Lars Maegdefessel

About me
Publications
Public outreach and news

Research

My research focus is on non-coding RNAs in vascular biology and medicine.
Please read more on my group's page [1].
[1] http://ki.se/en/meds/lars-maegdefessel-group

Articles

Article: MOLECULAR THERAPY. 2023;31(6):1775-1790

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression.

Winter H; Winski G; Busch A; Chernogubova E; Fasolo F; Wu Z; Bäcklund A; Khomtchouk BB; Van Booven DJ; Sachs N; Eckstein H-H; Wittig I; Boon RA; Jin H; Maegdefessel L
Article: VASCULAR PHARMACOLOGY. 2023;150:107167

Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification.

Skenteris NT; Hemme E; Delfos L; Karadimou G; Karlöf E; Lengquist M; Kronqvist M; Zhang X; Maegdefessel L; Schurgers LJ; Arnardottir H; Biessen EAL; Bot I; Matic L
Article: CARDIOVASCULAR RESEARCH. 2023;119(3):867-878

E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.

Mulorz J; Spin JM; Mulorz P; Wagenhäuser MU; Deng A; Mattern K; Rhee YH; Toyama K; Adam M; Schelzig H; Maegdefessel L; Tsao PS
Article: THROMBOSIS AND HAEMOSTASIS. 2023;123(5):545-554

Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging.

Ferraro B; Giustetto P; Schengel O; Weckbach LT; Maegdefessel L; Soehnlein O
Article: ATHEROSCLEROSIS. 2023;371:1-13

A comparative gene expression matrix in Apoe-deficient mice identifies unique and atherosclerotic disease stage-specific gene regulation patterns in monocytes and macrophages.

Härdtner C; Kumar A; Ehlert CA; Vico TA; Starz C; von Ehr A; Krebs K; Dufner B; Hoppe N; Stachon P; Heidt T; Wolf D; von Zur Mühlen C; Grüning B; Robbins CS; Maegdefessel L; Westermann D; Dederichs T-S; Hilgendorf I
Article: VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. 2023;52(2):124-132

CXCR4 - a possible serum marker for risk stratification of abdominal aortic aneurysms.

Reutersberg B; Metschl S; Salvermoser M; Eckstein H-H; Knappich C; Maegdefessel L; Jaroslav P; Busch A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(2):286-299

Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1).

Cynn E; Li DY; O'Reilly ME; Wang Y; Bashore AC; Jha A; Foulkes AS; Zhang H; Winter H; Maegdefessel L; Yan H; Li M; Ross L; Xue C; Reilly MP
Article: JVS-VASCULAR SCIENCE. 2023;4:100093

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth.

Zschäpitz D; Bohmann B; Lutz B; Eckstein H-H; Reeps C; Maegdefessel L; Gasser CT; Busch A
Article: SCIENTIFIC REPORTS. 2022;12(1):20990

Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms.

Lim C; Pratama MY; Rivera C; Silvestro M; Tsao PS; Maegdefessel L; Gallagher KA; Maldonado T; Ramkhelawon B
Article: CELL REPORTS. 2022;41(7):111670

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2.

Oo JA; Pálfi K; Warwick T; Wittig I; Prieto-Garcia C; Matkovic V; Tomašković I; Boos F; Izquierdo Ponce J; Teichmann T; Petriukov K; Haydar S; Maegdefessel L; Wu Z; Pham MD; Krishnan J; Baker AH; Günther S; Ulrich HD; Dikic I; Leisegang MS; Brandes RP
Article: NAT CARDIOVASC RES. 2022;1:1056-1071

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation.

Guillamat-Prats R; Hering D; Derle A; Rami M; Härdtner C; Santovito D; Rinne P; Bindila L; Hristov M; Pagano S; Vuilleumier N; Schmid S; Janjic A; Enard W; Weber C; Maegdefessel L; Faussner A; Hilgendorf I; Steffens S
Article: CARDIOVASCULAR RESEARCH. 2022;118(13):2792-2804

Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells.

Wang Y; Gao H; Wang F; Ye Z; Mokry M; Turner AW; Ye J; Koplev S; Luo L; Alsaigh T; Adkar SS; Elishaev M; Gao X; Maegdefessel L; Björkegren JLM; Pasterkamp G; Miller CL; Ross EG; Leeper NJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(10):512

Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation.

Brandhofer M; Hoffmann A; Blanchet X; Siminkovitch E; Rohlfing A-K; El Bounkari O; Nestele JA; Bild A; Kontos C; Hille K; Rohde V; Fröhlich A; Golemi J; Gokce O; Krammer C; Scheiermann P; Tsilimparis N; Sachs N; Kempf WE; Maegdefessel L; Otabil MK; Megens RTA; Ippel H; Koenen RR; Luo J; Engelmann B; Mayo KH; Gawaz M; Kapurniotu A; Weber C; von Hundelshausen P; Bernhagen J
Article: METABOLITES. 2022;12(9):840

Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR.

Bauer S; Eigenmann J; Zhao Y; Fleig J; Hawe JS; Pan C; Bongiovanni D; Wengert S; Ma A; Lusis AJ; Kovacic JC; Björkegren JLM; Maegdefessel L; Schunkert H; von Scheidt M
Article: THROMBOSIS AND HAEMOSTASIS. 2022;122(9):1513-1523

Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture.

Metschl S; Bruder L; Paloschi V; Jakob K; Reutersberg B; Reeps C; Maegdefessel L; Gee M; Eckstein H-H; Pelisek J
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2022;64(2-3):255-264

Radiation and Chemotherapy are Associated with Altered Aortic Aneurysm Growth in Patients with Cancer: Impact of Synchronous Cancer and Aortic Aneurysm.

Becker von Rose A; Kobus K; Bohmann B; Lindquist-Lilljequist M; Eilenberg W; Bassermann F; Reeps C; Eckstein H-H; Trenner M; Maegdefessel L; Neumayer C; Brostjan C; Roy J; Hultgren R; Schwaiger BJ; Busch A
Article: CIRCULATION RESEARCH. 2022;131(1):42-58

miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages.

Nguyen M-A; Hoang H-D; Rasheed A; Duchez A-C; Wyatt H; Cottee ML; Graber TE; Susser L; Robichaud S; Berber İ; Geoffrion M; Ouimet M; Kazan H; Maegdefessel L; Mulvihill EE; Alain T; Rayner KJ
Article: JOURNAL OF CELL SCIENCE. 2022;135(12):jcs259671

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing.

Kremer V; Stanicek L; van Ingen E; Bink DI; Hilderink S; Tijsen AJ; Wittig I; Mägdefessel L; Nossent AY; Boon RA
Article: NATURE COMMUNICATIONS. 2022;13(1):2867

ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.

Kaufmann JO; Brangsch J; Kader A; Saatz J; Mangarova DB; Zacharias M; Kempf WE; Schwaar T; Ponader M; Adams LC; Möckel J; Botnar RM; Taupitz M; Mägdefessel L; Traub H; Hamm B; Weller MG; Makowski MR
Article: EUROPEAN HEART JOURNAL. 2022;43(19):1864-1877

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques.

Edsfeldt A; Swart M; Singh P; Dib L; Sun J; Cole JE; Park I; Al-Sharify D; Persson A; Nitulescu M; Borges PDN; Kassiteridi C; Goddard ME; Lee R; Volkov P; Orho-Melander M; Maegdefessel L; Nilsson J; Udalova I; Goncalves I; Monaco C
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):197

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.

Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Röll W; Pfeifer A
Article: NAT CARDIOVASC RES. 2022;1(3):253-262

The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis.

Jarr K-U; Ye J; Kojima Y; Ye Z; Gao H; Schmid S; Luo L; Baylis RA; Lotfi M; Lopez N; Eberhard AV; Smith BR; Weissman IL; Maegdefessel L; Leeper NJ
Article: DIABETES. 2022;71(2):285-297

Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes.

Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(2):e682

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.

Skenteris NT; Seime T; Witasp A; Karlöf E; Wasilewski GB; Heuschkel MA; Jaminon AMG; Oduor L; Dzhanaev R; Kronqvist M; Lengquist M; Peeters FECM; Söderberg M; Hultgren R; Roy J; Maegdefessel L; Arnardottir H; Bengtsson E; Goncalves I; Quertermous T; Goettsch C; Stenvinkel P; Schurgers LJ; Matic L
Article: PLOS ONE. 2022;17(9):e0265160

Aging-regulated TUG1 is dispensable for endothelial cell function.

Gimbel AT; Koziarek S; Theodorou K; Schulz JF; Stanicek L; Kremer V; Ali T; Günther S; Kumar S; Jo H; Hübner N; Maegdefessel L; Dimmeler S; van Heesch S; Boon RA
Article: CARDIOVASCULAR RESEARCH. 2021;117(14):2767-2780

Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability.

Tsantilas P; Lao S; Wu Z; Eberhard A; Winski G; Vaerst M; Nanda V; Wang Y; Kojima Y; Ye J; Flores A; Jarr K-U; Pelisek J; Eckstein H-H; Matic L; Hedin U; Tsao PS; Paloschi V; Maegdefessel L; Leeper NJ
Article: BIOMOLECULES. 2021;11(11):1683

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.

Neiburga KD; Vilne B; Bauer S; Bongiovanni D; Ziegler T; Lachmann M; Wengert S; Hawe JS; Güldener U; Westerlund AM; Li L; Pang S; Yang C; Saar K; Huebner N; Maegdefessel L; DigiMed Bayern Consortium; Lange R; Krane M; Schunkert H; von Scheidt M
Article: CIRCULATION. 2021;144(19):1567-1583

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization.

Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Bäcklund A; Bergmark C; Paloschi V; Maegdefessel L
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2021;62(5):716-726

Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling.

Karlöf E; Buckler A; Liljeqvist ML; Lengquist M; Kronqvist M; Toonsi MA; Maegdefessel L; Matic LP; Hedin U
Article: EUROPEAN HEART JOURNAL. 2021;42(39):4077-4088

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

Hinterdobler J; Schott S; Jin H; Meesmann A; Steinsiek A-L; Zimmermann A-S; Wobst J; Müller P; Mauersberger C; Vilne B; Baecklund A; Chen C-S; Moggio A; Braster Q; Molitor M; Krane M; Kempf WE; Ladwig K-H; Hristov M; Hulsmans M; Hilgendorf I; Weber C; Wenzel P; Scheiermann C; Maegdefessel L; Soehnlein O; Libby P; Nahrendorf M; Schunkert H; Kessler T; Sager HB
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(17):e020231

Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression.

Gäbel G; Northoff BH; Balboa A; Becirovic-Agic M; Petri M; Busch A; Maegdefessel L; Mahlmann A; Ludwig S; Teupser D; de Waard V; Golledge J; Wanhainen A; Wågsäter D; Holdt LM; Lindeman JHN
Article: JCI INSIGHT. 2021;6(15):140364

Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility.

Busch A; Pauli J; Winski G; Bleichert S; Chernogubova E; Metschl S; Winter H; Trenner M; Wiegering A; Otto C; Fischer J; Reiser J; Werner J; Roy J; Brostjan C; Knappich C; Eckstein H-H; Paloschi V; Maegdefessel L
Article: TRANSLATIONAL RESEARCH. 2021;233:32-46

Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms.

Eilenberg W; Zagrapan B; Bleichert S; Ibrahim N; Knöbl V; Brandau A; Martelanz L; Grasl M-T; Hayden H; Nawrozi P; Rajic R; Häusler C; Potolidis A; Schirwani N; Scheuba A; Klopf J; Teubenbacher P; Weigl MP; Kirchweger P; Beitzke D; Stiglbauer-Tscholakoff A; Panzenböck A; Lang I; Mauracher L-M; Hell L; Pabinger I; Bailey MA; Scott DJA; Maegdefessel L; Busch A; Huk I; Neumayer C; Brostjan C
Article: MOLECULAR THERAPY-NUCLEIC ACIDS. 2021;24:188-199

MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening.

Schellinger IN; Wagenhäuser M; Chodisetti G; Mattern K; Dannert A; Petzold A; Jakubizka-Smorag J; Emrich F; Haunschild J; Schuster A; Schwob E; Schulz K; Maegdefessel L; Spin JM; Stumvoll M; Hasenfuß G; Tsao PS; Raaz U
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(6):2038-2048

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability.

Georgakis MK; van der Laan SW; Asare Y; Mekke JM; Haitjema S; Schoneveld AH; de Jager SCA; Nurmohamed NS; Kroon J; Stroes ESG; de Kleijn DPV; de Borst GJ; Maegdefessel L; Soehnlein O; Pasterkamp G; Dichgans M
Article: CELLS. 2021;10(6):1276

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.

Seime T; Akbulut AC; Liljeqvist ML; Siika A; Jin H; Winski G; van Gorp RH; Karlöf E; Lengquist M; Buckler AJ; Kronqvist M; Waring OJ; Lindeman JHN; Biessen EAL; Maegdefessel L; Razuvaev A; Schurgers LJ; Hedin U; Matic L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(5):1738-1750

Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.

Buckler AJ; Karlöf E; Lengquist M; Gasser TC; Maegdefessel L; Perisic Matic L; Hedin U
Article: REDOX BIOLOGY. 2021;41:101903

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm.

Gao P; Gao P; Zhao J; Shan S; Luo W; Slivano OJ; Zhang W; Tabuchi A; LeMaire SA; Maegdefessel L; Shen YH; Miano JM; Singer HA; Long X
Article: CIRCULATION. 2021;143(3):254-266

Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion.

Schumski A; Ortega-Gómez A; Wichapong K; Winter C; Lemnitzer P; Viola JR; Pinilla-Vera M; Folco E; Solis-Mezarino V; Völker-Albert M; Maas SL; Pan C; Perez Olivares L; Winter J; Hackeng T; Karlsson MCI; Zeller T; Imhof A; Baron RM; Nicolaes GAF; Libby P; Maegdefessel L; Kamp F; Benoit M; Döring Y; Soehnlein O
Journal article: CIRCULATION. 2021;144(19):1567-1583

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DYY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Backlund A; Bergmark C; Paloschi V; Maegdefessel L
Article: ATHEROSCLEROSIS. 2020;314:1-9

A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?

Rakipovski G; Rolin B; Barascuk N; Lund HE; Bjørn Bonde MF; Djordjevic D; Wulff-Larsen PG; Petersen M; Kirk RK; Hultman K; Manfe V; Blume N; Zahn S; Lengquist M; Maegdefessel L; Hovingh GK; Conde-Knape K; Hedin U; Matic L; Nyberg M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(12):2821-2828

18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.

Jarr K-U; Ye J; Kojima Y; Nanda V; Flores AM; Tsantilas P; Wang Y; Hosseini-Nassab N; Eberhard AV; Lotfi M; Käller M; Smith BR; Maegdefessel L; Leeper NJ
Article: NATURE COMMUNICATIONS. 2020;11(1):5981

Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.

Kontos C; El Bounkari O; Krammer C; Sinitski D; Hille K; Zan C; Yan G; Wang S; Gao Y; Brandhofer M; Megens RTA; Hoffmann A; Pauli J; Asare Y; Gerra S; Bourilhon P; Leng L; Eckstein H-H; Kempf WE; Pelisek J; Gokce O; Maegdefessel L; Bucala R; Dichgans M; Weber C; Kapurniotu A; Bernhagen J
Article: BASIC RESEARCH IN CARDIOLOGY. 2020;115(6):67

Functional investigation of the coronary artery disease gene SVEP1.

Winkler MJ; Müller P; Sharifi AM; Wobst J; Winter H; Mokry M; Ma L; van der Laan SW; Pang S; Miritsch B; Hinterdobler J; Werner J; Stiller B; Güldener U; Webb TR; Asselbergs FW; Björkegren JLM; Maegdefessel L; Schunkert H; Sager HB; Kessler T
Article: ANTIOXIDANTS & REDOX SIGNALING. 2020;33(9):602-620

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease.

Knappich C; Spin JM; Eckstein H-H; Tsao PS; Maegdefessel L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15818-15826

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade.

Wang Y; Nanda V; Direnzo D; Ye J; Xiao S; Kojima Y; Howe KL; Jarr K-U; Flores AM; Tsantilas P; Tsao N; Rao A; Newman AAC; Eberhard AV; Priest JR; Ruusalepp A; Pasterkamp G; Maegdefessel L; Miller CL; Lind L; Koplev S; Björkegren JLM; Owens GK; Ingelsson E; Weissman IL; Leeper NJ
Article: NEUROLOGY. 2020;94(22):e2346-e2360

Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.

Novotny J; Oberdieck P; Titova A; Pelisek J; Chandraratne S; Nicol P; Hapfelmeier A; Joner M; Maegdefessel L; Poppert H; Pircher J; Massberg S; Friedrich B; Zimmer C; Schulz C; Boeckh-Behrens T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(6):1464-1478

Macrophage-Enriched lncRNA RAPIA: A Novel Therapeutic Target for Atherosclerosis.

Sun C; Fu Y; Gu X; Xi X; Peng X; Wang C; Sun Q; Wang X; Qian F; Qin Z; Qu W; Piao M; Zhong S; Liu S; Zhang M; Fang S; Tian J; Li C; Maegdefessel L; Tian J; Yu B
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2020;75(15):1788-1800

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.

Hinkel R; Ramanujam D; Kaczmarek V; Howe A; Klett K; Beck C; Dueck A; Thum T; Laugwitz K-L; Maegdefessel L; Weber C; Kupatt C; Engelhardt S
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(2):412-425

MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice.

Cheng J; Cheng A; Clifford BL; Wu X; Hedin U; Maegdefessel L; Pamir N; Sallam T; Tarling EJ; de Aguiar Vallim TQ
Article: MOLECULAR THERAPY. 2019;27(9):1681-1693

The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment.

Kilari S; Cai C; Zhao C; Sharma A; Chernogubova E; Simeon M; Wu C-C; Song H-L; Maegdefessel L; Misra S
Article: ATHEROSCLEROSIS. 2019;288:175-185

Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization.

Karlöf E; Seime T; Dias N; Lengquist M; Witasp A; Almqvist H; Kronqvist M; Gådin JR; Odeberg J; Maegdefessel L; Stenvinkel P; Matic LP; Hedin U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(33):16410-16419

Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA.

Khyzha N; Khor M; DiStefano PV; Wang L; Matic L; Hedin U; Wilson MD; Maegdefessel L; Fish JE
Article: THROMBOSIS AND HAEMOSTASIS. 2019;119(8):1205-1211

Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis.

Paloschi V; Winter H; Viola J; Soehnlein O; Maegdefessel L
Article: CIRCULATION. 2019;139(21):2466-2482

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.

Centa M; Jin H; Hofste L; Hellberg S; Busch A; Baumgartner R; Verzaal NJ; Lind Enoksson S; Perisic Matic L; Boddul SV; Atzler D; Li DY; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Lutgens E; Binder CJ; Maegdesfessel L; Malin SG
Article: NATURE. 2019;569(7755):236-240

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

Silvestre-Roig C; Braster Q; Wichapong K; Lee EY; Teulon JM; Berrebeh N; Winter J; Adrover JM; Santos GS; Froese A; Lemnitzer P; Ortega-Gómez A; Chevre R; Marschner J; Schumski A; Winter C; Perez-Olivares L; Pan C; Paulin N; Schoufour T; Hartwig H; González-Ramos S; Kamp F; Megens RTA; Mowen KA; Gunzer M; Maegdefessel L; Hackeng T; Lutgens E; Daemen M; von Blume J; Anders H-J; Nikolaev VO; Pellequer J-L; Weber C; Hidalgo A; Nicolaes GAF; Wong GCL; Soehnlein O
Article: ATHEROSCLEROSIS. 2019;283:127-136

Dual roles of heparanase in human carotid plaque calcification.

Aldi S; Eriksson L; Kronqvist M; Lengquist M; Löfling M; Folkersen L; Matic LP; Maegdefessel L; Grinnemo K-H; Li J-P; Österholm C; Hedin U
Article: THROMBOSIS AND HAEMOSTASIS. 2019;119(4):542-552

Therapeutic Targeting of Neutrophil Extracellular Traps in Atherogenic Inflammation.

Van Avondt K; Maegdefessel L; Soehnlein O
Article: NON-CODING RNA. 2019;5(2):E31-31

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.

Gomes CPDC; Ágg B; Andova A; Arslan S; Baker A; Barteková M; Beis D; Betsou F; Wettinger SB; Bugarski B; Condorelli G; Silva GJJD; Danilin S; de Gonzalo-Calvo D; Buil A; Carmo-Fonseca M; Enguita FJ; Felekkis K; Ferdinandy P; Gyöngyösi M; Hackl M; Karaduzovic-Hadziabdic K; Hellemans J; Heymans S; Hlavackova M; Hoydal MA; Jankovic A; Jusic A; Kardassis D; Kerkelä R; Kuster GM; Lakkisto P; Leszek P; Lustrek M; Maegdefessel L; Martelli F; Novella S; O'Brien T; Papaneophytou C; Pedrazzini T; Pinet F; Popescu O; Potočnjak I; Robinson E; Sasson S; Scholz M; Simionescu M; Stoll M; Varga ZV; Vinciguerra M; Xuereb A; Yilmaz MB; Emanueli C; Devaux Y; on behalf of the EU-CardioRNA COST Action (CA17129
Article: CIRCULATION. 2019;139(10):1320-1334

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation.

Cremer S; Michalik KM; Fischer A; Pfisterer L; Jaé N; Winter C; Boon RA; Muhly-Reinholz M; John D; Uchida S; Weber C; Poller W; Günther S; Braun T; Li DY; Maegdefessel L; Perisic Matic L; Hedin U; Soehnlein O; Zeiher A; Dimmeler S
Article: JOURNAL OF CLINICAL MEDICINE. 2019;8(2):E251-251

Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank.

Pelisek J; Hegenloh R; Bauer S; Metschl S; Pauli J; Glukha N; Busch A; Reutersberg B; Kallmayer M; Trenner M; Wendorff H; Tsantilas P; Schmid S; Knappich C; Schaeffer C; Stadlbauer T; Biro G; Wertern U; Meisner F; Stoklasa K; Menges A-L; Radu O; Dallmann-Sieber S; Karlas A; Knipfer E; Reeps C; Zimmermann A; Maegdefessel L; Eckstein H-H
Article: CIRCULATION RESEARCH. 2019;124(4):619-630

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm.

Kumar S; Boon RA; Maegdefessel L; Dimmeler S; Jo H
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(1):72-82

miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease.

Eken SM; Christersdottir T; Winski G; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Backlund A; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
Article: NATURE METABOLISM. 2019;1(1):98-110

The long noncoding RNA CHROME regulates cholesterol homeostasis in primate.

Hennessy EJ; van Solingen C; Scacalossi KR; Ouimet M; Afonso MS; Prins J; Koelwyn GJ; Sharma M; Ramkhelawon B; Carpenter S; Busch A; Chernogubova E; Matic LP; Hedin U; Maegdefessel L; Caffrey BE; Hussein MA; Ricci EP; Temel RE; Garabedian MJ; Berger JS; Vickers KC; Kanke M; Sethupathy P; Teupser D; Holdt LM; Moore KJ
Article: JOURNAL OF VASCULAR RESEARCH. 2019;56(5):217-229

Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.

Sangha GS; Busch A; Acuna A; Berman AG; Phillips EH; Trenner M; Eckstein H-H; Maegdefessel L; Goergen CJ
Article: CARDIOVASCULAR RESEARCH. 2019;115(1):230-242

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling.

Hofmann P; Sommer J; Theodorou K; Kirchhof L; Fischer A; Li Y; Perisic L; Hedin U; Maegdefessel L; Dimmeler S; Boon RA
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(6):719-727

Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms.

Petri MH; Thul S; Andonova T; Lindquist-Liljeqvist M; Jin H; Skenteris N-T; Arnardottir H; Maegdefessel L; Caidahl K; Perretti M; Roy J; Bäck M
Article: CIRCULATION. 2018;138(15):1551-1568

H19 Induces Abdominal Aortic Aneurysm Development and Progression.

Li DY; Busch A; Jin H; Chernogubova E; Pelisek J; Karlsson J; Sennblad B; Liu S; Lao S; Hofmann P; Bäcklund A; Eken SM; Roy J; Eriksson P; Dacken B; Ramanujam D; Dueck A; Engelhardt S; Boon RA; Eckstein H-H; Spin JM; Tsao PS; Maegdefessel L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):1796-1805

Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm.

Adam M; Kooreman NG; Jagger A; Wagenhäuser MU; Mehrkens D; Wang Y; Kayama Y; Toyama K; Raaz U; Schellinger IN; Maegdefessel L; Spin JM; Hamming JF; Quax PHA; Baldus S; Wu JC; Tsao PS
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2018;56(1):102-109

Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion.

Busch A; Chernogubova E; Jin H; Meurer F; Eckstein H-H; Kim M; Maegdefessel L
Article: MOLECULAR THERAPY. 2018;26(4):1040-1055

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions.

Jin H; Li DY; Chernogubova E; Sun C; Busch A; Eken SM; Saliba-Gustafsson P; Winter H; Winski G; Raaz U; Schellinger IN; Simon N; Hegenloh R; Matic LP; Jagodic M; Ehrenborg E; Pelisek J; Eckstein H-H; Hedin U; Backlund A; Maegdefessel L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(8):1907-1912

Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.

Di Gennaro A; Araújo AC; Busch A; Jin H; Wågsäter D; Vorkapic E; Caidahl K; Eriksson P; Samuelsson B; Maegdefessel L; Haeggström JZ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(1):49-63

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration.

Nguyen M-A; Karunakaran D; Geoffrion M; Cheng HS; Tandoc K; Perisic Matic L; Hedin U; Maegdefessel L; Fish JE; Rayner KJ
Article: CIRCULATION JOURNAL. 2017;81(12):1945-1952

Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A.

Söderström LÅ; Jin H; Caravaca AS; Klement ML; Li Y; Gisterå A; Hedin U; Maegdefessel L; Hansson GK; Olofsson PS
Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2017;148(4):425-433

Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms.

Busch A; Grimm C; Hartmann E; Paloschi V; Kickuth R; Lengquist M; Otto C; Eriksson P; Kellersmann R; Lorenz U; Maegdefessel L
Article: CIRCULATION. 2017;136(1):65-79

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Leisegang MS; Fork C; Josipovic I; Richter FM; Preussner J; Hu J; Miller MJ; Epah J; Hofmann P; Günther S; Moll F; Valasarajan C; Heidler J; Ponomareva Y; Freiman TM; Maegdefessel L; Plate KH; Mittelbronn M; Uchida S; Künne C; Stellos K; Schermuly RT; Weissmann N; Devraj K; Wittig I; Boon RA; Dimmeler S; Pullamsetti SS; Looso M; Miller FJ; Brandes RP
Article: PLOS GENETICS. 2017;13(5):e1006750

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells.

Kim JB; Pjanic M; Nguyen T; Miller CL; Iyer D; Liu B; Wang T; Sazonova O; Carcamo-Orive I; Matic LP; Maegdefessel L; Hedin U; Quertermous T
Article: CIRCULATION RESEARCH. 2017;120(4):633-644

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions.

Eken SM; Jin H; Chernogubova E; Li Y; Simon N; Sun C; Korzunowicz G; Busch A; Bäcklund A; Österholm C; Razuvaev A; Renné T; Eckstein HH; Pelisek J; Eriksson P; González Díez M; Perisic Matic L; Schellinger IN; Raaz U; Leeper NJ; Hansson GK; Paulsson-Berne G; Hedin U; Maegdefessel L
Article: HUMAN MOLECULAR GENETICS. 2017;26(3):637-649

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

Sennblad B; Basu S; Mazur J; Suchon P; Martinez-Perez A; van Hylckama Vlieg A; Truong V; Li Y; Gådin JR; Tang W; Grossman V; de Haan HG; Handin N; Silveira A; Souto JC; Franco-Cereceda A; Morange P-E; Gagnon F; Soria JM; Eriksson P; Hamsten A; Maegdefessel L; Rosendaal FR; Wild P; Folsom AR; Trégouët D-A; Sabater-Lleal M
Article: CIRCULATION. 2016;134(24):1973-1990

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.

Hartmann D; Fiedler J; Sonnenschein K; Just A; Pfanne A; Zimmer K; Remke J; Foinquinos A; Butzlaff M; Schimmel K; Maegdefessel L; Hilfiker-Kleiner D; Lachmann N; Schober A; Froese N; Heineke J; Bauersachs J; Batkai S; Thum T
Article: NATURE MEDICINE. 2016;22(10):1140-1150

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.

Stellos K; Gatsiou A; Stamatelopoulos K; Perisic Matic L; John D; Lunella FF; Jaé N; Rossbach O; Amrhein C; Sigala F; Boon RA; Fürtig B; Manavski Y; You X; Uchida S; Keller T; Boeckel J-N; Franco-Cereceda A; Maegdefessel L; Chen W; Schwalbe H; Bindereif A; Eriksson P; Hedin U; Zeiher AM; Dimmeler S
Article: DIABETES. 2016;65(10):2888-2899

Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness.

Strawbridge RJ; Hilding A; Silveira A; Österholm C; Sennblad B; McLeod O; Tsikrika P; Foroogh F; Tremoli E; Baldassarre D; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Mannarino E; Grossi E; Syvänen A-C; Humphries SE; de Faire U; Östenson C-G; Maegdefessel L; Hamsten A; Bäcklund A; IMPROVE Study Group
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(9):1947-1961

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.

Perisic Matic L; Rykaczewska U; Razuvaev A; Sabater-Lleal M; Lengquist M; Miller CL; Ericsson I; Röhl S; Kronqvist M; Aldi S; Magné J; Paloschi V; Vesterlund M; Li Y; Jin H; Diez MG; Roy J; Baldassarre D; Veglia F; Humphries SE; de Faire U; Tremoli E; Odeberg J; Vukojević V; Lehtiö J; Maegdefessel L; Ehrenborg E; Paulsson-Berne G; Hansson GK; Lindeman JHN; Eriksson P; Quertermous T; Hamsten A; Hedin U
Article: NATURE. 2016;536(7614):86-90

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.

Kojima Y; Volkmer J-P; McKenna K; Civelek M; Lusis AJ; Miller CL; Direnzo D; Nanda V; Ye J; Connolly AJ; Schadt EE; Quertermous T; Betancur P; Maegdefessel L; Matic LP; Hedin U; Weissman IL; Leeper NJ
Article: SCIENCE ADVANCES. 2016;2(7):e1600224

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.

Karunakaran D; Geoffrion M; Wei L; Gan W; Richards L; Shangari P; DeKemp EM; Beanlands RA; Perisic L; Maegdefessel L; Hedin U; Sad S; Guo L; Kolodgie FD; Virmani R; Ruddy T; Rayner KJ
Article: RNA. 2016;22(5):667-676

Guidelines for the functional annotation of microRNAs using the Gene Ontology.

Huntley RP; Sitnikov D; Orlic-Milacic M; Balakrishnan R; D'Eustachio P; Gillespie ME; Howe D; Kalea AZ; Maegdefessel L; Osumi-Sutherland D; Petri V; Smith JR; Van Auken K; Wood V; Zampetaki A; Mayr M; Lovering RC
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(5):942-951

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.

Ouimet M; Hennessy EJ; van Solingen C; Koelwyn GJ; Hussein MA; Ramkhelawon B; Rayner KJ; Temel RE; Perisic L; Hedin U; Maegdefessel L; Garabedian MJ; Holdt LM; Teupser D; Moore KJ
Article: JOURNAL OF INTERNAL MEDICINE. 2016;279(3):293-308

Gene expression signatures, pathways and networks in carotid atherosclerosis.

Perisic L; Aldi S; Sun Y; Folkersen L; Razuvaev A; Roy J; Lengquist M; Åkesson S; Wheelock CE; Maegdefessel L; Gabrielsen A; Odeberg J; Hansson GK; Paulsson-Berne G; Hedin U
Article: CIRCULATION RESEARCH. 2016;118(2):230-240

CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.

Nanda V; Downing KP; Ye J; Xiao S; Kojima Y; Spin JM; DiRenzo D; Nead KT; Connolly AJ; Dandona S; Perisic L; Hedin U; Maegdefessel L; Dalman J; Guo L; Zhao X; Kolodgie FD; Virmani R; Davis HR; Leeper NJ
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(1):E81-81

Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology.

Busch A; Busch M; Scholz C-J; Kellersmann R; Otto C; Chernogubova E; Maegdefessel L; Zernecke A; Lorenz U
Article: PLOS ONE. 2016;11(2):e0149288

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression.

Azuma J; Wong RJ; Morisawa T; Hsu M; Maegdefessel L; Zhao H; Kalish F; Kayama Y; Wallenstein MB; Deng AC; Spin JM; Stevenson DK; Dalman RL; Tsao PS
Article: GENOMICS DATA. 2015;5:36-37

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap.

Nurnberg ST; Cheng K; Raiesdana A; Kundu R; Miller CL; Kim JB; Arora K; Carcamo-Oribe I; Xiong Y; Tellakula N; Nanda V; Murthy N; Boisvert WA; Hedin U; Perisic L; Aldi S; Maegdefessel L; Pjanic M; Owens GK; Tallquist MD; Quertermous T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(9):1945-1953

Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.

Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Li Y; Busch A; Heeger C-H; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Schrepfer S; Maegdefessel L
Article: CIRCULATION RESEARCH. 2015;117(6):513-524

Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus.

Raaz U; Schellinger IN; Chernogubova E; Warnecke C; Kayama Y; Penov K; Hennigs JK; Salomons F; Eken S; Emrich FC; Zheng WH; Adam M; Jagger A; Nakagami F; Toh R; Toyama K; Deng A; Buerke M; Maegdefessel L; Hasenfuß G; Spin JM; Tsao PS
Article: CIRCULATION RESEARCH. 2015;117(3):266-278

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis.

Karunakaran D; Thrush AB; Nguyen M-A; Richards L; Geoffrion M; Singaravelu R; Ramphos E; Shangari P; Ouimet M; Pezacki JP; Moore KJ; Perisic L; Maegdefessel L; Hedin U; Harper M-E; Rayner KJ
Article: CIRCULATION. 2015;131(20):1783-1795

Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development.

Raaz U; Zöllner AM; Schellinger IN; Toh R; Nakagami F; Brandt M; Emrich FC; Kayama Y; Eken S; Adam M; Maegdefessel L; Hertel T; Deng A; Jagger A; Buerke M; Dalman RL; Spin JM; Kuhl E; Tsao PS
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(5):1226-1235

ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability.

Magné J; Gustafsson P; Jin H; Maegdefessel L; Hultenby K; Wernerson A; Eriksson P; Franco-Cereceda A; Kovanen PT; Gonçalves I; Ehrenborg E
Article: PLOS GENETICS. 2015;11(5):e1005155

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.

Nurnberg ST; Cheng K; Raiesdana A; Kundu R; Miller CL; Kim JB; Arora K; Carcamo-Oribe I; Xiong Y; Tellakula N; Nanda V; Murthy N; Boisvert WA; Hedin U; Perisic L; Aldi S; Maegdefessel L; Pjanic M; Owens GK; Tallquist MD; Quertermous T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(1):2-6

MicroRNA regulation of vascular smooth muscle function and phenotype: early career committee contribution.

Maegdefessel L; Rayner KJ; Leeper NJ
Article: NATURE COMMUNICATIONS. 2014;5:5214

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.

Maegdefessel L; Spin JM; Raaz U; Eken SM; Toh R; Azuma J; Adam M; Nakagami F; Heymann HM; Chernogubova E; Jin H; Roy J; Hultgren R; Caidahl K; Schrepfer S; Hamsten A; Eriksson P; McConnell MV; Dalman RL; Tsao PS
Article: NATURE. 2014;509(7502):641-644

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.

Deuse T; Hua X; Wang D; Maegdefessel L; Heeren J; Scheja L; Bolaños JP; Rakovic A; Spin JM; Stubbendorff M; Ikeno F; Länger F; Zeller T; Schulte-Uentrop L; Stoehr A; Itagaki R; Haddad F; Eschenhagen T; Blankenberg S; Kiefmann R; Reichenspurner H; Velden J; Klein C; Yeung A; Robbins RC; Tsao PS; Schrepfer S
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(87)

Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.

Stubbendorff M; Hua X; Deuse T; Ali Z; Reichenspurner H; Maegdefessel L; Robbins RC; Schrepfer S
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(3):1083-1097

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.

Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Article: PLOS GENETICS. 2014;10(3):e1004263

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

Miller CL; Haas U; Diaz R; Leeper NJ; Kundu RK; Patlolla B; Assimes TL; Kaiser FJ; Perisic L; Hedin U; Maegdefessel L; Schunkert H; Erdmann J; Quertermous T; Sczakiel G
Article: VASCULAR MEDICINE. 2014;19(1):3-8

The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model.

Downing KP; Nead KT; Kojima Y; Assimes T; Maegdefessel L; Quertermous T; Cooke JP; Leeper NJ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(1):e1-e10

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.

Leeper NJ; Raiesdana A; Kojima Y; Kundu RK; Cheng H; Maegdefessel L; Toh R; Ahn G-O; Ali ZA; Anderson DR; Miller CL; Roberts SC; Spin JM; de Almeida PE; Wu JC; Xu B; Cheng K; Quertermous M; Kundu S; Kortekaas KE; Berzin E; Downing KP; Dalman RL; Tsao PS; Schadt EE; Owens GK; Quertermous T
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2012;(63):e3663

Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.

Hua X; Deuse T; Michelakis ED; Haromy A; Tsao PS; Maegdefessel L; Erben RG; Bergow C; Behnisch BB; Reichenspurner H; Robbins RC; Schrepfer S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(122):122ra22

MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion.

Maegdefessel L; Azuma J; Toh R; Deng A; Merk DR; Raiesdana A; Leeper NJ; Raaz U; Schoelmerich AM; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):497-506

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development.

Maegdefessel L; Azuma J; Toh R; Merk DR; Deng A; Chin JT; Raaz U; Schoelmerich AM; Raiesdana A; Leeper NJ; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: CIRCULATION RESEARCH. 2012;110(2):312-324

miR-29b participates in early aneurysm development in Marfan syndrome.

Merk DR; Chin JT; Dake BA; Maegdefessel L; Miller MO; Kimura N; Tsao PS; Iosef C; Berry GJ; Mohr FW; Spin JM; Alvira CM; Robbins RC; Fischbein MP
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2011;32(4):417-425

Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study.

Kaeberich A; Reindl I; Raaz U; Maegdefessel L; Vogt A; Linde T; Steinseifer U; Perzborn E; Hauroeder B; Buerke M; Werdan K; Schlitt A
Article: PHYSIOLOGICAL GENOMICS. 2011;43(17):993-1003

Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm.

Spin JM; Hsu M; Azuma J; Tedesco MM; Deng A; Dyer JS; Maegdefessel L; Dalman RL; Tsao PS
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2011;226(4):1035-1043

MicroRNA-26a is a novel regulator of vascular smooth muscle cell function.

Leeper NJ; Raiesdana A; Kojima Y; Chun HJ; Azuma J; Maegdefessel L; Kundu RK; Quertermous T; Tsao PS; Spin JM
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(2):270-279

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms.

Goergen CJ; Azuma J; Barr KN; Magdefessel L; Kallop DY; Gogineni A; Grewall A; Weimer RM; Connolly AJ; Dalman RL; Taylor CA; Tsao PS; Greve JM
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2011;7:693-699

Comparison of outcome in 1809 patients treated with drug-eluting stents or bare-metal stents in a real-world setting.

Vogt A; Schoelmerich A; Pollner F; Schlitt M; Raaz U; Maegdefessel L; Reindl I; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2011;2011:252141-10

Assessment of elastase-induced murine abdominal aortic aneurysms: comparison of ultrasound imaging with in situ video microscopy.

Azuma J; Maegdefessel L; Kitagawa T; Dalman RL; McConnell MV; Tsao PS
Article: THROMBOSIS RESEARCH. 2010;126(3):e196-e200

In vitro comparison of dabigatran, unfractionated heparin, and low-molecular-weight heparin in preventing thrombus formation on mechanical heart valves.

Maegdefessel L; Linde T; Krapiec F; Hamilton K; Steinseifer U; van Ryn J; Raaz U; Buerke M; Werdan K; Schlitt A
Article: THROMBOSIS AND HAEMOSTASIS. 2010;103(4):808-814

The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro.

Raaz U; Kaeberich A; Maegdefessel L; Buerke M; Busshardt M; Schubert S; Russ M; Plehn A; Ebelt H; Werdan K; Schlitt A
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2010;29(3):265-270

Efficacy of enoxaparin, certoparin and dalteparin in preventing cardiac catheter thrombosis: an in vitro approach.

Raaz U; Buerke M; Busshardt M; Maegdefessel L; Plehn A; Hauroeder B; Werdan K; Schlitt A
Article: LIPIDS. 2010;45(2):129-135

Serum phospholipid transfer protein activity after a high fat meal in patients with insulin-treated type 2 diabetes.

Schlitt A; Schwaab B; Fingscheidt K; Lackner KJ; Heine GH; Vogt A; Buerke M; Maegdefessel L; Raaz U; Werdan K; Jiang X-C
Article: THROMBOSIS AND HAEMOSTASIS. 2009;101(6):1163-1169

Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study.

Maegdefessel L; Linde T; Michel T; Hamilton K; Steinseifer U; Friedrich I; Schubert S; Hauroeder B; Raaz U; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF LIPID RESEARCH. 2009;50(4):723-729

PLTP activity is a risk factor for subsequent cardiovascular events in CAD patients under statin therapy: the AtheroGene study.

Schlitt A; Blankenberg S; Bickel C; Lackner KJ; Heine GH; Buerke M; Werdan K; Maegdefessel L; Raaz U; Rupprecht HJ; Munzel T; Jiang X-C
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2009;5:849-857

Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects.

Maegdefessel L; Schlitt A; Pippig S; Schwaab B; Fingscheidt K; Raaz U; Buerke M; Loppnow H
Article: THROMBOSIS AND HAEMOSTASIS. 2008;100(4):693-698

Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis. Results of an in-vitro study.

Maegdefessel L; Buerke M; Schubert S; Reindl I; Michel T; Hauroeder B; Carter JM; Peetz D; Werdan K; Schlitt A
Article: MEDIZINISCHE KLINIK. 2008;103(9):628-632

Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention. A single-center experience.

Maegdefessel L; Schlitt A; Faerber J; Bond SP; Messow C-M; Buerke M; Raaz U; Werdan K; Muenzel T; Weiss C
Article: INTERNIST. 2008;49(7):868-872

[27-year old pregnant woman with syncope and dyspnea after aortic alloplastic heart valve replacement 15 years ago].

Maegdefessel L; Issa H; Scheler C; Thäle V; Schlitt A; Hartelt U; Grabitz R; Buerke M
Article: CORONARY ARTERY DISEASE. 2008;19(4):279-284

In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus.

Schlitt A; Rupprecht HJ; Reindl I; Schubert S; Hauroeder B; Carter JM; Peetz D; Kropff SS; Maegdefessel L; Russ M; Schmidt H; Ebelt H; Werdan K; Buerke M
Article: JOURNAL OF HEART VALVE DISEASE. 2006;15(6):809-814

Comparison of fondaparinux, low molecular-weight heparin and unfractionated heparin in preventing thrombus formation on mechanical heart valves: results of an in-vitro study.

Schlitt A; Hamilton K; Maegdefessel L; Dahm M; Theis C; Eichler M; Brockmann O; Steinseifer U; Hauroeder B; Hitzler WE; Rupprecht HJ
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Editorial comment: EUROPEAN HEART JOURNAL. 2023;44(25):2267-2269

Targeting non-coding RNAs for novel treatment strategies in vascular diseases.

Winter H; Maegdefessel L
Review: ATHEROSCLEROSIS. 2023;374:99-106

Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing.

Bink DI; Pauli J; Maegdefessel L; Boon RA
Review: ATHEROSCLEROSIS. 2023;374:34-43

Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation.

Fasolo F; Paloschi V; Maegdefessel L
Preprint: BIORXIV. 2023;BIORXIV

INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10.

Zhang W; Zhao J; Deng L; Ishimwe N; Pauli J; Wu W; Shan S; Kempf W; Ballantyne MD; Kim D; Lyu Q; Bennett M; Rodor J; Turner AW; Lu YW; Gao P; Choi M; Warthi G; Kim HW; Barroso MM; Bryant WB; Miller CL; Weintraub NL; Maegdefessel L; Miano JM; Baker AH; Long X
Review: CARDIOVASCULAR RESEARCH. 2022;118(15):3016-3051

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart.

van der Velden J; Asselbergs FW; Bakkers J; Batkai S; Bertrand L; Bezzina CR; Bot I; Brundel BJJM; Carrier L; Chamuleau S; Ciccarelli M; Dawson D; Davidson SM; Dendorfer A; Duncker DJ; Eschenhagen T; Fabritz L; Falcão-Pires I; Ferdinandy P; Giacca M; Girao H; Gollmann-Tepeköylü C; Gyongyosi M; Guzik TJ; Hamdani N; Heymans S; Hilfiker A; Hilfiker-Kleiner D; Hoekstra AG; Hulot J-S; Kuster DWD; van Laake LW; Lecour S; Leiner T; Linke WA; Lumens J; Lutgens E; Madonna R; Maegdefessel L; Mayr M; van der Meer P; Passier R; Perbellini F; Perrino C; Pesce M; Priori S; Remme CA; Rosenhahn B; Schotten U; Schulz R; Sipido KR; Sluijter JPG; van Steenbeek F; Steffens S; Terracciano CM; Tocchetti CG; Vlasman P; Yeung KK; Zacchigna S; Zwaagman D; Thum T
Corrigendum: COMMUNICATIONS BIOLOGY. 2022;5(1):298

Author Correction: PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.

Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Röll W; Pfeifer A
Review: CARDIOVASCULAR RESEARCH. 2021;117(14):2742-2754

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.

Paloschi V; Sabater-Lleal M; Middelkamp H; Vivas A; Johansson S; van der Meer A; Tenje M; Maegdefessel L
Review: JVS-VASCULAR SCIENCE. 2021;2:219-234

Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.

Busch A; Bleichert S; Ibrahim N; Wortmann M; Eckstein H-H; Brostjan C; Wagenhäuser MU; Goergen CJ; Maegdefessel L
Editorial comment: EUROPEAN HEART JOURNAL. 2020;41(26):2469-2471

Linking obesity with abdominal aortic aneurysm development.

Eckstein H-H; Maegdefessel L
Meeting abstract: FASEB JOURNAL. 2020;34:1

The Interplay of Wnt- and PPARγ-signaling in macrophages & vascular smooth muscle cells during vascular calcification

Reinhold S; Temmerman L; Jin H; Maegdefessel L; Hedin U; Matic L; Biessen E; Schurgers L; Blankesteijn M; Foulquier S
Editorial comment: FRONTIERS IN PHYSIOLOGY. 2020;11:60

Editorial: Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System.

Zampetaki A; Maegdefessel L
Review: ATHEROSCLEROSIS. 2020;292:112-118

Long noncoding RNAs in key cellular processes involved in aortic aneurysms.

Wu Z-Y; Trenner M; Boon RA; Spin JM; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2019;115(12):1732-1756

Non-coding RNAs in cardiovascular cell biology and atherosclerosis.

Fasolo F; Di Gregoli K; Maegdefessel L; Johnson JL
Published conference paper: JOURNAL OF VASCULAR SURGERY. 2019;70(4):1318-1326.e5

The structural atrophy of the aneurysm wall in secondary expanding aortic aneurysms with endoleak type II.

Menges A-L; Busch A; Reutersberg B; Trenner M; Kath P; Chernogubova E; Maegdefessel L; Eckstein H-H; Zimmermann A
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e287

THE LONG NON-CODING RNA CHROMR REGULATES CHOLESTEROL HOMEOSTASIS IN PRIMATES

Van Solingen C; Hennessy E; Scacalossi K; Ouimet M; Afonso M; Prins J; Koelwyn G; Ramkhelawon B; Maegdefessel L; Teupser D; Holdt L; Moore K
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e269

TIME-DEPENDENT BIOPATHOLOGICAL ALTERNATIONS IN CAROTID ATHEROSCLEROTIC PLAQUES FROM SYMPTOMATIC PATIENTS

Pauli J; Tsantilas P; Kallmayer M; Maegdefessel L; Eckstein HH; Pelisek J
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e47

EPIGENETIC LINK BETWEEN HISTONE MODIFICATION, LONG NON-CODING RNAS AND EXPRESSION OF MATRIX METALLOPROTEINASES IN ATHEROSCLEROTIC LESIONS OF THE EXTRACRANIAL CAROTID ARTERY

Bauer S; Maegdefessel L; Pelisek J; Eckstein HH
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(5):2164

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.

Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Review: VASCULAR PHARMACOLOGY. 2019;114:110-121

Non-coding RNAs in aneurysmal aortopathy.

Spin JM; Li DY; Maegdefessel L; Tsao PS
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2018;68(2):656

Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion

Busch A; Chernogubova E; Jin H; Meurer F; Eckstein HH; Kim M; Maegdefessel L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:95

REGULATION OF CCL2 EXPRESSION IN VASCULAR ENDOTHELIAL CELLS BY A LONG NONCODING RNA

Khyzha N; Khor M; Hedin U; Maegdefessel L; Wilson MD; Fish JE
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:11-12

THERAPEUTICALLY TARGETING THE KINASE ACTIVITY OR GENE EXPRESSION OF RIP1 REDUCES INFLAMMATION-DRIVEN ATHEROSCLEROSIS AND PROMOTES PLAQUE STABILITY

Karunakaran D; Geoffrion M; Wei L; Gan W; Perisic L; Maegdefessel L; Hedin U; Sad S; Guo L; Kolodgie F; Ruddy T; Virmani R; Rayner K
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:9

LONG NON-CODING RNA MIAT REGULATES SMOOTH MUSCLE CELL AND MACROPHAGE ACTIVITY IN ATHEROSCLEROTIC LESIONS. A ROLE FOR LIPOPROTEIN(A)/OXIDIZED PHOSPHOLIPIDS

Bergmark CC; Maegdefessel L; Li Y; Perisic L
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2018;67(6):e236

Inhibition of Abdominal Aortic Aneurysm Expansion in a Preclinical Atherosclerotic LDLR^-/- Minipig Model by miR-29b-Coated Balloon Angioplasty

Busch A; Eckstein H-H; Maegdefessel L
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(5):982-983

TIMPing the Aorta: Smooth Muscle Cell-Specific Deletion of BMAL1 Limits Murine Abdominal Aortic Aneurysm Development.

Winter C; Soehnlein O; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Nudt6 Inhibition Limits Smooth Muscle Cell Apoptosis and Abdominal Aortic Aneurysm Progression

Jin H; Winter H; Chernogubova E; Li Y; Winski G; Backlund A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Genetic Depletion of the Long Non-coding RNA H19 in Mice Protects from Elastase-induced Abdominal Aortic Aneurysms

Chernogubova E; Busch A; Li Y; Jin H; Winski G; Hofmann P; Boon RA; Backlund A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

MicroRNA-29b Mediates the Chronic Inflammatory Response in Radiotherapy-induced Vascular Disease

Wiggle G; Eken SM; Christersdottir T; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Tornvall P; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Repression of Map1lc3a During Atherosclerosis Progression Plays an Important Role in the Regulation of Vascular Smooth Muscle Cell Phenotype

Magne J; Paloschi V; Goncalves I; Saliba-Gustafsson P; Skogsberg J; Razuvaev A; Jin H; Li Y; Ketelhuth DFJ; Maegdefessel L; Hedin U; Eriksson P; Ehrenborg E
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Regulation of CCL2 Expression in Vascular Endothelial Cells by a Long Noncoding RNA

Khyzha N; Khor M; Hedin U; Maegdefessel L; Wilson MD; Fish JE
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

CHI3L1 and Its Role in Vascular Smooth Muscle Cell Proliferation and Migration in Advanced Atherosclerosis

Tsantilas P; Lao S; Vaerst M; Li Y; Nanda V; Maegdefessel L; Leeper N
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Local Mir-29b Inhibition Using Drug-eluting Balloons Blocks Abdominal Aortic Aneurysm Expansion in Atherosclerotic Ldlr-/- Mini-pigs

Busch A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Aorta-on-a-chip: a Tool to Gain Molecular and Translational Insight Into Vascular Diseases

Paloschi V; Rolli C; Buchmann B; Meucci S; Rogowitz F; Bausch A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

H19 Induces Abdominal Aortic Aneurysm Development and Progression

Li DY; Busch A; Jin H; Chernogubova E; Pelisek J; Eriksson P; Roy J; Hofmann P; Boon R; Spin J; Tsao P; Maegdefessel L
Meeting abstract: CARDIOVASCULAR RESEARCH. 2018;114:s69

Hanging drops: a novel in vitro method to analyze human monocytes of relevance for atherosclerosis

Trattner M; Kehe K; Steinritz D; Pelisek J; Kuehnl A; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2018;114(4):611-621

Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease.

Leeper NJ; Maegdefessel L
Letter: CIRCULATION. 2018;137(7):750-753

Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation.

Kojima Y; Werner N; Ye J; Nanda V; Tsao N; Wang Y; Flores AM; Miller CL; Weissman I; Deng H; Xu B; Dalman RL; Eken SM; Pelisek J; Li Y; Maegdefessel L; Leeper NJ
Editorial comment: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2017;10(4):e001859

Towards Point-of-Care Measurements Using Noncoding RNAs: A Novel Tool to Monitor Aggravation of Advanced Atherosclerotic Lesions.

Paloschi V; Maegdefessel L
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2017;65(6):23S-24S

Combination of Preoperative CT and Carotid Plaque Gene Expression Profiling Demonstrates an Association Between Calcification and Plaque-Stabilizing Processes

Karlof E; Dias N; Lengquist M; Witasp A; Stenvinkel P; Maegdefessel L; Matic LP; Hedin U
Meeting abstract: TRANSPLANTATION. 2017;101(5):S28

Local microRNA Modulation is a Suitable Way to Prevent In-Stent Restenosis and Coronary Allograft Arteriosclerosis

Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Heeger C; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Maegdefessel L; Schrepfer S
Review: FRONTIERS IN PHYSIOLOGY. 2017;8:429

Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression.

Li Y; Maegdefessel L
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2016;4(12):236

Prospective and therapeutic screening value of non-coding RNA as biomarkers in cardiovascular disease.

Busch A; Eken SM; Maegdefessel L
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2016;4(7):144

My heart will go on-beneficial effects of anti-MiR-30 after myocardial infarction.

Li Y; Maegdefessel L
Letter: CIRCULATION. 2016;133(1):e11-e12

Response to Letters Regarding Article, "Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development".

Raaz U; Zöllner AM; Schellinger IN; Toh R; Nakagami F; Brandt M; Emrich FC; Kayama Y; Eken S; Adam M; Maegdefessel L; Hertel T; Deng A; Jagger A; Buerke M; Dalman RL; Spin JM; Kuhl E; Tsao PS
Meeting abstract: ATHEROSCLEROSIS. 2015;241(1):E1-E2

ATG16L1 EXPRESSION IN CAROTID ATHEROSCLEROTIC PLAQUES IS ASSOCIATED WITH PLAQUE VULNERABILITY

Magne J; Gustafsson P; Jin H; Maegdefessel L; Hultenby K; Wernerson A; Eriksson P; Franco-Cereceda A; Kovanen PT; Goncalves I; Ehrenborg E
Meeting abstract: VASCULAR MEDICINE. 2015;20(3):301-302

Membership spotlight.

Abola MTB; Levy PJ
Meeting abstract: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2015;34(4):S39

Coronary Allograft Arteriosclerosis: Local MicroRNA Modulation Using a Novel Anti-Mir-21-Eluting Stent Prevents in-Stent Restenosis

Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Heeger C; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Maegdefessel L; Schrepfer S
Corrigendum: NATURE COMMUNICATIONS. 2015;6:6506

Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.

Maegdefessel L; Spin JM; Raaz U; Eken SM; Toh R; Azuma J; Adam M; Nakagami F; Heymann HM; Chernogubova E; Jin H; Roy J; Hultgren R; Caidahl K; Schrepfer S; Hamsten A; Eriksson P; McConnell MV; Dalman RL; Tsao PS
Review: JOURNAL OF INTERNAL MEDICINE. 2014;276(6):633-644

The emerging role of microRNAs in cardiovascular disease.

Maegdefessel L
Editorial comment: THROMBOSIS AND HAEMOSTASIS. 2014;112(1):15

Micro-effects of smoking in cardiovascular disease aetiology.

Maegdefessel L
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2014;34(7):1339-1340

New ways to dismantle a ticking time bomb: microRNA 712/205 and abdominal aortic aneurysm development.

Maegdefessel L; Spin JM; Tsao PS
Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(6):914-928

Hemodynamic regulation of reactive oxygen species: implications for vascular diseases.

Raaz U; Toh R; Maegdefessel L; Adam M; Nakagami F; Emrich FC; Spin JM; Tsao PS
Review: ANNUAL REVIEW OF MEDICINE. 2014;65:49-62

Pathogenesis of abdominal aortic aneurysms: microRNAs, proteases, genetic associations.

Maegdefessel L; Dalman RL; Tsao PS
Review: TRENDS IN CARDIOVASCULAR MEDICINE. 2014;24(1):1-6

MicroRNA-29b regulation of abdominal aortic aneurysm development.

Maegdefessel L; Azuma J; Tsao PS
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013;14(7):14374-14394

Micromanaging abdominal aortic aneurysms.

Maegdefessel L; Spin JM; Adam M; Raaz U; Toh R; Nakagami F; Tsao PS
Editorial comment: CURRENT VASCULAR PHARMACOLOGY. 2013

Therapeutic Potential of MicroRNAs in Vascular Disease.

Maegdefessel L
Editorial comment: CURRENT VASCULAR PHARMACOLOGY. 2013;13(3):277-279

Editorial: Therapeutic Potential of microRNAs in Vascular Disease.

Maegdefessel L
Review: JOURNAL OF DIABETES RESEARCH. 2013;2013:834727-10

Making sense in antisense: therapeutic potential of noncoding RNAs in diabetes-induced vascular dysfunction.

Eken SM; Jin H; Chernogubova E; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2012;95(2):147-155

Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling.

Spin JM; Maegdefessel L; Tsao PS
Meeting abstract: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2012;31(4):S126-S127

Pyruvate Dehydrogenase Kinase 2 Controls Vascular Remodeling

Deuse T; Hun X; Laenger F; Gossler T; Stubbendorff M; Rakovic A; Klein C; Sutendra G; Dromparis P; Maegdefessel L; Tsao PS; Velden J; Reichenspurner H; Robbins RC; Haddad F; Michelakis E; Schrepfer S
Review: VASCULAR HEALTH AND RISK MANAGEMENT. 2010;6:339-349

New options with dabigatran etexilate in anticoagulant therapy.

Maegdefessel L; Spin JM; Azuma J; Tsao PS
Review: VASCULAR HEALTH AND RISK MANAGEMENT. 2010;6:95-103

Modern role for clopidogrel in management of atrial fibrillation and stroke reduction.

Maegdefessel L; Azuma J; Tsao PS
Letter: THROMBOSIS RESEARCH. 2009;124(2):242-243

INR matters: a case on managing argatroban for bridging oral anticoagulation in a patient with heparin induced thrombocytopenia type II after mechanical heart valve replacement.

Raaz U; Maegdefessel L; Buerke M; Janusch M; Werdan K; Schlitt A
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