Karoline Scholzen

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Articles

Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2024;146(8):5204-5214

Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology.

Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arnér ESJ; Thorn-Seshold O
Article: REDOX BIOLOGY. 2023;62:102703

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.

Cheff DM; Huang C; Scholzen KC; Gencheva R; Ronzetti MH; Cheng Q; Hall MD; Arnér ESJ
Article: ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 2023;79(Pt 6):545-555

Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans.

Mazurkewich S; Scholzen KC; Brusch RH; Poulsen JCN; Theibich Y; Hüttner S; Olsson L; Larsbrink J; Lo Leggio L
Article: CHEM. 2022;8(5):1493-1517

Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe.

Zeisel L; Felber JG; Scholzen KC; Poczka L; Cheff D; Maier MS; Cheng Q; Shen M; Hall MD; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
Article: NATURE COMMUNICATIONS. 2022;13(1):1754

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically.

Felber JG; Poczka L; Scholzen KC; Zeisel L; Maier MS; Busker S; Theisen U; Brandstädter C; Becker K; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
Article: CELL HOST & MICROBE. 2021;29(8):1316-1332.e12

Global mapping of Salmonella enterica-host protein-protein interactions during infection.

Walch P; Selkrig J; Knodler LA; Rettel M; Stein F; Fernandez K; Viéitez C; Potel CM; Scholzen K; Geyer M; Rottner K; Steele-Mortimer O; Savitski MM; Holden DW; Typas A
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021;143(23):8791-8803

Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif.

Felber JG; Zeisel L; Poczka L; Scholzen K; Busker S; Maier MS; Theisen U; Brandstädter C; Becker K; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O

Employments

Phd Student, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2022-2025

Degrees and Education

Master of Science, Biochemistry, An Evaluation of next Generation Redox Sensing Probes, University of Heidelberg, 2021
Bachelor of Science, Biochemistry, University of Heidelberg, 2019

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