J-Sebastian Muehlboeck

About me
Publications
Public outreach and news

About me

Neuroimaging research since 2005
Data and solutions architect
Software developer
Psychology MSc (Focus on statistics and I/O)
Interests:
* Big data
* Efficient data management and automated processing in Neuroimaging
* Machine learning
* Cloud (MaaS, SaaS)

Articles

Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2022;8(4):20552173221144230-205521732211442

Association between brain volume and disability over time in multiple sclerosis.

Moridi T; Stawiarz L; McKay KA; Ineichen BV; Ouellette R; Ferreira D; Muehlboeck J-S; Westman E; Kockum I; Olsson T; Piehl F; Hillert J; Manouchehrinia A; Granberg T
Article: NATURE COMMUNICATIONS. 2022;13(1):4566

Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer's disease.

Poulakis K; Pereira JB; Muehlboeck J-S; Wahlund L-O; Smedby Ö; Volpe G; Masters CL; Ames D; Niimi Y; Iwatsubo T; Ferreira D; Westman E; Japanese Alzheimer’s Disease Neuroimaging Initiati; Australian Imaging, Biomarkers and Lifestyle study
Article: NEUROLOGY. 2022;99(4):e323-e333

Neuropathologic Features of Antemortem Atrophy-Based Subtypes of Alzheimer Disease.

Mohanty R; Ferreira D; Frerich S; Muehlboeck J-S; Grothe MJ; Westman E; Alzheimer's Disease Neuroimaging Initiative
Article: AGING-US. 2021;13(16):19963-19977

The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline.

Cedres N; Diaz-Galvan P; Diaz-Flores L; Muehlboeck J-S; Molina Y; Barroso J; Westman E; Ferreira D
Article: AGING-US. 2021;13(10):13430-13442

Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts.

Wallert J; Rennie A; Ferreira D; Muehlboeck J-S; Wahlund L-O; Westman E; Ekman U; ADNI consortium, and MemClin steering committee
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:644611

Functional Connectivity and Compensation of Phonemic Fluency in Aging.

Mohanty R; Gonzalez-Burgos L; Diaz-Flores L; Muehlboeck J-S; Barroso J; Ferreira D; Westman E
Article: NEUROIMAGE. 2020;211:116607

Cholinergic white matter pathways make a stronger contribution to attention and memory in normal aging than cerebrovascular health and nucleus basalis of Meynert.

Nemy M; Cedres N; Grothe MJ; Muehlboeck J-S; Lindberg O; Nedelska Z; Stepankova O; Vyslouzilova L; Eriksdotter M; Barroso J; Teipel S; Westman E; Ferreira D
Article: BMC GERIATRICS. 2020;20(1):93

The MemClin project: a prospective multi memory clinics study targeting early stages of cognitive impairment.

Ekman U; Ferreira D; Muehlboeck J-S; Wallert J; Rennie A; Eriksdotter M; Wahlund L-O; Westman E
Article: FRONTIERS IN NEUROSCIENCE. 2020;14:15

Shape Information Improves the Cross-Cohort Performance of Deep Learning-Based Segmentation of the Hippocampus.

Brusini I; Lindberg O; Muehlboeck J-S; Smedby Ö; Westman E; Wang C
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa192

Comparison of subtyping methods for neuroimaging studies in Alzheimer's disease: a call for harmonization.

Mohanty R; Mårtensson G; Poulakis K; Muehlboeck J-S; Rodriguez-Vieitez E; Chiotis K; Grothe MJ; Nordberg A; Ferreira D; Westman E
Article: NEURODEGENERATIVE DISEASES. 2020;20(4):153-164

Brain Atrophy Subtypes and the ATN Classification Scheme in Alzheimer's Disease.

Cedres N; Ekman U; Poulakis K; Shams S; Cavallin L; Muehlboeck S; Granberg T; Wahlund L-O; Ferreira D; Westman E; Alzheimer’s Disease Neuroimaging Initiative
Article: NEUROIMAGE-CLINICAL. 2019;23:101872

AVRA: Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks.

Mårtensson G; Ferreira D; Cavallin L; Muehlboeck J-S; Wahlund L-O; Wang C; Westman E; Alzheimer's Disease Neuroimaging Initiative
Article: FRONTIERS IN AGING NEUROSCIENCE. 2018;10:439

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease.

Boccardi V; Westman E; Pelini L; Lindberg O; Muehlboeck J-S; Simmons A; Tarducci R; Floridi P; Chiarini P; Soininen H; Kloszewska I; Tsolaki M; Vellas B; Spenger C; Wahlund L-O; Lovestone S; Mecocci P
Article: HIPPOCAMPUS. 2017;27(6):653-667

The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals.

Ferreira D; Hansson O; Barroso J; Molina Y; Machado A; Hernández-Cabrera JA; Muehlboeck J-S; Stomrud E; Nägga K; Lindberg O; Ames D; Kalpouzos G; Fratiglioni L; Bäckman L; Graff C; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Lovestone S; Ahlström H; Lind L; Larsson E-M; Wahlund L-O; Simmons A; Westman E; the AddNeuroMed consortium, for the Alzheimer's Di; Australian Imaging Biomarkers and Lifestyle Study
Article: SCIENTIFIC REPORTS. 2017;7:46263

Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications.

Ferreira D; Verhagen C; Hernández-Cabrera JA; Cavallin L; Guo C-J; Ekman U; Muehlboeck J-S; Simmons A; Barroso J; Wahlund L-O; Westman E
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(3):1159-1174

A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease.

Khan W; Giampietro V; Banaschewski T; Barker GJ; Bokde ALW; Büchel C; Conrod P; Flor H; Frouin V; Garavan H; Gowland P; Heinz A; Ittermann B; Lemaître H; Nees F; Paus T; Pausova Z; Rietschel M; Smolka MN; Ströhle A; Gallinat J; Vellas B; Soininen H; Kloszewska I; Tsolaki M; Mecocci P; Spenger C; Villemagne VL; Masters CL; Muehlboeck J-S; Bäckman L; Fratiglioni L; Kalpouzos G; Wahlund L-O; Schumann G; Lovestone S; Williams SCR; Westman E; Simmons A; Alzheimer–s Disease Neuroimaging Initiative; AddNeuroMed Consortium, Australian, Imaging, Bioma; IMAGEN consortium
Article: NEUROIMAGE-CLINICAL. 2017;16:418-428

Monitoring disease progression in mild cognitive impairment: Associations between atrophy patterns, cognition, APOE and amyloid.

Falahati F; Ferreira D; Muehlboeck J-S; Eriksdotter M; Simmons A; Wahlund L-O; Westman E
Article: BRAIN TOPOGRAPHY. 2015;28(5):746-759

Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts.

Khan W; Westman E; Jones N; Wahlund L-O; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Spenger C; Lovestone S; Muehlboeck J-S; Simmons A; AddNeuroMed consortium and for the Alzheimer’s Dis
Article: JOURNAL OF INTERNAL MEDICINE. 2015;278(3):277-290

Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment.

Ferreira D; Cavallin L; Larsson E-M; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Lovestone S; Simmons A; Wahlund L-O; Westman E; AddNeuroMed consortium and the Alzheimer's Disease
Article: NEUROIMAGE. 2015;115:64-75

Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions.

Nam KW; Castellanos N; Simmons A; Froudist-Walsh S; Allin MP; Walshe M; Murray RM; Evans A; Muehlboeck J-S; Nosarti C
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;45(3):851-864

Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts.

Khondoker M; Newhouse S; Westman E; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Lovestone S; Dobson R; Simmons A; AddNeuroMed consortium; Alzheimer's Disease Neuroimaging Initiative
Article: PLOS ONE. 2015;10(8):e0134368

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease.

Khan W; Aguilar C; Kiddle SJ; Doyle O; Thambisetty M; Muehlboeck S; Sattlecker M; Newhouse S; Lovestone S; Dobson R; Giampietro V; Westman E; Simmons A; Alzheimer’s Disease Neuroimaging Initiative
Article: FRONTIERS IN NEUROINFORMATICS. 2014;7:49

TheHiveDB image data management and analysis framework.

Muehlboeck J-S; Westman E; Simmons A
Article: FRONTIERS IN AGING NEUROSCIENCE. 2014;6:145

Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort.

Aguilar C; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Wahlund L-O; Simmons A; Westman E; AddNeuroMed Consortium
Article: JOURNAL OF INTERNAL MEDICINE. 2013;273(6):602-621

Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol.

Mangialasche F; Westman E; Kivipelto M; Muehlboeck J-S; Cecchetti R; Baglioni M; Tarducci R; Gobbi G; Floridi P; Soininen H; Kłoszewska I; Tsolaki M; Vellas B; Spenger C; Lovestone S; Wahlund L-O; Simmons A; Mecocci P; AddNeuroMed consortium
Article: PSYCHIATRY RESEARCH. 2013;212(2):89-98

Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment.

Aguilar C; Westman E; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kloszewska I; Soininen H; Lovestone S; Spenger C; Simmons A; Wahlund L-O
Article: JOURNAL OF INTERNAL MEDICINE. 2013;273(4):396-409

An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment.

Spulber G; Simmons A; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Spenger C; Lovestone S; Wahlund L-O; Westman E; dNeuroMed consortium and for the Alzheimer Disease
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;33(3):755-766

Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease.

Velayudhan L; Proitsi P; Westman E; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Spenger C; Hodges A; Powell J; Lovestone S; Simmons A; dNeuroMed Consortium
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA. 2013;3(1):446-458

CERAD Neuropsychological Total Scores Reflect Cortical Thinning in Prodromal Alzheimer's Disease.

Paajanen T; Hänninen T; Aitken A; Hallikainen M; Westman E; Wahlund L-O; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Spenger C; Lovestone S; Simmons A; Soininen H; AddNeuroMed Consortium
Article: BRAIN TOPOGRAPHY. 2013;26(1):9-23

Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment.

Westman E; Aguilar C; Muehlboeck J-S; Simmons A
Article: NEURORADIOLOGY. 2012;54(9):929-938

Education increases reserve against Alzheimer's disease--evidence from structural MRI analysis.

Liu Y; Julkunen V; Paajanen T; Westman E; Wahlund L-O; Aitken A; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Spenger C; Lovestone S; Simmons A; Soininen H; AddNeuroMed Consortium
Article: NEUROIMAGE. 2012;62(1):229-238

Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion.

Westman E; Muehlboeck J-S; Simmons A
Article: NEUROIMAGE. 2011;58(3):818-828

AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America.

Westman E; Simmons A; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Weiner MW; Lovestone S; Spenger C; Wahlund L-O; AddNeuroMed consortium; Alzheimer's Disease Neuroimaging Initiative
Article: NEUROBIOLOGY OF AGING. 2011;32(7):1198-1206

Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study.

Liu Y; Paajanen T; Zhang Y; Westman E; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H; AddNeuroMed Consortium
Article: NEUROIMAGE. 2011;54(2):1178-1187

Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls.

Westman E; Simmons A; Zhang Y; Muehlboeck J-S; Tunnard C; Liu Y; Collins L; Evans A; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Lovestone S; Spenger C; Wahlund L-O; AddNeuroMed consortium
Article: PLOS ONE. 2011;6(7):e22506

Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease.

Westman E; Cavallin L; Muehlboeck J-S; Zhang Y; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Spenger C; Lovestone S; Simmons A; Wahlund L-O; AddNeuroMed consortium
Article: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2011;26(1):75-82

The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months.

Simmons A; Westman E; Muehlboeck S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Wahlund L-O; Soininen H; Lovestone S; Evans A; Spenger C
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;21(4):1141-1151

Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study.

Julkunen V; Niskanen E; Koikkalainen J; Herukka S-K; Pihlajamäki M; Hallikainen M; Kivipelto M; Muehlboeck S; Evans AC; Vanninen R; Hilkka Soininen
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;21(3):947-966

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.

Liu Y; Paajanen T; Westman E; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Proitsi P; Powell J; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H; AddNeuroMed Consortium
Article: NEUROBIOLOGY OF AGING. 2010;31(8):1375-1385

Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease.

Liu Y; Paajanen T; Zhang Y; Westman E; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H; AddNeuroMed Consortium
Article: ARCHIVES OF GENERAL PSYCHIATRY. 2010;67(7):739-748

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

Thambisetty M; Simmons A; Velayudhan L; Hye A; Campbell J; Zhang Y; Wahlund L-O; Westman E; Kinsey A; Güntert A; Proitsi P; Powell J; Causevic M; Killick R; Lunnon K; Lynham S; Broadstock M; Choudhry F; Howlett DR; Williams RJ; Sharp SI; Mitchelmore C; Tunnard C; Leung R; Foy C; O'Brien D; Breen G; Furney SJ; Ward M; Kloszewska I; Mecocci P; Soininen H; Tsolaki M; Vellas B; Hodges A; Murphy DGM; Parkins S; Richardson JC; Resnick SM; Ferrucci L; Wong DF; Zhou Y; Muehlboeck S; Evans A; Francis PT; Spenger C; Lovestone S
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2010;30(3):229-237

APOE ε2 allele is associated with larger regional cortical thicknesses and volumes.

Liu Y; Paajanen T; Westman E; Zhang Y; Wahlund L-O; Simmons A; Tunnard C; Sobow T; Proitsi P; Powell J; Mecocci P; Tsolaki M; Vellas B; Muehlboeck S; Evans A; Spenger C; Lovestone S; Soininen H; AddNeuroMed Consortium
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2009;28(5):404-412

Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease.

Julkunen V; Niskanen E; Muehlboeck S; Pihlajamäki M; Könönen M; Hallikainen M; Kivipelto M; Tervo S; Vanninen R; Evans A; Soininen H
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Letter: JOURNAL OF INTERNAL MEDICINE. 2021;290(2):473-476

Neurofilament light chain as a marker for cortical atrophy in multiple sclerosis without radiological signs of disease activity.

Ineichen BV; Moridi T; Ewing E; Ouellette R; Manouchehrinia A; Stawiarz L; Ferreira D; Muehlboeck SJ; Kuhle J; Westman E; Leppert D; Hillert J; Olsson T; Kockum I; Piehl F; Granberg T
Published conference paper: NEURODEGENERATIVE DISEASES. 2016;16(1-2):77-86

Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations.

Orellana C; Ferreira D; Muehlboeck J-S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Soininen H; Lovestone S; Simmons A; Wahlund L-O; Westman E; AddNeuronMed consortium and for the Alzheimer''s D
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1180:47-55

MRI measures of Alzheimer's disease and the AddNeuroMed study.

Simmons A; Westman E; Muehlboeck S; Mecocci P; Vellas B; Tsolaki M; Kłoszewska I; Wahlund L-O; Soininen H; Lovestone S; Evans A; Spenger C; AddNeuroMed Consortium
Published conference paper: BEHAVIOR RESEARCH METHODS. 2003;35(2):255-258

Animated diagrams in teaching statistics.

Wender KF; Muehlboeck JS

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