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Isabelle Magalhaes

Principal researcher

About me

Associate professor (Docent) in Immunology, Karolinska Institutet, Dept. of Oncology Pathology.

Since April 2019, Senior researcher, deputy group leader, Karolinska Institutet, Dept. of Oncology Pathology.

April 2015 - March 2019, Assistant professor, Karolinska Institutet, Dept. of Oncology Pathology.

September 2013 - March 2015, Postdoctoral fellow, U1016 INSERM, Institut Cochin, Dept. of Endocrinology, Metabolism and Diabetes (Paris, France).

September 2010 - August 2013, Researcher, Karolinska University Hospital Huddinge & Karolinska Institutet, Dept. of Laboratory Medicine.

June 2009 - August 2010, Postdoctoral fellow, Karolinska Institutet, Dept. of Microbiology, Tumor and Cell Biology.

2005-2009, PhD in Immunobiology, Karolinska Institutet, Dept. of Microbiology, Tumor and Cellular Biology. Thesis title: “CD8alpha/alpha+ T-cells and Immune Memory”. https://openarchive.ki.se/xmlui/handle/10616/39450

Research description

My goal is to contribute to the improvement of chimeric antigen receptor (CAR) T cell therapy for the treatment of cancer. Our group is working on the development of mesothelin (MSLN) CAR T cell therapy for the treatment of ovarian cancer. A preclinical model of orthotopic ovarian cancer in mice has been established in our group, which allows to test in vivo the antitumor efficacy of MSLN CAR T cells.

Teaching portfolio

I organize since 2016 the Antigen Presentation and T Cell Activation doctoral course (Karolinska Institutet #2363).

https://kiwas.ki.se/katalog/katalog/kurs/9195

Education

2002, Master in Immunology (Diplôme d’études approfondies), Paris VII University & Institut Pasteur (Paris, France).

2000, Bachelor in Cellular Biology and Physiology, Rennes II University (Rennes, France).

Academic honours, awards and prizes

Fellowship in Ovarian Cancer Research from Cancerfonden (2019-2022).