Isabelle Magalhaes
Affiliated to research
About me
Associate professor (Docent) in Immunology, Karolinska Institutet.
April 2019 - January 2023, Senior researcher, deputy group leader, Karolinska Institutet, Dept. of Oncology Pathology.
April 2015 - March 2019, Assistant professor, Karolinska Institutet, Dept. of Oncology Pathology.
September 2013 - March 2015, Postdoctoral fellow, U1016 INSERM, Institut Cochin, Dept. of Endocrinology, Metabolism and Diabetes (Paris, France).
September 2010 - August 2013, Researcher, Karolinska University Hospital Huddinge & Karolinska Institutet, Dept. of Laboratory Medicine.
June 2009 - August 2010, Postdoctoral fellow, Karolinska Institutet, Dept. of Microbiology, Tumor and Cell Biology.
2005-2009, PhD in Immunobiology, Karolinska Institutet, Dept. of Microbiology, Tumor and Cellular Biology. Thesis title: “CD8alpha/alpha+ T-cells and Immune Memory”. https://openarchive.ki.se/xmlui/handle/10616/39450
Research description
My goal is to contribute to the improvement of chimeric antigen receptor (CAR) T cell therapy for the treatment of cancer. Our group is working on the development of mesothelin (MSLN) CAR T cell therapy for the treatment of ovarian cancer. A preclinical model of orthotopic ovarian cancer in mice has been established in our group, which allows to test in vivo the antitumor efficacy of MSLN CAR T cells.
Teaching portfolio
I organize since 2016 the Antigen Presentation and T Cell Activation doctoral course (Karolinska Institutet #2363).
https://kiwas.ki.se/katalog/katalog/kurs/9195
Education
2002, Master in Immunology (Diplôme d’études approfondies), Paris VII University & Institut Pasteur (Paris, France).
2000, Bachelor in Cellular Biology and Physiology, Rennes II University (Rennes, France).
Academic honours, awards and prizes
Fellowship in Ovarian Cancer Research from Cancerfonden (2019-2022).