Dasiel Oscar Borroto Escuela
Understanding whether alterations in specific heteroreceptor complexes and their receptor-receptor interactions are associated with and/or play a role in brain disease development, e.g., depression
In the past years, I have been focused on the study of GPCR-GPCR and GPCR-RTK receptor-receptor interactions in the CNS and the characterization of their interface interactions, especially on the implementation of new innovative tools and screening technologies to identify GPCR oligomerization (e.g., RT-BRET, in situ PLA). A novel understanding of the pathophysiology of brain disease may take place based on pathological changes in discrete brain receptor heteromers. Therefore, I has been involved on understanding whether alterations in specific GPCR heteroreceptor complexes and their allosteric receptor-receptor interactions are associated with and/or play a role in pathogenetic mechanisms contributing to brain disease development, inter alia Parkinson's disease, Schizophrenia, addiction and depression. These homo and heteroreceptor complexes offer novel targets for treatment of psychiatry and neurological disorders.
I have been acting as a main supervisor of eighteen graduate students (9 BSc, 4 MSc, 4 PhD, 1 Postdoc). As a member of five international PhD thesis examination committee (Spain, Italy, Belgium).
2015-2023: Guest Professor. PhD Programme of the Department of Earth, Life and Environmental Sciences, Universitá Degli Studio di Urbino Carlo Bo, Urbino, Italy.
2012 M.B.A. Master of International Business. Pompeu Fabra University, Spain.
2008 Ph.D. in Polymers and Biopolymers. Polytechnic University of Catalonia, Spain.
2003 M.Sc. in Bioinformatics. Center for Genetic Engineering and Biotechnology, Cuba.
2003 B.S. in Biochemistry. College of Biological Science, University of Havana, Cuba.
Academic honours, awards and prizes
2018-2023 Board member of the Ph.D. comission in Biomolecular and Health Sciences at the University of Urbino Carlo Bo, Urbino, Italy.
2019 Chair of the FENS Regional Meeting Symposium " Understanding the role of GPCR heteroreceptor complexes in the neuronal networks of the brain in health and disease". Belgrade, July 10-14, 2019. Serbia
2019 Co-chair of the Karolinska Institutet Neuroscience Network Symposium 2019. Brain integrative processing through Oligomeric receptor complexes. Nobel Forum, KI, November 25, 2019. Stockholm, Sweden.
2015 Chair of the FENS Regional Meeting Symposium " The impact of receptor-receptor interactions on brain plasticity ". October 07-10, in Thessaloniki, Greece.
AWARDS AND PRIZES
2014 ECNP Fellowship Award. 27th ECNP Congress, 18-21 October, Berlin, Germany
2014 Neuroscience Travel Award. iSAMS 2014, 1-6 Octuber 2014, Tokyo, Japan
2014 FENS/IBRO travel grant. 9th FENS Forum of Neuroscience, Milano, Italy.
2013 Young Fellowship Award. FEBS-YSF Congress. Saint Petersburg, Russia.
2013 ESF-EMBO Grant. ESF-EMBO Conference on Protein-Protein Interactions.
2012 Royal Swedish Academy of Sciences Postdoctoral fellow. KI, Stockholm, Sweden
2012 IUBMB/FEBS Grant. 22nd IUBMB & 37th FEBS Congress, Seville, Spain.
2012 FENS/IBRO travel grant. 8th FENS, Barcelona, Spain.
2011 Excellence Thesis Award of the Polytechnic University of Catalonia. Spain.
2008 Technology Transfer Award. Barcelona, Spain.
2006 Fellowship for Advanced Studies Abroad (BE). Geneva, Switzerland
2008 PhD student Research Fellow from EU-ESF. Barcelona, Spain.