Johanna Simin

Doctoral Candidate in Clinical Epidemiology

Johanna Simin

PhD student

Doctoral Candidate in Clinical Epidemiology

About me

Currently, I am a Doctoral Candidate in Clinical Epidemiology (PhD) at the Centre for Translational Microbiome Research at Karolinska Institutet in Stockholm. I received my primary clinical training in Finland, most of my academic training in Sweden, and I have gained a broad knowledge and understanding of clinical epidemiology and a passion for women’s health.

 

My research aims to investigate the long-term effects of common prescription drugs on the risk of cancer and cancer-associated mortality. Specifically, my research focuses on the contemporary use of menopausal hormones, oral antibiotics, and proton pump inhibitors.  

Research description

Most of the projects are based on highly complete high-quality Swedish health data registries, linking data to numerous Swedish National Board of Health and Welfare supervised registries, including the  Prescribed Drug Registry, Cancer Registry, Causes of Death Registry, and Patient Registry (in- and outpatient care).  Several studies are extensive, prospective and nationwide cohort studies, including virtually all users of the investigated drug. 

 

Selected publications (as first author):

[PubMed ID: 33861686]. Simin J, Liu Q, Wang X, Fall K, Williams C, Callens S, et al. Prediagnostic use of estrogen-only therapy is associated with improved colorectal cancer survival in menopausal women: a Swedish population-based cohort study. Acta Oncologica; 2021.

[PubMed ID: 32968205]. Simin J, Fornes R, Liu Q, Olsen R, Callens S, Engstrand L, Brusselaers N. Antibiotic use and the risk of colorectal cancer: a systematic review and dose-response meta-analysis. The British Journal of Cancer, 2020.

[PubMed ID: 32679181]. Simin J, Tamimi RM, Engstrand L, Callens S, Brusselaers N. Antibiotic use and the risk of breast cancer: A systematic review and dose-response meta-analysis. Pharmacological Research, 2020.

[PubMed ID: 31836528]. Simin J, Liu Q, Fornes R, Brusselaers N. Safety of proton pump inhibitors questioned based on a large randomized trial of patients receiving rivaroxaban or aspirin. Gastroenterology, 2019.

[PubMed ID: 31584190]. Simin J, Tamimi RM, Callens S, Engstrand L, Brusselaers N. Menopausal hormone therapy treatment options and ovarian cancer risk: A Swedish prospective population-based matched-cohort study. International Journal of Cancer, 2019.

[PubMed ID: 28783542]. Simin J, Tamimi R, Lagergren J, Adami HO, Brusselaers N. Menopausal hormone therapy and cancer risk: An overestimated risk? European Journal of Cancer, 2017. 

 

Other selected publications:

[PMID: 33857339]. Liu Q, Simin J, Debelius J, Fall K, Sadr-Azodi O, Engstrand L, et al. Menopausal hormone therapies and risk of colorectal cancer: a Swedish matched-cohort study. Alimentary Pharmacology and Therapeutics; 2021.

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