Johanna Simin

Johanna Simin

PhD student

Doctor (PhD in Medical Science) - Clinical Epidemiology

About me

Currently, I am a Clinical Epidemiologist (PhD in Medical Science) at the Centre for Translational Microbiome Research at Karolinska Institutet in Stockholm. I received my primary clinical training in Finland and most of my academic training in Sweden. As a result, I have gained a broad knowledge and understanding of clinical pharmacoepidemiology and a passion for women’s health.


My research aims to investigate the long-term effects of common prescription drugs on the risk of cancer-associated outcomes. Specifically, my research focuses on the contemporary use of menopausal hormones, oral antibiotics, and proton pump inhibitors.  

Research description

Most of the projects are based on highly complete high-quality Swedish health data registries, linking data to numerous Swedish National Board of Health and Welfare supervised registries, including the  Prescribed Drug Registry, Cancer Registry, Causes of Death Registry and Patient Registry (in- and outpatient care).  Several studies are extensive, prospective and nationwide cohort studies, including virtually all users of the investigated drug. 


Selected publications (as the first author):

[PubMed ID: 33861686]. Simin J, Liu Q, Wang X, Fall K, Williams C, Callens S, Engstrand L, Brusselaers N. Prediagnostic use of estrogen-only therapy is associated with improved colorectal cancer survival in menopausal women: a Swedish population-based cohort study. Acta Oncologica; 2021.

[PubMed ID: 32968205]. Simin J, Fornes R, Liu Q, Olsen R, Callens S, Engstrand L, Brusselaers N. Antibiotic use and the risk of colorectal cancer: a systematic review and dose-response meta-analysis. The British Journal of Cancer; 2020.

[PubMed ID: 32679181]. Simin J, Tamimi RM, Engstrand L, Callens S, Brusselaers N. Antibiotic use and the risk of breast cancer: A systematic review and dose-response meta-analysis. Pharmacological Research;  2020.

[PubMed ID: 31836528]. Simin J, Liu Q, Fornes R, Brusselaers N. Safety of proton pump inhibitors questioned based on a large randomized trial of patients receiving rivaroxaban or aspirin. Gastroenterology; 2019.

[PubMed ID: 31584190]. Simin J, Tamimi RM, Callens S, Engstrand L, Brusselaers N. Menopausal hormone therapy treatment options and ovarian cancer risk: A Swedish prospective population-based matched-cohort study. International Journal of Cancer; 2019.

[PubMed ID: 28783542]. Simin J, Tamimi R, Lagergren J, Adami HO, Brusselaers N. Menopausal hormone therapy and cancer risk: An overestimated risk? European Journal of Cancer; 2017. 


Other selected publications:

Nele Brusslears; Johanna Simin. TRAITEMENT HORMONAL SUBSTITUTIF POUR LA MÉNOPAUSE ET CANCER : QUELS SONT LES RISQUES EN CAS D’UTILISATION CORRECTE ? [Onco Hemato (Vol. 15, n° 5, septembre-octobre 2021; p. 6-12)].

[PMID: 34291520]. Kamal H, Fornes R, Simin J, Stål P, Duberg A-S, Brusselaers N, Aleman S. Risk of hepatocellular carcinoma in hepatitis B and D virus co-infected patients: A systematic review and meta-analysis of longitudinal studies. Journal of Viral Hepatitis; 2021.

[PMID: 33857339]. Liu Q, Simin J, Debelius J, Fall K, Sadr-Azodi O, Engstrand L, Williams C, Brusselaers N. Menopausal hormone therapies and risk of colorectal cancer: a Swedish matched-cohort study. Alimentary Pharmacology and Therapeutics; 2021.

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