About me

Adjunct Professor of Paediatrics specialising in liver diseases at the Department of Clinical Science, Intervention and Technology as of 1 January 2021. Primary position: Consultant at the Astrid Lindgren Children’s Hospital, Karolinska University Hospital

Research description

Björn Fischler’s research deals with liver disease in children, particularly different forms of cholestasis. His research is conducted within international networks and in collaboration with preclinical groups. Fischler has demonstrated an association between cytomegalovirus (CMV) infection and biliary atresia. He now intends to study whether anti-CMV medica- tion can improve severe prognosis.

Fischler has planned and participated in an international clinical study showing that a new drug effectively mitigates the symptoms of the cholestatic condition PFIC and proba- bly improves survival rates. The phase III study has recently been concluded and licence processes have commenced. For another cholestatic disease, Alagille syndrome, which also affects other organs such as the heart, blood vessels and kidneys, Fischler is collaborating with Emma Andersson’s research group at KI, which has developed a mouse model. This, in combination with clinical data from patients, can be used to explain pathophysiologies and test new therapies.

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