The McInerney research group at MTC are interested in early interactions between viruses and their host cells. Using alphaviruses as model systems, we are exploring the role(s) of cellular processes such as stress responses, the interferon system and autophagy in viral infection. More information on our group website.
Since 2020, we have been developing SARS-CoV-2 neutralising nanobodies as part of the CoroNAb consortium.
5 selected recent publications:
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM Nat Commun 2020 09;11(1):4420
Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery. Götte B, Panas MD, Hellström K, Liu L, Samreen B, Larsson O, Ahola T, McInerney GM PLoS Pathog 2019 06;15(6):e1007842
Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes. Mazzon M, Castro C, Thaa B, Liu L, Mutso M, Liu X, Mahalingam S, Griffin JL, Marsh M, McInerney GM PLoS Pathog 2018 01;14(1):e1006835
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Schulte T, Liu L, Panas MD, Thaa B, Dickson N, Götte B, Achour A, McInerney GM Open Biol 2016 Jul;6(7):
Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation. Panas MD, Schulte T, Thaa B, Sandalova T, Kedersha N, Achour A, McInerney GM PLoS Pathog 2015 Feb;11(2):e1004659
I am involved in teaching at several levels at KI:
- Summer Research School with Biomedical Orientation for Gymnasium (High School) Students
- Immunology and Microbiology course for undergraduate students in Biomedicine
- Degree Project course for undergraduate students in Biomedicine