About me

Current position: Professor of Glial Cell Biology

Research group's website


Main interests: Single cell transcriptomics and epigenomics, t oligodendrocyte development, remyelination, multiple sclerosis, neuroimmunology

Previous research appointments:

Kouzarides' lab, The Gurdon Institute, University of Cambridge, United Kingdom Hermanson's lab, Department of Neuroscience, Karolinska Institutet, Sweden Arenas's lab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden Saraiva's lab, Institute for Molecular and Cellular Biology, University of Porto, Portugal

Research description

Our research group is interested in the molecular mechanisms defining the epigenetic state of oligodendrocyte lineage cells. We are particularly focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contributes to the transition between epigenetic states in oligodendrocyte precursor cells, and could thereby lead to targeted therapies for illnesses such as multiple sclerosis.

Selected publications: 

Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues.

Bartosovic M, Kabbe M, Castelo-Branco G

Nat Biotechnol 2021

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Sarah Jäkel*, Eneritz Agirre*, Ana Mendanha Falcão, David van Bruggen, Ka Wai Lee, Irene Knuesel, Dheeraj Malhotra, Charles ffrench-Constant, Anna Williams and Gonçalo Castelo-Branco.

Nature 2019

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Ana Mendanha Falcão*, David van Bruggen*, Sueli Marques, Mandy Meijer, Sarah Jäkel, Eneritz Agirre, Samudyata, Elisa M. Floriddia, Darya P. Vanichkina,  Charles ffrench-Constant, Anna Williams, André Ortlieb Guerreiro-Cacais & Gonçalo Castelo-Branco  Nature Medicine 2018 Dec;24(12):1837-1844

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development.

Marques *, van BruggenD*, Vanichkina D*, Floriddia EM, Munguba H, Väremo L, Giacomello S, Falcão AM, Meijer M, Björklund ÅK, Hjerling-Leffler J, Taft RJ, Castelo-Branco G.

Developmental Cell Volume 46, Issue 4, 20 August 2018, Pages 504-517.e7

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Sueli Marques†, Amit Zeisel†, Simone Codeluppi, David van Bruggen, Ana Mendanha Falcão, Lin Xiao, Huiliang Li, Martin Häring, Hannah Hochgerner, Roman A. Romanov, Daniel Gyllborg, Ana Muñoz Manchado, Gioele La Manno, Peter Lönnerberg, Elisa M. Floriddia, Fatemah Rezayee, Patrik Ernfors, Ernest Arenas, Jens Hjerling-Leffler, Tibor Harkany, William D. Richardson, Sten Linnarsson*, Gonçalo Castelo-Branco*

SCIENCE 2016 Jun;352(6291):1326-1329



Associate Professor (Docent), Karolinska Institutet, Stockholm, Sweden

Post-doctoral fellow, The Gurdon Institute, University of Cambridge, United Kingdom

Post-doctoral fellow, Department of Neuroscience, Karolinska Institutet, Sweden

PhD, Medical Biochemistry, Karolinska Institutet, Sweden

B.Sc., Biochemistry, University of Coimbra, Portugal