Lars Tjernberg

Publications
CV
Public outreach and news

Articles

Article: ALZHEIMERS & DEMENTIA. 2023;19(7):3244-3249

A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status.

Zhou RZ; Vetrano DL; Grande G; Duell F; Jönsson L; Laukka EJ; Fredolini C; Winblad B; Tjernberg L; Schedin-Weiss S
Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):196

Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer's disease brain extracts.

Sandberg A; Berenjeno-Correa E; Rodriguez RC; Axenhus M; Weiss SS; Batenburg K; Hoozemans JJM; Tjernberg LO; Scheper W
Article: GLYCOBIOLOGY. 2022;32(6):506-517

Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein.

Lin T; van Husen LS; Yu Y; Tjernberg LO; Schedin-Weiss S
Article: BMC GERIATRICS. 2022;22(1):365

Changes in dementia diagnoses in Sweden during the COVID-19 pandemic.

Axenhus M; Schedin-Weiss S; Tjernberg L; Wimo A; Eriksdotter M; Bucht G; Winblad B
Article: SCIENTIFIC DATA. 2021;8(1):312

Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis.

Haytural H; Benfeitas R; Schedin-Weiss S; Bereczki E; Rezeli M; Unwin RD; Wang X; Dammer EB; Johnson ECB; Seyfried NT; Winblad B; Tijms BM; Visser PJ; Frykman S; Tjernberg LO
Article: CHEMBIOCHEM. 2021;22(22):3208-3213

Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids.

van Husen LS; Katsori A-M; Meineke B; Tjernberg LO; Schedin-Weiss S; Elsässer SJ
Article: JOURNAL OF NEUROCHEMISTRY. 2021;159(2):292-304

The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease.

Gaunitz S; Tjernberg LO; Schedin-Weiss S
Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(2):833-852

A Super-Resolved View of the Alzheimer's Disease-Related Amyloidogenic Pathway in Hippocampal Neurons.

Yu Y; Gao Y; Winblad B; Tjernberg LO; Schedin-Weiss S
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4530

Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons.

Gao Y; Wennmalm S; Winblad B; Schedin-Weiss S; Tjernberg LO
Article: BRAIN COMMUNICATIONS. 2021;3(2):fcab079

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.

Haytural H; Jordà-Siquier T; Winblad B; Mulle C; Tjernberg LO; Granholm A-C; Frykman S; Barthet G
Article: CURRENT ALZHEIMER RESEARCH. 2021;17(9):858-867

Huntingtin Levels are Elevated in Hippocampal Post-Mortem Samples of Alzheimer's Disease Brain.

Axenhus M; Winblad B; Tjernberg LO; Schedin-Weiss S
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:735334

Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71.

Sandebring-Matton A; Axenhus M; Bogdanovic N; Winblad B; Schedin-Weiss S; Nilsson P; Tjernberg LO
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2020;1867(9):118737

Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons.

Hromadkova L; Bezdekova D; Pala J; Schedin-Weiss S; Tjernberg LO; Hoschl C; Ovsepian SV
Article: FEBS JOURNAL. 2020;287(15):3221-3234

Glycan biomarkers for Alzheimer disease correlate with T-tau and P-tau in cerebrospinal fluid in subjective cognitive impairment.

Schedin-Weiss S; Gaunitz S; Sui P; Chen Q; Haslam SM; Blennow K; Winblad B; Dell A; Tjernberg LO
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;75(1):321-335

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.

Schedin-Weiss S; Nilsson P; Sandebring-Matton A; Axenhus M; Sekiguchi M; Saito T; Winblad B; Saido T; Tjernberg LO
Article: BMC NEUROSCIENCE. 2020;21(1):6

Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.

Lundgren JL; Vandermeulen L; Sandebring-Matton A; Ahmed S; Winblad B; Di Luca M; Tjernberg LO; Marcello E; Frykman S
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(1):128-141

The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.

Haytural H; Mermelekas G; Emre C; Nigam SM; Carroll SL; Winblad B; Bogdanovic N; Barthet G; Granholm A-C; Orre LM; Tjernberg LO; Frykman S
Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;72(2):537-548

Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products.

van Husen LS; Schedin-Weiss S; Trung MN; Kazmi MA; Winblad B; Sakmar TP; Elsässer SJ; Tjernberg LO
Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;71(4):1163-1174

A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.

Hashimoto M; Yamazaki A; Ohno A; Kimura T; Winblad B; Tjernberg LO
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(3):2103-2114

Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen.

Bonito-Oliva A; Schedin-Weiss S; Younesi SS; Tiiman A; Adura C; Paknejad N; Brendel M; Romin Y; Parchem RJ; Graff C; Vukojević V; Tjernberg LO; Terenius L; Winblad B; Sakmar TP; Graham WV
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2019;95:86-95

APP depletion alters selective pre- and post-synaptic proteins.

Martinsson I; Capetillo-Zarate E; Faideau M; Willén K; Esteras N; Frykman S; Tjernberg LO; Gouras GK
Article: FRONTIERS IN AGING NEUROSCIENCE. 2019;11:273

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.

Haytural H; Lundgren JL; Köse TB; Jordà-Siquier T; Kalcheva M; Seed Ahmed M; Winblad B; Sundström E; Barthet G; Tjernberg LO; Frykman S
Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):175-184

Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro.

Eriksdotter M; Navarro-Oviedo M; Mitra S; Wahlberg L; Linderoth B; Tjernberg LO; Behbahani H
Article: LIFE SCIENCE ALLIANCE. 2018;1(3):e201800028

Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses.

Yu Y; Jans DC; Winblad B; Tjernberg LO; Schedin-Weiss S
Article: PROTEIN SCIENCE. 2017;26(11):2312-2318

Systemic AA amyloidosis in the red fox (Vulpes vulpes).

Rising A; Cederlund E; Palmberg C; Uhlhorn H; Gaunitz S; Nordling K; Ågren E; Ihse E; Westermark GT; Tjernberg L; Jörnvall H; Johansson J; Westermark P
Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):57

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels.

Schedin-Weiss S; Inoue M; Hromadkova L; Teranishi Y; Yamamoto NG; Wiehager B; Bogdanovic N; Winblad B; Sandebring-Matton A; Frykman S; Tjernberg LO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;483(1):352-358

Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).

Frykman S; Inoue M; Ikeda A; Teranishi Y; Kihara T; Lundgren JL; Yamamoto NG; Bogdanovic N; Winblad B; Schedin-Weiss S; Tjernberg LO
Article: LANCET NEUROLOGY. 2016;15(5):455-532

Defeating Alzheimer's disease and other dementias: a priority for European science and society.

Winblad B; Amouyel P; Andrieu S; Ballard C; Brayne C; Brodaty H; Cedazo-Minguez A; Dubois B; Edvardsson D; Feldman H; Fratiglioni L; Frisoni GB; Gauthier S; Georges J; Graff C; Iqbal K; Jessen F; Johansson G; Jönsson L; Kivipelto M; Knapp M; Mangialasche F; Melis R; Nordberg A; Rikkert MO; Qiu C; Sakmar TP; Scheltens P; Schneider LS; Sperling R; Tjernberg LO; Waldemar G; Wimo A; Zetterberg H
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016;4:29

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse.

Schedin-Weiss S; Caesar I; Winblad B; Blom H; Tjernberg LO
Article: ANALYTICAL CHEMISTRY. 2015;87(23):11700-11705

Highly Sensitive FRET-FCS Detects Amyloid β-Peptide Oligomers in Solution at Physiological Concentrations.

Wennmalm S; Chmyrov V; Widengren J; Tjernberg L
Article: MOLECULAR NEUROBIOLOGY. 2015;52(3):1077-1092

Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.

Lucotte B; Tajhizi M; Alkhatib D; Samuelsson E-B; Wiehager B; Schedin-Weiss S; Sundström E; Winblad B; Tjernberg LO; Behbahani H
Article: JOURNAL OF NEUROCHEMISTRY. 2015;135(3):606-615

ADAM10 and BACE1 are localized to synaptic vesicles.

Lundgren JL; Ahmed S; Schedin-Weiss S; Gouras GK; Winblad B; Tjernberg LO; Frykman S
Article: PROTEOMICS. 2015;15(19):3349-3355

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Nilsson P; Loganathan K; Sekiguchi M; Winblad B; Iwata N; Saido TC; Tjernberg LO
Article: FEBS JOURNAL. 2015;282(17):3438-3451

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.

Teranishi Y; Inoue M; Yamamoto NG; Kihara T; Wiehager B; Ishikawa T; Winblad B; Schedin-Weiss S; Frykman S; Tjernberg LO
Article: FEBS JOURNAL. 2015;282(14):2587-2599

Human brain proteins showing neuron-specific interactions with γ-secretase.

Inoue M; Hur J-Y; Kihara T; Teranishi Y; Yamamoto NG; Ishikawa T; Wiehager B; Winblad B; Tjernberg LO; Schedin-Weiss S
Article: NEUROSCIENCE LETTERS. 2014;566:125-130

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.

Lundgren JL; Ahmed S; Winblad B; Gouras GK; Tjernberg LO; Frykman S
Article: FEBS OPEN BIO. 2014;4:393-406

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlström H
Article: PLOS ONE. 2013;8(2):e55847

The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease.

Sandebring A; Welander H; Winblad B; Graff C; Tjernberg LO
Article: PLOS ONE. 2013;8(5):e63962

Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.

Schedin-Weiss S; Inoue M; Teranishi Y; Yamamoto NG; Karlström H; Winblad B; Tjernberg LO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;424(3):476-481

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.

Teranishi Y; Hur J-Y; Gu GJ; Kihara T; Ishikawa T; Nishimura T; Winblad B; Behbahani H; Kamali-Moghaddam M; Frykman S; Tjernberg LO
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(8):1686-1700

Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease.

Hashimoto M; Bogdanovic N; Nakagawa H; Volkmann I; Aoki M; Winblad B; Sakai J; Tjernberg LO
Article: NEUROCHEMISTRY INTERNATIONAL. 2012;61(1):108-118

Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing.

Frykman S; Teranishi Y; Hur J-Y; Sandebring A; Yamamoto NG; Ancarcrona M; Nishimura T; Winblad B; Bogdanovic N; Schedin-Weiss S; Kihara T; Tjernberg LO
Article: NEUROBIOLOGY OF AGING. 2012;33(5):1010.e1-1010.e13

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.

Philipson O; Lord A; Lalowski M; Soliymani R; Baumann M; Thyberg J; Bogdanovic N; Olofsson T; Tjernberg LO; Ingelsson M; Lannfelt L; Kalimo H; Nilsson LNG
Article: JOURNAL OF NEUROSCIENCE METHODS. 2012;205(2):364-367

A novel approach for Aβ₁₋₄₀ quantification using immuno-PCR.

Hashimoto M; Aoki M; Winblad B; Tjernberg LO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(15):11991-12005

Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.

Hur J-Y; Teranishi Y; Kihara T; Yamamoto NG; Inoue M; Hosia W; Hashimoto M; Winblad B; Frykman S; Tjernberg LO
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2011;15(10):2150-2163

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.

Hedskog L; Petersen CAH; Svensson AI; Welander H; Tjernberg LO; Karlström H; Ankarcrona M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(36):31153-31158

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Pamrén A; Wanngren J; Tjernberg LO; Winblad B; Bhat R; Näslund J; Karlström H
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2010;14(11):2675-2686

Affinity pulldown of γ-secretase and associated proteins from human and rat brain.

Teranishi Y; Hur J-Y; Welander H; Frånberg J; Aoki M; Winblad B; Frykman S; Tjernberg LO
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2010;18(11):1202-1208

The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions.

Keller L; Welander H; Chiang H-H; Tjernberg LO; Nennesmo I; Wallin AK; Graff C
Article: ACTA NEUROPATHOLOGICA. 2010;119(5):543-554

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology.

Hashimoto M; Bogdanovic N; Volkmann I; Aoki M; Winblad B; Tjernberg LO
Article: PLOS ONE. 2010;5(3):e9772

gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.

Frånberg J; Karlström H; Winblad B; Tjernberg LO; Frykman S
Article: PLOS ONE. 2010;5(1):e8948

Synaptic and endosomal localization of active gamma-secretase in rat brain.

Frykman S; Hur J-Y; Frånberg J; Aoki M; Winblad B; Nahalkova J; Behbahani H; Tjernberg LO
Article: NEUROCHEMISTRY INTERNATIONAL. 2010;56(1):67-76

CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2.

Nahalkova J; Volkmann I; Aoki M; Winblad B; Bogdanovic N; Tjernberg LO; Behbahani H
Article: JOURNAL OF NEUROCHEMISTRY. 2009;110(2):697-706

Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.

Welander H; Frånberg J; Graff C; Sundström E; Winblad B; Tjernberg LO
Article: NEUROREPORT. 2008;19(11):1085-1089

Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain.

Aoki M; Volkmann I; Tjernberg LO; Winblad B; Bogdanovic N
Article: FEBS JOURNAL. 2008;275(6):1174-1187

Active gamma-secretase is localized to detergent-resistant membranes in human brain.

Hur J-Y; Welander H; Behbahani H; Aoki M; Frånberg J; Winblad B; Frykman S; Tjernberg LO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;361(4):822-828

Unwinding fibril formation of medin, the peptide of the most common form of human amyloid.

Larsson A; Söderberg L; Westermark GT; Sletten K; Engström U; Tjernberg LO; Näslund J; Westermark P
Article: BIOCHEMISTRY. 2007;46(25):7647-7654

Rat brain gamma-secretase activity is highly influenced by detergents.

Frånberg J; Welander H; Aoki M; Winblad B; Tjernberg LO; Frykman S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(39):29096-29104

Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP.

Falkevall A; Alikhani N; Bhushan S; Pavlov PF; Busch K; Johnson KA; Eneqvist T; Tjernberg L; Ankarcrona M; Glaser E
Article: BIOCHEMISTRY. 2006;45(32):9849-9856

Analysis of single Alzheimer solid plaque cores by laser capture microscopy and nanoelectrospray/tandem mass spectrometry.

Söderberg L; Bogdanovic N; Axelsson B; Winblad B; Näslund J; Tjernberg LO
Article: BIOCHEMISTRY. 2005;44(47):15602-15609

CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation.

Kakuyama H; Söderberg L; Horigome K; Winblad B; Dahlqvist C; Näslund J; Tjernberg LO
Article: JOURNAL OF CELL BIOLOGY. 2005;171(1):87-98

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.

Yu WH; Cuervo AM; Kumar A; Peterhoff CM; Schmidt SD; Lee J-H; Mohan PS; Mercken M; Farmery MR; Tjernberg LO; Jiang Y; Duff K; Uchiyama Y; Näslund J; Mathews PM; Cataldo AM; Nixon RA
Article: FEBS JOURNAL. 2005;272(9):2231-2236

Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.

Söderberg L; Dahlqvist C; Kakuyama H; Thyberg J; Ito A; Winblad B; Näslund J; Tjernberg LO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(2):1007-1015

Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site.

Söderberg L; Kakuyama H; Möller A; Ito A; Winblad B; Tjernberg LO; Näslund J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(49):51654-51660

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.

Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
Article: BIOCHEMISTRY. 2004;43(16):4655-4661

Folding into a beta-hairpin can prevent amyloid fibril formation.

Hosia W; Bark N; Liepinsh E; Tjernberg A; Persson B; Hallén D; Thyberg J; Johansson J; Tjernberg L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(27):24277-24284

Partial purification and characterization of gamma-secretase from post-mortem human brain.

Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; Näslund J
Article: NEUROSCIENCE LETTERS. 2003;337(2):111-113

No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients.

Lilius L; Forsell C; Axelman K; Winblad B; Graff C; Tjernberg L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(45):43243-43246

Charge attraction and beta propensity are necessary for amyloid fibril formation from tetrapeptides.

Tjernberg L; Hosia W; Bark N; Thyberg J; Johansson J
Article: BIOCHEMICAL JOURNAL. 2002;366(Pt 1):343-351

Assembling amyloid fibrils from designed structures containing a significant amyloid beta-peptide fragment.

Tjernberg LO; Tjernberg A; Bark N; Shi Y; Ruzsicska BP; Bu Z; Thyberg J; Callaway DJE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(3):1673-1678

Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands.

Kuner P; Bohrmann B; Tjernberg LO; Näslund J; Huber G; Celenk S; Grüninger-Leitch F; Richards JG; Jakob-Roetne R; Kemp JA; Nordstedt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(15):8669-8674

Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.

Häggqvist B; Näslund J; Sletten K; Westermark GT; Mucchiano G; Tjernberg LO; Nordstedt C; Engström U; Westermark P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(23):15990-15995

Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues.

Bohrmann B; Tjernberg L; Kuner P; Poli S; Levet-Trafit B; Näslund J; Richards G; Huber W; Döbeli H; Nordstedt C
Article: FEBS LETTERS. 1999;451(3):238-242

Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease.

Oppermann UC; Salim S; Tjernberg LO; Terenius L; Jörnvall H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(18):12619-12625

A molecular model of Alzheimer amyloid beta-peptide fibril formation.

Tjernberg LO; Callaway DJ; Tjernberg A; Hahne S; Lilliehöök C; Terenius L; Thyberg J; Nordstedt C
Article: CHEMISTRY AND BIOLOGY. 1999;6(1):53-62

Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy.

Tjernberg LO; Pramanik A; Björling S; Thyberg P; Thyberg J; Nordstedt C; Berndt KD; Terenius L; Rigler R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(19):12601-12605

Controlling amyloid beta-peptide fibril formation with protease-stable ligands.

Tjernberg LO; Lilliehöök C; Callaway DJ; Näslund J; Hahne S; Thyberg J; Terenius L; Nordstedt C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(3):1870-1875

Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis.

Tjernberg LO; Näslund J; Thyberg J; Gandy SE; Terenius L; Nordstedt C
Article: JOURNAL OF NEUROCHEMISTRY. 1996;67(1):294-301

High-resolution separation of amyloid beta-peptides: structural variants present in Alzheimer's disease amyloid.

Näslund J; Karlström AR; Tjernberg LO; Schierhorn A; Terenius L; Nordstedt C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(15):8545-8548

Arrest of beta-amyloid fibril formation by a pentapeptide ligand.

Tjernberg LO; Näslund J; Lindqvist F; Johansson J; Karlström AR; Thyberg J; Terenius L; Nordstedt C
Article: NEURON. 1995;15(1):219-228

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

Näslund J; Thyberg J; Tjernberg LO; Wernstedt C; Karlström AR; Bogdanovic N; Gandy SE; Lannfelt L; Terenius L; Nordstedt C
Article: LAKARTIDNINGEN. 1995;92(18):1899-1900

[A breakthrough for research on Alzheimer disease. A model for drug testing].

Nordstedt C; Näslund J; Tjernberg LO; Terenius L
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All other publications

Review: BIOMEDICINES. 2021;9(7):801

Neuronal Trafficking of the Amyloid Precursor Protein-What Do We Really Know?

Lin T; Tjernberg LO; Schedin-Weiss S
Review: BIOMOLECULES. 2021;11(6):858

What Can N-glycomics and N-glycoproteomics of Cerebrospinal Fluid Tell Us about Alzheimer Disease?

Gaunitz S; Tjernberg LO; Schedin-Weiss S
Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(2):153-163

Transmissible amyloid.

Tjernberg LO; Rising A; Johansson J; Jaudzems K; Westermark P
Review: FEBS JOURNAL. 2014;281(1):46-62

The role of protein glycosylation in Alzheimer disease.

Schedin-Weiss S; Winblad B; Tjernberg LO
Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2010;14(4):741-757

Gene therapy in Alzheimer's disease - potential for disease modification.

Nilsson P; Iwata N; Muramatsu S-I; Tjernberg LO; Winblad B; Saido TC
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s549

Localization of nicastrin/presenilin/APH-1/PEN-2 complexes to mitochondria

Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s148

Analysis of single Alzheimer plaque cores by laser-capture microscopy and nano-electrospray/tandem mass spectrometry

Tjernberg LO; Bogdanovic N; Axelsson B; Winblad B; Näslund J
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(3):326-335

Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide.

Johansson J; Weaver TE; Tjernberg LO
Review: LAKARTIDNINGEN. 1995;92(42):3881-3884

[Future drugs against aging? New research on molecular background of aging].

Nordstedt C; Näslund J; Tjernberg LO; Karlström A

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