Hugo Zeberg

Assistant professor

Research description

We study gene flow from Neandertals and Denisovans into modern humans. In addition, we are interested in genetic variability and the functional consequences thereof, particularly for membrane-bound proteins such as receptors and ion channels. Other topics of interest include the genetic predisposition to infectious diseases, such as COVID-19 (see https://swecovid.org/).

The Zeberg laboratory is pleased to consider applications from prospective master- and PhD students, particularly keen experimentalists.

Group members: Richard Ågren, Kristoffer Sahlholm, Hugh Robinson

Selection of recent publications

Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Hultström M, Frithiof R, Grip J, /.../, Lipcsey M, Zeberg H*  & Eriksson O* Nature Immunology 2022 May

The major genetic risk factor for severe COVID-19 is associated with protection against HIV. Zeberg H PNAS 2022 Feb

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. Huffman JE, Butler-Laporte G, Khan A, /.../, Kiryluk K, Richards JB & Zeberg H Nature Genetics 2022 Jan

A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans. Coppo C, Mishra  P, Siefert  N , Holmgren  A, Pääbo  S & Zeberg H Science Advances 2022 Jan

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Nakanishi T, Pigazzini S, Degenhardt F, /.../, Zeberg H, Richards JB & Ganna A J Clin Invest 2021 Oct

Mapping the human genetic architecture of COVID-19. COVID-19 Host Genetics Initiative (incl. SweCovid). Nature 2021 Jul

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. Zhou S, Butler-Laporte G, Nakanishi T, /.../, Zeberg H, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE & Richards JB Nature Medicine 2021 Feb

A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Zeberg H & Pääbo S PNAS 2021

Longitudinal variability in mortality predicts COVID-19 deaths. Lundberg JO & Zeberg H Eur J Epidemiol 2021 Jul

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Zeberg H & Pääbo S Nature 2020

A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. Zeberg H, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, et al Curr. Biol. 2020

The Neandertal Progesterone Receptor. Zeberg H, Kelso J & Pääbo S Mol. Biol. Evol. 2020

Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects. Zeberg H & Sahlholm K Nature Commun 2018