Isabelle Magalhaes

Isabelle Magalhaes

Affiliated to Research | Docent
Visiting address: NEO Medicinaren 25, HERM plan 7, Hälsovägen 7C (lastkaj), 14157 Huddinge
Postal address: H7 Medicin, Huddinge, H7 Hematologi Uhlin, 171 77 Stockholm
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About me

  • Associate professor (Docent) in Immunology, Karolinska Institutet.
    Since February 2023, group leader, Karolinska Institutet, Dept. of Clinical
    Science, Intervention and Technology.
    April 2019 - January 2023, Senior researcher, deputy group leader, Karolinska
    Institutet, Dept. of Oncology Pathology.
    April 2015 - March 2019, Assistant professor, Karolinska Institutet, Dept. of
    Oncology Pathology.
    September 2013 - March 2015, Postdoctoral fellow, U1016 INSERM, Institut
    Cochin, Dept. of Endocrinology, Metabolism and Diabetes (Paris, France).
    September 2010 - August 2013, Researcher, Karolinska University Hospital
    Huddinge & Karolinska Institutet, Dept. of Laboratory Medicine.
    June 2009 - August 2010, Postdoctoral fellow, Karolinska Institutet, Dept. of
    Microbiology, Tumor and Cell Biology.
    2005-2009, PhD in Immunobiology, Karolinska Institutet, Dept. of
    Microbiology, Tumor and Cellular Biology. Thesis title: “/CD8alpha/alpha+
    T-cells and Immune Memory/”./
    https://openarchive.ki.se/xmlui/handle/10616/39450/
    Fellowship in Ovarian Cancer Research from Cancerfonden (2019-2022).
    2002, Master in Immunology (Diplôme d’études approfondies), Paris VII
    University & Institut Pasteur (Paris, France).
    2000, Bachelor in Cellular Biology and Physiology, Rennes II University
    (Rennes, France).

Research

  • My goal is to contribute to the improvement of chimeric antigen receptor
    (CAR) T cell therapy for the treatment of cancer. Our group is working on the
    development of mesothelin (MSLN) CAR T cell therapy for the treatment of
    ovarian cancer. A preclinical model of orthotopic ovarian cancer in mice has
    been established in our group, which allows to test /in vivo/ the antitumor
    efficacy of MSLN CAR T cells.
    Recent publications:
    Schoutrop E, Poiret T, El-Serafi I, Zhao Y, He R, Moter A, Henriksson J,
    Hassan M, Magalhaes I*, Mattsson J*. Tuned activation of MSLN-CAR T cells
    induces superior antitumor responses in ovarian cancer models. [1]J
    Immunother Cancer. 2023 Feb
  • 11(2). doi: 10.1136/jitc-2022-005691.
    Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand
    H, Magalhaes I. Molecular, cellular and systemic aspects of epithelial
    ovarian cancer and its tumor microenvironment. [2]Semin Cancer Biol. 2022
    Nov
  • 86(Pt 3):207-223. doi: 10.1016/j.semcancer.2022.03.027.
    Schoutrop E, Renken S, Micallef Nilsson I, Hahn P, Poiret T, Kiessling R,
    Wickström SL, Mattsson J, Magalhaes I. Trogocytosis and fratricide killing
    impede MSLN-directed CAR T cell functionality.
    [3]Oncoimmunology. 2022
  • 11(1):2093426. doi: 10.1080/2162402X.2022.2093426.
    Renken S, Nakajima T, Magalhaes I, Mattsson J, Lundqvist A, Arnér ESJ,
    Kiessling R, Wickström SL. Targeting of Nrf2 improves antitumoral responses
    by human NK cells, TIL and CAR T cells during oxidative stress. [4]J
    Immunother Cancer. 2022 Jun
  • 10(6). doi: 10.1136/jitc-2021-004458.
    Schoutrop E, El-Serafi I, Poiret T, Zhao Y, Gultekin O, He R, Moyano-Galceran
    L, Carlson JW, Lehti K, Hassan M, Magalhaes I*, Mattsson
    J*. Mesothelin-Specific CAR T Cells Target Ovarian Cancer. [5]Cancer
    Res. 2021 Jun 1
  • 81(11):3022-3035. doi: 10.1158/0008-5472.CAN-20-2701.
    Magalhaes I, Fernebro J, Abd Own S, Glaessgen D, Corvigno S, Remberger M,
    Mattsson J, Dahlstrand H. Mesothelin Expression in Patients with High-Grade
    Serous Ovarian Cancer Does Not Predict Clinical Outcome But Correlates with
    CD11c+ Expression in Tumor. [6]Adv Ther. 2020 Dec
  • 37(12):5023-5031. doi:
    10.1007/s12325-020-01520-w.
    [1] https://www.ncbi.nlm.nih.gov/pubmed/36746513/
    [2] https://www.ncbi.nlm.nih.gov/pubmed/35395389/
    [3] https://www.ncbi.nlm.nih.gov/pubmed/35898704/
    [4] https://www.ncbi.nlm.nih.gov/pubmed/35738800/
    [5] https://www.ncbi.nlm.nih.gov/pubmed/33795251/
    [6] https://www.ncbi.nlm.nih.gov/pubmed/33052561/

Teaching

Articles

All other publications

Employments

  • Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026

Degrees and Education

  • Docent, Karolinska Institutet, 2021
  • Degree Of Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2009

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