Johanna Nilsson

Publications
CV
Public outreach and news

Articles

Article: SCIENTIFIC REPORTS. 2019;9(1):8175

Closed and open state dependent block of potassium channels cause opposing effects on excitability - a computational approach.

Ågren R; Nilsson J; Århem P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2018;21(12):1102-1108

The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation.

Ågren R; Århem P; Nilsson J; Sahlholm K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;496(1):101-104

Point mutation of a conserved aspartate, D69, in the muscarinic M2 receptor does not modify voltage-sensitive agonist potency.

Ågren R; Sahlholm K; Nilsson J; Århem P
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2018;12:33

The Importance of the Dissociation Rate in Ion Channel Blocking.

Zeberg H; Nilsson J; Århem P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(3):467-476

The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor.

Sahlholm K; Zeberg H; Nilsson J; Ögren SO; Fuxe K; Århem P
Article: MOLECULAR PAIN. 2015;11:44

G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.

Lyu C; Mulder J; Barde S; Sahlholm K; Zeberg H; Nilsson J; Århem P; Hökfelt T; Fried K; Shi T-JS
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(1):149-155

Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D2 receptor.

Sahlholm K; Marcellino D; Nilsson J; Ögren SO; Fuxe K; Århem P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695

Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model.

Shi T-JS; Zhang M-D; Zeberg H; Nilsson J; Grünler J; Liu S-X; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hökfelt TGM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(12):3081-3089

Voltage sensitivities and deactivation kinetics of histamine H₃ and H₄ receptors.

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;394(4):988-992

Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer.

Marcellino D; Navarro G; Sahlholm K; Nilsson J; Agnati LF; Canela EI; Lluís C; Århem P; Franco R; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;377(4):1216-1221

Voltage-sensitivity at the human dopamine D2S receptor is agonist-specific.

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;95(11):5138-5152

Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics.

Nilsson J; Madeja M; Elinder F; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;374(3):496-501

Differential voltage-sensitivity of D2-like dopamine receptors.

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;591(1-3):52-58

Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes.

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: SYNAPSE. 2008;62(6):476-480

Voltage-dependence of the human dopamine D2 receptor.

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;94(8):3014-3022

A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivation.

Klement G; Nilsson J; Arhem P; Elinder F
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):1-7

On the opening of voltage-gated ion channels.

Elinder F; Nilsson J; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;567(3):206-210

The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes.

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: DIABETOLOGIA. 2007;50(8):1670-1677

Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif.

Bränström R; Leibiger IB; Leibiger B; Klement G; Nilsson J; Arhem P; Aspinwall CA; Corkey BE; Larsson O; Berggren P-O
Article: BMC NEUROSCIENCE. 2005;6:65

A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction.

Persson A-S; Klement G; Almgren M; Sahlholm K; Nilsson J; Petersson S; Arhem P; Schalling M; Lavebratt C
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3231-3240

Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly.

Petersson S; Persson A-S; Johansen JE; Ingvar M; Nilsson J; Klement G; Arhem P; Schalling M; Lavebratt C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1652(1):35-51

Computational modelling of the open-state Kv 1.5 ion channel block by bupivacaine.

Luzhkov VB; Nilsson J; Arhem P; Aqvist J
Article: MOLECULAR PHARMACOLOGY. 2003;63(6):1417-1429

Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action.

Nilsson J; Madeja M; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;360(1):21-29

Mechanisms of bupivacaine action on Na+ and K+ channels in myelinated axons of Xenopus laevis.

Nilsson J; Elinder F; Arhem P
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All other publications

Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S520

The fast-off hypothesis revisited: on-rates and reversibility of antipsychotic antagonism at the D2 receptor

Sahlholm K; Zeberg H; Marcellino D; Nilsson J; Ogren SO; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):126A

Local Anesthetics on Kv Channels - Closed State Binding of Bupivacaine?

Nilsson J; Zeberg H; Madeja M; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):26A

Novel Aspects of the Reversibility of the Antagonism at the Dopamine D2 Receptor by Antipsychotics

Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Ogren SO; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):134A

The Action of the Neuroprotective Compound Riluzole on Kv Channels

Nilsson J; Kempka M; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):517A

Dopamine D2 Receptor Antagonist Unbinding Rates Investigated using a Time-Resolved Ion Channel Activation Assay

Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):213A

Kv Channel Modulation: Closed State Block of Benzocaine But Not of Bupivacaine

Nilsson J; Madeja M; Sahlholm K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):290A

Agonist-Specific Effects of TM V Serine Mutations on Dopamine D2S Receptor Voltage-Sensitivity

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2009;96(3):369A

Differential Voltage-sensitivities Of Agonists At The Dopamine D_2S Receptor

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Published conference paper: NEUROPSYCHOPHARMACOLOGY. 2003;28 Suppl 1:S40-S47

Mechanisms of anesthesia: towards integrating network, cellular, and molecular level modeling.

Arhem P; Klement G; Nilsson J

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2025

Degrees and Education

Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2004
University Medical Degree, Karolinska Institutet, 1997

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