Laura Sanz Ortega

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About me

Laura received her PhD on new nanomedicine-based therapeutic applications developed to treat cancer from Universidad Autónoma de Madrid, Spain, 2019. With her background in immune cell homing to the tumor microenvironment, her post-doctoral work focuses on understanding how tumor cells can impair NK cell homing to the bone marrow in acute myeloid leukemia (AML) and how to genetically modified NK cells to overcome this limitation, with the overall aim of optimizing adoptive NK cell infusion. Her work is supported by Cancerfonden.

Articles

Article: JOURNAL OF IMMUNOLOGY. 2024;212(5):868-880

KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.

Leijonhufvud C; Sanz-Ortega L; Schlums H; Gaballa A; Andersson A; Eriksson C; Segerberg F; Uhlin M; Bryceson YT; Carlsten M
Article: LEUKEMIA. 2024;38(3):579-589

Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow.

Sanz-Ortega L; Andersson A; Carlsten M
Journal article: ACS APPLIED MATERIALS & INTERFACES. 2021;13(7):7924-7944

Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas.

Portilla Y; Mellid S; Paradela A; Ramos-Fernández A; Daviu N; Sanz-Ortega L; Pérez-Yagüe S; Morales MP; Barber DF
Journal article: PHARMACEUTICS. 2020;12(9):812

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting.

Sanz-Ortega L; Rojas JM; Barber DF
Journal article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2019;21:102063

Polyethylenimine-coated superparamagnetic iron oxide nanoparticles impair in vitro and in vivo angiogenesis.

Mulens-Arias V; Rojas JM; Sanz-Ortega L; Portilla Y; Pérez-Yagüe S; Barber DF
Journal article: JOURNAL OF NANOBIOTECHNOLOGY. 2019;17(1):87

Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes.

Sanz-Ortega L; Portilla Y; Pérez-Yagüe S; Barber DF
Journal article: JOURNAL OF NANOBIOTECHNOLOGY. 2019;17(1):14

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field.

Sanz-Ortega L; Rojas JM; Marcos A; Portilla Y; Stein JV; Barber DF
Journal article: FRONTIERS IN IMMUNOLOGY. 2019;10:2073

Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions.

Sanz-Ortega L; Rojas JM; Portilla Y; Pérez-Yagüe S; Barber DF
Journal article: ACTA BIOMATERIALIA. 2017;58:181-195

Time-course assessment of the aggregation and metabolization of magnetic nanoparticles.

Rojas JM; Gavilán H; Del Dedo V; Lorente-Sorolla E; Sanz-Ortega L; da Silva GB; Costo R; Perez-Yagüe S; Talelli M; Marciello M; Morales MP; Barber DF; Gutiérrez L
Journal article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(6):1285-1296

PI3K p85 β regulatory subunit deficiency does not affect NK cell differentiation and increases NKG2D-mediated activation.

Rojas JM; Spada R; Sanz-Ortega L; Morillas L; Mejías R; Mulens-Arias V; Pérez-Yagüe S; Barber DF
Journal article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2016;12(4):1127-1138

Superparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasion.

Rojas JM; Sanz-Ortega L; Mulens-Arias V; Gutiérrez L; Pérez-Yagüe S; Barber DF

All other publications

Letter: HEMASPHERE. 2023;7(11):e974

Improved Leukemia Clearance After Adoptive Transfer of NK Cells Expressing the Bone Marrow Homing Receptor CXCR4R334X.

Segerberg F; Lambert M; Sanz-Ortega L; Andersson A; Childs RW; Carlsten M

Employments

Postdoctoral Researcher, Department of Laboratory Medicine, Karolinska Institutet, 2024-2025
Postdoctoral Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2021-2024

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