Cesare Patrone
Senior lecturer/clinical position
About me
Associate Professor/Senior Lecturer
Researh Group: https://ki.se/en/kisos/the-neurocardiometabol-group
In February 2009 I was recruited to Karolinska Institutet to start up a research group about the neurological complications of type 2 diabetes, with main focus on stroke. I am responsible for planning, coordinating and executing work in the area of experimental stroke in diabetes.
2001-2009: Senior Researcher and Manager at Neuronova AB, Stockholm, Sweden
2000-2001: Postdoctoral Fellow, Karolinska Institutet, Stockholm, Sweden
1998-2000: Postdoctoral Fellow, Uppsala University, Sweden
1998: PhD in Neurobiology, Milano University, Italy
Research description
Stroke and Diabetes
The focus is along two research lines, see also the Research Group at: https://ki.se/en/kisos/the-neurocardiometabol-group
- The identification of efficacious preclinical therapies for the treatment of stroke in diabetes.
- The study of the cellular mechanisms at the basis of the neurological complications of diabetes.
Stroke affects several million people worldwide, of which a substantial proportion of cases present in patients suffering from diabetes. Diabetes is widespread and represents a leading cause of death. About 90 % of the medical and social costs associated with diabetes are dominated by care for macrovascular complications such as stroke. Therefore it is important to identify strategies aimed at prevent stroke in diabetes but also improve post-stroke recovery in diabetic individuals.
-We recently showed that decreasing weight in diabetes to the extent that glucose metabolism is normalized significantly improves stroke recovery: https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes. The findings have been published in Cardiovascular Diabetology
-GLP-1R agonists are commonly used drugs for the treatment of type 2 diabetes. We were the first in 2012 to show that the activation of the glucagon-like receptor 1 (GLP-1R) is neuroprotective against stroke in type 2 diabetic rodents. The findings have been published in Clinical Science: https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/
In 2021, we showed that this pharmacological strategy can also improve post-stroke functional recovery. The findings have been published in the British Journal of Pharmacology https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/
-We demonstrated a similar stroke efficacy as for the GLP-1R agonists for another class of clinically used drugs against diabetes called DPP-4 inhibitors. The findings were published in Diabetes in 2012 https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/ and 2021 https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/.
See also the press release about the findings 2012 https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke
-We identified several cellular mechanisms that are induced by diabetes and play a detrimental role in the impairment of stroke recovery. Among the most recent publications are the findings recently published in Clinical Science https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/ and Acta Neuropathologica Communications https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/
Teaching portfolio
July 2013- ongoing, Project Coordinator/Examiner in degree projects in medicine, Department of Medical Epidemiology and Biostatistics, KI. The position involves reviewing the students’ work-plan, half time and final thesis, arrange seminars and examine the work.
2015- 2020 Visiting Professor (1 week/year), Univ. of Piemonte Orientale, Novara, Italy
Education
2018 Assess the structure of examination of projects, Workshop, Karolinska Institutet
2013 Docent in neuroscience, Karolinska Institutet
2011 Course in "Assessment in Higher Education", Karolinska Institutet
2011 Basic Course in Education for University Teachers, Karolinska Institutet
2010 Introductory Doctoral Supervision Course, Karolinska Institutet
2010 Work environment issues and manager responsibilities , Karolinska Institutet
2009 Laboratory Animal Science (FELASA) certificate, Karolinska Institutet
2008 Applied Project Management Courses, Wenell Management AB, Stockholm
2007 Courses in Clinical Trials, Trial Form Support AB, Lund
1998 PhD in Neurobiology, University of Milan, Italy.
1992 University of Milan, Italy, Laurea and M.Sc. Biological Sciences
Academic honours, awards and prizes
Research grants and awards as PI
- The Swedish Research Council (Vetenskasprådet); 2022-2025
- Hjärnfonden 2022
- Hjärnfonden 2021
- Diabetesfonden; 2020-2021
- The Swedish Research Council (Vetenskasprådet); 2018-2021
- European Foundation for the Study of Diabetes/Sanofi European Diabetes Research Programme in Macrovascular Complications; 2019
- Award “Investigator Study IIS” Boehringer Ing. Sweden; 2018
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; 2012-2017
- Åhlén Stiftelse; 2012-2018
- O. E. och Edla Johanssons Stiftelse; 2016-2018
- Magnus Bergvalls Stiftelse; 2011-2016
- STROKE Riksförbundet; 2018-2020
- Diabetesfonden; 2014-2015
- Novo Nordisk Foundation; 2014
- Syskonen Svensson Stiftelse; 2017
- European Foundation for the Study of Diabetes; 2013
- Diabetes Wellness; 2010
- Stohnes stiftelse; 2010, 2012, 2015
- STROKE Riksförbundet; 2011-2014
- European Foundation for the Study of Diabetes; 2009