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Charlotte Hedin

Affiliated to research

Department and organisational affiliation:

About me

Dr Charlotte Hedin is a specialist in gastroenterology and internal medicine at the Karolinska University Hospital in Stockholm. She completed her PhD "Microbial, immunological, phenotypic and genetic markers of risk: aspects of Crohn’s disease that are shared by unaffected siblings" at King’s College London and Queen Mary University of London. In 2017 she was awarded a UEG Rising Star award for her research in IBD and in 2018 she was awarded the Karolina prize for “Exemplary patient flow and quality work” at the Karolinska Hospital. She holds a clinical post-doctorate from the Karolinska Hospital. She is a member of the Swedish Organisation for the study of IBD (SOIBD)) and is committee member for the European Crohn’s and Colitis Organisation (ECCO). Dr Hedin’s research focusses on: 1. Extraintestinal inflammation in IBD inlcuding PSC, 2. Delineating pathogenic pathways in IBD through studying at-risk individuals (families of IBD patients) and 3. Defining the process of mucosal healing.

Research description

Lynch KD, Chapman RW, Keshav S, Montano-Loza AJ, Mason AL, Kremer AE, Vetter M, de Krijger M, Ponsioen CY, Trivedi P, Hirschfield G, Schramm C, Liu CH, Bowlus CL, Estes DJ, Pratt D, Hedin C, Bergquist A, de Vries AC, van der Woude CJ, Yu L, Assis DN, Boyer J, Ytting H, Hallibasic E, Trauner M, Marschall HU, Daretti LM, Marzioni M, Yimam KK, Perin N, Floreani A, Beretta-Piccoli BT, Rogers JK; International Primary Sclerosing Cholangitis Study Group (IPSCSG), Levy C. Effects of Vedolizumab in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 Jan;18(1):179-187

Hedin CRH, Vavricka SR, Stagg AJ, Schoepfer A, Raine T, Puig L, Pleyer U, Navarini A, van der Meulen-de Jong AE, Maul J, Katsanos K, Kagramanova A, Greuter T, González-Lama Y, van Gaalen F, Ellul P, Burisch J, Bettenworth D, Becker MD, Bamias G, Rieder F. The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy. J Crohns Colitis. 2019 Apr 26;13(5):541-554.

Hedin C, van der Gast CJ, Rogers GB, Cuthbertson L, McCartney S, Stagg AJ, Lindsay JO, Whelan K. Siblings of patients with Crohn's disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities. Gut. 2016 Jun;65(6):944-53

Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K, Lindsay JO. Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings. Gut. 2014 Oct; 63(10):1578-86

Hedin CRH, Stagg AJ, Whelan K, Lindsay JO. Family studies in Crohn’s disease: New horizons in understanding disease pathogenesis, risk and prevention. Gut 2012; 61: 311-318

Hedin CRH, Mullard M, Sharratt E, Jansen C, Sanderson JD, Shirlaw P, Howe LC, Djemal S, Stagg AJ, Lindsay JO and Whelan K Probiotic and Prebiotic Use in Patients with Inflammatory Bowel Disease: A Case-Control Study. Inflammatory Bowel Diseases 2010; 16(12): 2099-108

Hedin C, Whelan K, Lindsay JO Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials. Proc Nutr Soc 2007; 66 (3): 307-315

McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM, Wildemann M, Bashir Z, Whelan K, Sanderson I, Lindsay JO, Stagg AJ. Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn's disease. J Clin Invest. 2015; 125(8):3215-25.

Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG, Sanderson JD, Hart AL, Kamm MA, Knight SC, Forbes A, Stagg AJ, Lindsay JO, Whelan K. Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota Inflammatory Bowel Diseases 2012; 18(6): 1092–1100

Goodhand J, Hedin CR, Croft NM, Lindsay JO. Adolescents with IBD: The importance of structured transition care. Journal of Crohn's and Colitis 2011; 5(6): 509-519

Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K, and Lindsay JO A randomised, double blind placebo controlled trial of fructo-oligosaccharides in active Crohn’s disease. Gut 2011; 60: 923-929

Hedin CRH. In: Smith P, Gill J, Nijjer S, and Levy J, eds. Secrets of Success: Getting into academic training. 1 ed. Royal Society of Medicine Press Ltd, 2010.

Academic honours, awards and prizes

2018 Karolina prize for “Exemplary patient flow and quality work”

2017 UEG Rising Star Award

2016 Swedish Medical Society prize for best scientific application

2013 Prize for best inflammatory bowel disease oral presentation of an abstract at the British Society of Gastroenterology Annual Meeting

2011 First prize in the oral presentation competition in the King’s College London Postgraduate Research Symposium

2010 Runner-up in poster competition King’s College London Postgraduate Research Symposium

2004 British Infection Society Spring Meeting presentation prize

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