Affiliated to research
I am a researcher focused on developing bioactive materials using primarily clickable chemistry, bioorthogonal chemistry, and green chemistry. My very recent research activity has been focused on developing bioinspired synthetic "mucin-like" gels for lubrication and infection prophylaxis such as HIV-1 and HSV-2, as well as engineered "stable" mucin gels and gel microdroplets for microencapsulation of microtissues.
Mater's dissertation projects are available. Please feel free to contact me.
CURRENT RESEARCH INTEREST AND SELECTED PUBLICATIONS WITHIN 5 YEARS
- Biopolymer-derived hydrogels for lubrication, prophylaxis against infection, implantation, and regenerative medicine
Martin Kretschmer, Rafeal Ceña-Diez, et al., Thomas Crouzier, and Hongji Yan*. Synthetic Mucin Gels with Self-healing Properties Augment Lubricity and Inhibit HIV-1 and HSV-2 Transmission. Advanced Science. 2022/09/14. 2203898. (Corresponding author).
Hongji Yan*, Marcus Melin, et al., Haakan N. Joensson, and Thomas Crouzier. Immune-Modulating Mucin Hydrogel Microdroplets for the Encapsulation of Cell and Microtissue. Advanced Functional Materials. 2021/07/21. (Corresponding author).
Kun Jiang, Hongji Yan, Carolin Rickert, et al., Oliver Lieleg, and Thomas Crouzier. Modulating the bioactivity of mucin hydrogels with crosslinking architecture. Advanced Functional Materials. 2021/03/03.
Hongji Yan, Morgan Hjorth,et al., Olver Lieleg, and Thomas Crouzier. Glyco-modification of mucin hydrogels to investigate its immune activity. ACS Applied Materials & Interfaces. 2020/04/17.
Hongji Yan, Cédric Seignez,et al., Mia Phillipson, and Thomas Crouzier. Immune-informed mucin hydrogels evade fibrotic foreign body response n vivo. Advanced Functional Materials. 2019/09/12.
VR starting grant 2023-2026. Applicant.
- Mucin-derived nanoparticles.
Hongji Yan, Cristina Chircov, et al., Yolanda Hedberg, and, Thomas Crouzier. Reversible condensation of mucins into nanoparticles. Langmuir. 2018/10/26. 34(45). 13615-13625)
Ceren Kimna, Theresa Monika Lutz, Hongji Yan, Jian Song, Thomas Crouzier and Oliver Lieleg. DNA StrandsTrigger the Intracellular Release of Drugs from Mucin-Based Nanocarriers. ACS Nano. 2020/08/07
- Advanced cancer models with the aim of refining, reducing, and replacing animal use in research.
VR-3R grant 2021-2023 (Applicant and the primary beneficiary of the project)
Juzhi Zhao, Ruiqi wang, et al., Hongji Yan*, and Weiming Tian*. A novel 4D Cell Culture Mimicking Stomach Peristalsis Altered Gastric Cancer Spheroids Growth and Malignance. Biofabrication. 2021/03/24. (Corresponding author)
Shupei Qiao, Yufang Zhao, et al., Hongji Yan*, and Weiming Tian*. 3D Co-cultured Endothelial Cells and Monocytes Promoted Cancer Stem Cells Stemness and Malignancy. ACS Applied Bio Materials. 2020/12/03. (Corresponding author)