Carl Sellgren Majkowitz

About me
Publications
CV
Public outreach and news

About me

I am a Group leader and Associate Professor at the Department of Physiology and Pharmacology. I obtained my MD and PhD at the Karolinska Institutet and completed my residency in psychiatry at Psykiatri Nordväst (Stockholm County) in 2011. My postdoctoral training was performed at the Broad Institiute of MIT and Harvard.

Research

Neurodevelopment, developmental biology, neurodevelopmental disorder, psychiatry, disease modeling, glial biology.

Articles

Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;117:313-319

Lower complement C1q levels in first-episode psychosis and in schizophrenia.

Koskuvi M; Malwade S; Gracias Lekander J; Hörbeck E; Bruno S; Holmen Larsson J; Pelanis A; Isgren A; Goulding A; Fatouros-Bergman H; Samudyata; Schalling M; Piehl F; Erhardt S; Landen M; Cervenka S; Orhan F; Sellgren CM
Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;116:150-159

Dissecting the impact of complement component 4A in bipolar disorder.

Hörbeck E; Jonsson L; Malwade S; Karlsson R; Pålsson E; Sigström R; Sellgren CM; Landén M
Article: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2023;77(12):665-671

Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis.

Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Troßbach S; Willbold D; Erhardt S; Bannach O; Korth C
Journal article: BIOMARKERS IN NEUROPSYCHIATRY. 2023;9:100078

Altered brain dopamine metabolism is a trait marker for bipolar disorder

Pålsson E; Sellgren C; Pelanis A; Zetterberg H; Blennow K; Landén M
Article: BRAIN BEHAVIOR AND IMMUNITY. 2023;111:376-385

Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity.

Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40

CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance.

Orhan F; Goiny M; Becklén M; Mathé L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2213880120

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

Schijven D; Postema MC; Fukunaga M; Matsumoto J; Miura K; de Zwarte SMC; van Haren NEM; Cahn W; Hulshoff Pol HE; Kahn RS; Ayesa-Arriola R; Ortiz-García de la Foz V; Tordesillas-Gutierrez D; Vázquez-Bourgon J; Crespo-Facorro B; Alnæs D; Dahl A; Westlye LT; Agartz I; Andreassen OA; Jönsson EG; Kochunov P; Bruggemann JM; Catts SV; Michie PT; Mowry BJ; Quidé Y; Rasser PE; Schall U; Scott RJ; Carr VJ; Green MJ; Henskens FA; Loughland CM; Pantelis C; Weickert CS; Weickert TW; de Haan L; Brosch K; Pfarr J-K; Ringwald KG; Stein F; Jansen A; Kircher TTJ; Nenadić I; Krämer B; Gruber O; Satterthwaite TD; Bustillo J; Mathalon DH; Preda A; Calhoun VD; Ford JM; Potkin SG; Chen J; Tan Y; Wang Z; Xiang H; Fan F; Bernardoni F; Ehrlich S; Fuentes-Claramonte P; Garcia-Leon MA; Guerrero-Pedraza A; Salvador R; Sarró S; Pomarol-Clotet E; Ciullo V; Piras F; Vecchio D; Banaj N; Spalletta G; Michielse S; van Amelsvoort T; Dickie EW; Voineskos AN; Sim K; Ciufolini S; Dazzan P; Murray RM; Kim W-S; Chung Y-C; Andreou C; Schmidt A; Borgwardt S; McIntosh AM; Whalley HC; Lawrie SM; du Plessis S; Luckhoff HK; Scheffler F; Emsley R; Grotegerd D; Lencer R; Dannlowski U; Edmond JT; Rootes-Murdy K; Stephen JM; Mayer AR; Antonucci LA; Fazio L; Pergola G; Bertolino A; Díaz-Caneja CM; Janssen J; Lois NG; Arango C; Tomyshev AS; Lebedeva I; Cervenka S; Sellgren CM; Georgiadis F; Kirschner M; Kaiser S; Hajek T; Skoch A; Spaniel F; Kim M; Kwak YB; Oh S; Kwon JS; James A; Bakker G; Knöchel C; Stäblein M; Oertel V; Uhlmann A; Howells FM; Stein DJ; Temmingh HS; Diaz-Zuluaga AM; Pineda-Zapata JA; López-Jaramillo C; Homan S; Ji E; Surbeck W; Homan P; Fisher SE; Franke B; Glahn DC; Gur RC; Hashimoto R; Jahanshad N; Luders E; Medland SE; Thompson PM; Turner JA; van Erp TGM; Francks C
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14)

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Schijven D; Postema MC; Fukunaga M; Matsumoto J; Miura K; de Zwarte SMC; van Haren NEM; Cahn W; Pol HEH; Kahn RS; Ayesa-Arriola R; de la Foz VO-G; Tordesillas-Gutierrez D; Vazquez-Bourgoni J; Crespo-Facorro B; Alnaes D; Dahl A; Westlye LT; Agartz I; Andreassen OA; Jonsson EG; Kochunov P; Bruggemann JM; Catts SV; Michie PT; Mowry BJ; Quide Y; Rasser PE; Schall U; Scott RJ; Carr VJ; Green MJ; Henskens FA; Loughland CM; Pantelis C; Weickert CS; Weickert TW; de Haan L; Brosch K; Pfarr J-K; Ringwald KG; Stein F; Jansen A; Kircher TTJ; Nenadic I; Kramer B; Gruber O; Satterthwaite TD; Bustillo J; Mathalon DH; Preda A; Calhoun VD; Ford JM; Potkin SG; Chen J; Tan Y; Wang Z; Xiang H; Fan F; Bernardoni F; Ehrlich S; Fuentes-Claramonte P; Garcia-Leon MA; Guerrero-Pedraza A; Salvador R; Sarro S; Pomarol-Clotet E; Ciullo V; Piras F; Vecchio D; Banaj N; Spalletta G; Michielse S; van Amelsvoort T; Dickie EW; Voineskos AN; Sim K; Ciufolini S; Dazzan P; Murray RM; Kim W-S; Chung Y-C; Andreou C; Schmidt A; Borgwardt S; McIntosh AM; Whalley HC; Lawrie SM; du Plessis S; Luckhoff HK; Scheffler F; Emsley R; Grotegerd D; Lencer R; Dannlowski U; Edmond JT; Rootes-Murdy K; Stephen JM; Mayer AR; Antonucci LA; Fazio L; Pergola G; Bertolino A; Diaz-Caneja CM; Janssen J; Lois NG; Arango C; Tomyshev AS; Lebedeva I; Cervenka S; Sellgren CM; Georgiadis F; Kirschner M; Kaiser S; Hajek T; Skoch A; Spaniel F; Kim M; Bin Kwak Y; Oh S; Kwon JS; James A; Bakker G; Knochel C; Stablein M; Oertel V; Uhlmann A; Howells FM; Stein DJ; Temmingh HS; Diaz-Zuluaga AM; Pineda-Zapata JA; Lopez-Jaramillo C; Homan S; Ji E; Surbeck W; Homan P; Fisher SE; Franke B; Glahn DC; Gur RC; Hashimoto R; Jahanshad N; Luders E; Medland SE; Thompson PM; Turner JA; van Erp TGM; Francks C
Journal article: NEUROSCIENCE APPLIED. 2023;2:101139

Functional connectivity alterations of the somatomotor network in euthymic bipolar disorder

Klahn AL; Thompson WH; Abé C; Liberg B; Sellgren CM; Klahn P; Landén M
Journal article: NEUROSCIENCE APPLIED. 2023;2:103319

Human 2D and 3D models of oligodendrocyte progenitor cell development and function

Gkogka A; Samudyata S; Malwade S; Koskuvi M; Sellgren C
Journal article: NEUROSCIENCE APPLIED. 2023;2:103551

Kynurenic acid promotes activity-dependent synaptic pruning and associates with genetic risk variance for schizophrenia

Orhan F; Malwade S; Schwieler L; Tiihonen J; Koistinahu J; Erhardt S; Engberg G; Kent J; Samudyata S; Sellgren C
Journal article: NEUROSCIENCE APPLIED. 2023;2:102643

Elevated synaptic pruning by microglia in schizophrenia across patient-derived brain organoids

Malwade S; Lekander JG; Samudyata S; Koskuvi M; Storvik M; Sellgren CM
Journal article: NEUROSCIENCE APPLIED. 2023;2:102623

Modelling human cytomegalovirus infection in immunocompetent brain organoids

Koskuvi M; Samudyata S; Malwade S; Almazán NM; Gkogka A; Söderberg-Nauclér C; Sellgren CM
Journal article: NEUROSCIENCE APPLIED. 2023;2:103444

Comparative studies of microglia-like cells, in anorexia nervosa patients versus healthy controls

Xu J; Orhan F; Sellgren C; Nilsson I
Journal article: NEUROSCIENCE APPLIED. 2023;2:103649

Modeling lithium’s effect on neurogenesis using induced pluripotent stem cell-derived neural stem cells and brain organoids

Lundberg M; Koskuvi M; Samudyata S; Malwade S; Schalling M; Sellgren C
Article: NATURE COMMUNICATIONS. 2022;13(1):6427

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia.

Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel İŞ; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VAC; Göpfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Article: MOLECULAR PSYCHIATRY. 2022;27(11):4568-4574

Cerebrospinal fluid proteomic study of two bipolar disorder cohorts.

Isgren A; Göteson A; Holmén-Larsson J; Pelanis A; Sellgren C; Joas E; Sparding T; Zetterberg H; Smedler E; Jakobsson J; Landén M
Article: MOLECULAR PSYCHIATRY. 2022;27(10):3939-3950

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids.

Samudyata; Oliveira AO; Malwade S; Rufino de Sousa N; Goparaju SK; Gracias J; Orhan F; Steponaviciute L; Schalling M; Sheridan SD; Perlis RH; Rothfuchs AG; Sellgren CM
Article: HELIYON. 2022;8(9):e10424

Facial affect recognition in first-episode psychosis is impaired but not associated with psychotic symptoms.

Larsson C; Lee M; Lundgren T; Erhardt S; Sellgren CM; Cervenka S; Borg J; Bölte S; Fatouros-Bergman H
Article: MOLECULAR PSYCHIATRY. 2022;27(8):3247-3261

Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia.

Mätlik K; Garton DR; Montaño-Rodríguez AR; Olfat S; Eren F; Casserly L; Damdimopoulos A; Panhelainen A; Porokuokka LL; Kopra JJ; Turconi G; Schweizer N; Bereczki E; Piehl F; Engberg G; Cervenka S; Piepponen TP; Zhang F-P; Sipilä P; Jakobsson J; Sellgren CM; Erhardt S; Andressoo J-O
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):229

Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients.

Shang P; Ho AM-C; Tufvesson-Alm M; Lindberg DR; Grant CW; Orhan F; Eren F; Bhat M; Engberg G; Schwieler L; Fatouros-Bergman H; Imbeault S; Iverson RM; Dasari S; Piehl F; Cervenka S; Sellgren CM; Erhardt S; Choi D-S
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240

Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis.

Plavén-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: BRAIN AND BEHAVIOR. 2022;12(1):e2472

Serum concentration of zinc is elevated in clinically stable bipolar disorder patients.

Jonsson BH; Orhan F; Bruno S; Oliveira AO; Sparding T; Landen M; Sellgren CM
Article: HUMAN BRAIN MAPPING. 2022;43(1):352-372

A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.

Gutman BA; van Erp TGM; Alpert K; Ching CRK; Isaev D; Ragothaman A; Jahanshad N; Saremi A; Zavaliangos-Petropulu A; Glahn DC; Shen L; Cong S; Alnaes D; Andreassen OA; Doan NT; Westlye LT; Kochunov P; Satterthwaite TD; Wolf DH; Huang AJ; Kessler C; Weideman A; Nguyen D; Mueller BA; Faziola L; Potkin SG; Preda A; Mathalon DH; Bustillo J; Calhoun V; Ford JM; Walton E; Ehrlich S; Ducci G; Banaj N; Piras F; Piras F; Spalletta G; Canales-Rodríguez EJ; Fuentes-Claramonte P; Pomarol-Clotet E; Radua J; Salvador R; Sarró S; Dickie EW; Voineskos A; Tordesillas-Gutiérrez D; Crespo-Facorro B; Setién-Suero E; van Son JM; Borgwardt S; Schönborn-Harrisberger F; Morris D; Donohoe G; Holleran L; Cannon D; McDonald C; Corvin A; Gill M; Filho GB; Rosa PGP; Serpa MH; Zanetti MV; Lebedeva I; Kaleda V; Tomyshev A; Crow T; James A; Cervenka S; Sellgren CM; Fatouros-Bergman H; Agartz I; Howells F; Stein DJ; Temmingh H; Uhlmann A; de Zubicaray GI; McMahon KL; Wright M; Cobia D; Csernansky JG; Thompson PM; Turner JA; Wang L
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):566

Screening for pathogenic neuronal autoantibodies in serum and CSF of patients with first-episode psychosis.

Theorell J; Ramberger M; Harrison R; Mgbachi V; Jacobson L; Waters P; Erhardt S; Sellgren CM; Cervenka S; Piehl F; Irani SR
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6820-6832

GRK3 deficiency elicits brain immune activation and psychosis.

Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hökfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landén M; Engberg G; Erhardt S
Article: NPJ SCHIZOPHRENIA. 2021;7(1):46

No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.

Lee M; Fatouros-Bergman H; Plavén-Sigray P; Ikonen Victorsson P; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2021;46(4):E441-E450

Genetic risk for bipolar disorder and schizophrenia predicts structure and function of the ventromedial prefrontal cortex.

Abé C; Petrovic P; Ossler W; Thompson WH; Liberg B; Song J; Bergen SE; Sellgren CM; Fransson P; Ingvar M; Landén M
Article: BJPSYCH OPEN. 2021;7(4):e115

Long-term trajectory of cognitive performance in people with bipolar disorder and controls: 6-year longitudinal study.

Sparding T; Joas E; Clements C; Sellgren CM; Pålsson E; Landén M
Article: SCIENTIFIC REPORTS. 2021;11(1):7527

Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis.

Becklén M; Orhan F; Piehl F; Cervenka S; Sellgren CM; Flyckt L; Erhardt S; Fatouros-Bergman H
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):179

Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.

Sheridan SD; Thanos JM; De Guzman RM; McCrea LT; Horng JE; Fu T; Sellgren CM; Perlis RH; Edlow AG
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;43:52-62

Central levels of tryptophan metabolites in subjects with bipolar disorder.

Trepci A; Sellgren CM; Pålsson E; Brundin L; Khanlarkhani N; Schwieler L; Landén M; Erhardt S
Article: BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2020;5(12):1095-1103

Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study.

Tønnesen S; Kaufmann T; de Lange A-MG; Richard G; Doan NT; Alnæs D; van der Meer D; Rokicki J; Moberget T; Maximov II; Agartz I; Aminoff SR; Beck D; Barch DM; Beresniewicz J; Cervenka S; Fatouros-Bergman H; Craven AR; Flyckt L; Gurholt TP; Haukvik UK; Hugdahl K; Johnsen E; Jönsson EG; Karolinska Schizophrenia Project; Kolskår KK; Kroken RA; Lagerberg TV; Løberg E-M; Nordvik JE; Sanders A-M; Ulrichsen K; Andreassen OA; Westlye LT
Article: NATURE COMMUNICATIONS. 2020;11(1):4016

The genetic architecture of human brainstem structures and their involvement in common brain disorders.

Elvsåshagen T; Bahrami S; van der Meer D; Agartz I; Alnæs D; Barch DM; Baur-Streubel R; Bertolino A; Beyer MK; Blasi G; Borgwardt S; Boye B; Buitelaar J; Bøen E; Celius EG; Cervenka S; Conzelmann A; Coynel D; Di Carlo P; Djurovic S; Eisenacher S; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Gelao B; Harbo HF; Hartman CA; Håberg A; Heslenfeld D; Hoekstra PJ; Høgestøl EA; Jonassen R; Jönsson EG; Karolinska Schizophrenia Project (KaSP) consortium; Kirsch P; Kłoszewska I; Lagerberg TV; Landrø NI; Le Hellard S; Lesch K-P; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Nordvik JE; Nyberg L; Connell KSO; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; de Quervain D; Reif A; Rokicki J; van Rooij D; Shadrin AA; Schmidt A; Schwarz E; Selbæk G; Soininen H; Sowa P; Steen VM; Tsolaki M; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Kaufmann T
Article: IBRO REPORTS. 2020;8:136-142

CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects.

Xu C; Sellgren CM; Fatouros-Bergman H; Piehl F; Blennow K; Zetterberg H; Brinkmalm A; Santillo AF; Lundgren S; Cervenka S; Engberg G; Erhardt S; Karolinska Schizophrenia Project (KaSP) Consortium
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2020;141(6):534-540

Reporting trigger factors for (hypo)manic episodes in bipolar disorder: association with personality and prognosis.

Smedler E; Sparding T; Hattab A; Sellgren CM; Landén M
Article: NEUROPSYCHOPHARMACOLOGY. 2020;45(4):656-665

Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics.

Amoah SK; Rodriguez BA; Logothetis CN; Chander P; Sellgren CM; Weick JP; Sheridan SD; Jantzie LL; Webster MJ; Mellios N
Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):58

Genome-wide study of immune biomarkers in cerebrospinal fluid and serum from patients with bipolar disorder and controls.

Zhang R; Song J; Isgren A; Jakobsson J; Blennow K; Sellgren CM; Zetterberg H; Bergen SE; Landén M
Article: BIOLOGICAL PSYCHIATRY. 2020;87(3):271-281

Longitudinal Cortical Thickness Changes in Bipolar Disorder and the Relationship to Genetic Risk, Mania, and Lithium Use.

Abé C; Liberg B; Song J; Bergen SE; Petrovic P; Ekman CJ; Sellgren CM; Ingvar M; Landén M
Article: JAMA PSYCHIATRY. 2019;76(7):739-748

Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.

Alnæs D; Kaufmann T; van der Meer D; Córdova-Palomera A; Rokicki J; Moberget T; Bettella F; Agartz I; Barch DM; Bertolino A; Brandt CL; Cervenka S; Djurovic S; Doan NT; Eisenacher S; Fatouros-Bergman H; Flyckt L; Di Giorgio A; Haatveit B; Jönsson EG; Kirsch P; Lund MJ; Meyer-Lindenberg A; Pergola G; Schwarz E; Smeland OB; Quarto T; Zink M; Andreassen OA; Westlye LT; Karolinska Schizophrenia Project Consortium
Article: NATURE NEUROSCIENCE. 2019;22(3):374-385

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.

Sellgren CM; Gracias J; Watmuff B; Biag JD; Thanos JM; Whittredge PB; Fu T; Worringer K; Brown HE; Wang J; Kaykas A; Karmacharya R; Goold CP; Sheridan SD; Perlis RH
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):37

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls.

Sellgren CM; Gracias J; Jungholm O; Perlis RH; Engberg G; Schwieler L; Landen M; Erhardt S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2018;138(5):432-440

Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis.

Orhan F; Schwieler L; Fatouros-Bergman H; Malmqvist A; Cervenka S; Collste K; Flyckt L; Farde L; Sellgren CM; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Engberg G; Erhardt S
Article: MOLECULAR PSYCHIATRY. 2018;23(5):1244-1250

CSF GABA is reduced in first-episode psychosis and associates to symptom severity.

Orhan F; Fatouros-Bergman H; Goiny M; Malmqvist A; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Cervenka S; Collste K; Victorsson P; Sellgren CM; Flyckt L; Erhardt S; Engberg G
Article: PSYCHIATRY RESEARCH. 2017;258:9-14

Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls.

Cremaschi L; Kardell M; Johansson V; Isgren A; Sellgren CM; Altamura AC; Hultman CM; Landén M
Article: BRAIN BEHAVIOR AND IMMUNITY. 2017;65:195-201

Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes.

Isgren A; Sellgren C; Ekman C-J; Holmén-Larsson J; Blennow K; Zetterberg H; Jakobsson J; Landén M
Article: COGNITIVE NEUROPSYCHIATRY. 2017;22(5):407-421

Classification of cognitive performance in bipolar disorder.

Sparding T; Silander K; Pålsson E; Östlind J; Ekman CJ; Sellgren CM; Joas E; Hansen S; Landén M
Article: JOURNAL OF NEURAL TRANSMISSION. 2017;124(9):1135-1143

Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls.

Pålsson E; Sellgren C; Rydén E; Kizza R; Pelanis A; Zetterberg H; Blennow K; Landén M
Article: MALARIA JOURNAL. 2017;16(1):303

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria.

Holmberg D; Franzén-Röhl E; Idro R; Opoka RO; Bangirana P; Sellgren CM; Wickström R; Färnert A; Schwieler L; Engberg G; John CC
Article: PSYCHOLOGICAL MEDICINE. 2017;47(6):1107-1115

Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis.

Pavlova B; Perlis RH; Mantere O; Sellgren CM; Isometsä E; Mitchell PB; Alda M; Uher R
Article: MOLECULAR PSYCHIATRY. 2017;22(2):170-177

Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors.

Sellgren CM; Sheridan SD; Gracias J; Xuan D; Fu T; Perlis RH
Article: SCHIZOPHRENIA BULLETIN. 2017;43(1):99-107

A History of Psychosis in Bipolar Disorder is Associated With Gray Matter Volume Reduction.

Ekman CJ; Petrovic P; Johansson AGM; Sellgren C; Ingvar M; Landén M
Article: MOLECULAR PSYCHIATRY. 2016;21(11):1504-1510

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.

Yoshimi N; Futamura T; Bergen SE; Iwayama Y; Ishima T; Sellgren C; Ekman CJ; Jakobsson J; Pålsson E; Kakumoto K; Ohgi Y; Yoshikawa T; Landén M; Hashimoto K
Article: MOLECULAR PSYCHIATRY. 2016;21(10):1342-1350

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.

Sellgren CM; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Vawter MP; Backlund L; Sullivan PF; Sklar P; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Schalling M; Engberg G; Erhardt S; Landén M
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(8):e865

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.

Brundin L; Sellgren CM; Lim CK; Grit J; Pålsson E; Landén M; Samuelsson M; Lundgren K; Brundin P; Fuchs D; Postolache TT; Traskman-Bendz L; Guillemin GJ; Erhardt S
Article: SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE. 2016;11(7):1041-1049

Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation.

Petrovic P; Ekman CJ; Klahr J; Tigerström L; Rydén G; Johansson AGM; Sellgren C; Golkar A; Olsson A; Öhman A; Ingvar M; Landén M
Article: BBA CLINICAL. 2016;5:151-158

Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder.

Yoshimi N; Futamura T; Kakumoto K; Salehi AM; Sellgren CM; Holmén-Larsson J; Jakobsson J; Pålsson E; Landén M; Hashimoto K
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2016;41(4):240-250

Cortical thickness, volume and surface area in patients with bipolar disorder types I and II.

Abé C; Ekman C-J; Sellgren C; Petrovic P; Ingvar M; Landén M
Article: COGNITIVE NEUROPSYCHIATRY. 2016;21(3):271-278

Polymorphisms of BDNF and CACNA1C are not associated with cognitive functioning in bipolar disorder or healthy controls.

Rolstad S; Sellgren Majkowitz C; Joas E; Ekman CJ; Pålsson E; Landén M
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):51

Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients.

Schwieler L; Samuelsson M; Frye MA; Bhat M; Schuppe-Koistinen I; Jungholm O; Johansson AG; Landén M; Sellgren CM; Erhardt S
Article: BRITISH JOURNAL OF PSYCHIATRY. 2016;208(2):195-196

CACNA1C polymorphism and altered phosphorylation of tau in bipolar disorder.

Jakobsson J; Pålsson E; Sellgren C; Rydberg F; Ekman A; Zetterberg H; Blennow K; Landén M
Article: BIPOLAR DISORDERS. 2015;17(8):859-868

Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder.

Rolstad S; Pålsson E; Ekman CJ; Eriksson E; Sellgren C; Landén M
Article: BRAIN. 2015;138(Pt 11):3440-3448

Manic episodes are related to changes in frontal cortex: a longitudinal neuroimaging study of bipolar disorder 1.

Abé C; Ekman C-J; Sellgren C; Petrovic P; Ingvar M; Landén M
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(8):1091-1098

CSF neuroinflammatory biomarkers in bipolar disorder are associated with cognitive impairment.

Rolstad S; Jakobsson J; Sellgren C; Isgren A; Ekman CJ; Bjerke M; Blennow K; Zetterberg H; Pålsson E; Landén M
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(4):250-258

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder.

Jakobsson J; Bjerke M; Sahebi S; Isgren A; Ekman CJ; Sellgren C; Olsson B; Zetterberg H; Blennow K; Pålsson E; Landén M
Article: BRAIN IMAGING AND BEHAVIOR. 2015;9(2):333-341

Subcortical morphometry and psychomotor function in euthymic bipolar disorder with a history of psychosis.

Liberg B; Ekman CJ; Sellgren C; Johansson AG; Landén M
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2015;131(4):269-278

Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels.

Janelidze S; Suchankova P; Ekman A; Erhardt S; Sellgren C; Samuelsson M; Westrin A; Minthon L; Hansson O; Träskman-Bendz L; Brundin L
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(2):126-133

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.

Schwieler L; Larsson MK; Skogh E; Kegel ME; Orhan F; Abdelmoaty S; Finn A; Bhat M; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schuppe-Koistinen I; Svensson C; Erhardt S; Engberg G
Article: PLOS ONE. 2015;10(5):e0127100

Cognitive performance and cerebrospinal fluid biomarkers of neurodegeneration: a study of patients with bipolar disorder and healthy controls.

Rolstad S; Jakobsson J; Sellgren C; Ekman C-J; Blennow K; Zetterberg H; Pålsson E; Landén M
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(1):133-140

Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.

Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman C-J; Ågren H; Hashimoto K; Landén M
Article: BRAIN BEHAVIOR AND IMMUNITY. 2015;43:198-204

Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment.

Isgren A; Jakobsson J; Pålsson E; Ekman CJ; Johansson AGM; Sellgren C; Blennow K; Zetterberg H; Landén M
Article: PLOS ONE. 2015;10(1):e0115562

Cognitive functioning in clinically stable patients with bipolar disorder I and II.

Sparding T; Silander K; Pålsson E; Östlind J; Sellgren C; Ekman CJ; Joas E; Hansen S; Landén M
Article: SCHIZOPHRENIA BULLETIN. 2014;40(6):1552-1559

The association between schizophrenia and rheumatoid arthritis: a nationwide population-based Swedish study on intraindividual and familial risks.

Sellgren C; Frisell T; Lichtenstein P; Landèn M; Askling J
Article: NEUROPSYCHOPHARMACOLOGY. 2014;39(10):2349-2356

Elevated concentrations of neurofilament light chain in the cerebrospinal fluid of bipolar disorder patients.

Jakobsson J; Bjerke M; Ekman CJ; Sellgren C; Johansson AGM; Zetterberg H; Blennow K; Landén M
Article: PSYCHIATRY RESEARCH. 2014;217(3):143-146

Blood-cerebrospinal fluid barrier dysfunction in patients with bipolar disorder in relation to antipsychotic treatment.

Zetterberg H; Jakobsson J; Redsäter M; Andreasson U; Pålsson E; Ekman CJ; Sellgren C; Johansson AG; Blennow K; Landén M
Article: PSYCHIATRY RESEARCH. 2014;221(3):173-178

Vertex-based morphometry in euthymic bipolar disorder implicates striatal regions involved in psychomotor function.

Liberg B; Ekman CJ; Sellgren C; Johansson A; Landén M
Article: MOLECULAR PSYCHIATRY. 2014;19(3):334-341

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.

Lavebratt C; Olsson S; Backlund L; Frisén L; Sellgren C; Priebe L; Nikamo P; Träskman-Bendz L; Cichon S; Vawter MP; Osby U; Engberg G; Landén M; Erhardt S; Schalling M
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:15-22

Imbalanced kynurenine pathway in schizophrenia.

Kegel ME; Bhat M; Skogh E; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schwieler L; Engberg G; Schuppe-Koistinen I; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2013;38(4):E21-E26

Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder.

Jakobsson J; Stridsberg M; Zetterberg H; Blennow K; Ekman C-J; Johansson AGM; Sellgren C; Landén M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e4

Can routinely collected data be used for research on bipolar disorder? data from the St. Göran bipolar project

Landén M; Rydén E; Johansson A; Wetterberg L; Jakobsson J; Pålsson E; Ekman CJ; Sellgren C; Olsson S; Erhardt S; Båve U
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e42

Working memory performance in bipolar disorder

Sellgren C; Engberg G; Erhardt S; Lichtenstein P; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e41-e42

The Kynurenine pathway and cognitive performance in Euthymic bipolar disorder

Sellgren C; Olsson S; Erhardt S; Engberg G; Lichtenstein P; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e25

Genome-wide study of CSF kynurenic acid in bipolar disorder implicates a molecular pathway underlying psychosis

Sellgren C; Kegel M; Ekman C; Olsson S; Svensson C; Hultman C; Lichtenstein P; Purcell S; Sullivan P; Sklar P; Engberg G; Erhardt S; Landèn M
Article: BIPOLAR DISORDERS. 2012;14(7):719-726

Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder.

Olsson SK; Sellgren C; Engberg G; Landén M; Erhardt S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2011;124(6):447-453

Validity of bipolar disorder hospital discharge diagnoses: file review and multiple register linkage in Sweden.

Sellgren C; Landén M; Lichtenstein P; Hultman CM; Långström N
Article: DIGESTIVE AND LIVER DISEASE. 2011;43(8):616-622

Increased suicide risk in coeliac disease--a Swedish nationwide cohort study.

Ludvigsson JF; Sellgren C; Runeson B; Långström N; Lichtenstein P
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All other publications

Preprint: BIORXIV. 2023;BIORXIV

Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization.

Ge R; Yu Y; Qi YX; Fan YV; Chen S; Gao C; Haas SS; Modabbernia A; New F; Agartz I; Asherson P; Ayesa-Arriola R; Banaj N; Banaschewski T; Baumeister S; Bertolino A; Boomsma DI; Borgwardt S; Bourque J; Brandeis D; Breier A; Brodaty H; Brouwer RM; Buckner R; Buitelaar JK; Cannon DM; Caseras X; Cervenka S; Conrod PJ; Crespo-Facorro B; Crivello F; Crone EA; de Haan L; de Zubicaray GI; Di Giorgio A; Erk S; Fisher SE; Franke B; Frodl T; Glahn DC; Grotegerd D; Gruber O; Gruner P; Gur RE; Gur RC; Harrison BJ; Hatton SN; Hickie I; Howells FM; Pol HEH; Huyser C; Jernigan TL; Jiang J; Joska JA; Kahn RS; Kalnin AJ; Kochan NA; Koops S; Kuntsi J; Lagopoulos J; Lazaro L; Lebedeva IS; Lochner C; Martin NG; Mazoyer B; McDonald BC; McDonald C; McMahon KL; Nakao T; Nyberg L; Piras F; Portella MJ; Qiu J; Roffman JL; Sachdev PS; Sanford N; Satterthwaite TD; Saykin AJ; Schumann G; Sellgren CM; Sim K; Smoller JW; Soares J; Sommer IE; Spalletta G; Stein DJ; Tamnes CK; Thomopolous SI; Tomyshev AS; Tordesillas-Gutiérrez D; Trollor JN; van 't Ent D; van den Heuvel OA; van Erp TG; van Haren NE; Vecchio D; Veltman DJ; Walter H; Wang Y; Weber B; Wei D; Wen W; Westlye LT; Wierenga LM; Williams SC; Wright MJ; Medland S; Wu M-J; Yu K; Jahanshad N; Thompson PM; Frangou S
Letter: BRAIN BEHAVIOR AND IMMUNITY. 2023;114:163-164

Preanalytic handling of clinical blood samples in assessing immunological proteins - Role of storage duration.

Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Preprint: BIORXIV. 2023

Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia

Orhan F; Malwade S; Khanlarkhani N; Gkoga A; Jungholm O; Koskuvi M; Lehtonen Š; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren CM
Preprint: PSYARXIV. 2023

Functional connectivity alterations of the somatomotor network in euthymic bipolar disorder

Klahn AL; Thompson WH; Abe C; Liberg B; Sellgren CM; Klahn P; Landén M
Preprint: MEDRXIV. 2023

Disrupted-in-schizophrenia 1 (DISC1) protein aggregates in cerebrospinal fluid are elevated in first-episode psychosis patients

Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Troßbach S; Willbold D; Erhardt S; Bannach O; Korth C
Review: MOLECULAR PSYCHIATRY. 2023;28(1):34-43

Neurodevelopmental disorders-high-resolution rethinking of disease modeling.

Khodosevich K; Sellgren CM
Preprint: MEDRXIV. 2022

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Schijven D; Postema MC; Fukunaga M; Matsumoto J; Miura K; de Zwarte SMC; van Haren NEM; Cahn W; Pol HEH; Kahn RS; Ayesa-Arriola R; de la Foz VO-G; Tordesillas-Gutierrez D; Vázquez-Bourgon J; Crespo-Facorro B; Alnæs D; Dahl A; Westlye LT; Agartz I; Andreassen OA; Jönsson EG; Kochunov P; Bruggemann JM; Catts SV; Michie PT; Mowry BJ; Quidé Y; Rasser PE; Schall U; Scott RJ; Carr VJ; Green MJ; Henskens FA; Loughland CM; Pantelis C; Weickert CS; Weickert TW; de Haan L; Brosch K; Pfarr J-K; Ringwald KG; Stein F; Jansen A; Kircher TTJ; Nenadic I; Krämer B; Gruber O; Satterthwaite TD; Bustillo J; Mathalon DH; Preda A; Calhoun VD; Ford JM; Potkin SG; Chen J; Tan Y; Wang Z; Xiang H; Fan F; Bernardoni F; Ehrlich S; Fuentes-Claramonte P; Garcia-Leon MA; Guerrero-Pedraza A; Salvador R; Sarró S; Pomarol-Clotet E; Ciullo V; Piras F; Vecchio D; Banaj N; Spalletta G; Michielse S; van Amelsvoort T; Dickie EW; Voineskos AN; Sim K; Ciufolini S; Dazzan P; Murray RM; Kim W-S; Chung Y-C; Andreou C; Schmidt A; Borgwardt S; McIntosh AM; Whalley HC; Lawrie SM; du Plessis S; Luckhoff HK; Scheffler F; Emsley R; Grotegerd D; Lencer R; Dannlowski U; Edmond JT; Rootes-Murdy K; Stephen JM; Mayer AR; Antonucci LA; Fazio L; Pergola G; Bertolino A; Díaz-Caneja CM; Janssen J; Lois NG; Arango C; Tomyshev AS; Lebedeva I; Cervenka S; Sellgren CM; Georgiadis F; Kirschner M; Kaiser S; Hajek T; Skoch A; Spaniel F; Kim M; Bin Kwak Y; Oh S; Kwon JS; James A; Bakker G; Knöchel C; Stäblein M; Oertel V; Uhlmann A; Howells FM; Stein DJ; Temmingh HS; Diaz-Zuluaga AM; Pineda-Zapata JA; López-Jaramillo C; Homan S; Ji E; Surbeck W; Homan P; Fisher SE; Franke B; Glahn DC; Gur RC; Hashimoto R; Jahanshad N; Luders E; Medland SE; Thompson PM; Turner JA; van Erp TGM; Francks C
Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855

Correction: GRK3 deficiency elicits brain immune activation and psychosis.

Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hökfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landén M; Engberg G; Erhardt S
Review: PHARMACOLOGICAL REVIEWS. 2022;74(1):141-206

Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives.

Youhanna S; Kemas AM; Preiss L; Zhou Y; Shen JX; Cakal SD; Paqualini FS; Goparaju SK; Shafagh RZ; Lind JU; Sellgren CM; Lauschke VM
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:378-379

Proteomic Plasma Profiling of Patients With First-Episode Psychosis Identifies Inflammatory Markers Associated With Illness Severity

Erhardt S; Schwieler L; Sellgren CM; Eren F; Cervenka S; Piehl F; Bergman HF; Orhan F; Engberg G
Preprint: MEDRXIV. 2021

Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia

Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VAC; Göpfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Preprint: RESEARCH SQUARE. 2021

SARS-CoV-2 Neurotropism and Single Cell Responses in Brain Organoids Containing Innately Developing Microglia

Samudyata S; Oliveira A; Malwade S; de Sousa NR; Goparaju S; Orhan F; Steponaviciute L; Sheridan S; Perlis R; Rothfuchs A; Sellgren C
Preprint: BIORXIV. 2021

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

Samudyata; Oliveira AO; Malwade S; de Sousa NR; Goparaju S; Lekander JG; Orhan F; Steponaviciute L; Schalling M; Sheridan S; Perlis R; Rothfuchs A; Sellgren C
Conference publication: BIOLOGICAL PSYCHIATRY. 2021;89(9):S34

Genomic Variation Within the C4 Locus and Cerebro-spinal Fluid Levels of C4 Isotype Proteins in Acute and Chronic Schizophrenia

Gracias J; Horbeck E; Holmen-Larsson J; Pelanis A; Goold C; Goulding A; Annerbrink K; Isgren A; Sparding T; Blennow K; Zetterberg H; Vuijk P; Doyle AAE; Sheridan S; Perlis R; Landen M; Sellgren C
Preprint: BIORXIV. 2020;BIORXIV

Umbilical cord blood derived microglia-like cells to model COVID-19 exposure.

Sheridan SD; Thanos JM; De Guzman RM; McCrea LT; Horng J; Fu T; Sellgren CM; Perlis RH; Edlow AG
Review: FRONTIERS IN PSYCHIATRY. 2020;11:586083

Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder.

Lundberg M; Millischer V; Backlund L; Martinsson L; Stenvinkel P; Sellgren CM; Lavebratt C; Schalling M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S193-S194

The genetic risk for bipolar disorder predicts cortical thickness of the medial orbitofrontal cortex in patients and healthy controls

Abe C; Ossler W; Liberg B; Song J; Sarah B; Petrovic P; Ekman CJ; Sellgren C; Ingvar M; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S341

Large-scale serum biomarker profiling in patients with bipolar disorder

Palsson E; Jakobsson J; Isgren A; Sellgren C; Ekman CJ; Holmen-Larsson J; Landen M
Conference publication: GLIA. 2019;67:E325

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Gracias J; Watmuff B; Biag J; Thanos J; Whittredge P; Fu T; Worringer K; Brown H; Wang J; Kaykas A; Karmacharya R; Goold C; Sheridan S; Sellgren C; Perlis R
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):490-491

Role of GRK3 in Brain Immune Activation and Psychosis

Erhardt S; Sellgren CM; Schwieler L; Imbeault S; Engberg G
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):169-170

Synaptic Elimination in First-Episode Psychosis Subjects

Engberg G; Xu C; Sellgren C; Fatouros-Bergman H; Blennow K; Zetterberg H; Brinkmalm A; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2018;195:406-408

First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction.

Orhan F; Fatouros-Bergman H; Schwieler L; Cervenka S; Flyckt L; Sellgren CM; Karolinska Schizophrenia Project (KaSP) consortium; Engberg G; Erhardt S
Preprint: BIORXIV. 2017

Increased microglial synapse elimination in patient-specific models of schizophrenia

Sellgren CM; Gracias J; Watmuff B; Goold CP; Thanos JM; Fu T; Karmacharya R; Brown HE; Wang J; Sheridan SD; Perlis RH
Conference publication: BIPOLAR DISORDERS. 2017;19:115

Proteome-wide study of cerebrospinal fluid biomarkers for bipolar disorder

Larsson JH; Holtta M; Sellgren CM; Zetterberg H; Blennow K; Landen M; Gobom J
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2017;42:S220-S221

First-Episode Psychosis Patients Display Increased Plasma IL-18 That Correlates With Cognitive Dysfunctions

Schwieler L; Orhan F; Fatouros-Bergman H; Cervenka S; Flyckt L; Farde L; Sellgren CM; Engberg G; Erhardt S
Conference publication: BIPOLAR DISORDERS. 2017;19:126

Altered cerebrospinal monoamine metabolite concentrations in bipolar disorder

Palsson E; Ryden E; Pelanis A; Zetterberg H; Blennow K; Sellgren C; Landen M
Conference publication: BIPOLAR DISORDERS. 2017;19:39-40

Cognitive impairments in bipolar disorder

Sparding T; Silander K; Palsson E; Ostlind J; Sellgren C; Ekman CJ; Joas E; Hansen S; Landen M
Conference publication: BIOLOGICAL PSYCHIATRY. 2016;79(9):338S-339S

An Enzyme in the Kynurenine Pathway That Governs Vulnerability to Develop Suicidal Behavior

Brundin L; Sellgren C; Lim C; Grit J; Palsson E; Landen M; Brundin P; Fuchs D; Postolache T; Traskman-Bendz L; Guillemin G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S429-S430

Microglial activation in mood stabilised bipolar disorder patients

Jakobsson J; Isgren A; Palsson E; Ekman CJ; Johansson AGM; Sellgren C; Blennow K; Zetterberg H; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S426

Cerebrospinal fluid biomarkers of neurodegeneration affect cognitive functions in bipolar disorder but not healthy controls

Rolstad S; Jakobsson J; Sparding T; Sellgren C; Ekman CJ; Blennow KAJ; Zetterberg H; Palson E; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S423-S424

Sense of coherence as a predictor of suicide attempts in bipolar disorder

Palsson E; Lundberg U; Johnson L; Ekman CJ; Sellgren C; Landen M
KI thesis / dissertation: 2014

On neuroinflammation in psychotic disorders

Sellgren, Carl
Conference publication: BIPOLAR DISORDERS. 2014;16:65

An inflammatory pathway linked to psychosis in bipolar disorder

Sellgren C; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Sullivan PF; Sklar P; Purcell S; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Engberg G; Erhardt S; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23:S385-S386

Cerebrospinal fluid cytokine concentrations in bipolar disorder patients and healthy controls

Isgren A; Jakobsson J; Palsson E; Ekman CJ; Johansson A; Sellgren C; Blennow K; Zetterberg H; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23:S376-S377

Associations between cerebrospinal fluid markers and on-going medical treatment in patients with bipolar disorder

Jakobsson J; Palsson E; Bjerke M; Olsson B; Ekman CJ; Sellgren C; Johansson AGM; Blennow K; Zetterberg H; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23:S94-S95

Cerebrospinal fluid biomarkers of brain injury in bipolar disorder

Jakobsson J; Palsson E; Ekman CJ; Sellgren C; Johansson AGM; Zetterberg H; Blennow K; Landen M
Conference publication: BIPOLAR DISORDERS. 2011;13:87

Plasticity related gene 5, kynurenic acid, and psychotic features in bipolar disorder

Sellgren C; Olsson S; Lichtenstein P; Erhardt S; Engberg G; Grankvist A; Landen M
Preprint: BIORXIV.

Oligodendrocyte precursor cells engulf synapses in a model of the developing human forebrain

Gkogka A; Malwade S; Koskuvi M; Bose R; Ceccatelli S; Koistinaho J; Tiihonen J; Schalling M; Samudyata; Sellgren CM
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Employments

Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2017-
Assistant Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2020-2026

Degrees and Education

Associate Professor, physiology and pharmacology, Karolinska Institute, 2023
Docent, Karolinska Institutet, 2023
Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2014
University Medical Degree, Karolinska Institutet, 2004

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