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Jay Achar

PhD student

About me

I trained as a medical doctor at University College London before moving to Melbourne, Australia to complete my specialist training in Internal Medicine and Infectious Diseases. Over the past decade, I have gained extensive international experience in low resource settings both in health programming and operational research. 

Following an intensive 18 months supporting West African Ebola interventions in Sierra Leone, Liberia and Guinea, my work has focused more strongly on TB and HIV both in the ex-CIS countries (Belarus, Russia, Armenia, Georgia, Uzbekistan, Tajikistan) and in sub-Saharan Africa (South Sudan, DR Congo, Chad). 

Within the TB community, I have contributed to a number of policy and consultation documents to help improve the support given to national programmes and continue to participate in a wide range of initiatives to train colleagues who treat people suffering with TB. 

After completing my specialist training, I have been awarded a MSc with distinction in Epidemiology from the London School of Hygiene and Tropical Medicine and have received a Diploma in Tropical Medicine and Hygiene from the Royal College of Physicians, London. 

Research description

Doctoral project

Funded by Venenskapsrådet (Swedish Research Council), my PhD project will investigate the ability of aerosol detection of tuberculosis to predict household transmission. The project includes a number of laboratory and clinical studies in Sweden, South Africa and Mozambique establishing the performance of a new device to detect aerosolised pathogens and to then investigate the association between detection in adult patients and transmission within the household. 

TB research

I continue to collaborate with old colleagues in a number of academic institutions in the field of TB both to contribute to a chronically underfunded and poorly understood research field and to learn new things from experienced collaborators. I am particularily interested in the treatment of drug-resistant tuberculosis in adults and children as well as the impact of treatment of TB infection. 

Data-driven decision-making

After working with large quantities of diverse data, I believe strongly in the role of well managed data in supporting health-related decision making. I have extensive practical experience in data collection and data management in challenging environments (Wired) and have built on the knowledge of regression modelling I gained during my MSc. 

 

Publications

Outcomes with a shorter multidrug-resistant tuberculosis regimen from Karakalpakstan, Uzbekistan. du Cros P, Khamraev A, Tigay Z, Abdrasuliev T, Greig J, Cooke G, Herboczek K, Pylypenko T, Berry C, Ronnachit A, Lister D, Dietrich S, Ariti C, Safaev K, Nyang'wa BT, Parpieva N, Tillashaikhov M, Achar J ERJ Open Res 2021 Jan;7(1):

Factors associated with culture conversion among adults treated for pulmonary extensively drug-resistant tuberculosis during 2018-2019 in the Russian Federation: an observational cohort study. Russkikh A, Korotych O, Sereda Y, Samoilova A, Achar J, Yedilbayev A, Dara M, Vasilyeva I Monaldi Arch Chest Dis 2021 Jan;91(1):

Factors associated with time to sputum culture conversion of rifampicin-resistant tuberculosis patients in Klaipeda, Lithuania in 2016-2019: a cohort study. Diktanas S, Korotych O, Sereda Y, Gozalov O, Rubcova O, Achar J Monaldi Arch Chest Dis 2021 Jan;91(1):

Accuracy of molecular drug susceptibility testing amongst tuberculosis patients in Karakalpakstan, Uzbekistan. Gil H, Margaryan H, Azamat I, Ziba B, Bayram H, Nazirov P, Gomez D, Singh J, Zayniddin S, Parpieva N, Achar J Trop Med Int Health 2021 04;26(4):421-427

Patient and health-care worker perspectives on the short-course regimen for treatment of drug-resistant tuberculosis in Karakalpakstan, Uzbekistan. Horter S, Achar J, Gray N, Parpieva N, Tigay Z, Singh J, Stringer B PLoS One 2020 ;15(11):e0242359

A case report of a child with probable drug resistant tuberculous pericarditis with a review of challenges involved in diagnosis, treatment and follow up of children with DR-TB pericarditis. Swaminathan A, du Cros P, Achar J, Kliescikova J, Mirgayosieva S, Pirmahmadzoda B BMC Infect Dis 2020 Apr;20(1):298

Person-centred care in practice: perspectives from a short course regimen for multi-drug resistant tuberculosis in Karakalpakstan, Uzbekistan. Horter S, Stringer B, Gray N, Parpieva N, Safaev K, Tigay Z, Singh J, Achar J BMC Infect Dis 2020 Sep;20(1):675

Standardised shorter regimens versus individualised longer regimens for rifampin- or multidrug-resistant tuberculosis. Abidi S, Achar J, Assao Neino MM, Bang D, Benedetti A, Brode S, Campbell JR, Casas EC, Conradie F, Dravniece G, du Cros P, Falzon D, Jaramillo E, Kuaban C, Lan Z, Lange C, Li PZ, Makhmudova M, Maug AKJ, Menzies D, Migliori GB, Miller A, Myrzaliev B, Ndjeka N, Noeske J, Parpieva N, Piubello A, Schwoebel V, Sikhondze W, Singla R, Souleymane MB, Trébucq A, Van Deun A, Viney K, Weyer K, Zhang BJ, Ahmad Khan F Eur Respir J 2020 03;55(3):

Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis. Osman M, Harausz EP, Garcia-Prats AJ, Schaaf HS, Moore BK, Hicks RM, Achar J, Amanullah F, Barry P, Becerra M, Chiotan DI, Drobac PC, Flood J, Furin J, Gegia M, Isaakidis P, Mariandyshev A, Ozere I, Shah NS, Skrahina A, Yablokova E, Seddon JA, Hesseling AC, Emerg Infect Dis 2019 03;25(3):441-450

Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis. Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Ioana Chiotan D, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, Méndez-Echevarría A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Ur-Rehman S, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim JJ, Furin J, Hesseling AC, PLoS Med 2018 07;15(7):e1002591

Impact of pyrazinamide resistance on multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan. Kuhlin J, Smith C, Khaemraev A, Tigay Z, Parpieva N, Tillyashaykhov M, Achar J, Hajek J, Greig J, du Cros P, Moore D Int J Tuberc Lung Dis 2018 05;22(5):544-550

Delivering HIV care in challenging operating environments: the MSF experience towards differentiated models of care for settings with multiple basic health care needs. Ssonko C, Gonzalez L, Mesic A, da Fonseca MS, Achar J, Safar N, Martin B, Wong S, Casas EC J Int AIDS Soc 2017 07;20(Suppl 4):21654

Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis. Achar J, Hewison C, Cavalheiro AP, Skrahina A, Cajazeiro J, Nargiza P, Herboczek K, Rajabov AS, Hughes J, Ferlazzo G, Seddon JA, du Cros P Emerg Infect Dis 2017 10;23(10):

Ebola management centre proximity associated with reduced delays of healthcare of Ebola Virus Disease (EVD) patients, Tonkolili, Sierra Leone, 2014-15. Theocharopoulos G, Danis K, Greig J, Hoffmann A, De Valk H, Jimissa A, Tejan S, Sankoh M, Kleijer K, Turner W, Achar J, Duncombe J, Lokuge K, Gayton I, Broeder R, Kremer R, Caleo G PLoS One 2017 ;12(5):e0176692

Electronic medical records in humanitarian emergencies - the development of an Ebola clinical information and patient management system. Jobanputra K, Greig J, Shankar G, Perakslis E, Kremer R, Achar J, Gayton I F1000Res 2016 ;5():1477

Modelling the effect of short-course multidrug-resistant tuberculosis treatment in Karakalpakstan, Uzbekistan. Trauer JM, Achar J, Parpieva N, Khamraev A, Denholm JT, Falzon D, Jaramillo E, Mesic A, du Cros P, McBryde ES BMC Med 2016 Nov;14(1):187

New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis. Practice-based Recommendations. Harausz EP, Garcia-Prats AJ, Seddon JA, Schaaf HS, Hesseling AC, Achar J, Bernheimer J, Cruz AT, D'Ambrosio L, Detjen A, Graham SM, Hughes J, Jonckheere S, Marais BJ, Migliori GB, McKenna L, Skrahina A, Tadolini M, Wilson P, Furin J, Am J Respir Crit Care Med 2017 05;195(10):1300-1310

WHO recommendations for multidrug-resistant tuberculosis. Berry C, Achar J, du Cros P Lancet 2016 11;388(10057):2234

Inpatient signs and symptoms and factors associated with death in children aged 5 years and younger admitted to two Ebola management centres in Sierra Leone, 2014: a retrospective cohort study. Shah T, Greig J, van der Plas LM, Achar J, Caleo G, Squire JS, Turay AS, Joshy G, D'Este C, Banks E, Vogt F, Lokuge K Lancet Glob Health 2016 07;4(7):e495-501

Treating children for drug-resistant tuberculosis in Tajikistan with Group 5 medications. Swaminathan A, du Cros P, Seddon JA, Quinnell S, Bobokhojaev OI, Dusmatova Z, Achar J Int J Tuberc Lung Dis 2016 Apr;20(4):474-8

Prognostic Indicators for Ebola Patient Survival. Crowe SJ, Maenner MJ, Kuah S, Erickson BR, Coffee M, Knust B, Klena J, Foday J, Hertz D, Hermans V, Achar J, Caleo GM, Van Herp M, Albariño CG, Amman B, Basile AJ, Bearden S, Belser JA, Bergeron E, Blau D, Brault AC, Campbell S, Flint M, Gibbons A, Goodman C, McMullan L, Paddock C, Russell B, Salzer JS, Sanchez A, Sealy T, Wang D, Saffa G, Turay A, Nichol ST, Towner JS Emerg Infect Dis 2016 Feb;22(2):217-23

Multidrug-Resistant Tuberculosis in Child Successfully Treated with 9-Month Drug Regimen. Achar J, Berry C, Herboczek K, Parpieva N, Tillyashaykhov MN, Tigay ZN, Khamraev A, Velivela K, Seddon JA, du Cros P Emerg Infect Dis 2015 Nov;21(11):2105-6

Ebola viral disease and pregnancy. Black BO, Caluwaerts S, Achar J Obstet Med 2015 Sep;8(3):108-113

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