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Juan Jesus Carrero

Professor

Department and organisational affiliation:

About me

I serve as professor in cardio-renal Epidemiology at the Department of Medical Epidemiology and Biostatistics (MEB) and lektor at Örebro University, School of Medicine . My professional ambition is to improve the prevention and management of persons with chronic kidney disease,  and to integrate kidney function assessment into the medical decision process.

Since my arrival at KI, I have authored more than 300 articles as well as 25 book chapters on epidemics and complications of chronic kidney disease, with special emphasis on modifiable risk factors: diet, lifestyle and inapropriate use of medication. My work has received over 10 000 citations and my H index is currently 52 according to Web of Science. I am a frequent invited lecturer to national and international scientific conferences worldwide.

Engagements at Karolinska Institutet

  • Steering Committee member for the Center for Gender Medicine
  • Steering Commitee member and KI coordinator for the research alliance with Merck-Sharpe & Dome (MSD).

Engagements in National/International Societies

  • Co-director of the educational outreach program at the International Society of Renal Nutrition and Metabolism (ISRNM).
  • Vice-Chair and Founder of the Renal Nutrition working group of the European Renal Association-European Dialysis and Transplantation Association (ERA-EDTA).

Engagements in guideline making

  • Section Chair of the Kidney Disease Outcomes Quality Initative (KDOQI) / U.S. Academy of Nutrition and Dietetics (AND) Clinical Practice Guideline for Nutrition in CKD (2015-2019).
  • Guideline Developer Board member of the European Society of Parenteral and Enteral Nutrition consensus guideline on “Clinical nutrition on nephrology” (2019-2022)
  • Section Chair of the Kidney Disease: Improving Global Outcomes (KDIGO) Controversies guideline on Chronic Kidney Disease and Arrhythmias (2017). 
  • Section Chair of the KDIGO Controversies guideline on potassium management in CKD (2018). 

Engagements in editorial work

  • Associate Editor for Nephrology Dialysis and Transplantation 
  • Associate Editor for Journal of Renal Nutrition

Research description

Defended PhD students (main supervision)

  • Xiaoyan Huang, KI 2013
  • Carolina Gracia-Iguacel, Univ Complutense, Madrid, 2014
  • Christiaan Meuwese, Leiden University, The Netherlands, 2014
  • Desiree Luis Rodriguez, University of Las Palmas, Spain, 2016
  • Hong Xu, KI 2018

Current PhD students (main supervision)

  • Marco Trevisan, KI
  • Björn Runesson, KI
  • Mikael Eklund, Örebro university

Postdoctoral researchers

  • Hong Xu, MEB, KI
  • Marie Evans, CLINTEC, KI (affiliated)
  • Karolina Szummer, Medicine, KI (affiliated)
  • Erik Nilsson, Örebro University (affiliated)

Biostatisticians

  • Mikael Andersson-Franko, senior biostat (part time)
  • Hanna Bower, postdoc biostat (part time)

Research Areas

My long term goal is to improve patient care by integrating kidney function aspects in the medical decision process.

To that end we pursue clinical epidemiological analyses in National and International population-based and healthcare-related registers. These include, among others:

In addition, we coordinate the unique  Stockholm CREAtinine Measurements (SCREAM) project.

SCREAM is a complete healthcare utilisation cohort of Stockholm residents. SCREAM has been made possible by agreements with Stockhom County Council and the main laboratory service providers of our region (Unilabs, Karolinska and Aleris), which together run the vast majority of laboratory analyses of the County.

Included are all resident of the region of Stockholm that underwent  plasma creatinine or albuminuria testing in connection to a healthcare consultation.

  • The first phase (period 2006-2011) includes 1.3 million adults (68% of the population census for that period).
  • The second phase (period 2006-2018) is currently under construction.

Together with kidney function estimates, a wide range of laboratory measurements is also available. Laboratory data was thereafter  linked with variety of Regional and National Health Care Registers to conform the largest and most comprehensive healthcare utilisation cohort of Sweden.

SCREAM is coupled with practical implementation program within Stockholm Healthcare (Stockholm Läns Landsting, SLL) aimed at raising awareness among prescribers of the importance of kidney dysfunction and drug interactions.

SCREAM receives and/or has received financial suport from the Swedish Research Council (Vetenskåpsrådet), Stockholm Healthcare, Swedish Heart and Lung Foundation, Westman Foundation, Martin Rind's Foundation and the US National Institutes of Health (NIH)

We welcome research collaborations. Please, do contact us if you share our fascination for cardiorenal epidemiology research

 

Recent publications 

CHRONIC KIDNEY DISEASE EPIDEMICS AND NEPHROLOGY CARE

Gasparini A, Evans M, Coresh J, Grams ME, Norin O, Qureshi AR, Runesson B, Barany P, Ärnlöv J, Jernberg T, Wettermark B, Elinder CG and Carrero JJ. Prevalence and recognition of CKD in Stockholm healthcare. Nephrol Dial Transplant. 2016 Dec;31(12):2086-2094.

Carrero JJ, Grams ME, Sang Y, Ärnlöv J, Gasparini A, Matsushita K, Qureshi AR, Evans ME, Barany PB, Lindholm B, Ballew SH, Levey AS, Gansevoort RT, Elinder CG and Coresh J. Albuminuria changes are associated with subsequent risk of end-stage renal disease and mortality. Kidney Int. 2017 Jan;91(1):244-251.

Xu H, Gasparini A, Ishigami J, Mzayen K, Su GB, Barany P, Arnlov J, Lindholm B, Elinder CG, Matsushita K, Carrero JJ. Kidney function and the risk of community-acquired infections. Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1399-1408.

Nilsson E, Gasparini A, Ärnlöv J, Xu H, Henriksson KM, Coresh J, Grams ME, Carrero JJ. Incidence and determinants of hypokalemia and hyperkalemia in a large healthcare system. Int J Cardiol. 2017 Oct 15;245:277-284.

Carrero JJ, Hecking M, Chesnaye NC, Jager KJ. Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nat Rev Nephrol. 2018 Mar;14(3):151-164.

Carrero JJ, Trevisan M, Sood MM, Barany P, Xu H, Evans M, Friberg L, Szummer K. Incident Atrial Fibrillation and the Risk of Stroke in Adults with Chronic Kidney Disease; the Stockholm CREAtinine Measurements (SCREAM) project. Clin J Am Soc Nephrol. 2018 Sep 7;13(9):1314-1320.

Nilsson E, De Deco P, Bellocco R, Lund LH, Lindholm B, Evans M, Coresh J, Carrero JJ. A real-world cohort study on the quality of potassium and creatinine monitoring during initiation of mineralocorticoid receptor antagonists in patients with heart failure. Eur Heart J - Qual Care Clin Outcomes. 2018 May 2. doi: 10.1093/ehjqcco/qcy019.

Ishigami J, Trevisan M, Xu H, Coresh J, Matsushita K, Carrero JJ. Estimated GFR and Hospital-Acquired Infections Following Major Surgery. Am J Kidney Dis. 2018 Sep 7. pii: S0272-6386(18)30837-0.  [Epub ahead of print].

 

PHARMACOSAFETY IN CHRONIC KIDNEY DISEASE

Carrero JJ, Evans M, Szummer K, Spaak J, Lindhagen L, Edfors R, Stenvinkel P, Jacobson S, Jernberg T. Warfarin treatment, kidney dysfunction and outcomes in acute myocardial infarction patients with atrial fibrillation. JAMA. March 2014; 311(9):913-915.

Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, Wettermark B, Ärnlöv J, Janmaat CJ, Lindholm B, Dekker FW, Coresh J, Grams ME, Carrero JJ. Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease. Gastroenterology. 2017 Sep;153(3):702-710.

Carrero JJ, Varenhorst C, Jensevik K, Szummer K, Lagerqvist B, Evans M, Spaak J, Held C, James S, Jernberg T. Long-term versus short-term dual antiplatelet therapy was similarly associated with a lower risk of death, stroke, or infarction in patients with acute coronary syndrome regardless of underlying kidney disease. Kidney Int. 2017 Jan;91(1):216-226.

Szummer K, Gasparini A, Eliasson S, Ärnlöv J, Qureshi AR, Bárány P, Evans M, Friberg L, Jernberg T, Carrero JJ. Time in Therapeutic Range and Outcomes After Warfarin Initiation in Newly Diagnosed Atrial Fibrillation Patients with Renal Dysfunction. J Am Heart Assoc. 2017 Mar 1;6(3). pii: e004925. doi: 10.1161/JAHA.116.004925.

Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander B, Rotzinsky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and mortality risk in a nation-wide referred chronic kidney disease cohort. Nephrol Dial Transplant. 2017 Nov 1;32(11):1892-1901.

Evans M, Methven S, Barany P, Birnie K, MacNeill S, May MT, Caskey FJ, Carrero JJ. Cinacalcet use and the risk of cardiovascular events, fractures and mortality in CKD patients with secondary hyperparathyroidism. Sci Rep. 2018 Feb 1;8(1):2103.

Trevisan M, de Deco P, Xu H, Evans M, Lindholm N, Bellocco R, Barany P, Jernberg T, Lund LH, Carrero JJ. Incidence, predictors and clinical management of hyperkalemia in real-world new users of mineralocorticoid receptor antagonists. Eur J Heart Fail. 2018 Aug;20(8):1217-1226.

NUTRITION AND CHRONIC KIDNEY DISEASE

Carrero JJ, Johansen KL, Lindholm B, Stenvinkel P, Cuppari L, Avesani CM. Screening for muscle wasting and dysfunction in patients with chronic kidney disease. Kidney Int. 2016 Jul;90(1):53-66.

Xu H, Åkesson A, Orsini N, Håkansson N, Wolk A, Carrero JJ. Dietary acid load and risk of all-cause and cardiovascular mortality in adults. J Nutr. 2016 Aug;146(8):1580-5.

Kelly JT, Palmer SC, Wai SN, Ruospo M, Carrero JJ, Campbell KL, Strippoli GFM. Healthy eating patterns and risk of mortality or end-stage kidney disease among adults with chronic kidney disease: meta-analysis of cohort studies. Clin J Am Soc Nephrol. 2017 Feb 7;12(2):272-279.

Kittiskulnam P, Carrero JJ, Chertow GM, Kaysen GA, Delgado C, Johansen KL. Sarcopenia among Patients Receiving Hemodialysis: Weighing the Evidence. J Cachexia Sarcopenia Muscle. 2017 Feb;8(1):57-68.

Xu H, Evans M, Gasparini A, Szummer K, Spaak, J, Ärnlöv, J, Lindholm, B, Jernberg, T, Carrero JJ. Outcomes associated with serum phosphate levels in patients with suspected acute coronary syndrome. Int J Cardiol. 2017 Oct 15;245:20-26.

Molina P, Vizcaíno B, Molina MD, Beltrán S, González-Moya M, Mora A, Castro-Alonso C, Kanter J, Ávila AI, Górriz JL, Estañ N, Pallardó LM, Fouque D, Carrero JJ. The effect of high-volume online haemodiafiltration on nutritional status and body composition: the ProtEin Stores prEservaTion (PESET) study. Nephrol Dial Transplant. 2018 Jul 1;33(7):1223-1235.

Antón-Pérez G, Santana-del-Pino A, Henríquez-Palop F, Monzón T, Sánchez AY, Valga F, Morales-Umpierrez A, García-Cantón C, Rodríguez-Pérez JC, Carrero JJ. Diagnostic usefulness of protein energy wasting criteria in prevalent hemodialysis patients. J Ren Nutr. 2018 Jul 5. [Epub ahead of print].

Saglimbene VM, Wong G, Ruospo M, Palmer SP, Campbell K, Garcia Larsen V, Natale P, Teixeira-Pinto A, Carrero JJ, Stenvinkel P, Gargano L, Murgo AM, Johnson DW, Tonelli M, Frazão JM, n Gelfman RG, Celia E, Ecder T, G Bernat AG, Del Castillo D, Timofte D, Török M, Bednarek-Skublewska A, Duława J, Stroumza P, Hoischen S, Hansis M, Fabricius E, Wollheim C, Hegbrant J, Craig JC, Strippoli GFM. The association between Mediterranean and DASH diets with mortality in adults on hemodialysis: The DIET-HD Multinational Cohort Study. J Am Soc Nephrol. 2018 Jun;29(6):1741-1751.

Education

2019 Professor in epidemiology, Karolinska Institutet, Sweden

2013 Associate Professor (Docent) in Renal Medicine

2008, PhD in Medicine, Karolinska Institutet, Sweden

2005, PhD in Pharmacy, University of Granada, Spain

2002, Master in Business and Administration, University of Granada, Spain

2000, Bachelor in Pharmacy, University of Granada, Spain

Academic honours, awards and prizes

2016 Distinguished Fellow of the US National Kidney Foundation (FNKF) 2015 Distinguised Fellow of the European Renal Association - ERA-EDTA (FERA)

2014, Italian Society of Nephrology, Journal of Nephrology (JN) award for most cited article during 2013

2014, US National Kidney Foundation “Joel D. Kopple” award for contributions to Renal Nutrition Research

2012, Awarded recognition for scientific achievements at "VIII International Conference on Hypertension and the Kidney". Madrid, Spain

Award for young researchers at Karolinska Institutet funds in 2013, 2011 and 2008

Research grant for best research project by young investigators (ESPEN, European Society for Parenteral and Enteral Nutrition, 2006)

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