About me

I am a MD specialized in geriatric medicine at the Catholic University of Rome, with a PhD in geriatric epidemiology from Karolinska Institutet.

I am currently a postdoctoral fellow at the Aging Research Center of Karolinska Institutet, in the research group of prof. Laura Fratiglioni. 

Research description

My main research interests are:

Multimorbidity development and its prognosis. Multimorbidity, the co-occurrence of multiple diseases in the same individual, is the most common condition encountered in older people. During the past years, I focused my attention on the definition of multimorbidity and its measurement in older individuals. Together with a group of colleagues from KI and other international Institutions, we refined the concept of multimorbidity clusters and that of speed of multimorbidity development. We investigate the impact of multimorbidity clusters on several health-related outcomes, and we recently started looking at the risk factors and determinants (i.e., psychosocial, biological etc.) of fast disease accumulation.        

Multidimensional assessment of health and biological age in older people. Aging is a complex and heterogeneous process which greatly departs from the linearity of calendar time. We combine clinical, biological, functional and socio-demographic information a) to build reliable prognostic tools for risk stratification as for example the frailty index; b) to build measures of biological and phenotypic age; c) to identify homogeneous groups of individuals with specific needs, that may benefit from given preventive and therapeutic interventions. The combination of information on disease status with functional parameters (physical and cognitive) and frailty status has been investigated in several studies I authored and co-authored.   


Full publication list here

Google Scholar profile here


Selected publications: 

Grande G, Haaksma ML,...Vetrano DL. Co-occurrence of cognitive impairment and physical frailty, and incidence of dementia: Systematic review and meta-analysis. Neurosci Biobehav Rev. 2019 Sep 3;107:96-103.

Dekhtyar S, Vetrano DL,...Calderón-Larrañaga A. Association Between Speed of Multimorbidity Accumulation in Old Age and Life Experiences: A Cohort Study. Am J Epidemiol. 2019 Sep 1;188(9):1627-1636.

Grande G, Triolo F,...Vetrano DL. Measuring gait speed to better identify prodromal dementia. Exp Gerontol. 2019 Sep;124:110625.

Vetrano DL, Rizzuto D,...Fratiglioni L. Walking Speed Drives the Prognosis of Older Adults with Cardiovascular and Neuropsychiatric Multimorbidity. Am J Med. 2019 May 27. pii: S0002-9343(19)30432-2.

Calderón-Larrañaga A, Vetrano DL (co-first),...Fratiglioni L. Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways. J Intern Med. 2019 Mar;285(3):255-271.

Marengoni A, Vetrano DL,...Onder G. Multimorbidity and patient-centred care in the 3D trial. Lancet. 2019 Jan 12;393(10167):127-128.

Vetrano DL, Palmer K,...Onder G; Joint Action ADVANTAGE WP4 Group. Frailty and Multimorbidity: A Systematic Review and Meta-analysis. J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):659-666.

Vetrano DL, Rizzuto D,...Fratiglioni L. Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish cohort study. PLoS Med. 2018 Mar 6;15(3):e1002503.

Marengoni A, Vetrano DL,...Palmer K. The Relationship Between COPD and Frailty: A Systematic Review and Meta-Analysis of Observational Studies. Chest. 2018 Jul;154(1):21-40.

Vetrano DL, Calderón-Larrañaga A,...Fratiglioni L. An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room. J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1350-1356.

Calderón-Larrañaga A, Vetrano DL,...Fratiglioni L. Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1417-1423.

Teaching portfolio

As part of my pedagogical activity, I have been lecturing to both masters' and PhD students. I have also been a supervisor of several MD students and residents in geriatrics. I am currently co-supervising two PhD students and supervising several masters' students and research assistants. 


- 2019 PhD in Geriatric Epidemiology

- 2016 Specialization in Geriatrics

- 2010 Medical Doctor degree

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