Ph.D. | Assoc. Professor of Metabolism

Erik Norberg

Researcher

About me

2019-present:  Assoc. Professor of Metabolism (Docent), Karolinska Inst.

2014-2018: Asst. Professor, Karolinska Inst.          

2011-2013: PostDoc at Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA. 

2011: Ph.D. Karolinska Institute, Stockholm, Sweden.

2006: MSc. Stockholm Research School in Molecular Life Science.

2005: MSc. Uppsala University, Uppsala, Sweden.

 

Research description

We are mainly focusing on the following overarching topics:

1. Metabolic Adaptations to Oncogenes and Tumor Suppressors. 

2. Metabolic Signal Transduction.   

3. Molecular Regulators of Metabolic Heterogeneity

 

Research Group ' Cellular Metabolism:

Boxi Zhang, PhD, PostDoc.

Lyudmila Krassikova, PhD, PostDoc.

Divya Nagarajan, PhD, PostDoc.

Vagelis Samakidis, MSc, Lab technician.

Alumni:

Dawn E Comstock, MD-PhD student, Harvard Medical School. Yiwei Ai, MD, research student

Dominique Smith, Masters student, Uppsala University.

Wirood Aldjezani, Masters Student, Uppsala University.

 

Select Original Publications:

1. The deubiquitinase JOSD2 is a positive regulator of glucose metabolism. Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E, Vakifahmetoglu-Norberg H, Norberg E. Cell Death Differ. 2020 Oct 20. doi: 10.1038/s41418-020-00639-1. Online ahead of print.

>News: https://news.ki.se/newly-discovered-mechanism-controls-cancer-cell-grow…

2. Ambroise G, Yu TT, Zhang B, Kacal M, Hao Y, Queiroz AL, Ouchida AT, Lindskog C, Norberg E#, Vakifahmetoglu-Norberg H#. Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas. British Journal of Cancer. 2020 Sep;123(7):1164-1177.       # co-corresponding author

3. Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M, Vakifahmetoglu-Norberg, H, Norberg E. PHGDH Defines a metabolic subtype in lung adenocarcinomas with poor prognosis. Cell Reports 2017 Jun 13;19(11):2289-2303.

>Selected as 'Issue Highlight' by Cell Reports.

4. Eriksson M, Ambroise G, Ouchida AT, Queiroz AL, Smith D, Gimenez-Cassina A, Iwanicki MP, Muller PA, Norberg E#, Vakifahmetoglu-Norberg H#. The effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism. Mol Cell Biol. 2017 Nov 28;37(24)      # Co-corresponding author.

>Selected for the Cover volume 37, issue 24.

5. Zhang B, Tornmalm J, Widengren J, Vakifahmetoglu-Norberg H, Norberg E. Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival. Journal of Cancer 2017; 8(11):2088-2096. 

 

Select Reviews/Editorials:

1. Queiroz AL, Vakifahmetoglu-Norberg H, Norberg E. Resistant to Targeted Therapy - Aim for Metabolic Liabilities. Theranostics 2018; 8(7): 2061-2063.

2. Vakifahmetoglu-Norberg H, Ouchida A, Norberg E. The role of Mitochondria in Metabolism and Cell Death. Biochem Biophys Res Commun. (2017) Jan 15;482(3):426-431

>As of July/August 2017, this Review received enough citations to place it in the top 1% of the academic field of Biology & Biochemistry (Web of Science).

3. Stanley I, Ribeiro S, Gimenez-Cassina A, Norberg E, Danial NN. Changing appetites: The adaptive advantages of fuel choice. Trends in Cell Biology. 2014 Feb;24(2):118-27

 

Open Positions:

Master of Science Project,

-Profiling of Post translational modifications in tumor cells. (start 2019-2020.)

 

PhD student project:

1 PhD student position available from end of 2020 or begining of 2021.

PostDocs: 2 positions available.

Teaching portfolio

 

Academic honours, awards and prizes

  1. Dimitris N Chorafas Prize - for best Ph.D. thesis at the Karolinska Institute 2011.
  2. The Lennart Philipson Award 2015 - Awarded biannuallly to one researcher at the Karolinska Institute.

 

 

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