Hugo Zeberg
Assistant professor
Research description
We study gene flow from Neandertals and Densiovans into modern humans. In addition, we are interested in genetic variability and the functional consequences thereof, particularly for membrane-bound proteins such as receptors and ion channels. Other topics of interest include the genetic predisposition to infectious diseases, such as COVID-19 (see https://swecovid.org/).
Selection of recent publications
Mapping the human genetic architecture of COVID-19. COVID-19 Host Genetics Initiative (incl. SweCovid). Nature 2021 Jul;():
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. Zhou S, Butler-Laporte G, Nakanishi T, /.../, Zeberg H, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE, Richards JB Nature Medicine 2021 Feb;():
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Zeberg H, Pääbo S Proc Natl Acad Sci U S A 2021 03;118(9):
Longitudinal variability in mortality predicts COVID-19 deaths. Lundberg JO, Zeberg H Eur J Epidemiol 2021 Jul;():
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Zeberg H, Pääbo S Nature 2020 11;587(7835):610-612
A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. Zeberg H, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, et al Curr. Biol. 2020 Jul;():
The Neandertal Progesterone Receptor. Zeberg H, Kelso J, Pääbo S Mol. Biol. Evol. 2020 May;():
Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects. Zeberg H, Sahlholm K Nature Commun 2018 09;9(1):3577