Johan Öckinger

About me
Publications
CV
Public outreach and news

Research

Conduction translational research focused on the role of cigarette smoking in
regulation of the immune system, and in development of autoimmune disease

Articles

Article: EUROSURVEILLANCE. 2021;26(45):2001675

Meta-analysis of the clinical performance of commercial SARS-CoV-2 nucleic acid and antibody tests up to 22 August 2020.

Van Walle I; Leitmeyer K; Broberg EK; European COVID-19 microbiological laboratories gro
Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking.

Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlström J; Grunewald J; Brynedal B; Jagodic M; Ekström TJ; Öckinger J; Kular L
Article: BMJ NEUROLOGY OPEN. 2020;2(1):e000044

Hospital diagnosed pneumonia before age 20 years and multiple sclerosis risk.

Smith KA; Hiyoshi A; Burkill S; Bahmanyar S; Öckinger J; Alfredsson L; Olsson T; Montgomery S
Article: EBIOMEDICINE. 2019;46:290-304

Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells.

Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjöholm LK; Slavec L; Kullberg S; Wahlström J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Öckinger J; Ekström TJ
Article: RESPIRATORY RESEARCH. 2018;19(1):68

Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals.

Berg T; Hegelund-Myrbäck T; Öckinger J; Zhou X-H; Brännström M; Hagemann-Jensen M; Werkström V; Seidegård J; Grunewald J; Nord M; Gustavsson L
Article: MICROBIOME. 2016;4(1):60

The lung microbiota in early rheumatoid arthritis and autoimmunity.

Scher JU; Joshua V; Artacho A; Abdollahi-Roodsaz S; Öckinger J; Kullberg S; Sköld M; Eklund A; Grunewald J; Clemente JC; Ubeda C; Segal LN; Catrina AI
Article: CLINICAL IMMUNOLOGY. 2016;169:114-120

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis.

Öckinger J; Hagemann-Jensen M; Kullberg S; Engvall B; Eklund A; Grunewald J; Piehl F; Olsson T; Wahlström J
Article: PLOS ONE. 2016;11(10):e0164751

Distinctive Regulatory T Cells and Altered Cytokine Profile Locally in the Airways of Young Smokers with Normal Lung Function.

Ostadkarampour M; Müller M; Öckinger J; Kullberg S; Lindén A; Eklund A; Grunewald J; Wahlström J
Article: PLOS GENETICS. 2014;10(3):e1004265

Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.

Stridh P; Ruhrmann S; Bergman P; Thessén Hedreul M; Flytzani S; Beyeen AD; Gillett A; Krivosija N; Öckinger J; Ferguson-Smith AC; Jagodic M
Article: SCIENTIFIC DATA. 2014;1:140011

Genomes and phenomes of a population of outbred rats and its progenitors.

Baud A; Guryev V; Hummel O; Johannesson M; Rat Genome Sequencing and Mapping Consortium; Flint J
Article: HUMAN MOLECULAR GENETICS. 2013;22(24):4952-4966

Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity.

Thessen Hedreul M; Möller S; Stridh P; Gupta Y; Gillett A; Daniel Beyeen A; Öckinger J; Flytzani S; Diez M; Olsson T; Jagodic M
Article: NATURE GENETICS. 2013;45(7):767-775

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.

Rat Genome Sequencing and Mapping Consortium; Baud A; Hermsen R; Guryev V; Stridh P; Graham D; McBride MW; Foroud T; Calderari S; Diez M; Ockinger J; Beyeen AD; Gillett A; Abdelmagid N; Guerreiro-Cacais AO; Jagodic M; Tuncel J; Norin U; Beattie E; Huynh N; Miller WH; Koller DL; Alam I; Falak S; Osborne-Pellegrin M; Martinez-Membrives E; Canete T; Blazquez G; Vicens-Costa E; Mont-Cardona C; Diaz-Moran S; Tobena A; Hummel O; Zelenika D; Saar K; Patone G; Bauerfeind A; Bihoreau M-T; Heinig M; Lee Y-A; Rintisch C; Schulz H; Wheeler DA; Worley KC; Muzny DM; Gibbs RA; Lathrop M; Lansu N; Toonen P; Ruzius FP; de Bruijn E; Hauser H; Adams DJ; Keane T; Atanur SS; Aitman TJ; Flicek P; Malinauskas T; Jones EY; Ekman D; Lopez-Aumatell R; Dominiczak AF; Johannesson M; Holmdahl R; Olsson T; Gauguier D; Hubner N; Fernandez-Teruel A; Cuppen E; Mott R; Flint J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(28):11282-11287

Critical role for calcium mobilization in activation of the NLRP3 inflammasome.

Murakami T; Ockinger J; Yu J; Byles V; McColl A; Hofer AM; Horng T
Article: PLOS ONE. 2012;7(7):e39794

Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats.

Adzemovic MZ; Öckinger J; Zeitelhofer M; Hochmeister S; Beyeen AD; Paulson A; Gillett A; Thessen Hedreul M; Covacu R; Lassmann H; Olsson T; Jagodic M
Article: JOURNAL OF IMMUNOLOGY. 2010;185(11):6883-6890

IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.

Beyeen AD; Adzemovic MZ; Ockinger J; Stridh P; Becanovic K; Laaksonen H; Lassmann H; Harris RA; Hillert J; Alfredsson L; Celius EG; Harbo HF; Kockum I; Jagodic M; Olsson T
Article: PLOS ONE. 2010;5(9):e12716

Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat.

Stridh P; Thessen Hedreul M; Beyeen AD; Adzemovic MZ; Laaksonen H; Gillett A; Ockinger J; Marta M; Lassmann H; Becanovic K; Jagodic M; Olsson T
Article: GENES AND IMMUNITY. 2010;11(2):142-154

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.

Ockinger J; Stridh P; Beyeen AD; Lundmark F; Seddighzadeh M; Oturai A; Sørensen PS; Lorentzen AR; Celius EG; Leppä V; Koivisto K; Tienari PJ; Alfredsson L; Padyukov L; Hillert J; Kockum I; Jagodic M; Olsson T
Article: GENES AND IMMUNITY. 2010;11(1):21-36

Multiple loci comprising immune-related genes regulate experimental neuroinflammation.

Marta M; Stridh P; Becanovic K; Gillett A; Ockinger J; Lorentzen JC; Jagodic M; Olsson T
Article: JOURNAL OF IMMUNOLOGY. 2009;182(7):4432-4438

Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome.

Huberle A; Beyeen AD; Ockinger J; Ayturan M; Jagodic M; de Graaf KL; Fissolo N; Marta M; Olofsson P; Hultqvist M; Holmdahl R; Olsson T; Weissert R
Article: GENOME RESEARCH. 2009;19(1):150-158

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.

Johannesson M; Lopez-Aumatell R; Stridh P; Diez M; Tuncel J; Blázquez G; Martinez-Membrives E; Cañete T; Vicens-Costa E; Graham D; Copley RR; Hernandez-Pliego P; Beyeen AD; Ockinger J; Fernández-Santamaría C; Gulko PS; Brenner M; Tobeña A; Guitart-Masip M; Giménez-Llort L; Dominiczak A; Holmdahl R; Gauguier D; Olsson T; Mott R; Valdar W; Redei EE; Fernández-Teruel A; Flint J
Article: JOURNAL OF IMMUNOLOGY. 2008;180(5):3289-3296

Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis.

Harnesk K; Swanberg M; Ockinger J; Diez M; Lidman O; Wallström E; Lobell A; Olsson T; Piehl F
Article: GENETICS. 2006;173(3):1539-1545

Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice.

Ockinger J; Serrano-Fernández P; Möller S; Ibrahim SM; Olsson T; Jagodic M
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Employments

Affiliated to Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2023-2026

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2009
Master Of Medical Science, Karolinska Institutet, 2004

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