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Research description

The Reinius laboratory's research is focused on revealing principal features of gene regulation, and in particular the regulation of active and inactive chromatin states. A main topic in the lab is X-chromosome inactivation.

Reinius lab webpage:  www.reiniuslab.com

 

Publications

bioRxiv. 2019: Transcriptional kinetics of X-chromosome upregulation. Larsson AJM, Coucoravas​ C, Sandberg R, Reinius B.

Cell Reports. 2019: Single-cell RNA-seq reveals cellular heterogeneity of pluripotency transition and X-chromosome dynamics during early mouse development. Cheng S*, Pei Y*, He L, Peng G, Reinius B, Tam PPL, Jing N, Deng Q.

Nature. 2019: Genomic encoding of transcriptional burst kinetics. Larsson AJM, Johnsson P, Hagemann-Jensen M, Hartmanis L, Faridani OR, Reinius B, Segerstolpe Å, Rivera CM, Ren B, Sandberg R.

Nature Genetics. 2018: Reply to: High prevalence of clonal monoallelic expression. Reinius B and Sandberg R. 

Nature Communications. 2018: Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells. Vértesy Á, Arindrarto W, Roost MS, Reinius B, Torrens-Juaneda V, Bialecka M, Moustakas I, Ariyurek Y, Kuijk E, Mei H, Sandberg R, van Oudenaarden A, Chuva de Sousa Lopes SM. 

Molecular Cell. 2017: Comparative Analysis of Single-Cell RNA Sequencing Methods. Ziegenhain C, Vieth, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W. 

Nature Genetics. 2016: Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq. Reinius B*, Mold JE*, Ramsköld D, Deng Q, Johnsson P, Michaëlsson J, Frisén J, Sandberg R. 

Bioinformatics. 2016: scphaser: haplotype inference using single-cell RNA-seq data. Edsgärd D, Reinius B, Sandberg R. 

Cell. 2016: Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos. Petropoulos S*, Edsgärd D*, Reinius B*, Deng Q, Panula SP, Codeluppi S, Plaza Reyes A, Linnarsson S, Sandberg R, Lanner F.  (*Co-first author)

Genome Research. 2016: Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation. Chen G, Schell JP, Benitez JA, Petropoulos S, Yilmaz M, Reinius B, Alekseenko Z, Shi L, Hedlund E, Lanner F, Sandberg R, Deng Q. 

Nature Reviews Genetics. 2015: Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation. Reinius B, Sandberg R. 

Nature Communications. 2015: MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures. Mondal T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James AR, Hoberg E, Moustakas A, Gyllensten U, Jones SJ, Gustafsson CM, Sims AH, Westerlund F, Gorab E, Kanduri C. 

Frontiers in Behavioral Neuroscience. 2015: Conditional targeting of medium spiny neurons in the striatal matrix. Reinius B, Blunder M, Brett FM, Eriksson A, Patra K, Jonsson J, Jazin E, Kullander K.

Genome Research. 2014: Tn5 transposase and tagmentation procedures for massively scaled sequencing projects. Picelli S, Björklund AK, Reinius B, Sagasser S, Winberg G, Sandberg R.

Science. 2014: Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Deng Q*, Ramsköld D*, Reinius B, Sandberg R. 

Human Molecular Genetics. 2013: RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes. Radomska KJ, Halvardson J, Reinius B, Lindholm Carlström E, Emilsson L, Feuk L, Jazin E.

PLoS One. 2013: Elevated expression of H19 and Igf2 in the female mouse eye. Reinius B, Kanduri C.

BMC Genomics. 2012: Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome. Reinius B, Johansson MM, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Sandberg R, Williams RW, Jazin E. 

Acta Universitatis Upsaliensis. 2011: Sexually dimorphic gene expression in the mammalian brain. Reinius B. 

Neuron. 2010: VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, Kullander K. 

BMC Genomics. 2010: Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. Reinius B, Shi C, Hengshuo L, Sandhu KS, Radomska KJ, Rosen GD, Lu Lu, Kullander K, Williams RW, Jazin E.

Molecular Psychiatry. 2009: Prenatal sex differences in the human brain. Reinius B, Jazin E. 

PLoS Genetics. 2008: An evolutionarily conserved sexual signature in the primate brain. Reinius B, Saetre P, Leonard JA, Blekhman R, Merino-Martinez R, Gilad Y, Jazin E.

 

 

Academic honours, awards and prizes

Ragnar Söderberg Fellowship in Medicine

Swedish Research Council Starting grant

Åke Wiberg's Fundation (Medicine)

Faculty Funded Postion as Assistant Professor at KI (FoAss)

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