Professor Elisabet Stener-Victorin is principle investigator of the research group Reproductive Endocrinology and Metabolism at the Department of Physiology and Pharmacology at Karolinska Institutet. Through financial support from the Swedish Research Council, Novo Nordisk Foundation, clinical funding, and The Strategic Research Program for Diabetes at Karolinska Institutet, her lab bridging preclinical and clinical investigations of polycystic ovary syndrome (PCOS) the most common endocrine and metabolic disorder.
My lab is interested in dissecting the genetic versus epigenetic heritability in the transmission of PCOS and associated comorbidities such as type 2 diabetes and mental-health disorders across generations by dissecting the molecular, mechanistic, and causal links, and to determine whether men can also transmit the disease. We use different PCOS-like mice models to delineate the main trigger of PCOS and define whether germ cells drive the transmission of the syndrome in the absence of PCOS-associated gene variants. Moreover, we translate our findings in mice to the clinical situation and perform detailed phenotyping of women with and without PCOS and collect serum/blood and endometrium, fat and skeletal muscle tissue biopsies and investigate the effect of different treatments. Frequently used techniques are single-cell/nuclei RNA sequencing, whole genome bisulfite sequencing, small-noncoding RNA sequencing, 3D endometrial organoid, stem cell differentiation modeling e.g. adipogenesis and myogenesis.