Iryna Kolosenko

Publications
CV
Public outreach and news

Articles

Article: BLOOD CANCER JOURNAL. 2023;13(1):139

PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia.

Shah K; Nasimian A; Ahmed M; Al Ashiri L; Denison L; Sime W; Bendak K; Kolosenko I; Siino V; Levander F; Palm-Apergi C; Massoumi R; Lock RB; Kazi JU
Article: FASEB JOURNAL. 2021;35(7):e21741

Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.

Goroshchuk O; Kolosenko I; Kunold E; Vidarsdottir L; Pirmoradian M; Azimi A; Jafari R; Palm-Apergi C
Article: FASEB JOURNAL. 2021;35(5):e21476

RNAi prodrugs decrease elevated mRNA levels of Polo-like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients.

Kolosenko I; Goroshchuk O; Vidarsdottir L; Björklund A-C; Dowdy SF; Palm-Apergi C
Journal article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2020;20:s163

ALL-166: Novel RNAi Prodrugs Targeting Plk1 Induce Specific mRNA Cleavage in Pediatric Acute B-Cell Lymphoblastic Leukemia

Goroshchuk O; Vidarsdottir L; Björklund A-C; Hamil A; Kolosenko I; Dowdy S; Palm-Apergi C
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945

Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.

Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grandér D; Arnér ESJ; Tamm KP; Page BDG
Article: SCIENTIFIC REPORTS. 2020;10(1):2688

Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients.

Goroshchuk O; Vidarsdottir L; Björklund A-C; Hamil AS; Kolosenko I; Dowdy SF; Palm-Apergi C
Article: SCIENTIFIC REPORTS. 2019;9(1):536

STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes.

Edsbäcker E; Serviss JT; Kolosenko I; Palm-Apergi C; De Milito A; Tamm KP
Article: METHODS IN MOLECULAR BIOLOGY. 2019;2036:53-72

Designing siRNA and Evaluating Its Effect on RNA Targets Using qPCR and Western Blot.

Vidarsdottir L; Goroshchuk O; Kolosenko I; Palm-Apergi C
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2018;160:80-88

STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.

Desroses M; Busker S; Astorga-Wells J; Attarha S; Kolosenko I; Zubarev RA; Helleday T; Grandér D; Page BDG
Article: CANCER CELL INTERNATIONAL. 2018;18:147

A drug screening assay on cancer cells chronically adapted to acidosis.

Pellegrini P; Serviss JT; Lundbäck T; Bancaro N; Mazurkiewicz M; Kolosenko I; Yu D; Haraldsson M; D'Arcy P; Linder S; De Milito A
Article: JOURNAL OF CONTROLLED RELEASE. 2017;261:199-206

RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients.

Kolosenko I; Edsbäcker E; Björklund A-C; Hamil AS; Goroshchuk O; Grandér D; Dowdy SF; Palm-Apergi C
Article: PLOS ONE. 2017;12(6):e0178844

Identification of novel small molecules that inhibit STAT3-dependent transcription and function.

Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Palm Apergi C; Helleday T; Tamm KP; Page BDG; Grander D
Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(4):E51-E61

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs.

Kolosenko I; Fryknäs M; Forsberg S; Johnsson P; Cheon H; Holvey-Bates EG; Edsbäcker E; Pellegrini P; Rassoolzadeh H; Brnjic S; Larsson R; Stark GR; Grandér D; Linder S; Tamm KP; De Milito A
Article: CURRENT MEDICINAL CHEMISTRY. 2014;21(26):3042-3047

IL-6 activated JAK/STAT3 pathway and sensitivity to Hsp90 inhibitors in multiple myeloma.

Kolosenko I; Grander D; Tamm KP
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(5):600-611

An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.

Lin H; Kolosenko I; Björklund A-C; Protsyuk D; Österborg A; Grandér D; Tamm KP
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;39(2):311-318

miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer.

Akçakaya P; Ekelund S; Kolosenko I; Caramuta S; Ozata DM; Xie H; Lindforss U; Olivecrona H; Lui W-O
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(1):9-19

Activation of STAT1 is required for interferon-alpha-mediated cell death.

Arulampalam V; Kolosenko I; Hjortsberg L; Björklund A-C; Grandér D; Tamm KP

All other publications

Editorial comment: FUTURE MEDICINAL CHEMISTRY. 2020;12(16):1457-1460

Small-molecule inhibitors for targeting polo-like kinase 1.

Kolosenko I; Palm-Apergi C
Conference publication: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2020;20:S163

Novel RNAi Prodrugs Targeting Plk1 Induce Specific mRNA Cleavage in Pediatric Acute B-Cell Lymphoblastic Leukemia

Goroshchuk O; Vidarsdottir L; Bjorklund A-C; Hamil A; Kolosenko I; Dowdy S; Palm-Apergi C
Review: ONCOGENE. 2019;38(1):1-16

Polo-like kinases and acute leukemia.

Goroshchuk O; Kolosenko I; Vidarsdottir L; Azimi A; Palm-Apergi C
Review: SEMINARS IN CANCER BIOLOGY. 2017;43:119-133

Therapeutic implications of tumor interstitial acidification.

Kolosenko I; Avnet S; Baldini N; Viklund J; De Milito A
Thesis / dissertation: 2016

Therapeutic response in human cancers : the dual role of STAT signalling

Kolosenko, Iryna
Conference publication: CYTOKINE. 2015;76(1):105

Cell-to-cell contact triggers the expression of the interferon-stimulated genes and mediates therapy resistance in cancer cell lines through a soluble factor

Kolosenko I; Grander D; Pokrovskaja K; De Milito A
Conference publication: CYTOKINE. 2013;63(3):303

Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Tamm KP; Kolosenko I; Fryknas M; Johnsson P; Forsberg S; Brnjic S; Rassoolzadeh H; Pellegrini P; Grander D; Larsson R; Linder S; De Milito A
Conference publication: CYTOKINE. 2013;63(3):278

Cell crowding results in accumulation of interferon-stimulated genes independently of STAT1

Kolosenko I; Edsbacker E; Fryknas M; Johnsson P; Grander D; Tamm KP; Lindera S; De Milito A
Conference publication: CANCER RESEARCH. 2013;73(8):3999

Spontaneous time-dependent accumulation of interferon-regulatory factor 9 induces chemo-resistance in colon carcinoma cells independently of STAT1 signaling

Kolosenko I; Fryknas M; Rassoolzadeh H; Pellegrini P; Brnjic S; Johnsson P; Di Lernia G; Grander D; Larsson R; Pokrovskaja K; Linder S; De Milito ADM
Conference publication: CYTOKINE. 2011;56(1):41-42

Activated JAK-STAT3 pathway is associated with sensitivity to Hsp90 inhibitors in multiple myeloma

Tamm KP; Kolosenko I; Lin H; Grander D
Conference publication: CYTOKINE. 2011;56(1):41

Inhibition of Hsp90 induces apoptosis in multiple myeloma cell lines through downregulation of STAT3 activity

Kolosenko I; Lin H; Grander D; Tamm KP

Employments

Laboratory Manager, Department of Medicine, Karolinska Institutet, 2023-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2016
Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2010

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