Laura Baqué Vidal

Laura Baqué Vidal

Phd Student
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi C1:77, 14181 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLT Obstetrik o gynekologi Lanner, 171 77 Stockholm
Part of:

About me

  • PhD student on regenerative medicine in Lanner's lab.

    Awarded with the KI travel grant 2022 to assist in ARVO Annual Meeting in Denver 2022.
    Awarded with the KI travel grant 2023 to assist in ISCT Annual Meeting in Paris 2023.
    Awarded with the ISCT 2023 Early Stage Professionals Abstract Award.

Research

  • Project 1:
    After the extraordinary efforts of my former colleagues in the lab (Petrus-Reuer, Stem Cells Translational Medicine, 2020
  • Plaza Reyes and
    Petrus-Reuer, Nat Comm, 2020
  • and Petrus-Reuer and Winbland, Stem Cells Report, 2020), we are ready to take our RPE product to clinical trials.
    Together with Saint Eriks Eye Hospital and Novo Nordisk A/S (https://news.ki.se/karolinska-institutet-st-erik-eye-hospital-and-novo-nordisk-collaborate-to-find-a-cure-for-age), we aim to test our RPE product in a Swedish small group of patients in the next few years.
    My involvement in this project is on the development and validation of some quality control assays of the RPE product as well as the production of
    the cells. I have been involved in the development and validation of the delivery of the target dose.

    Project 2:
    Our protocol to produce robustly hESC-RPE has been published before by Plaza Reyes and Petrus-Reuer, Nat Comm, 2020, but we were intrigued to know how this differentiation occurs. For that we employed scRNAseq to transcriptionally characterize different timepoints throughout the hESC-RPE protocol until the final drug product to be used on clinical applications. This work has been published in the pre-print (Petrus-Reurer, S. Lederer, A. R., Baqué-Vidal, L. et al., Molecular profiling of retinal pigment epithelial cell differentiation. Stem Cell Reports, 2022.

Teaching

  • -Sept 2021- June 2022 supervisor of Nefeli Beri from Biomedicine Master Program from Karolinska Institutet on her Research project entitled
    "Cryopreservation of human embryonic stem cell derived retinal pigmented epithelium for clinical applications" and Master Thesis entitled "Device
    tolerability and dose accuracy study for CellThRPE1", passed with honors.

    -Sept 2021-June 2022 co-supervisor of Hugo Metzger from the Molecular and Cellular Biology Bachelor's degree program from the University of Strasbourg, France, with the research project entitled "Investigating the mechanism of action hPSC-RPE cryopreservation".

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