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.

Werz O; Tretiakova I; Michel A; Ulke-Lemee A; Hörnig M; Franke L; Schneider G; Samuelsson B; Rådmark O; Steinhilber D
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1749(1):123-131

Mutation analysis of the human 5-lipoxygenase C-terminus: support for a stabilizing C-terminal loop.

Okamoto H; Hammarberg T; Zhang Y-Y; Persson B; Watanabe T; Samuelsson B; Rådmark O
Article: JOURNAL OF BIOMOLECULAR NMR. 2004;30(3):353-356

NMR structure of human coactosin-like protein.

Liepinsh E; Rakonjac M; Boissonneault V; Provost P; Samuelsson B; Rådmark O; Otting G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(25):22199-22209

Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.

Thorén S; Weinander R; Saha S; Jegerschöld C; Pettersson PL; Samuelsson B; Hebert H; Hamberg M; Morgenstern R; Jakobsson P-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(3):1238-1243

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.

Spanbroek R; Grabner R; Lotzer K; Hildner M; Urbach A; Ruhling K; Moos MPW; Kaiser B; Cohnert TU; Wahlers T; Zieske A; Plenz G; Robenek H; Salbach P; Kuhn H; Radmark O; Samuelsson B; Habenicht AJR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):16648-16653

Dicer is required for chromosome segregation and gene silencing in fission yeast cells.

Provost P; Silverstein RA; Dishart D; Walfridsson J; Djupedal I; Kniola B; Wright A; Samuelsson B; Radmark O; Ekwall K
Article: EMBO JOURNAL. 2002;21(21):5864-5874

Ribonuclease activity and RNA binding of recombinant human Dicer.

Provost P; Dishart D; Doucet J; Frendewey D; Samuelsson B; Rådmark O
Article: FASEB JOURNAL. 2002;16(12):1648-1650

Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors.

Thunnissen MMGM; Andersson B; Samuelsson B; Wong C-H; Haeggström JZ
Article: FASEB JOURNAL. 2002;16(11):1441-1443

Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes.

Werz O; Bürkert E; Fischer L; Szellas D; Dishart D; Samuelsson B; Rådmark O; Steinhilber D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(7):4215-4220

Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.

Rudberg PC; Tholander F; Thunnissen MMGM; Samuelsson B; Haeggstrom JZ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2002;71(3):477-486

Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes.

Bürkert E; Rådmark O; Samuelsson B; Steinhilber D; Werz O
Article: BLOOD. 2002;99(3):1044-1052

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.

Werz O; Bürkert E; Samuelsson B; Rådmark O; Steinhilber D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;290(2):783-789

Molecular cloning and functional characterization of mouse coactosin-like protein.

Doucet J; Provost P; Samuelsson B; Rådmark O
Article: NEUROSCIENCE. 2002;115(3):891-897

Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system.

Fetissov SO; Schröder O; Jakobsson P-J; Samuelsson B; Haeggström JZ; Hökfelt T
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2001;70(5):830-838

p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.

Werz O; Klemm J; Rådmark O; Samuelsson B
Article: BIOCHEMICAL JOURNAL. 2001;359(Pt 2):255-263

Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75.

Provost P; Doucet J; Stock A; Gerisch G; Samuelsson B; Rådmark O
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(19):16520-16527

5-Lipoxygenase interacts with coactosin-like protein.

Provost P; Doucet J; Hammarberg T; Gerisch G; Samuelsson B; Radmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(9):5152-5157

IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression.

Spanbroek R; Hildner M; Köhler A; Müller A; Zintl F; Kühn H; Rådmark O; Samuelsson B; Habenicht AJ
Article: BLOOD. 2001;97(8):2487-2495

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes.

Werz O; Klemm J; Samuelsson B; Rådmark O
Article: CELL AND TISSUE RESEARCH. 2001;303(2):235-252

Cyclooxygenase-1 and cyclooxygenase-2 expression in rat kidney and adrenal gland after stimulation with systemic lipopolysaccharide: in situ hybridization and immunocytochemical studies.

Ichitani Y; Holmberg K; Maunsbach AB; Haeggström JZ; Samuelsson B; De Witt D; Hökfelt T
Article: BLOOD. 2000;96(12):3857-3865

5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs.

Spanbroek R; Hildner M; Steinhilber D; Fusenig N; Yoneda K; Rådmark O; Samuelsson B; Habenicht AJ
Article: BIOCHEMICAL JOURNAL. 2000;351 Pt 3(Pt 3):697-707

Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences.

Zhang YY; Hammarberg T; Radmark O; Samuelsson B; Ng CF; Funk CD; Loscalzo J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(10):5261-5266

5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.

Werz O; Klemm J; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(13):7220-7225

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(5):1881-1885

Interaction of 5-lipoxygenase with cellular proteins.

Provost P; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE AMERICAN PHILOSOPHICAL SOCIETY. 1999;143(1):50-51

New drugs: The role of basic science

Samuelsson B
Article: CHEMISTRY-A EUROPEAN JOURNAL. 1998;4(9):1698-1713

Probing the activities and mechanisms of leukotriene A₄ hydrolase with synthetic inhibitors

Hogg JH; Ollmann IR; Wetterholm A; Andberg MB; Haeggstrom J; Samuelsson B; Wong CH
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 1998;19(2):316-323

Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants.

Silverman ES; Du J; De Sanctis GT; Rådmark O; Samuelsson B; Drazen JM; Collins T
Article: FEBS JOURNAL. 1998;254(2):275-281

Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation.

Härle D; Rådmark O; Samuelsson B; Steinhilber D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(2):663-668

5-Lipoxygenase expression in Langerhans cells of normal human epidermis.

Spanbroek R; Stark HJ; Janssen-Timmen U; Kraft S; Hildner M; Andl T; Bosch FX; Fusenig NE; Bieber T; Rådmark O; Samuelsson B; Habenicht AJ
Article: NEUROREPORT. 1997;8(13):2949-2952

Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study.

Ichitani Y; Shi T; Haeggstrom JZ; Samuelsson B; Hökfelt T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;236(2):355-359

Effects of metal ions on the binding activity of the human leukocyte leukotriene B4 receptor.

Ng CF; Haeggström JZ; Samuelsson B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(40):24345-24348

Leukotriene A4 hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A4 into an isomer of leukotriene B4.

Mueller MJ; Andberg MB; Samuelsson B; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(12):5931-5935

Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.

Mueller MJ; Blomster M; Oppermann UC; Jörnvall H; Samuelsson B; Haeggström JZ
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1995;275(1):31-37

Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes.

Wetterholm A; Haeggström JZ; Samuelsson B; Yuan W; Munoz B; Wong CH
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 1995;3(10):1405-1415

Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase.

Hogg JH; Ollmann IR; Haeggström JZ; Wetterholm A; Samuelsson B; Wong CH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(18):8383-8387

Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.

Mueller MJ; Wetterholm A; Blomster M; Jörnvall H; Samuelsson B; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(15):6966-6970

Expression of 5-lipoxygenase in differentiating human skin keratinocytes.

Janssen-Timmen U; Vickers PJ; Wittig U; Lehmann WD; Stark HJ; Fusenig NE; Rosenbach T; Rådmark O; Samuelsson B; Habenicht AJ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 1995;3(7):969-995

Investigation of the inhibition of leukotriene A4 hydrolase.

Ollmann IR; Hogg JH; Muñoz B; Haeggström JZ; Samuelsson B; Wong CH
Article: FEBS JOURNAL. 1995;230(2):401-407

Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase.

Hammarberg T; Zhang YY; Lind B; Radmark O; Samuelsson B
Article: BIOCHEMISTRY. 1995;34(11):3536-3543

Chemical modification of leukotriene A4 hydrolase. Indications for essential tyrosyl and arginyl residues at the active site.

Mueller MJ; Samuelsson B; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(1):107-111

Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3.

Brungs M; Rådmark O; Samuelsson B; Steinhilber D
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All other publications

Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1851(4):331-339

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.

Rådmark O; Werz O; Steinhilber D; Samuelsson B
Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2010;268(1):5-14

Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.

Rådmark O; Samuelsson B
Review: PHARMACOLOGICAL REVIEWS. 2007;59(3):207-224

Membrane prostaglandin E synthase-1: a novel therapeutic target.

Samuelsson B; Morgenstern R; Jakobsson P-J
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2007;32(7):332-341

5-Lipoxygenase: regulation of expression and enzyme activity.

Rådmark O; Werz O; Steinhilber D; Samuelsson B
Review: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;338(1):102-110

Regulation of 5-lipoxygenase enzyme activity.

Rådmark O; Samuelsson B
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;507:287-291

Characterization of microsomal, glutathione dependent prostaglandin E synthase.

Jakobsson P-J; Thorén S; Morgenstern R; Samuelsson B
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):153-154

Prostaglandin E synthase:: a microsomal, glutathione dependent, inducible member of the MAPEG superfamily

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2 Pt 2):S2-S6

The discovery of the leukotrienes.

Samuelsson B
Published conference paper: HYPERTENSION. 2000;35(1 Pt 2):373-378

Cyclooxygenase-2 involved in stimulation of renal mechanosensitive neurons.

Kopp UC; Cicha MZ; Smith LA; Haeggström JZ; Samuelsson B; Hökfelt T
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1999;469:105-111

Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line Mono Mac 6 by transforming growth factor-beta and 1,25-dihydroxyvitamin D3.

Härle D; Rådmark O; Samuelsson B; Steinhilber D
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:375-378

Leukotriene A4 hydrolase activity in Xenopus laevis.

Strömberg F; Rosenqvist U; Dahlén SE; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:351-354

Human beta-trace in normal and pathological CNS tissues, genital organs and body fluids.

Olsson JE
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:331-338

Hsp70: a subunit of the cytosolic 12(S)-HETE binding complex.

Kühme T; Herbertsson H; Hammarström S
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:315-318

Histamine potentiates leukotriene B4-induced leukocyte adhesion: a potential role of histamine1-receptor antagonism in allergic leukocyte recruitment.

Thorlacius H; Raud J; Lindbom L; Hedqvist P
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:159-162

Urinary 9 alpha, 11 beta-PGF2 as a marker of mast cell activation in allergic and aspirin-intolerant asthma.

O'Sullivan S; Dahlén B; Roquet A; Larsson L; Dahlén SE; Kumlin M
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:149-152

Mutation of Tyr-383 in leukotriene A4 hydrolase: effects on enzyme activities.

Andberg M; Wetterholm A; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:123-126

Bisallylic hydroxylation of linoleic and arachidonic acids by adult and fetal human liver microsomes and a comparison with human recombinant cytochromes P450.

Hörnsten L; Bylund J; Oliw EH
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:99-102

Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation.

Ohd JF; Adolfsson JL; Sjölander A
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:69-72

Avenoleic acid: a new oxylipin from oat seeds.

Hamberg M
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:65-68

Catalytic and spectroscopic properties of linoleate diol synthase of the fungus Gaümannomyces graminis.

Oliw EH; Su C
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:61-64

Biosynthesis of novel divinyl ether oxylipins by enzyme from garlic (Allium sativum L.) bulbs.

Grechkin AN; Hamberg M
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:1-7

Some recent advances in leukotriene research.

Samuelsson B
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;407:1-7

Studies on the active site of leukotriene A4 hydrolase.

Wetterholm A; Mueller MJ; Blomster M; Samuelsson B; Haeggström JZ
Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:513-518

Preclinical pharmacology of latanoprost, a phenyl-substituted PGF2 alpha analogue.

Stjernschantz J; Selén G; Sjöquist B; Resul B
Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:353-355

Leukotrienes and other mediators of the Schultz-Dale reaction in guinea-pig lung parenchyma.

Jonsson EW; Dahlén SE
Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:293-298

The 5-lipoxygenase pathway in normal and malignant human B lymphocytes.

Jakobsson PJ; Larsson P; Feltenmark S; Odlander B; Runarsson G; Björkholm M; Claesson HE
Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:283-285

Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature.

Coleman RA; Eglen RM; Jones RL; Narumiya S; Shimizu T; Smith WL; Dahlén SE; Drazen JM; Gardiner PJ; Jackson WT
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:63-68

Prostaglandins as ocular hypotensive agents; development of an analogue for glaucoma treatment.

Stjernschantz J
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:527-532

Comparative phase III clinical trial of latanoprost and timolol in patients with elevated intraocular pressure.

Alm A
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:449-451

Transforming growth factor-beta and 1,25-dihydroxyvitamin D3 induce 5-lipoxygenase activity during myeloid cell maturation.

Steinhilber D; Brungs M; Rådmark O; Samuelsson B
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:419-421

Mechanisms for lipoxin A4 induced neutrophil dependent cytotoxicity for human endothelial cells.

Bratt J; Lerner R; Ringertz B; Palmblad J
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:333-335

Regulation of leukotriene C4 synthase in human platelets via receptor-mediated mechanisms.

Edenius C; Tornhamre S; Näsman-Glaser B; Eriksson I; Björkholm S; Lindgren JA
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:329-331

5-lipoxygenase expression in cultured human keratinocytes.

Janssen-Timmen U; Vickers P; Beilecke U; Lehmann WD; Stark HJ; Fusenig NE; Rosenbach T; Goerig M; Rådmark O; Samuelsson B
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:193-198

Biosynthesis and degradation of alpha-paranaric acid and related conjugated tetraene fatty acids.

Hamberg M
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:179-181

Metal inhibition of LTA4 hydrolase and cellular 5-lipoxygenase activity.

Wetterholm A; Macchia L; Haeggström JZ
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:141-143

11-hydroxythromboxane B2 dehydrogenase from porcine kidney is identical to cytosolic aldehyde dehydrogenase.

Westlund P; Fylling AC; Helander A; Cederlund E; Jörnvall H
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:1-9

5-lipoxygenase: structure and stability of recombinant enzyme, regulation in Mono Mac 6 cells.

Rådmark O; Zhang YY; Hammarberg T; Lind B; Hamberg M; Brungs M; Steinhilber D; Samuelsson B
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Affiliated to Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2026
Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 1994-1999

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Docent, 1960

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