Jacob Grünler

About me
Publications
Public outreach and news

Research

Jacob Grünler is responsible for studies on inflammatory processes in
development of atherosclerosis in diabetics especially the effect of
antioxidants, like coenzyme Q10 and vitamin E.
These involves studies of cytokine production, studied in human blood
monocytes, lymfocytes and urine samples, animal models and HPLC-methodology,
flow-cytometry, cell culture studies.
He is also responsible for the laboratory environmental issues, animal
housing and ethic applications.
Research group Growth and metabolism [1]
*Selected publications*
[pubmed:19057015]
[pubmed:15153069]
[pubmed:15038955]
[pubmed:14670990]
[pubmed:10437779]
[1] http://default/node/2970

Articles

Article: ELIFE. 2022;11:e70714

Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.

Zheng X; Narayanan S; Xu C; Eliasson Angelstig S; Grünler J; Zhao A; Di Toro A; Bernardi L; Mazzone M; Carmeliet P; Del Sole M; Solaini G; Forsberg EA; Zhang A; Brismar K; Schiffer TA; Rajamand Ekberg N; Botusan IR; Palm F; Catrina S-B
Article: ISCIENCE. 2021;24(5):102494

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance.

Zhang J; Terán G; Popa M; Madapura H; Ladds MJGW; Lianoudaki D; Grünler J; Arsenian-Henriksson M; McCormack E; Rottenberg ME; Catrina S-B; Laín S; Darekar S
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(3):659-671

miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes.

Li D; Peng H; Qu L; Sommar P; Wang A; Chu T; Li X; Bi X; Liu Q; Gallais Sérézal I; Rollman O; Lohcharoenkal W; Zheng X; Eliasson Angelstig S; Grünler J; Pivarcsi A; Sonkoly E; Catrina S-B; Xiao C; Ståhle M; Mi Q-S; Zhou L; Xu Landén N
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):768

HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism.

Narayanan S; Eliasson Angelstig S; Xu C; Grünler J; Zhao A; Zhu W; Xu Landén N; Ståhle M; Zhang J; Ivan M; Maltesen RG; Botusan IR; Rajamand Ekberg N; Zheng X; Catrina S-B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(14):6985-6994

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.

Zheng X; Narayanan S; Sunkari VG; Eliasson S; Botusan IR; Grünler J; Catrina AI; Radtke F; Xu C; Zhao A; Ekberg NR; Lendahl U; Catrina S-B
Article: PLOS ONE. 2018;13(3):e0193084

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate.

Botusan IR; Zheng X; Narayanan S; Grünler J; Sunkari VG; Calissendorff FS; Ansurudeen I; Illies C; Svensson J; Jansson J-O; Ohlsson C; Brismar K; Catrina S-B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638

MicroRNA-132 with Therapeutic Potential in Chronic Wounds.

Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grünler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrström M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Ståhle M; Xu Landén N
Article: BBA CLINICAL. 2015;4:14-20

Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients.

Montano SJ; Grünler J; Nair D; Tekle M; Fernandes AP; Hua X; Holmgren A; Brismar K; Ungerstedt JS
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2015;29(8):1152-1158

Coenzyme Q10 and oxidative stress, the association with peripheral sensory neuropathy and cardiovascular disease in type 2 diabetes mellitus.

Forsberg E; Xu C; Grünler J; Frostegård J; Tekle M; Brismar K; Kärvestedt L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(8):3008-3026

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.

Li D; Wang A; Liu X; Meisgen F; Grünler J; Botusan IR; Narayanan S; Erikci E; Li X; Blomqvist L; Du L; Pivarcsi A; Sonkoly E; Chowdhury K; Catrina S-B; Ståhle M; Landén NX
Article: GROWTH HORMONE & IGF RESEARCH. 2015;25(1):34-40

Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts.

Brandt K; Grünler J; Brismar K; Wang J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(2):478-482

Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity.

Brauner H; Lüthje P; Grünler J; Ekberg NR; Dallner G; Brismar K; Brauner A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695

Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model.

Shi T-JS; Zhang M-D; Zeberg H; Nilsson J; Grünler J; Liu S-X; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hökfelt TGM
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2011;27(5):470-479

Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes.

Savu O; Sunkari VG; Botusan IR; Grünler J; Nikoshkov A; Catrina S-B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(49):19426-19431

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.

Botusan IR; Sunkari VG; Savu O; Catrina AI; Grünler J; Lindberg S; Pereira T; Ylä-Herttuala S; Poellinger L; Brismar K; Catrina S-B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(30):21024-21035

Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants.

Skorupinska-Tudek K; Poznanski J; Wojcik J; Bienkowski T; Szostkiewicz I; Zelman-Femiak M; Bajda A; Chojnacki T; Olszowska O; Grunler J; Meyer O; Rohmer M; Danikiewicz W; Swiezewska E
Article: BRITISH JOURNAL OF CANCER. 2005;92(8):1467-1474

Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival.

Catrina S-B; Lewitt M; Massambu C; Dricu A; Grünler J; Axelson M; Biberfeld P; Brismar K
Article: BIOCHEMICAL JOURNAL. 2004;382(Pt 2):519-526

Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.

Forsgren M; Attersand A; Lake S; Grünler J; Swiezewska E; Dallner G; Climent I
Article: ENDOCRINOLOGY. 2004;145(3):1137-1143

Gender-specific pattern of insulin-like growth factor-binding protein-3 protease activity in mouse thyroid.

Wang J; Grünler J; Lewitt MS
Article: ANALYTICAL BIOCHEMISTRY. 2001;297(2):137-143

Separation and quantitation of phospholipids and their ether analogues by high-performance liquid chromatography.

Guan Z; Grünler J; Piao S; Sindelar PJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(36):33297-33300

A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.

Stenmark P; Grünler J; Mattsson J; Sindelar PJ; Nordlund P; Berthold DA
Article: FEBS LETTERS. 1999;455(3):233-237

Subcellular distribution of farnesyl protein transferase in rat liver.

Grünler J; Parmryd I
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1998;353(2):191-198

Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase.

Bentinger M; Grünler J; Peterson E; Swiezewska E; Dallner G
Article: FEBS LETTERS. 1995;358(3):230-232

Estimation of dolichol and cholesterol synthesis in microsomes and peroxisomes isolated from rat liver.

Grünler J; Olsson JM; Dallner G
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All other publications

Editorial comment: ENDOCRINE. 2014;46(2):347-350

Selective blockade of estrogen receptor beta improves wound healing in diabetes.

Sunkari VG; Botusan IR; Savu O; Grünler J; Zheng X; Gustafsson J-Å; Brismar K; Catrina S-B
Published paper: AMINO ACIDS. 2012;43(1):127-134

Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes.

Ansurudeen I; Sunkari VG; Grünler J; Peters V; Schmitt CP; Catrina S-B; Brismar K; Forsberg EA
Meeting abstract: CHEMISTRY AND PHYSICS OF LIPIDS. 2008;154:S41-S42

Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants

Skorupinska-Tudek K; Poznanski J; Wojcik J; Bienkowski T; Szostkiewicz I; Zelman-Femiak M; Bajda A; Chojnacki T; Olszowska O; Grunler J; Meyer O; Rohmer M; Danikiewicz W; Swiezewska E
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2004;378:3-17

Investigation of regulatory mechanisms in coenzyme Q metabolism.

Grünler J; Dallner G

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