Keying Zhu
Postdoctoral Researcher
E-mail: keying.zhu@ki.se
Visiting address: L8:04, CMM Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 Neuro Harris, 171 77 Stockholm
Research
- My current research interest lies in the field of neuroimmunology with a main focus on multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD). I'm currently a postdoctoral researcher in Robert Harris's group, and we are trying to understand the role of microglia and peripheral-derived macrophages in CNS disorders. We aim to develop strategies to combat neuroinflammatory disorders by regulating dysfunctional microglia and other myeloid cells. (Master's students with relevant expertise and experience in animal experiments are welcome to contact us for internship opportunities.) Currently, I'm leading the following projects: 1. Drug repurposing and nanoengineering for neuroinflammatory diseases. 2. Deciphering the TGF-β signaling in microglia. 3. Corepressor complexes in the regulation of microglial function and the CNS homeostasis. 4. The TRPV1 receptor in demyelination and remyelination.
Teaching
- Supervised 4 master students for their master project reports: Timas Shin-Yu Kung (8 months, Karolinska Institutet) Projects: 1. Microglial reprogramming for neuroinflammatory disorders
- 2. Topoisomerase 1 inhibition mitigates microglial activation and neuroinflammation. Cindy Bay (2 months, Heidelberg University) Project: Topoisomerase 1 inhibition attenuates neuroinflammation. Zoë Keasberry (6 months, Vrije Universiteit Amsterdam) Project: Improvement of microglial replacement therapy in severe neurological diseases: understanding the depletion and repopulation pattern of microglia following CSF1R inhibition. Yiming Xia (10 months, Karolinska Institutet) Projection: Transcritptional coregulator in control of microglia function.
Articles
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Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675
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Journal article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;127:111408
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Article: JCI INSIGHT. 2023;8(17):e167656
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Article: ACTA PHARMACOLOGICA SINICA. 2023;44(4):766-779
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Article: JOURNAL OF NEUROINFLAMMATION. 2023;20(1):83
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Article: EMBO REPORTS. 2022;23(7):e54499
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Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
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Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2021;99(3):793-805
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Article: CARBOHYDRATE POLYMERS. 2021;254:117291
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824
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Article: NATURE COMMUNICATIONS. 2020;11(1):4071
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Article: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2020;2020:3205176-13
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Article: GLIA. 2020;68(7):1466-1478
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Article: BRAIN RESEARCH. 2019;1710:33-42
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Article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2019;4:27
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Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
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Journal article: BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2017;40(8):1306-1313
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Journal article: FRONTIERS IN NEUROSCIENCE. 2016;10:613
All other publications
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Preprint: 2023;bioRxiv
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KI thesis / dissertation: 2023
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Review: GLIA. 2019;67(2):217-231
Grants
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NEURO Sweden1 January 2024 - 31 December 2024
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Oligodendroglial Primary Cilia in White Matter Injury Repair: Function, Signaling mechanism, and Proteome RepertoireSwedish Research Council1 January 2024 - 31 December 2027
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Swedish Research Council1 December 2021 - 30 November 2026
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StratNeuro1 June 2021 - 31 May 2023
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NEURO Sweden1 January 2021 - 1 January 2022
Employments
- Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2025
- Phd Student, Department of Clinical Neuroscience, Karolinska Institutet, 2018-2023
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2023