Karin Wirdefeldt

About me
Publications
CV
Public outreach and news

About me

I am docent and adjunct professor of neuroepidemiology at the Department of
Medical Epidemiology and Biostatistics [1] and senior neurologist at the
Department of Neurology at the Karolinska University Hospital, Solna.
* MD, Karolinska Institutet, 1996
* Licence to practice as a physician (Swedish "Läkarlegitimation"), 2000
* PhD, Karolinska Institutet, 2004
* Specialist in neurology, 2011
[1] https://ki.se/en/meb

Research

*Current supervision of PhD students*
* Xiaoying Kang [1]
[1] https://staff.ki.se/people/xiaoying-kang

Articles

Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(11):3430-3439

Gastrointestinal biopsy of normal mucosa or nonspecific inflammation and risk of neurodegenerative disease: Nationwide matched cohort study.

Sun J; Ludvigsson JF; Roelstraete B; Pedersen NL; Pawitan Y; Wirdefeldt K; Fang F
Article: ANNALS OF NEUROLOGY. 2023;93(5):1023-1028

β2-Adrenoreceptor Agonists, Montelukast, and Parkinson Disease Risk.

Liu B; Svenningsson P; Ludvigsson JF; Lundholm C; Wallin J; Larsson H; Sjölander A; Williams DM; Pedersen NL; Wirdefeldt K
Article: MOVEMENT DISORDERS. 2023;38(4):604-615

Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.

Sugier P-E; Lucotte EA; Domenighetti C; Law MH; Iles MM; Brown K; Amos C; McKay JD; Hung RJ; Karimi M; Bacq-Daian D; Boland-Augé A; Olaso R; Deleuze J-F; Lesueur F; Ostroumova E; Kesminiene A; de Vathaire F; Guénel P; EPITHYR consortium; Sreelatha AAK; Schulte C; Grover S; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschländer AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrøm L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen N; Ran C; Belin AC; Puschmann A; Rödström EY; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Kruger R; Gasser T; Sharma M; Comprehensive Unbiased Risk Factor Assessment for ; Truong T; Elbaz A
Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad002

Genetic overlap between Parkinson's disease and inflammatory bowel disease.

Kang X; Ploner A; Wang Y; Ludvigsson JF; Williams DM; Pedersen NL; Wirdefeldt K
Article: PLOS MEDICINE. 2022;19(9):e1004092

Hospital-treated infections in early- and mid-life and risk of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis: A nationwide nested case-control study in Sweden.

Sun J; Ludvigsson JF; Ingre C; Piehl F; Wirdefeldt K; Zagai U; Ye W; Fang F
Article: MOVEMENT DISORDERS. 2022;37(9):1929-1937

The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited.

Domenighetti C; Douillard V; Sugier P-E; Sreelatha AAK; Schulte C; Grover S; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Gourraud P-A; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschländer AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Duga S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrøm L; Correia Guedes L; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Ygland Rödström E; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Krüger R; Gasser T; Sharma M; Vince N; Elbaz A; Comprehensive Unbiased Risk Factor Assessment for
Article: NEUROLOGY. 2022;99(7):e698-e710

Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.

Grover S; Kumar Sreelatha AA; Pihlstrom L; Domenighetti C; Schulte C; Sugier P-E; Radivojkov-Blagojevic M; Lichtner P; Mohamed O; Portugal B; Landoulsi Z; May P; Bobbili D; Edsall C; Bartusch F; Hanussek M; Krüger J; Hernandez DG; Blauwendraat C; Mellick GD; Zimprich A; Pirker W; Tan M; Rogaeva E; Lang A; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschländer AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Burbulla LF; Matsuo H; Kawamura Y; Hattori N; Nishioka K; Chung SJ; Kim YJ; Pavelka L; van de Warrenburg BPC; Bloem BR; Singleton AB; Aasly J; Toft M; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Krainc D; Farrer MJ; Kruger R; Elbaz A; Gasser T; Sharma M; and the Comprehensive Unbiased Risk Factor Assessm
Article: NEUROSCIENCE LETTERS. 2022;784:136767

Glucocerebrosidase variant T369M is not a risk factor for Parkinson's disease in Sweden.

Ran C; Brodin L; Gellhaar S; Westerlund M; Fardell C; Nissbrandt H; Söderkvist P; Sydow O; Markaki I; Hertz E; Wirdefeldt K; Svenningsson P
Article: MOVEMENT DISORDERS. 2022;37(4):857-864

Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.

Domenighetti C; Sugier P-E; Ashok Kumar Sreelatha A; Schulte C; Grover S; Mohamed O; Portugal B; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschländer AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Duga S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Kawamura Y; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrøm L; Correia Guedes L; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Krüger R; Gasser T; Sharma M; Elbaz A; Comprehensive Unbiased Risk Factor Assessment for
Article: EBIOMEDICINE. 2022;76:103824

Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population.

Kang X; Jiao T; Wang H; Pernow J; Wirdefeldt K
Article: JOURNAL OF PARKINSONS DISEASE. 2022;12(1):267-282

Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease.

Domenighetti C; Sugier P-E; Sreelatha AAK; Schulte C; Grover S; Mohamed O; Portugal B; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschländer AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Duga S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Kawamura Y; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BP; Bloem BR; Aasly J; Toft M; Pihlstrøm L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Krüger R; Gasser T; Sharma M; Elbaz A; Comprehensive Unbiaised Risk Factor Assessment for
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2021;36(10):1055-1064

Heart rate, intelligence in adolescence, and Parkinson's disease later in life.

Longinetti E; Zhan Y; Sata M; Larsson H; D Onofrio BM; Iso H; Wirdefeldt K; Fang F
Article: JOURNAL OF PARKINSONS DISEASE. 2021;11(3):1325-1334

Neuroticism, Smoking, and the Risk of Parkinson's Disease.

Sieurin J; Zhan Y; Pedersen NL; Wirdefeldt K
Article: MOVEMENT DISORDERS. 2021;36(8):1919-1926

Association Between Microscopic Colitis and Parkinson's Disease in a Swedish Population.

Kang X; Ploner A; Roelstraete B; Khalili H; Williams DM; Pedersen NL; Ludvigsson JF; Wirdefeldt K
Article: NEUROLOGY. 2021;96(12):e1672-e1679

Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study.

Kang X; Ploner A; Pedersen NL; Bandres-Ciga S; Noyce AJ; Wirdefeldt K; Williams DM
Article: NPJ PARKINSONS DISEASE. 2021;7(1):5

Irritable bowel syndrome and Parkinson's disease risk: register-based studies.

Liu B; Sjölander A; Pedersen NL; Ludvigsson JF; Chen H; Fang F; Wirdefeldt K
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2020;27(11):2134-2141

Clostridium difficile infection and risk of Parkinson's disease: a Swedish population-based cohort study.

Kang X; Ploner A; Ludvigsson JF; Williams DM; Larsson H; Pedersen NL; Wirdefeldt K
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa152

Creatinine and C-reactive protein in amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease.

Cui C; Sun J; Pawitan Y; Piehl F; Chen H; Ingre C; Wirdefeldt K; Evans M; Andersson J; Carrero J-J; Fang F
Article: JAMA NEUROLOGY. 2020;77(6):700-709

Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases.

Song H; Sieurin J; Wirdefeldt K; Pedersen NL; Almqvist C; Larsson H; Valdimarsdóttir UA; Fang F
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2020;51(11):1022-1030

Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register-based matched cohort study.

Liu B; Wanders A; Wirdefeldt K; Sjölander A; Sachs MC; Eberhardson M; Ye W; Ekbom A; Olén O; Ludvigsson JF
Article: FRONTIERS IN NEUROLOGY. 2020;11:548

Longitudinal Monitoring of Parkinson's Disease in Different Ethnic Cohorts: The DodoNA and LONG-PD Study.

Markopoulou K; Aasly J; Chung SJ; Dardiotis E; Wirdefeldt K; Premkumar AP; Schoneburg B; Kartha N; Wilk G; Wei J; Simon KC; Tideman S; Epshteyn A; Hadsell B; Garduno L; Pham A; Frigerio R; Maraganore D
Article: FRONTIERS IN NEUROLOGY. 2020;11:510

Appendectomy, Tonsillectomy and Parkinson's Disease Risk: A Swedish Register-Based Study.

Liu B; Fang F; Ye W; Wirdefeldt K
Article: NEUROLOGY. 2019;93(21):e1964-e1970

Family history increases the risk of late seizures after stroke.

Eriksson H; Wirdefeldt K; Åsberg S; Zelano J
Article: ACTA NEUROLOGICA SCANDINAVICA. 2019;140(5):342-349

Incidence of osmotic demyelination syndrome in Sweden: A nationwide study.

Aegisdottir H; Cooray C; Wirdefeldt K; Piehl F; Sveinsson O
Article: PARKINSONISM & RELATED DISORDERS. 2019;66:158-165

Low prevalence of known pathogenic mutations in dominant PD genes: A Swedish multicenter study.

Puschmann A; Jiménez-Ferrer I; Lundblad-Andersson E; Mårtensson E; Hansson O; Odin P; Widner H; Brolin K; Mzezewa R; Kristensen J; Soller M; Rödström EY; Ross OA; Toft M; Breedveld GJ; Bonifati V; Brodin L; Zettergren A; Sydow O; Linder J; Wirdefeldt K; Svenningsson P; Nissbrandt H; Belin AC; Forsgren L; Swanberg M
Article: CIRCULATION RESEARCH. 2019;125(6):643-652

Lipids, Apolipoproteins, and the Risk of Parkinson Disease.

Fang F; Zhan Y; Hammar N; Shen X; Wirdefeldt K; Walldius G; Mariosa D
Article: ANNALS OF INTERNAL MEDICINE. 2019;170(10):673-681

Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study.

Liu B; Luo Z; Pinto JM; Shiroma EJ; Tranah GJ; Wirdefeldt K; Fang F; Harris TB; Chen H
Article: MOVEMENT DISORDERS. 2018;33(9):1456-1464

Occupational stress and risk for Parkinson's disease: A nationwide cohort study.

Sieurin J; Andel R; Tillander A; Valdes EG; Pedersen NL; Wirdefeldt K
Article: NEUROLOGY. 2018;90(16):e1413-e1417

Body mass index, sitting time, and risk of Parkinson disease.

Roos E; Grotta A; Yang F; Bellocco R; Ye W; Adami H-O; Wirdefeldt K; Trolle Lagerros Y
Article: MOVEMENT DISORDERS. 2017;32(11):1631-1636

Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts.

Yang F; Wolk A; Håkansson N; Pedersen NL; Wirdefeldt K
Article: BRAIN. 2017;140(10):2653-2662

Migraine and risk of stroke: a national population-based twin study.

Lantz M; Sieurin J; Sjölander A; Waldenlind E; Sjöstrand C; Wirdefeldt K
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2017;46(3):872-880

Moist smokeless tobacco (Snus) use and risk of Parkinson's disease.

Yang F; Pedersen NL; Ye W; Liu Z; Norberg M; Forsgren L; Trolle Lagerros Y; Bellocco R; Alfredsson L; Knutsson A; Jansson J-H; Wennberg P; Galanti MR; Lager ACJ; Araghi M; Lundberg M; Magnusson C; Wirdefeldt K
Article: NEUROLOGY. 2017;88(21):1996-2002

Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study.

Liu B; Fang F; Pedersen NL; Tillander A; Ludvigsson JF; Ekbom A; Svenningsson P; Chen H; Wirdefeldt K
Article: PARKINSONS DISEASE. 2017;2017:4020198-7

Genetic Variations and mRNA Expression of NRF2 in Parkinson's Disease.

Ran C; Wirdefeldt K; Brodin L; Ramezani M; Westerlund M; Xiang F; Anvret A; Willows T; Sydow O; Johansson A; Galter D; Svenningsson P; Belin AC
Article: NEUROBIOLOGY OF AGING. 2017;49:217.e1-217.e4

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.

Wang L; Heckman MG; Aasly JO; Annesi G; Bozi M; Chung SJ; Clarke C; Crosiers D; Eckstein G; Garraux G; Hadjigeorgiou GM; Hattori N; Jeon B; Kim YJ; Kubo M; Lesage S; Lin JJ; Lynch T; Lichtner P; Mellick GD; Mok V; Morrison KE; Quattrone A; Satake W; Silburn PA; Stefanis L; Stockton JD; Tan EK; Toda T; Brice A; Van Broeckhoven C; Uitti RJ; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Maraganore DM; Gasser T; Krüger R; Farrer MJ; Ross OA; Sharma M; GEOPD Consortium
Article: PLOS ONE. 2017;12(5):e0173565

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.

Khare S; Nick JA; Zhang Y; Galeano K; Butler B; Khoshbouei H; Rayaprolu S; Hathorn T; Ranum LPW; Smithson L; Golde TE; Paucar M; Morse R; Raff M; Simon J; Nordenskjöld M; Wirdefeldt K; Rincon-Limas DE; Lewis J; Kaczmarek LK; Fernandez-Funez P; Nick HS; Waters MF
Article: NEUROBIOLOGY OF AGING. 2016;45:212.e5-212.e11

Strong association between glucocerebrosidase mutations and Parkinson's disease in Sweden.

Ran C; Brodin L; Forsgren L; Westerlund M; Ramezani M; Gellhaar S; Xiang F; Fardell C; Nissbrandt H; Söderkvist P; Puschmann A; Ygland E; Olson L; Willows T; Johansson A; Sydow O; Wirdefeldt K; Galter D; Svenningsson P; Belin AC
Article: MEDICINE. 2016;95(30):e4337

Socioeconomic status in relation to Parkinson's disease risk and mortality: A population-based prospective study.

Yang F; Johansson ALV; Pedersen NL; Fang F; Gatz M; Wirdefeldt K
Article: OPEN NEUROLOGY JOURNAL. 2016;10:25-29

No Association Between rs7077361 in ITGA8 and Parkinson's Disease in Sweden.

Ran C; Mehdi RN; Fardell C; Xiang F; Nissbrandt H; Sydow O; Wirdefeldt K; Belin AC
Article: NEUROLOGY. 2016;86(24):2271-2277

Depression in amyotrophic lateral sclerosis.

Roos E; Mariosa D; Ingre C; Lundholm C; Wirdefeldt K; Roos PM; Fang F
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2016;31(2):169-175

Personality traits and the risk for Parkinson disease: a prospective study.

Sieurin J; Gustavsson P; Weibull CE; Feldman AL; Petzinger GM; Gatz M; Pedersen NL; Wirdefeldt K
Article: PLOS ONE. 2016;11(4):e0152841

Early-Life Factors and Risk of Parkinson's Disease: A Register-Based Cohort Study.

Liu B; Chen H; Fang F; Tillander A; Wirdefeldt K
Article: NEUROLOGY. 2015;85(15):1283-1292

Large-scale assessment of polyglutamine repeat expansions in Parkinson disease.

Wang L; Aasly JO; Annesi G; Bardien S; Bozi M; Brice A; Carr J; Chung SJ; Clarke C; Crosiers D; Deutschländer A; Eckstein G; Farrer MJ; Goldwurm S; Garraux G; Hadjigeorgiou GM; Hicks AA; Hattori N; Klein C; Jeon B; Kim YJ; Lesage S; Lin J-J; Lynch T; Lichtner P; Lang AE; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Opala G; Pihlstrøm L; Pramstaller PP; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Silburn PA; Theuns J; Tan EK; Tomiyama H; Toft M; Van Broeckhoven C; Uitti RJ; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yueh K-C; Zhao Y; Gasser T; Maraganore DM; Krüger R; Sharma M; GEO-PD Consortium
Article: BRAIN. 2015;138(Pt 2):269-275

Physical activity and risk of Parkinson's disease in the Swedish National March Cohort.

Yang F; Trolle Lagerros Y; Bellocco R; Adami H-O; Fang F; Pedersen NL; Wirdefeldt K
Article: NEUROEPIDEMIOLOGY. 2015;45(4):282-297

Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease--Report of the JPND Working Group BioLoC-PD.

Lerche S; Liepelt-Scarfone I; Alves G; Barone P; Behnke S; Ben-Shlomo Y; Berendse H; Burn D; Dodel R; Grosset D; Heinzel S; Hu M; Kasten M; Krüger R; Maetzler W; Moccia M; Mollenhauer B; Oertel W; Roeben B; Sünkel U; Walter U; Wirdefeldt K; Berg D
Article: PLOS ONE. 2015;10(4):e0122960

Is a cancer diagnosis associated with subsequent risk of transient global amnesia?

Zhu J; Lu D; Sveinsson O; Wirdefeldt K; Fall K; Piehl F; Valdimarsdóttir U; Fang F
Article: MOVEMENT DISORDERS. 2014;29(8):1053-1057

Alpha-synuclein repeat variants and survival in Parkinson's disease.

Chung SJ; Biernacka JM; Armasu SM; Anderson K; Frigerio R; Aasly JO; Annesi G; Bentivoglio AR; Brighina L; Chartier-Harlin M-C; Goldwurm S; Hadjigeorgiou G; Jasinska-Myga B; Jeon BS; Kim YJ; Krüger R; Lesage S; Markopoulou K; Mellick G; Morrison KE; Puschmann A; Tan E-K; Crosiers D; Theuns J; Van Broeckhoven C; Wirdefeldt K; Wszolek ZK; Elbaz A; Maraganore DM; Genetic Epidemiology of Parkinson's Disease Consor
Article: PLOS ONE. 2014;9(9):e106676

Occupational complexity and risk of Parkinson's disease.

Valdés EG; Andel R; Sieurin J; Feldman AL; Edwards JD; Långström N; Gatz M; Wirdefeldt K
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2014;179(1):85-94

Parkinson's disease and cancer: A register-based family study.

Wirdefeldt K; Weibull CE; Chen H; Kamel F; Lundholm C; Fang F; Ye W
Article: NEUROBIOLOGY OF AGING. 2014;35(1):266.e5-266.14

Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.

Heckman MG; Elbaz A; Soto-Ortolaza AI; Serie DJ; Aasly JO; Annesi G; Auburger G; Bacon JA; Boczarska-Jedynak M; Bozi M; Brighina L; Chartier-Harlin M-C; Dardiotis E; Destée A; Ferrarese C; Ferraris A; Fiske B; Gispert S; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Jasinska-Myga B; Jeon BS; Kim YJ; Klein C; Kruger R; Kyratzi E; Lin C-H; Lohmann K; Loriot M-A; Lynch T; Mellick GD; Mutez E; Opala G; Park SS; Petrucci S; Quattrone A; Sharma M; Silburn PA; Sohn YH; Stefanis L; Tadic V; Tomiyama H; Uitti RJ; Valente EM; Vassilatis DK; Vilariño-Güell C; White LR; Wirdefeldt K; Wszolek ZK; Wu R-M; Xiromerisiou G; Maraganore DM; Farrer MJ; Ross OA; Genetic Epidemiology Of Parkinson's Disease (GEO-P
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2014;29(1):49-56

Evidence for modest familial co-aggregation between dementia and parkinsonism.

Feldman AL; Wirdefeldt K; Johansson ALV; Gatz M; Pedersen NL
Article: MOVEMENT DISORDERS. 2013;28(12):1740-1744

Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.

Heckman MG; Soto-Ortolaza AI; Aasly JO; Abahuni N; Annesi G; Bacon JA; Bardien S; Bozi M; Brice A; Brighina L; Carr J; Chartier-Harlin M-C; Dardiotis E; Dickson DW; Diehl NN; Elbaz A; Ferrarese C; Fiske B; Gibson JM; Gibson R; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Boczarska-Jedynak M; Jasinska-Myga B; Jeon BS; Kim YJ; Klein C; Kruger R; Kyratzi E; Lesage S; Lin C-H; Lynch T; Maraganore DM; Mellick GD; Mutez E; Nilsson C; Opala G; Park SS; Petrucci S; Puschmann A; Quattrone A; Sharma M; Silburn PA; Sohn YH; Stefanis L; Tadic V; Theuns J; Tomiyama H; Uitti RJ; Valente EM; Van Broeckhoven C; van de Loo S; Vassilatis DK; Vilariño-Güell C; White LR; Wirdefeldt K; Wszolek ZK; Wu R-M; Hentati F; Farrer MJ; Ross OA; Genetic Epidemiology of Parkinson's Disease (GEO-P
Article: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. 2013;14(5-6):362-368

Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden.

Fang F; Al-Chalabi A; Ronnevi L-O; Turner MR; Wirdefeldt K; Kamel F; Ye W
Article: JOURNAL OF MEDICAL GENETICS. 2012;49(11):721-726

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.

Sharma M; Ioannidis JPA; Aasly JO; Annesi G; Brice A; Bertram L; Bozi M; Barcikowska M; Crosiers D; Clarke CE; Facheris MF; Farrer M; Garraux G; Gispert S; Auburger G; Vilariño-Güell C; Hadjigeorgiou GM; Hicks AA; Hattori N; Jeon BS; Jamrozik Z; Krygowska-Wajs A; Lesage S; Lill CM; Lin J-J; Lynch T; Lichtner P; Lang AE; Libioulle C; Murata M; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Meitnger T; Zimprich A; Opala G; Pramstaller PP; Pichler I; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Satake W; Silburn PA; Strom TM; Theuns J; Tan E-K; Toda T; Tomiyama H; Uitti RJ; Van Broeckhoven C; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yomono HS; Yueh K-C; Zhao Y; Gasser T; Maraganore D; Krüger R; GEOPD consortium
Article: MOVEMENT DISORDERS. 2012;27(13):1632-1635

Head injury and Parkinson's disease: a population-based study.

Fang F; Chen H; Feldman AL; Kamel F; Ye W; Wirdefeldt K
Article: NEUROLOGY. 2012;79(7):659-667

Large-scale replication and heterogeneity in Parkinson disease genetic loci.

Sharma M; Ioannidis JPA; Aasly JO; Annesi G; Brice A; Van Broeckhoven C; Bertram L; Bozi M; Crosiers D; Clarke C; Facheris M; Farrer M; Garraux G; Gispert S; Auburger G; Vilariño-Güell C; Hadjigeorgiou GM; Hicks AA; Hattori N; Jeon B; Lesage S; Lill CM; Lin J-J; Lynch T; Lichtner P; Lang AE; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Opala G; Pramstaller PP; Pichler I; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Satake W; Silburn PA; Theuns J; Tan E-K; Toda T; Tomiyama H; Uitti RJ; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yueh K-C; Zhao Y; Gasser T; Maraganore D; Krüger R; GEO-PD Consortium
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2012;41(4):1042-1049

CNS infections, sepsis and risk of Parkinson's disease.

Fang F; Wirdefeldt K; Jacks A; Kamel F; Ye W; Chen H
Article: NEUROEPIDEMIOLOGY. 2012;38(3):186-193

Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers.

Feldman AL; Johansson ALV; Gatz M; Flensburg M; Petzinger GM; Widner H; Lew MF; Pedersen NL; Wirdefeldt K
Article: NEUROBIOLOGY OF AGING. 2011;32(11):2108.e1-2108.e5

Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.

Sharma M; Maraganore DM; Ioannidis JPA; Riess O; Aasly JO; Annesi G; Abahuni N; Bentivoglio AR; Brice A; Van Broeckhoven C; Chartier-Harlin M-C; Destée A; Djarmati A; Elbaz A; Farrer M; Ferrarese C; Gibson JM; Gispert S; Hattori N; Jasinska-Myga B; Klein C; Lesage S; Lynch T; Lichtner P; Lambert J-C; Lang AE; Mellick GD; De Nigris F; Opala G; Quattrone A; Riva C; Rogaeva E; Ross OA; Satake W; Silburn PA; Theuns J; Toda T; Tomiyama H; Uitti RJ; Wirdefeldt K; Wszolek Z; Gasser T; Krüger R; Genetic Epidemiology of Parkinson's Disease Consor
Article: PARKINSONISM & RELATED DISORDERS. 2011;17(9):677-682

Occupational exposure in parkinsonian disorders: a 43-year prospective cohort study in men.

Feldman AL; Johansson ALV; Nise G; Gatz M; Pedersen NL; Wirdefeldt K
Article: NEUROBIOLOGY OF AGING. 2011;32(10):1923.e1-1923.e8

Heritability of Parkinson disease in Swedish twins: a longitudinal study.

Wirdefeldt K; Gatz M; Reynolds CA; Prescott CA; Pedersen NL
Article: LANCET NEUROLOGY. 2011;10(10):898-908

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.

Ross OA; Soto-Ortolaza AI; Heckman MG; Aasly JO; Abahuni N; Annesi G; Bacon JA; Bardien S; Bozi M; Brice A; Brighina L; Van Broeckhoven C; Carr J; Chartier-Harlin M-C; Dardiotis E; Dickson DW; Diehl NN; Elbaz A; Ferrarese C; Ferraris A; Fiske B; Gibson JM; Gibson R; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Jasinska-Myga B; Jeon BS; Kim YJ; Klein C; Kruger R; Kyratzi E; Lesage S; Lin C-H; Lynch T; Maraganore DM; Mellick GD; Mutez E; Nilsson C; Opala G; Park SS; Puschmann A; Quattrone A; Sharma M; Silburn PA; Sohn YH; Stefanis L; Tadic V; Theuns J; Tomiyama H; Uitti RJ; Valente EM; van de Loo S; Vassilatis DK; Vilariño-Güell C; White LR; Wirdefeldt K; Wszolek ZK; Wu R-M; Farrer MJ; Genetic Epidemiology Of Parkinson's Disease (GEO-P
Article: ANNALS OF NEUROLOGY. 2011;69(5):778-792

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

Elbaz A; Ross OA; Ioannidis JPA; Soto-Ortolaza AI; Moisan F; Aasly J; Annesi G; Bozi M; Brighina L; Chartier-Harlin M-C; Destée A; Ferrarese C; Ferraris A; Gibson JM; Gispert S; Hadjigeorgiou GM; Jasinska-Myga B; Klein C; Krüger R; Lambert J-C; Lohmann K; van de Loo S; Loriot M-A; Lynch T; Mellick GD; Mutez E; Nilsson C; Opala G; Puschmann A; Quattrone A; Sharma M; Silburn PA; Stefanis L; Uitti RJ; Valente EM; Vilariño-Güell C; Wirdefeldt K; Wszolek ZK; Xiromerisiou G; Maraganore DM; Farrer MJ; Genetic Epidemiology of Parkinson's Disease (GEO-P
Article: NEUROBIOLOGY OF AGING. 2011;32(3):548.e9-548.18

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.

Krüger R; Sharma M; Riess O; Gasser T; Van Broeckhoven C; Theuns J; Aasly J; Annesi G; Bentivoglio AR; Brice A; Djarmati A; Elbaz A; Farrer M; Ferrarese C; Gibson JM; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Jasinska-Myga B; Klein C; Lambert J-C; Lesage S; Lin J-J; Lynch T; Mellick GD; de Nigris F; Opala G; Prigione A; Quattrone A; Ross OA; Satake W; Silburn PA; Tan EK; Toda T; Tomiyama H; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Maraganore DM; Genetic Epidemiology of Parkinson's disease consor
Article: PLOS ONE. 2011;6(12):e29749

Infection of the central nervous system, sepsis and amyotrophic lateral sclerosis.

Fang F; Chen H; Wirdefeldt K; Ronnevi L-O; Al-Chalabi A; Peters TL; Kamel F; Ye W
Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 2010;153B(1):220-228

Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.

Evangelou E; Maraganore DM; Annesi G; Brighina L; Brice A; Elbaz A; Ferrarese C; Hadjigeorgiou GM; Krueger R; Lambert J-C; Lesage S; Markopoulou K; Mellick GD; Meeus B; Pedersen NL; Quattrone A; Van Broeckhoven C; Sharma M; Silburn PA; Tan E-K; Wirdefeldt K; Ioannidis JPA; Genetic Epidemiology of Parkinson's Disease (GEOPD
Article: NEUROBIOLOGY OF AGING. 2008;29(12):1765-1773

Complete ascertainment of Parkinson disease in the Swedish Twin Registry.

Wirdefeldt K; Gatz M; Bakaysa SL; Fiske A; Flensburg M; Petzinger GM; Widner H; Lew MF; Welsh M; Pedersen NL
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2008;82(3):763-771

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.

Bruder CEG; Piotrowski A; Gijsbers AACJ; Andersson R; Erickson S; Diaz de Ståhl T; Menzel U; Sandgren J; von Tell D; Poplawski A; Crowley M; Crasto C; Partridge EC; Tiwari H; Allison DB; Komorowski J; van Ommen G-JB; Boomsma DI; Pedersen NL; den Dunnen JT; Wirdefeldt K; Dumanski JP
Article: LANCET NEUROLOGY. 2006;5(11):917-923

Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.

Elbaz A; Nelson LM; Payami H; Ioannidis JPA; Fiske BK; Annesi G; Carmine Belin A; Factor SA; Ferrarese C; Hadjigeorgiou GM; Higgins DS; Kawakami H; Krüger R; Marder KS; Mayeux RP; Mellick GD; Nutt JG; Ritz B; Samii A; Tanner CM; Van Broeckhoven C; Van Den Eeden SK; Wirdefeldt K; Zabetian CP; Dehem M; Montimurro JS; Southwick A; Myers RM; Trikalinos TA
Article: ANNALS OF NEUROLOGY. 2005;57(1):27-33

Risk and protective factors for Parkinson's disease: a study in Swedish twins.

Wirdefeldt K; Gatz M; Pawitan Y; Pedersen NL
Article: NEUROLOGY. 2004;63(2):305-311

No evidence for heritability of Parkinson disease in Swedish twins.

Wirdefeldt K; Gatz M; Schalling M; Pedersen NL
Article: BMC NEUROLOGY. 2003;3:6

A linkage study of candidate loci in familial Parkinson's Disease.

Wirdefeldt K; Burgess CE; Westerberg L; Payami H; Schalling M
Article: BRAIN RESEARCH. 2001;92(1-2):58-65

Expression of alpha-synuclein in the human brain: relation to Lewy body disease.

Wirdefeldt K; Bogdanovic N; Westerberg L; Payami H; Schalling M; Murdoch G
Article: NEUROSCIENCE LETTERS. 1999;272(2):140-142

Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease.

Zareparsi S; Wirdefeldt K; Burgess CE; Nutt J; Kramer P; Schalling M; Payami H
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Letter: MOVEMENT DISORDERS. 2021;36(10):2453

Reply to: "Association between Microscopic Colitis and Parkinson's Disease in a Swedish Population".

Kang X; Ploner A; Roelstraete B; Khalili H; Williams DM; Pedersen NL; Ludvigsson JF; Wirdefeldt K
Letter: CNS DRUGS. 2016;30(10):1009-1010

Authors' Reply to Lambarth: "Levodopa-Carbidopa Intestinal Gel in Patients with Parkinson's Disease: A Systematic Review".

Wirdefeldt K; Odin P; Nyholm D
Letter: MOVEMENT DISORDERS. 2016;31(9):1422-1423

Reduced incidence of Parkinson's disease after dipeptidyl peptidase-4 inhibitors-A nationwide case-control study.

Svenningsson P; Wirdefeldt K; Yin L; Fang F; Markaki I; Efendic S; Ludvigsson JF
Review: CNS DRUGS. 2016;30(5):381-404

Levodopa-Carbidopa Intestinal Gel in Patients with Parkinson's Disease: A Systematic Review.

Wirdefeldt K; Odin P; Nyholm D
Review: FRONTIERS IN AGING NEUROSCIENCE. 2016;8:147

Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.

Heinzel S; Roeben B; Ben-Shlomo Y; Lerche S; Alves G; Barone P; Behnke S; Berendse HW; Bloem BR; Burn D; Dodel R; Grosset DG; Hu M; Kasten M; Krüger R; Moccia M; Mollenhauer B; Oertel W; Suenkel U; Walter U; Wirdefeldt K; Liepelt-Scarfone I; Maetzler W; Berg D
Editorial comment: FRONTIERS IN AGING NEUROSCIENCE. 2016;8:121

Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.

Lerche S; Heinzel S; Alves GW; Barone P; Behnke S; Ben-Shlomo Y; Berendse H; Bloem BR; Burn D; Dodel R; Grosset DG; Hipp G; Hu MT; Kasten M; Krüger R; Liepelt-Scarfone I; Maetzler W; Moccia M; Mollenhauer B; Oertel W; Roeben B; Walter U; Wirdefeldt K; Berg D
Review: NEUROEPIDEMIOLOGY. 2014;42(2):69-80

Familial coaggregation of Alzheimer's disease and Parkinson's disease: systematic review and meta-analysis.

Feldman AL; Johansson ALV; Lambert PC; Sieurin J; Yang F; Pedersen NL; Wirdefeldt K
Review: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2011;26 Suppl 1:S1-58

Epidemiology and etiology of Parkinson's disease: a review of the evidence.

Wirdefeldt K; Adami H-O; Cole P; Trichopoulos D; Mandel J

Employments

Adjunct Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2023-2026
Adjunct Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2015
Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2004
University Medical Degree, Karolinska Institutet, 1996

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