Leonid Padyukov

Publications
CV
Public outreach and news

Articles

Article: RHEUMATOLOGY. 2024;:keae146

Identification of early risk factors for anti-citrullinated-protein-antibody positive rheumatoid arthritis-a prospective cohort study.

Cîrciumaru A; Kisten Y; Hansson M; Mathsson-Alm L; Joshua V; Wähämaa H; Haarhaus ML; Lindqvist J; Padyukov L; Catrina S-B; Fei G; Vivar N; Rezaei H; Af Klint E; Antovic A; Réthi B; Catrina AI; Hensvold A
Article: EBIOMEDICINE. 2023;96:104804

Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies.

Leclair V; Galindo-Feria AS; Rothwell S; Kryštůfková O; Zargar SS; Mann H; Diederichsen LP; Andersson H; Klein M; Tansley S; Rönnblom L; Lindblad-Toh K; Syvänen A-C; Wahren-Herlenius M; Sandling JK; Dissect Consortium and The Immunoarray Development; McHugh N; Lamb JA; Vencovský J; Chinoy H; Holmqvist M; Bianchi M; Padyukov L; Lundberg IE; Diaz-Gallo L-M
Article: NATURE IMMUNOLOGY. 2023;24(9):1540-1551

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH; Stacey D; Eriksson N; Macdonald-Dunlop E; Hedman ÅK; Kalnapenkis A; Enroth S; Cozzetto D; Digby-Bell J; Marten J; Folkersen L; Herder C; Jonsson L; Bergen SE; Gieger C; Needham EJ; Surendran P; Estonian Biobank Research Team; Paul DS; Polasek O; Thorand B; Grallert H; Roden M; Võsa U; Esko T; Hayward C; Johansson Å; Gyllensten U; Powell N; Hansson O; Mattsson-Carlgren N; Joshi PK; Danesh J; Padyukov L; Klareskog L; Landén M; Wilson JF; Siegbahn A; Wallentin L; Mälarstig A; Butterworth AS; Peters JE
Journal article: IMMUNOBIOLOGY. 2023;228(5):152581

Low Gene Copy Numbers (GCN) of complement C4 and C4A deficiency are highly significant genetic risk factors for idiopathic inflammatory myopathies and its major subgroups

Zhou D; King E; Rothwell S; Krystufkova O; Notarnicola A; Coss S; Aziz R; Miller K; Dang A; Yu R; Drew J; Lundstrom E; Pachman L; Mamyrova G; Curiel R; De Paepe B; De Bleecker J; Payton A; Ollier W; O'Hanlon T; Targoff I; Flegel W; Sivaraman V; Obele E; Akoghlanian S; Driest K; Spencer C; Wu YL; Nagaraja H; Ardoin S; Chinoy H; Rider L; Miller F; Lundberg I; Padyukov L; Vencovsky J; Lamb J; Yu C-Y
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2023;38(7):809-819

Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study.

Qin C; Diaz-Gallo L-M; Tang B; Wang Y; Nguyen T-D; Harder A; Lu Y; Padyukov L; Askling J; Hägg S
Article: SCIENTIFIC REPORTS. 2023;13(1):10058

Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs.

Hedman ÅK; Winter E; Yoosuf N; Benita Y; Berg L; Brynedal B; Folkersen L; Klareskog L; Maciejewski M; Sirota-Madi A; Spector Y; Ziemek D; Padyukov L; Shen-Orr SS; Jelinsky SA
Article: RHEUMATOLOGY. 2023;:kead301

Genome-wide investigation of persistence to treatment with methotrexate in early rheumatoid arthritis.

Öberg Sysojev A; Saevarsdottir S; Diaz-Gallo LM; Silberberg GN; Alfredsson L; Klareskog L; Baecklund E; Björkman L; Kastbom A; Rantapää-Dahlqvist S; Turesson C; Jonsdottir I; Stefansson K; Frisell T; Padyukov L; Askling J; Westerlind H
Article: NATURE COMMUNICATIONS. 2023;14(1):3453

Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality.

Oddsson A; Sulem P; Sveinbjornsson G; Arnadottir GA; Steinthorsdottir V; Halldorsson GH; Atlason BA; Oskarsson GR; Helgason H; Nielsen HS; Westergaard D; Karjalainen JM; Katrinardottir H; Fridriksdottir R; Jensson BO; Tragante V; Ferkingstad E; Jonsson H; Gudjonsson SA; Beyter D; Moore KHS; Thordardottir HB; Kristmundsdottir S; Stefansson OA; Rantapää-Dahlqvist S; Sonderby IE; Didriksen M; Stridh P; Haavik J; Tryggvadottir L; Frei O; Walters GB; Kockum I; Hjalgrim H; Olafsdottir TA; Selbaek G; Nyegaard M; Erikstrup C; Brodersen T; Saevarsdottir S; Olsson T; Nielsen KR; Haraldsson A; Bruun MT; Hansen TF; DBDS Genomic Consortium; Steingrimsdottir T; Jacobsen RL; Lie RT; Djurovic S; Alfredsson L; Lopez de Lapuente Portilla A; Brunak S; Melsted P; Halldorsson BV; Saemundsdottir J; Magnusson OT; Padyukov L; Banasik K; Rafnar T; Askling J; Klareskog L; Pedersen OB; Masson G; Havdahl A; Nilsson B; Andreassen OA; Daly M; Ostrowski SR; Jonsdottir I; Stefansson H; Holm H; Helgason A; Thorsteinsdottir U; Stefansson K; Gudbjartsson DF
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(6):1021-1027

Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation.

Rothwell S; Amos CI; Miller FW; Rider LG; Lundberg IE; Gregersen PK; Vencovsky J; McHugh N; Limaye V; Selva-O'Callaghan A; Hanna MG; Machado PM; Pachman LM; Reed AM; Molberg Ø; Benveniste O; Mathiesen P; Radstake T; Doria A; De Bleecker JL; De Paepe B; Maurer B; Ollier WE; Padyukov L; O'Hanlon TP; Lee A; Wedderburn LR; Chinoy H; Lamb JA; Myositis Genetics Consortium
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):247.08

Complement C4 gene copy number variations and polymorphisms, autoantibodies, and clinical manifestations of juvenile dermatomyositis– a multi-center study

Coss SL; Aziz RA; Zhou D; Zhou B; Miller K; Wu YL; Ardoin S; Oberle E; Driest K; Al Ahmed O; Patwardhan A; Akoghlanian S; Sivaraman V; Barbar-Smiley F; Drew J; Spencer C; Pachman L; Morgan G; Mamyrova G; Curiel R; Jones O; O’Hanlon T; Rider L; Miller F; Padyukov L; Lundberg I; Notarnicola A; Vencovský J; Stibůrková B; Kryštůfková O; Yu C-Y
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(3):316-323

Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking.

Tang B; Liu Q; Ilar A; Wiebert P; Hägg S; Padyukov L; Klareskog L; Alfredsson L; Jiang X
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(2):235-245

Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies.

Zhou D; King EH; Rothwell S; Krystufkova O; Notarnicola A; Coss S; Abdul-Aziz R; Miller KE; Dang A; Yu GR; Drew J; Lundström E; Pachman LM; Mamyrova G; Curiel RV; De Paepe B; De Bleecker JL; Payton A; Ollier W; O'Hanlon TP; Targoff IN; Flegel WA; Sivaraman V; Oberle E; Akoghlanian S; Driest K; Spencer CH; Wu YL; Nagaraja HN; Ardoin SP; Chinoy H; Rider LG; Miller FW; Lundberg IE; Padyukov L; Vencovský J; Lamb JA; Yu C-Y; for MYOGEN Investigators
Article: FRONTIERS IN MEDICINE. 2023;10:1061654

Functional link between sarcoidosis-associated gene variants and quantitative levels of bronchoalveolar lavage fluid cell types.

Abo Al Hayja M; Kullberg S; Eklund A; Padyukov L; Grunewald J; Rivera NV
Article: FRONTIERS IN MEDICINE. 2023;10:1146353

Molecular signature of methotrexate response among rheumatoid arthritis patients.

Brynedal B; Yoosuf N; Ulfarsdottir TB; Ziemek D; Maciejewski M; Folkersen L; Westerlind H; Müller M; Sahlström P; Jelinsky SA; Hensvold A; Padyukov L; Pomiano NV; Catrina A; Klareskog L; Berg L
Article: FRONTIERS IN MEDICINE. 2023;10:1132799

Sex differences in the genetics of sarcoidosis across European and African ancestry populations.

Xiong Y; Kullberg S; Garman L; Pezant N; Ellinghaus D; Vasila V; Eklund A; Rybicki BA; Iannuzzi MC; Schreiber S; Müller-Quernheim J; Montgomery CG; Grunewald J; Padyukov L; Rivera NV
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1073414

Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity.

Hardt U; Corcoran MM; Narang S; Malmström V; Padyukov L; Karlsson Hedestam GB
Article: MOLECULAR IMMUNOLOGY. 2022;152:106-110

Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain.

Houtman M; Dzebisashvili A; Dubnovitsky A; Kozhukh G; Rönnblom L; Klareskog L; Malmström V; Padyukov L
Article: NATURE GENETICS. 2022;54(11):1640-1651

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

Ishigaki K; Sakaue S; Terao C; Luo Y; Sonehara K; Yamaguchi K; Amariuta T; Too CL; Laufer VA; Scott IC; Viatte S; Takahashi M; Ohmura K; Murasawa A; Hashimoto M; Ito H; Hammoudeh M; Emadi SA; Masri BK; Halabi H; Badsha H; Uthman IW; Wu X; Lin L; Li T; Plant D; Barton A; Orozco G; Verstappen SMM; Bowes J; MacGregor AJ; Honda S; Koido M; Tomizuka K; Kamatani Y; Tanaka H; Tanaka E; Suzuki A; Maeda Y; Yamamoto K; Miyawaki S; Xie G; Zhang J; Amos CI; Keystone E; Wolbink G; van der Horst-Bruinsma I; Cui J; Liao KP; Carroll RJ; Lee H-S; Bang S-Y; Siminovitch KA; de Vries N; Alfredsson L; Rantapää-Dahlqvist S; Karlson EW; Bae S-C; Kimberly RP; Edberg JC; Mariette X; Huizinga T; Dieudé P; Schneider M; Kerick M; Denny JC; BioBank Japan Project; Matsuda K; Matsuo K; Mimori T; Matsuda F; Fujio K; Tanaka Y; Kumanogoh A; Traylor M; Lewis CM; Eyre S; Xu H; Saxena R; Arayssi T; Kochi Y; Ikari K; Harigai M; Gregersen PK; Yamamoto K; Louis Bridges S; Padyukov L; Martin J; Klareskog L; Okada Y; Raychaudhuri S
Article: BIOLOGICAL PSYCHIATRY GLOBAL OPEN SCIENCE. 2022;2(4):368-378

Common Genetic Variation and Age of Onset of Anorexia Nervosa.

Watson HJ; Thornton LM; Yilmaz Z; Baker JH; Coleman JRI; Adan RAH; Alfredsson L; Andreassen OA; Ask H; Berrettini WH; Boehnke M; Boehm I; Boni C; Buehren K; Bulant J; Burghardt R; Chang X; Cichon S; Cone RD; Courtet P; Crow S; Crowley JJ; Danner UN; de Zwaan M; Dedoussis G; DeSocio JE; Dick DM; Dikeos D; Dina C; Djurovic S; Dmitrzak-Weglarz M; Docampo-Martinez E; Duriez P; Egberts K; Ehrlich S; Eriksson JG; Escaramís G; Esko T; Estivill X; Farmer A; Fernández-Aranda F; Fichter MM; Föcker M; Foretova L; Forstner AJ; Frei O; Gallinger S; Giegling I; Giuranna J; Gonidakis F; Gorwood P; Gratacòs M; Guillaume S; Guo Y; Hakonarson H; Hauser J; Havdahl A; Hebebrand J; Helder SG; Herms S; Herpertz-Dahlmann B; Herzog W; Hinney A; Hübel C; Hudson JI; Imgart H; Jamain S; Janout V; Jiménez-Murcia S; Jones IR; Julià A; Kalsi G; Kaminská D; Kaprio J; Karhunen L; Kas MJH; Keel PK; Kennedy JL; Keski-Rahkonen A; Kiezebrink K; Klareskog L; Klump KL; Knudsen GPS; La Via MC; Le Hellard S; Leboyer M; Li D; Lilenfeld L; Lin B; Lissowska J; Luykx J; Magistretti P; Maj M; Marsal S; Marshall CR; Mattingsdal M; Meulenbelt I; Micali N; Mitchell KS; Monteleone AM; Monteleone P; Myers R; Navratilova M; Ntalla I; O'Toole JK; Ophoff RA; Padyukov L; Pantel J; Papežová H; Pinto D; Raevuori A; Ramoz N; Reichborn-Kjennerud T; Ricca V; Ripatti S; Ripke S; Ritschel F; Roberts M; Rotondo A; Rujescu D; Rybakowski F; Scherag A; Scherer SW; Schmidt U; Scott LJ; Seitz J; Silén Y; Šlachtová L; Slagboom PE; Slof-Op 't Landt MCT; Slopien A; Sorbi S; Świątkowska B; Tortorella A; Tozzi F; Treasure J; Tsitsika A; Tyszkiewicz-Nwafor M; Tziouvas K; van Elburg AA; van Furth EF; Walton E; Widen E; Zerwas S; Zipfel S; Bergen AW; Boden JM; Brandt H; Crawford S; Halmi KA; Horwood LJ; Johnson C; Kaplan AS; Kaye WH; Mitchell JE; Olsen CM; Pearson JF; Pedersen NL; Strober M; Werge T; Whiteman DC; Woodside DB; Gordon S; Maguire S; Larsen JT; Parker R; Petersen LV; Jordan J; Kennedy M; Wade TD; Birgegård A; Lichtenstein P; Landén M; Martin NG; Mortensen PB; Breen G; Bulik CM
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1085-1095

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.

Saevarsdottir S; Stefansdottir L; Sulem P; Thorleifsson G; Ferkingstad E; Rutsdottir G; Glintborg B; Westerlind H; Grondal G; Loft IC; Sorensen SB; Lie BA; Brink M; Ärlestig L; Arnthorsson AO; Baecklund E; Banasik K; Bank S; Bjorkman LI; Ellingsen T; Erikstrup C; Frei O; Gjertsson I; Gudbjartsson DF; Gudjonsson SA; Halldorsson GH; Hendricks O; Hillert J; Hogdall E; Jacobsen S; Jensen DV; Jonsson H; Kastbom A; Kockum I; Kristensen S; Kristjansdottir H; Larsen MH; Linauskas A; Hauge E-M; Loft AG; Ludviksson BR; Lund SH; Markusson T; Masson G; Melsted P; Moore KHS; Munk H; Nielsen KR; Norddahl GL; Oddsson A; Olafsdottir TA; Olason PI; Olsson T; Ostrowski SR; Hørslev-Petersen K; Rognvaldsson S; Sanner H; Silberberg GN; Stefansson H; Sørensen E; Sørensen IJ; Turesson C; Bergman T; Alfredsson L; Kvien TK; Brunak S; Steinsson K; Andersen V; Andreassen OA; Rantapää-Dahlqvist S; Hetland ML; Klareskog L; Askling J; Padyukov L; Pedersen OB; Thorsteinsdottir U; Jonsdottir I; Stefansson K; Members of the DBDS Genomic Consortium; Danish RA Genetics Working Group; Swedish Rheumatology Quality Register Biobank Stud
Article: ARTHRITIS CARE & RESEARCH. 2022;74(6):879-888

Toward Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis: A Pharmacogenomics-Driven Machine Learning Approach.

Myasoedova E; Athreya AP; Crowson CS; Davis JM; Warrington KJ; Walchak RC; Carlson E; Kalari KR; Bongartz T; Tak PP; van Vollenhoven RF; Padyukov L; Emery P; Morgan A; Wang L; Weinshilboum RM; Matteson EL; Pharmacogenetics of Methotrexate in Rheumatoid Art
Article: RHEUMATOLOGY. 2022;61(4):1680-1689

Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis.

Yoosuf N; Maciejewski M; Ziemek D; Jelinsky SA; Folkersen L; Müller M; Sahlström P; Vivar N; Catrina A; Berg L; Klareskog L; Padyukov L; Brynedal B
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(2):342-352

Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort.

Bianchi M; Kozyrev SV; Notarnicola A; Hultin Rosenberg L; Karlsson Å; Pucholt P; Rothwell S; Alexsson A; Sandling JK; Andersson H; Cooper RG; Padyukov L; Tjärnlund A; Dastmalchi M; ImmunoArray Development Consortium; DISSECT Consortium; Meadows JRS; Pyndt Diederichsen L; Molberg Ø; Chinoy H; Lamb JA; Rönnblom L; Lindblad-Toh K; Lundberg IE
Article: ACR OPEN RHEUMATOLOGY. 2022;4(1):27-39

Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations.

Diaz-Gallo L-M; Oke V; Lundström E; Elvin K; Ling Wu Y; Eketjäll S; Zickert A; Gustafsson JT; Jönsen A; Leonard D; Birmingham DJ; Nordmark G; Bengtsson AA; Rönnblom L; Gunnarsson I; Yu C-Y; Padyukov L; Svenungsson E
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2021;39(4):775-780

HLA-B*27 is significantly enriched in Nordic patients with psoriatic arthritis mutilans.

Nikamo P; Gudbjornsson B; Laasonen L; Ejstrup L; Iversen L; Lindqvist U; Padyukov L; Ståhle M
Article: ARTHRITIS & RHEUMATOLOGY. 2021;73(6):963-969

HLA-B*08 Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti-Carbamylated Protein Antibody-Positive/Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.

Regueiro C; Casares-Marfil D; Lundberg K; Knevel R; Acosta-Herrera M; Rodriguez-Rodriguez L; Lopez-Mejias R; Perez-Pampin E; Triguero-Martinez A; Nuño L; Ferraz-Amaro I; Rodriguez-Carrio J; Lopez-Pedrera R; Robustillo-Villarino M; Castañeda S; Remuzgo-Martinez S; Alperi M; Alegre-Sancho JJ; Balsa A; Gonzalez-Alvaro I; Mera A; Fernandez-Gutierrez B; Gonzalez-Gay MA; Trouw LA; Grönwall C; Padyukov L; Martin J; Gonzalez A
Article: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES. 2021;24(5):663-670

Clinical characteristics of Vietnamese patients with idiopathic inflammatory myopathies and autoantibodies to aminoacyl-transfer RNA synthetases.

Phuong TNT; Ngoc LNT; Rönnelid J; Padyukov L; Lundberg IE
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):108

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study.

Zhu J; Niu Z; Alfredsson L; Klareskog L; Padyukov L; Jiang X
Article: ARTHRITIS & RHEUMATOLOGY. 2021;73(2):203-211

Obesity-Related Traits and the Development of Rheumatoid Arthritis: Evidence From Genetic Data.

Tang B; Shi H; Alfredsson L; Klareskog L; Padyukov L; Jiang X
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):46

The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study.

Tan LK; Too CL; Diaz-Gallo LM; Wahinuddin S; Lau IS; Heselynn H; Nor-Shuhaila S; Gun SC; Eashwary M; Mohd-Shahrir MS; Ainon MM; Azmillah R; Muhaini O; Shahnaz M; Alfredsson L; Klareskog L; Padyukov L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(1):109-117

Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing.

Sandling JK; Pucholt P; Hultin Rosenberg L; Farias FHG; Kozyrev SV; Eloranta M-L; Alexsson A; Bianchi M; Padyukov L; Bengtsson C; Jonsson R; Omdal R; Lie BA; Massarenti L; Steffensen R; Jakobsen MA; Lillevang ST; ImmunoArray Development Consortium and DISSECT con; Lerang K; Molberg Ø; Voss A; Troldborg A; Jacobsen S; Syvänen A-C; Jönsen A; Gunnarsson I; Svenungsson E; Rantapää-Dahlqvist S; Bengtsson AA; Sjöwall C; Leonard D; Lindblad-Toh K; Rönnblom L
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:707217

Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients.

Houtman M; Hesselberg E; Rönnblom L; Klareskog L; Malmström V; Padyukov L
Article: ADDICTION BIOLOGY. 2021;26(1):e12880

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

Munn-Chernoff MA; Johnson EC; Chou Y-L; Coleman JRI; Thornton LM; Walters RK; Yilmaz Z; Baker JH; Hübel C; Gordon S; Medland SE; Watson HJ; Gaspar HA; Bryois J; Hinney A; Leppä VM; Mattheisen M; Ripke S; Yao S; Giusti-Rodríguez P; Hanscombe KB; Adan RAH; Alfredsson L; Ando T; Andreassen OA; Berrettini WH; Boehm I; Boni C; Boraska Perica V; Buehren K; Burghardt R; Cassina M; Cichon S; Clementi M; Cone RD; Courtet P; Crow S; Crowley JJ; Danner UN; Davis OSP; de Zwaan M; Dedoussis G; Degortes D; DeSocio JE; Dick DM; Dikeos D; Dina C; Dmitrzak-Weglarz M; Docampo E; Duncan LE; Egberts K; Ehrlich S; Escaramís G; Esko T; Estivill X; Farmer A; Favaro A; Fernández-Aranda F; Fichter MM; Fischer K; Föcker M; Foretova L; Forstner AJ; Forzan M; Franklin CS; Gallinger S; Giegling I; Giuranna J; Gonidakis F; Gorwood P; Gratacos Mayora M; Guillaume S; Guo Y; Hakonarson H; Hatzikotoulas K; Hauser J; Hebebrand J; Helder SG; Herms S; Herpertz-Dahlmann B; Herzog W; Huckins LM; Hudson JI; Imgart H; Inoko H; Janout V; Jiménez-Murcia S; Julià A; Kalsi G; Kaminská D; Karhunen L; Karwautz A; Kas MJH; Kennedy JL; Keski-Rahkonen A; Kiezebrink K; Kim Y-R; Klump KL; Knudsen GPS; La Via MC; Le Hellard S; Levitan RD; Li D; Lilenfeld L; Lin BD; Lissowska J; Luykx J; Magistretti PJ; Maj M; Mannik K; Marsal S; Marshall CR; Mattingsdal M; McDevitt S; McGuffin P; Metspalu A; Meulenbelt I; Micali N; Mitchell K; Monteleone AM; Monteleone P; Nacmias B; Navratilova M; Ntalla I; O'Toole JK; Ophoff RA; Padyukov L; Palotie A; Pantel J; Papezova H; Pinto D; Rabionet R; Raevuori A; Ramoz N; Reichborn-Kjennerud T; Ricca V; Ripatti S; Ritschel F; Roberts M; Rotondo A; Rujescu D; Rybakowski F; Santonastaso P; Scherag A; Scherer SW; Schmidt U; Schork NJ; Schosser A; Seitz J; Slachtova L; Slagboom PE; Slof-Op't Landt MCT; Slopien A; Sorbi S; Świątkowska B; Szatkiewicz JP; Tachmazidou I; Tenconi E; Tortorella A; Tozzi F; Treasure J; Tsitsika A; Tyszkiewicz-Nwafor M; Tziouvas K; van Elburg AA; van Furth EF; Wagner G; Walton E; Widen E; Zeggini E; Zerwas S; Zipfel S; Bergen AW; Boden JM; Brandt H; Crawford S; Halmi KA; Horwood LJ; Johnson C; Kaplan AS; Kaye WH; Mitchell J; Olsen CM; Pearson JF; Pedersen NL; Strober M; Werge T; Whiteman DC; Woodside DB; Grove J; Henders AK; Larsen JT; Parker R; Petersen LV; Jordan J; Kennedy MA; Birgegård A; Lichtenstein P; Norring C; Landén M; Mortensen PB; Polimanti R; McClintick JN; Adkins AE; Aliev F; Bacanu S-A; Batzler A; Bertelsen S; Biernacka JM; Bigdeli TB; Chen L-S; Clarke T-K; Degenhardt F; Docherty AR; Edwards AC; Foo JC; Fox L; Frank J; Hack LM; Hartmann AM; Hartz SM; Heilmann-Heimbach S; Hodgkinson C; Hoffmann P; Hottenga J-J; Konte B; Lahti J; Lahti-Pulkkinen M; Lai D; Ligthart L; Loukola A; Maher BS; Mbarek H; McIntosh AM; McQueen MB; Meyers JL; Milaneschi Y; Palviainen T; Peterson RE; Ryu E; Saccone NL; Salvatore JE; Sanchez-Roige S; Schwandt M; Sherva R; Streit F; Strohmaier J; Thomas N; Wang J-C; Webb BT; Wedow R; Wetherill L; Wills AG; Zhou H; Boardman JD; Chen D; Choi D-S; Copeland WE; Culverhouse RC; Dahmen N; Degenhardt L; Domingue BW; Frye MA; Gäebel W; Hayward C; Ising M; Keyes M; Kiefer F; Koller G; Kramer J; Kuperman S; Lucae S; Lynskey MT; Maier W; Mann K; Männistö S; Müller-Myhsok B; Murray AD; Nurnberger JI; Preuss U; Räikkönen K; Reynolds MD; Ridinger M; Scherbaum N; Schuckit MA; Soyka M; Treutlein J; Witt SH; Wodarz N; Zill P; Adkins DE; Boomsma DI; Bierut LJ; Brown SA; Bucholz KK; Costello EJ; de Wit H; Diazgranados N; Eriksson JG; Farrer LA; Foroud TM; Gillespie NA; Goate AM; Goldman D; Grucza RA; Hancock DB; Harris KM; Hesselbrock V; Hewitt JK; Hopfer CJ; Iacono WG; Johnson EO; Karpyak VM; Kendler KS; Kranzler HR; Krauter K; Lind PA; McGue M; MacKillop J; Madden PAF; Maes HH; Magnusson PKE; Nelson EC; Nöthen MM; Palmer AA; Penninx BWJH; Porjesz B; Rice JP; Rietschel M; Riley BP; Rose RJ; Shen P-H; Silberg J; Stallings MC; Tarter RE; Vanyukov MM; Vrieze S; Wall TL; Whitfield JB; Zhao H; Neale BM; Wade TD; Heath AC; Montgomery GW; Martin NG; Sullivan PF; Kaprio J; Breen G; Gelernter J; Edenberg HJ; Bulik CM; Agrawal A
Article: RMD OPEN. 2020;6(3):e001402

Cigarette smoking patterns preceding primary Sjögren's syndrome.

Mofors J; Björk A; Richardsdotter Andersson E; Kvarnström M; Forsblad d'Elia H; Magnusson-Bucher S; Padyukov L; Kockum I; Hillert J; Eriksson P; Mandl T; Nordmark G; Alfredsson L; Wahren-Herlenius M
Article: NATURE. 2020;584(7822):619-623

FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.

Saevarsdottir S; Olafsdottir TA; Ivarsdottir EV; Halldorsson GH; Gunnarsdottir K; Sigurdsson A; Johannesson A; Sigurdsson JK; Juliusdottir T; Lund SH; Arnthorsson AO; Styrmisdottir EL; Gudmundsson J; Grondal GM; Steinsson K; Alfredsson L; Askling J; Benediktsson R; Bjarnason R; Geirsson AJ; Gudbjornsson B; Gudjonsson H; Hjaltason H; Hreidarsson AB; Klareskog L; Kockum I; Kristjansdottir H; Love TJ; Ludviksson BR; Olsson T; Onundarson PT; Orvar KB; Padyukov L; Sigurgeirsson B; Tragante V; Bjarnadottir K; Rafnar T; Masson G; Sulem P; Gudbjartsson DF; Melsted P; Thorleifsson G; Norddahl GL; Thorsteinsdottir U; Jonsdottir I; Stefansson K
Article: NATURE COMMUNICATIONS. 2020;11(1):1569

Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction.

Sakaue S; Hirata J; Kanai M; Suzuki K; Akiyama M; Lai Too C; Arayssi T; Hammoudeh M; Al Emadi S; Masri BK; Halabi H; Badsha H; Uthman IW; Saxena R; Padyukov L; Hirata M; Matsuda K; Murakami Y; Kamatani Y; Okada Y
Article: JOURNAL OF AUTOIMMUNITY. 2020;106:102340

Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus.

Enocsson H; Wirestam L; Dahle C; Padyukov L; Jönsen A; Urowitz MB; Gladman DD; Romero-Diaz J; Bae S-C; Fortin PR; Sanchez-Guerrero J; Clarke AE; Bernatsky S; Gordon C; Hanly JG; Wallace DJ; Isenberg DA; Rahman A; Merrill JT; Ginzler E; Alarcón GS; Chatham WW; Petri M; Khamashta M; Aranow C; Mackay M; Dooley MA; Manzi S; Ramsey-Goldman R; Nived O; Steinsson K; Zoma AA; Ruiz-Irastorza G; Lim SS; Kalunian KC; Inanc M; van Vollenhoven RF; Ramos-Casals M; Kamen DL; Jacobsen S; Peschken CA; Askanase A; Stoll T; Bruce IN; Wetterö J; Sjöwall C
Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):60

Sex differences in clinical presentation of systemic lupus erythematosus.

Ramírez Sepúlveda JI; Bolin K; Mofors J; Leonard D; Svenungsson E; Jönsen A; Bengtsson C; DISSECT consortium; Nordmark G; Rantapää Dahlqvist S; Bengtsson AA; Rönnblom L; Sjöwall C; Gunnarsson I; Wahren-Herlenius M
Article: CELL. 2019;179(7):1469-1482.e11

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

Cross-Disorder Group of the Psychiatric Genomics C; Cross-Disorder Group of the Psychiatric Genomics C
Article: SCIENTIFIC REPORTS. 2019;9(1):18633

A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.

Rivera NV; Patasova K; Kullberg S; Diaz-Gallo LM; Iseda T; Bengtsson C; Alfredsson L; Eklund A; Kockum I; Grunewald J; Padyukov L
Article: NATURE COMMUNICATIONS. 2019;10(1):5120

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.

Lyons PA; Peters JE; Alberici F; Liley J; Coulson RMR; Astle W; Baldini C; Bonatti F; Cid MC; Elding H; Emmi G; Epplen J; Guillevin L; Jayne DRW; Jiang T; Gunnarsson I; Lamprecht P; Leslie S; Little MA; Martorana D; Moosig F; Neumann T; Ohlsson S; Quickert S; Ramirez GA; Rewerska B; Schett G; Sinico RA; Szczeklik W; Tesar V; Vukcevic D; European Vasculitis Genetics Consortium; Terrier B; Watts RA; Vaglio A; Holle JU; Wallace C; Smith KGC
Article: NATURE COMMUNICATIONS. 2019;10(1):4955

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

López-Isac E; Acosta-Herrera M; Kerick M; Assassi S; Satpathy AT; Granja J; Mumbach MR; Beretta L; Simeón CP; Carreira P; Ortego-Centeno N; Castellvi I; Bossini-Castillo L; Carmona FD; Orozco G; Hunzelmann N; Distler JHW; Franke A; Lunardi C; Moroncini G; Gabrielli A; de Vries-Bouwstra J; Wijmenga C; Koeleman BPC; Nordin A; Padyukov L; Hoffmann-Vold A-M; Lie B; European Scleroderma Group†; Proudman S; Stevens W; Nikpour M; Australian Scleroderma Interest Group (ASIG); Vyse T; Herrick AL; Worthington J; Denton CP; Allanore Y; Brown MA; Radstake TRDJ; Fonseca C; Chang HY; Mayes MD; Martin J
Article: GENETIC EPIDEMIOLOGY. 2019;43(7):844-863

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

Din L; Sheikh M; Kosaraju N; Smedby KE; Bernatsky S; Berndt SI; Skibola CF; Nieters A; Wang S; McKay JD; Cocco P; Maynadié M; Foretová L; Staines A; Mack TM; de Sanjosé S; Vyse TJ; Padyukov L; Monnereau A; Arslan AA; Moore A; Brooks-Wilson AR; Novak AJ; Glimelius B; Birmann BM; Link BK; Stewart C; Vajdic CM; Haioun C; Magnani C; Conti DV; Cox DG; Casabonne D; Albanes D; Kane E; Roman E; Muzi G; Salles G; Giles GG; Adami H-O; Ghesquières H; De Vivo I; Clavel J; Cerhan JR; Spinelli JJ; Hofmann J; Vijai J; Curtin K; Costenbader KH; Onel K; Offit K; Teras LR; Morton L; Conde L; Miligi L; Melbye M; Ennas MG; Liebow M; Purdue MP; Glenn M; Southey MC; Din M; Rothman N; Camp NJ; Wong Doo N; Becker N; Pradhan N; Bracci PM; Boffetta P; Vineis P; Brennan P; Kraft P; Lan Q; Severson RK; Vermeulen RCH; Milne RL; Kaaks R; Travis RC; Weinstein SJ; Chanock SJ; Ansell SM; Slager SL; Zheng T; Zhang Y; Benavente Y; Taub Z; Madireddy L; Gourraud P-A; Oksenberg JR; Cozen W; Hjalgrim H; Khankhanian P
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;105(3):616-624

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype.

Terao C; Brynedal B; Chen Z; Jiang X; Westerlind H; Hansson M; Jakobsson P-J; Lundberg K; Skriner K; Serre G; Rönnelid J; Mathsson-Alm L; Brink M; Dahlqvist SR; Padyukov L; Gregersen PK; Barton A; Alfredsson L; Klareskog L; Raychaudhuri S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16955-16960

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.

Tengvall K; Huang J; Hellström C; Kammer P; Biström M; Ayoglu B; Lima Bomfim I; Stridh P; Butt J; Brenner N; Michel A; Lundberg K; Padyukov L; Lundberg IE; Svenungsson E; Ernberg I; Olafsson S; Dilthey AT; Hillert J; Alfredsson L; Sundström P; Nilsson P; Waterboer T; Olsson T; Kockum I
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(8):1055-1061

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39.

Spiliopoulou A; Colombo M; Plant D; Nair N; Cui J; Coenen MJ; Ikari K; Yamanaka H; Saevarsdottir S; Padyukov L; Bridges SL; Kimberly RP; Okada Y; van Riel PLC; Wolbink G; van der Horst-Bruinsma IE; de Vries N; Tak PP; Ohmura K; Canhão H; Guchelaar H-J; Huizinga TW; Criswell LA; Raychaudhuri S; Weinblatt ME; Wilson AG; Mariette X; Isaacs JD; Morgan AW; Pitzalis C; Barton A; McKeigue P
Article: NATURE GENETICS. 2019;51(8):1207-1214

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Watson HJ; Yilmaz Z; Thornton LM; Hübel C; Coleman JRI; Gaspar HA; Bryois J; Hinney A; Leppä VM; Mattheisen M; Medland SE; Ripke S; Yao S; Giusti-Rodríguez P; Anorexia Nervosa Genetics Initiative; Hanscombe KB; Purves KL; Eating Disorders Working Group of the Psychiatric ; Adan RAH; Alfredsson L; Ando T; Andreassen OA; Baker JH; Berrettini WH; Boehm I; Boni C; Perica VB; Buehren K; Burghardt R; Cassina M; Cichon S; Clementi M; Cone RD; Courtet P; Crow S; Crowley JJ; Danner UN; Davis OSP; de Zwaan M; Dedoussis G; Degortes D; DeSocio JE; Dick DM; Dikeos D; Dina C; Dmitrzak-Weglarz M; Docampo E; Duncan LE; Egberts K; Ehrlich S; Escaramís G; Esko T; Estivill X; Farmer A; Favaro A; Fernández-Aranda F; Fichter MM; Fischer K; Föcker M; Foretova L; Forstner AJ; Forzan M; Franklin CS; Gallinger S; Giegling I; Giuranna J; Gonidakis F; Gorwood P; Mayora MG; Guillaume S; Guo Y; Hakonarson H; Hatzikotoulas K; Hauser J; Hebebrand J; Helder SG; Herms S; Herpertz-Dahlmann B; Herzog W; Huckins LM; Hudson JI; Imgart H; Inoko H; Janout V; Jiménez-Murcia S; Julià A; Kalsi G; Kaminská D; Kaprio J; Karhunen L; Karwautz A; Kas MJH; Kennedy JL; Keski-Rahkonen A; Kiezebrink K; Kim Y-R; Klareskog L; Klump KL; Knudsen GPS; La Via MC; Le Hellard S; Levitan RD; Li D; Lilenfeld L; Lin BD; Lissowska J; Luykx J; Magistretti PJ; Maj M; Mannik K; Marsal S; Marshall CR; Mattingsdal M; McDevitt S; McGuffin P; Metspalu A; Meulenbelt I; Micali N; Mitchell K; Monteleone AM; Monteleone P; Munn-Chernoff MA; Nacmias B; Navratilova M; Ntalla I; O'Toole JK; Ophoff RA; Padyukov L; Palotie A; Pantel J; Papezova H; Pinto D; Rabionet R; Raevuori A; Ramoz N; Reichborn-Kjennerud T; Ricca V; Ripatti S; Ritschel F; Roberts M; Rotondo A; Rujescu D; Rybakowski F; Santonastaso P; Scherag A; Scherer SW; Schmidt U; Schork NJ; Schosser A; Seitz J; Slachtova L; Slagboom PE; Slof-Op 't Landt MCT; Slopien A; Sorbi S; Świątkowska B; Szatkiewicz JP; Tachmazidou I; Tenconi E; Tortorella A; Tozzi F; Treasure J; Tsitsika A; Tyszkiewicz-Nwafor M; Tziouvas K; van Elburg AA; van Furth EF; Wagner G; Walton E; Widen E; Zeggini E; Zerwas S; Zipfel S; Bergen AW; Boden JM; Brandt H; Crawford S; Halmi KA; Horwood LJ; Johnson C; Kaplan AS; Kaye WH; Mitchell JE; Olsen CM; Pearson JF; Pedersen NL; Strober M; Werge T; Whiteman DC; Woodside DB; Stuber GD; Gordon S; Grove J; Henders AK; Juréus A; Kirk KM; Larsen JT; Parker R; Petersen L; Jordan J; Kennedy M; Montgomery GW; Wade TD; Birgegård A; Lichtenstein P; Norring C; Landén M; Martin NG; Mortensen PB; Sullivan PF; Breen G; Bulik CM
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(7):996-1002

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.

Rothwell S; Chinoy H; Lamb JA; Miller FW; Rider LG; Wedderburn LR; McHugh NJ; Mammen AL; Betteridge ZE; Tansley SL; Bowes J; Vencovský J; Deakin CT; Dankó K; Vidya L; Selva-O'Callaghan A; Pachman LM; Reed AM; Molberg Ø; Benveniste O; Mathiesen PR; Radstake TRDJ; Doria A; de Bleecker J; Lee AT; Hanna MG; Machado PM; Ollier WE; Gregersen PK; Padyukov L; O'Hanlon TP; Cooper RG; Lundberg IE; Myositis Genetics Consortium (MYOGEN)
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(6):773-780

Sequencing of the MHC region defines HLA-DQA1 as the major genetic risk for seropositive rheumatoid arthritis in Han Chinese population.

Guo J; Zhang T; Cao H; Li X; Liang H; Liu M; Zou Y; Zhang Y; Wang Y; Sun X; Hu F; Du Y; Mo X; Liu X; Yang Y; Yang H; Wu X; Zhang X; Jia H; Jiang H; Hou Y; Liu X; Su Y; Zhang M; Yang H; Wang J; Sun L; Liu L; Padyukov L; Lai L; Yamamoto K; Zhang X; Klareskog L; Xu X; Li Z
Article: JOURNAL OF RHEUMATOLOGY. 2019;46(5):492-500

Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort.

Wirestam L; Enocsson H; Skogh T; Padyukov L; Jönsen A; Urowitz MB; Gladman DD; Romero-Diaz J; Bae S-C; Fortin PR; Sanchez-Guerrero J; Clarke AE; Bernatsky S; Gordon C; Hanly JG; Wallace D; Isenberg DA; Rahman A; Merrill J; Ginzler E; Alarcón GS; Chatham WW; Petri M; Khamashta M; Aranow C; Mackay M; Dooley MA; Manzi S; Ramsey-Goldman R; Nived O; Steinsson K; Zoma A; Ruiz-Irastorza G; Lim S; Kalunian K; Inanc M; van Vollenhoven R; Ramos-Casals M; Kamen DL; Jacobsen S; Peschken C; Askanase A; Stoll T; Bruce IN; Wetterö J; Sjöwall C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(3):311-319

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

Acosta-Herrera M; Kerick M; González-Serna D; Myositis Genetics Consortium; Scleroderma Genetics Consortium; Wijmenga C; Franke A; Gregersen PK; Padyukov L; Worthington J; Vyse TJ; Alarcón-Riquelme ME; Mayes MD; Martin J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(10):1454-1462

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis.

Diaz-Gallo L-M; Ramsköld D; Shchetynsky K; Folkersen L; Chemin K; Brynedal B; Uebe S; Okada Y; Alfredsson L; Klareskog L; Padyukov L
Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):188

T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients.

Houtman M; Ekholm L; Hesselberg E; Chemin K; Malmström V; Reed AM; Lundberg IE; Padyukov L
Article: PHARMACOGENOMICS JOURNAL. 2018;18(4):528-538

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.

Taylor JC; Bongartz T; Massey J; Mifsud B; Spiliopoulou A; Scott IC; Wang J; Morgan M; Plant D; Colombo M; Orchard P; Twigg S; McInnes IB; Porter D; Freeston JE; Nam JL; Cordell HJ; Isaacs JD; Strathdee JL; Arnett D; de Hair MJH; Tak PP; Aslibekyan S; van Vollenhoven RF; Padyukov L; Bridges SL; Pitzalis C; Cope AP; Verstappen SMM; Emery P; Barnes MR; Agakov F; McKeigue P; Mushiroda T; Kubo M; Weinshilboum R; Barton A; Morgan AW; Barrett JH; MATURA; and PAMERA; Consortia
Article: SCIENCE. 2018;360(6395):1313

Analysis of shared heritability in common disorders of the brain.

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Article: JOURNAL OF AUTOIMMUNITY. 2018;90:28-38

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus.

Houtman M; Shchetynsky K; Chemin K; Hensvold AH; Ramsköld D; Tandre K; Eloranta M-L; Rönnblom L; Uebe S; Catrina AI; Malmström V; Padyukov L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(5):736-743

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Imgenberg-Kreuz J; Carlsson Almlöf J; Leonard D; Alexsson A; Nordmark G; Eloranta M-L; Rantapää-Dahlqvist S; Bengtsson AA; Jönsen A; Padyukov L; Gunnarsson I; Svenungsson E; Sjöwall C; Rönnblom L; Syvänen A-C; Sandling JK
Article: JOURNAL OF IMMUNOLOGY. 2017;199(8):2613-2617

Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression.

Eriksson K; Svensson A; Hait AS; Schlüter K; Tunbäck P; Nordström I; Padyukov L; Liljeqvist J-Å; Mogensen TH; Paludan SR
Article: CLINICAL IMMUNOLOGY. 2017;183:304-315

Depressed serum IgM levels in SLE are restricted to defined subgroups.

Grönwall C; Hardt U; Gustafsson JT; Elvin K; Jensen-Urstad K; Kvarnström M; Grosso G; Rönnelid J; Padykov L; Gunnarsson I; Silverman GJ; Svenungsson E
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(9):1529-1536

Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up.

Manivel VA; Mullazehi M; Padyukov L; Westerlind H; Klareskog L; Alfredsson L; Saevarsdottir S; Rönnelid J
Article: SCIENTIFIC REPORTS. 2017;7(1):6236

Novel risk genes for systemic lupus erythematosus predicted by random forest classification.

Almlöf JC; Alexsson A; Imgenberg-Kreuz J; Sylwan L; Bäcklin C; Leonard D; Nordmark G; Tandre K; Eloranta M-L; Padyukov L; Bengtsson C; Jönsen A; Dahlqvist SR; Sjöwall C; Bengtsson AA; Gunnarsson I; Svenungsson E; Rönnblom L; Sandling JK; Syvänen A-C
Article: SCIENTIFIC REPORTS. 2017;7(1):5623

Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.

Rivera NV; Hagemann-Jensen M; Ferreira MAR; Kullberg S; Eklund A; Martin NG; Padyukov L; Grunewald J
Article: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2017;76:195-203

Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism.

D'Addario C; Shchetynsky K; Pucci M; Cifani C; Gunnar A; Vukojević V; Padyukov L; Terenius L
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(5):1090-1099

Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.

Rothwell S; Cooper RG; Lundberg IE; Gregersen PK; Hanna MG; Machado PM; Herbert MK; Pruijn GJM; Lilleker JB; Roberts M; Bowes J; Seldin MF; Vencovsky J; Danko K; Limaye V; Selva-O'Callaghan A; Platt H; Molberg Ø; Benveniste O; Radstake TRDJ; Doria A; De Bleecker J; De Paepe B; Gieger C; Meitinger T; Winkelmann J; Amos CI; Ollier WE; Padyukov L; Lee AT; Lamb JA; Chinoy H; Myositis Genetics Consortium
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2017;185(8):681-687

Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk of Follicular Lymphoma.

Baecklund F; Foo J-N; Askling J; Eloranta S; Glimelius I; Liu J; Hjalgrim H; Rosenquist R; Padyukov L; Smedby KE
Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):71

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.

Meng W; Zhu Z; Jiang X; Too CL; Uebe S; Jagodic M; Kockum I; Murad S; Ferrucci L; Alfredsson L; Zou H; Klareskog L; Feinberg AP; Ekström TJ; Padyukov L; Liu Y
Article: GUT. 2017;66(3):421-428

Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.

Westerlind H; Mellander M-R; Bresso F; Munch A; Bonfiglio F; Assadi G; Rafter J; Hübenthal M; Lieb W; Källberg H; Brynedal B; Padyukov L; Halfvarson J; Törkvist L; Bjork J; Andreasson A; Agreus L; Almer S; Miehlke S; Madisch A; Ohlsson B; Löfberg R; Hultcrantz R; Franke A; D'Amato M
Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):19

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.

Shchetynsky K; Diaz-Gallo L-M; Folkersen L; Hensvold AH; Catrina AI; Berg L; Klareskog L; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(1):58-69

Differences in the Spectrum of Anti-Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis.

Too CL; Murad S; Hansson M; Alm LM; Dhaliwal JS; Holmdahl R; Jakobsson P-J; Alfredsson L; Klareskog L; Rönnelid J; Padyukov L
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:422

SNP Variants in Major Histocompatibility Complex Are Associated with Sarcoidosis Susceptibility-A Joint Analysis in Four European Populations.

Wolin A; Lahtela EL; Anttila V; Petrek M; Grunewald J; van Moorsel CHM; Eklund A; Grutters JC; Kolek V; Mrazek F; Kishore A; Padyukov L; Pietinalho A; Ronninger M; Seppänen M; Selroos O; Lokki M-L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(1):286-294

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.

Márquez A; Vidal-Bralo L; Rodríguez-Rodríguez L; González-Gay MA; Balsa A; González-Álvaro I; Carreira P; Ortego-Centeno N; Ayala-Gutiérrez MM; García-Hernández FJ; González-Escribano MF; Sabio JM; Tolosa C; Suárez A; González A; Padyukov L; Worthington J; Vyse T; Alarcón-Riquelme ME; Martín J
Article: GENES AND IMMUNITY. 2017;18(1):48-56

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.

Guerreiro-Cacais AO; Norin U; Gyllenberg A; Berglund R; Beyeen AD; Rheumatoid Arthritis Consortium International (RAC; Petit-Teixeira E; Cornélis F; Saoudi A; Fournié GJ; Holmdahl R; Alfredsson L; Klareskog L; Jagodic M; Olsson T; Kockum I; Padyukov L
Article: ARTHRITIS RESEARCH & THERAPY. 2016;18(1):288

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study.

Jiang X; Askling J; Saevarsdottir S; Padyukov L; Alfredsson L; Viatte S; Frisell T
Article: MOLECULAR MEDICINE. 2016;22:322-328

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.

Folkersen L; Brynedal B; Diaz-Gallo LM; Ramsköld D; Shchetynsky K; Westerlind H; Sundström Y; Schepis D; Hensvold A; Vivar N; Eloranta M-L; Rönnblom L; Brunak S; Malmström V; Catrina A; Moerch UG; Klareskog L; Padyukov L; Berg L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(9):1599-1606

Gene copy-number variations (CNVs) of complement C4 and C4A deficiency in genetic risk and pathogenesis of juvenile dermatomyositis.

Lintner KE; Patwardhan A; Rider LG; Abdul-Aziz R; Wu YL; Lundström E; Padyukov L; Zhou B; Alhomosh A; Newsom D; White P; Jones KB; O'Hanlon TP; Miller FW; Spencer CH; Yu CY
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(9):2338-2344

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.

López-Isac E; Martín J-E; Assassi S; Simeón CP; Carreira P; Ortego-Centeno N; Freire M; Beltrán E; Narváez J; Alegre-Sancho JJ; Spanish Scleroderma Group; Fernández-Gutiérrez B; Balsa A; Ortiz AM; González-Gay MA; Beretta L; Santaniello A; Bellocchi C; Lunardi C; Moroncini G; Gabrielli A; Witte T; Hunzelmann N; Distler JHW; Riekemasten G; van der Helm-van Mil AH; de Vries-Bouwstra J; Magro-Checa C; Voskuyl AE; Vonk MC; Molberg Ø; Merriman T; Hesselstrand R; Nordin A; Padyukov L; Herrick A; Eyre S; Koeleman BPC; Denton CP; Fonseca C; Radstake TRDJ; Worthington J; Mayes MD; Martín J
Article: NATURE COMMUNICATIONS. 2016;7:12460

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Sieberts SK; Zhu F; García-García J; Stahl E; Pratap A; Pandey G; Pappas D; Aguilar D; Anton B; Bonet J; Eksi R; Fornés O; Guney E; Li H; Marín MA; Panwar B; Planas-Iglesias J; Poglayen D; Cui J; Falcao AO; Suver C; Hoff B; Balagurusamy VSK; Dillenberger D; Neto EC; Norman T; Aittokallio T; Ammad-Ud-Din M; Azencott C-A; Bellón V; Boeva V; Bunte K; Chheda H; Cheng L; Corander J; Dumontier M; Goldenberg A; Gopalacharyulu P; Hajiloo M; Hidru D; Jaiswal A; Kaski S; Khalfaoui B; Khan SA; Kramer ER; Marttinen P; Mezlini AM; Molparia B; Pirinen M; Saarela J; Samwald M; Stoven V; Tang H; Tang J; Torkamani A; Vert J-P; Wang B; Wang T; Wennerberg K; Wineinger NE; Xiao G; Xie Y; Yeung R; Zhan X; Zhao C; Members of the Rheumatoid Arthritis Challenge Cons; Greenberg J; Kremer J; Michaud K; Barton A; Coenen M; Mariette X; Miceli C; Shadick N; Weinblatt M; de Vries N; Tak PP; Gerlag D; Huizinga TWJ; Kurreeman F; Allaart CF; Louis Bridges S; Criswell L; Moreland L; Klareskog L; Saevarsdottir S; Padyukov L; Gregersen PK; Friend S; Plenge R; Stolovitzky G; Oliva B; Guan Y; Mangravite LM
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;84(2):100-109

Autoantibody Specificities and Type I Interferon Pathway Activation in Idiopathic Inflammatory Myopathies.

Ekholm L; Vosslamber S; Tjärnlund A; de Jong TD; Betteridge Z; McHugh N; Plestilova L; Klein M; Padyukov L; Voskuyl AE; Bultink IEM; Michiel Pegtel D; Mavragani CP; Crow MK; Vencovsky J; Lundberg IE; Verweij CL
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(8):1558-1566

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.

Rothwell S; Cooper RG; Lundberg IE; Miller FW; Gregersen PK; Bowes J; Vencovsky J; Danko K; Limaye V; Selva-O'Callaghan A; Hanna MG; Machado PM; Pachman LM; Reed AM; Rider LG; Cobb J; Platt H; Molberg Ø; Benveniste O; Mathiesen P; Radstake T; Doria A; De Bleecker J; De Paepe B; Maurer B; Ollier WE; Padyukov L; O'Hanlon TP; Lee A; Amos CI; Gieger C; Meitinger T; Winkelmann J; Wedderburn LR; Chinoy H; Lamb JA; Myositis Genetics Consortium
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(26):E3716-E3724

Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis.

Yau ACY; Tuncel J; Haag S; Norin U; Houtman M; Padyukov L; Holmdahl R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(6):997-1002

Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study.

Too CL; Muhamad NA; Ilar A; Padyukov L; Alfredsson L; Klareskog L; Murad S; Bengtsson C; MyEIRA Study Group
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193(9):1008-1022

High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.

Rivera NV; Ronninger M; Shchetynsky K; Franke A; Nöthen MM; Müller-Quernheim J; Schreiber S; Adrianto I; Karakaya B; van Moorsel CHM; Navratilova Z; Kolek V; Rybicki BA; Iannuzzi MC; Petrek M; Grutters JC; Montgomery C; Fischer A; Eklund A; Padyukov L; Grunewald J
Article: RHEUMATOLOGY. 2016;55(1):149-155

An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.

Jiang X; Källberg H; Chen Z; Ärlestig L; Rantapää-Dahlqvist S; Davila S; Klareskog L; Padyukov L; Alfredsson L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(12):4612-4624

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies.

Albrecht I; Wick C; Hallgren Å; Tjärnlund A; Nagaraju K; Andrade F; Thompson K; Coley W; Phadke A; Diaz-Gallo L-M; Bottai M; Nennesmo I; Chemin K; Herrath J; Johansson K; Wikberg A; Ytterberg AJ; Zubarev RA; Danielsson O; Krystufkova O; Vencovsky J; Landegren N; Wahren-Herlenius M; Padyukov L; Kämpe O; Lundberg IE
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2015;44(5):1706-1721

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Lee SH; Byrne EM; Hultman CM; Kähler A; Vinkhuyzen AAE; Ripke S; Andreassen OA; Frisell T; Gusev A; Hu X; Karlsson R; Mantzioris VX; McGrath JJ; Mehta D; Stahl EA; Zhao Q; Kendler KS; Sullivan PF; Price AL; O'Donovan M; Okada Y; Mowry BJ; Raychaudhuri S; Wray NR; Schizophrenia Working Group of the Psychiatric Gen; Schizophrenia Working Group of the Psychiatric Gen; Byerley W; Cahn W; Cantor RM; Cichon S; Cormican P; Curtis D; Djurovic S; Escott-Price V; Gejman PV; Georgieva L; Giegling I; Hansen TF; Ingason A; Kim Y; Konte B; Lee PH; McIntosh A; McQuillin A; Morris DW; Nöthen MM; O'Dushlaine C; Olincy A; Olsen L; Pato CN; Pato MT; Pickard BS; Posthuma D; Rasmussen HB; Rietschel M; Rujescu D; Schulze TG; Silverman JM; Thirumalai S; Werge T; Schizophrenia Working Group of the Psychiatric Gen; Agartz I; Amin F; Azevedo MH; Bass N; Black DW; Blackwood DHR; Bruggeman R; Buccola NG; Choudhury K; Cloninger RC; Corvin A; Craddock N; Daly MJ; Datta S; Donohoe GJ; Duan J; Dudbridge F; Fanous A; Freedman R; Freimer NB; Friedl M; Gill M; Gurling H; De Haan L; Hamshere ML; Hartmann AM; Holmans PA; Kahn RS; Keller MC; Kenny E; Kirov GK; Krabbendam L; Krasucki R; Lawrence J; Lencz T; Levinson DF; Lieberman JA; Lin D-Y; Linszen DH; Magnusson PKE; Maier W; Malhotra AK; Mattheisen M; Mattingsdal M; McCarroll SA; Medeiros H; Melle I; Milanova V; Myin-Germeys I; Neale BM; Ophoff RA; Owen MJ; Pimm J; Purcell SM; Puri V; Quested DJ; Rossin L; Ruderfer D; Sanders AR; Shi J; Sklar P; St Clair D; Stroup TS; Van Os J; Visscher PM; Wiersma D; Zammit S; Rheumatoid Arthritis Consortium International Auth; Bridges SL; Choi HK; Coenen MJH; de Vries N; Dieud P; Greenberg JD; Huizinga TWJ; Padyukov L; Siminovitch KA; Tak PP; Worthington J; Rheumatoid Arthritis Consortium International Coll; De Jager PL; Denny JC; Gregersen PK; Klareskog L; Mariette X; Plenge RM; van Laar M; van Riel P
Article: GENES AND IMMUNITY. 2015;16(7):470-480

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

Miller FW; Chen W; O'Hanlon TP; Cooper RG; Vencovsky J; Rider LG; Danko K; Wedderburn LR; Lundberg IE; Pachman LM; Reed AM; Ytterberg SR; Padyukov L; Selva-O'Callaghan A; Radstake TR; Isenberg DA; Chinoy H; Ollier WER; Scheet P; Peng B; Lee A; Byun J; Lamb JA; Gregersen PK; Amos CI; Myositis Genetics Consortium
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2015;192(6):727-736

Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk.

Fischer A; Ellinghaus D; Nutsua M; Hofmann S; Montgomery CG; Iannuzzi MC; Rybicki BA; Petrek M; Mrazek F; Pabst S; Grohé C; Grunewald J; Ronninger M; Eklund A; Padyukov L; Mihailovic-Vucinic V; Jovanovic D; Sterclova M; Homolka J; Nöthen MM; Herms S; Gieger C; Strauch K; Winkelmann J; Boehm BO; Brand S; Büning C; Schürmann M; Ellinghaus E; Baurecht H; Lieb W; Nebel A; Müller-Quernheim J; Franke A; Schreiber S; GenPhenReSa Consortium
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):239

Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate.

Hensvold AH; Joshua V; Li W; Larkin M; Qureshi F; Israelsson L; Padyukov L; Lundberg K; Defranoux N; Saevarsdottir S; Catrina AI
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(9):1772-1777

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation.

Ytterberg AJ; Joshua V; Reynisdottir G; Tarasova NK; Rutishauser D; Ossipova E; Haj Hensvold A; Eklund A; Sköld CM; Grunewald J; Malmström V; Jakobsson PJ; Rönnelid J; Padyukov L; Zubarev RA; Klareskog L; Catrina AI
Article: CLINICAL IMMUNOLOGY. 2015;158(1):19-28

Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis.

Shchetynsky K; Protsyuk D; Ronninger M; Diaz-Gallo L-M; Klareskog L; Padyukov L
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):109

Histological antiphospholipid-associated nephropathy versus lupus nephritis in patients with systemic lupus erythematosus: an observational cross-sectional study with longitudinal follow-up.

Gerhardsson J; Sundelin B; Zickert A; Padyukov L; Svenungsson E; Gunnarsson I
Article: NATURE COMMUNICATIONS. 2015;6:6916

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.

Yin X; Low HQ; Wang L; Li Y; Ellinghaus E; Han J; Estivill X; Sun L; Zuo X; Shen C; Zhu C; Zhang A; Sanchez F; Padyukov L; Catanese JJ; Krueger GG; Duffin KC; Mucha S; Weichenthal M; Weidinger S; Lieb W; Foo JN; Li Y; Sim K; Liany H; Irwan I; Teo Y; Theng CTS; Gupta R; Bowcock A; De Jager PL; Qureshi AA; de Bakker PIW; Seielstad M; Liao W; Ståhle M; Franke A; Zhang X; Liu J
Article: NATURE COMMUNICATIONS. 2015;6:6804

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.

Li J; Jørgensen SF; Maggadottir SM; Bakay M; Warnatz K; Glessner J; Pandey R; Salzer U; Schmidt RE; Perez E; Resnick E; Goldacker S; Buchta M; Witte T; Padyukov L; Videm V; Folseraas T; Atschekzei F; Elder JT; Nair RP; Winkelmann J; Gieger C; Nöthen MM; Büning C; Brand S; Sullivan KE; Orange JS; Fevang B; Schreiber S; Lieb W; Aukrust P; Chapel H; Cunningham-Rundles C; Franke A; Karlsen TH; Grimbacher B; Hakonarson H; Hammarström L; Ellinghaus E
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(3):e15

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.

Bossini-Castillo L; de Kovel C; Kallberg H; van 't Slot R; Italiaander A; Coenen M; Tak PP; Posthumus MD; Wijmenga C; Huizinga T; van der Helm-van Mil AHM; Stoeken-Rijsbergen G; Rodriguez-Rodriguez L; Balsa A; González-Álvaro I; González-Gay MÁ; Gómez-Vaquero C; Franke B; LifeLines Cohort Study; Vermeulen S; van der Horst-Bruinsma I; Dijkmans BAC; Wolbink GJ; Ophoff RA; Maehlen MT; van Riel P; Merriman M; Klareskog L; Lie BA; Merriman T; Crusius JBA; Brouwer E; Martin J; de Vries N; Toes R; Padyukov L; Koeleman BPC
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(3):e13

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

Kim K; Bang S-Y; Lee H-S; Cho S-K; Choi C-B; Sung Y-K; Kim T-H; Jun J-B; Yoo DH; Kang YM; Kim S-K; Suh C-H; Shim S-C; Lee S-S; Lee J; Chung WT; Choe J-Y; Shin HD; Lee J-Y; Han B-G; Nath SK; Eyre S; Bowes J; Pappas DA; Kremer JM; Gonzalez-Gay MA; Rodriguez-Rodriguez L; Ärlestig L; Okada Y; Diogo D; Liao KP; Karlson EW; Raychaudhuri S; Rantapää-Dahlqvist S; Martin J; Klareskog L; Padyukov L; Gregersen PK; Worthington J; Greenberg JD; Plenge RM; Bae S-C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(3):e19

Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.

Gazal S; Sacre K; Allanore Y; Teruel M; Goodall AH; (The CARDIOGENICS consortium); Tohma S; Alfredsson L; Okada Y; Xie G; Constantin A; Balsa A; Kawasaki A; Nicaise P; Amos C; Rodriguez-Rodriguez L; Chiocchia G; Boileau C; Zhang J; Vittecoq O; Barnetche T; Gonzalez Gay MA; Furukawa H; Cantagrel A; Le Loët X; Sumida T; Hurtado-Nedelec M; Richez C; Chollet-Martin S; Schaeverbeke T; Combe B; Khoryati L; Coustet B; El-Benna J; Siminovitch K; Plenge R; Padyukov L; Martin J; Tsuchiya N; Dieudé P
Article: INTERNATIONAL JOURNAL OF GENOMICS. 2015;2015:256818-13

Genetic vectors as a tool in association studies: definitions and application for study of rheumatoid arthritis.

Sandalov I; Padyukov L
Article: PLOS ONE. 2015;10(4):e0122271

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

Diogo D; Bastarache L; Liao KP; Graham RR; Fulton RS; Greenberg JD; Eyre S; Bowes J; Cui J; Lee A; Pappas DA; Kremer JM; Barton A; Coenen MJH; Franke B; Kiemeney LA; Mariette X; Richard-Miceli C; Canhão H; Fonseca JE; de Vries N; Tak PP; Crusius JBA; Nurmohamed MT; Kurreeman F; Mikuls TR; Okada Y; Stahl EA; Larson DE; Deluca TL; O'Laughlin M; Fronick CC; Fulton LL; Kosoy R; Ransom M; Bhangale TR; Ortmann W; Cagan A; Gainer V; Karlson EW; Kohane I; Murphy SN; Martin J; Zhernakova A; Klareskog L; Padyukov L; Worthington J; Mardis ER; Seldin MF; Gregersen PK; Behrens T; Raychaudhuri S; Denny JC; Plenge RM
Article: CELL REPORTS. 2014;9(4):1417-1429

A role for noncoding variation in schizophrenia.

Roussos P; Mitchell AC; Voloudakis G; Fullard JF; Pothula VM; Tsang J; Stahl EA; Georgakopoulos A; Ruderfer DM; Charney A; Okada Y; Siminovitch KA; Worthington J; Padyukov L; Klareskog L; Gregersen PK; Plenge RM; Raychaudhuri S; Fromer M; Purcell SM; Brennand KJ; Robakis NK; Schadt EE; Akbarian S; Sklar P
Article: MOLECULAR PSYCHIATRY. 2014;19(10):1085-1094

A genome-wide association study of anorexia nervosa.

Boraska V; Franklin CS; Floyd JAB; Thornton LM; Huckins LM; Southam L; Rayner NW; Tachmazidou I; Klump KL; Treasure J; Lewis CM; Schmidt U; Tozzi F; Kiezebrink K; Hebebrand J; Gorwood P; Adan RAH; Kas MJH; Favaro A; Santonastaso P; Fernández-Aranda F; Gratacos M; Rybakowski F; Dmitrzak-Weglarz M; Kaprio J; Keski-Rahkonen A; Raevuori A; Van Furth EF; Slof-Op 't Landt MCT; Hudson JI; Reichborn-Kjennerud T; Knudsen GPS; Monteleone P; Kaplan AS; Karwautz A; Hakonarson H; Berrettini WH; Guo Y; Li D; Schork NJ; Komaki G; Ando T; Inoko H; Esko T; Fischer K; Männik K; Metspalu A; Baker JH; Cone RD; Dackor J; DeSocio JE; Hilliard CE; O'Toole JK; Pantel J; Szatkiewicz JP; Taico C; Zerwas S; Trace SE; Davis OSP; Helder S; Bühren K; Burghardt R; de Zwaan M; Egberts K; Ehrlich S; Herpertz-Dahlmann B; Herzog W; Imgart H; Scherag A; Scherag S; Zipfel S; Boni C; Ramoz N; Versini A; Brandys MK; Danner UN; de Kovel C; Hendriks J; Koeleman BPC; Ophoff RA; Strengman E; van Elburg AA; Bruson A; Clementi M; Degortes D; Forzan M; Tenconi E; Docampo E; Escaramís G; Jiménez-Murcia S; Lissowska J; Rajewski A; Szeszenia-Dabrowska N; Slopien A; Hauser J; Karhunen L; Meulenbelt I; Slagboom PE; Tortorella A; Maj M; Dedoussis G; Dikeos D; Gonidakis F; Tziouvas K; Tsitsika A; Papezova H; Slachtova L; Martaskova D; Kennedy JL; Levitan RD; Yilmaz Z; Huemer J; Koubek D; Merl E; Wagner G; Lichtenstein P; Breen G; Cohen-Woods S; Farmer A; McGuffin P; Cichon S; Giegling I; Herms S; Rujescu D; Schreiber S; Wichmann H-E; Dina C; Sladek R; Gambaro G; Soranzo N; Julia A; Marsal S; Rabionet R; Gaborieau V; Dick DM; Palotie A; Ripatti S; Widén E; Andreassen OA; Espeseth T; Lundervold A; Reinvang I; Steen VM; Le Hellard S; Mattingsdal M; Ntalla I; Bencko V; Foretova L; Janout V; Navratilova M; Gallinger S; Pinto D; Scherer SW; Aschauer H; Carlberg L; Schosser A; Alfredsson L; Ding B; Klareskog L; Padyukov L; Courtet P; Guillaume S; Jaussent I; Finan C; Kalsi G; Roberts M; Logan DW; Peltonen L; Ritchie GRS; Barrett JC; Wellcome Trust Case Control Consortium 3; Estivill X; Hinney A; Sullivan PF; Collier DA; Zeggini E; Bulik CM
Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(4):414

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.

Snir O; Gomez-Cabrero D; Montes A; Perez-Pampin E; Gómez-Reino JJ; Seddighzadeh M; Klich KU; Israelsson L; Ding B; Catrina AI; Holmdahl R; Alfredsson L; Klareskog L; Tegnér J; Gonzalez A; Malmström V; Padyukov L
Article: HUMAN MOLECULAR GENETICS. 2014;23(15):4177-4184

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.

Viktorin A; Frankowiack M; Padyukov L; Chang Z; Melén E; Sääf A; Kull I; Klareskog L; Hammarström L; Magnusson PKE
Article: ANNALS OF THE RHEUMATIC DISEASES. 2014;73(6):1096-1100

Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study.

Bengtsson C; Padyukov L; Källberg H; Saevarsdottir S
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(4):522-532

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Han B; Diogo D; Eyre S; Kallberg H; Zhernakova A; Bowes J; Padyukov L; Okada Y; González-Gay MA; Rantapää-Dahlqvist S; Martin J; Huizinga TWJ; Plenge RM; Worthington J; Gregersen PK; Klareskog L; de Bakker PIW; Raychaudhuri S
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(4):485-495

GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease.

Liu Y; Li X; Aryee MJ; Ekström TJ; Padyukov L; Klareskog L; Vandiver A; Moore AZ; Tanaka T; Ferrucci L; Fallin MD; Feinberg AP
Article: HLA. 2014;83(4):267-272

HLA-alleles associated with increased risk for extra-pulmonary involvement in sarcoidosis.

Darlington P; Gabrielsen A; Sörensson P; Tallstedt L; Padyukov L; Eklund A; Grunewald J
Article: GENES AND IMMUNITY. 2014;15(3):162-167

Variability in the CIITA gene interacts with HLA in multiple sclerosis.

Gyllenberg A; Piehl F; Alfredsson L; Hillert J; Bomfim IL; Padyukov L; Orho-Melander M; Lindholm E; Landin-Olsson M; Lernmark Å; Swedish Childhood Diabetes Study Group; Diabetes Incidence in Sweden Study Group; Olsson T; Kockum I
Article: NATURE. 2014;506(7488):376-381

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Okada Y; Wu D; Trynka G; Raj T; Terao C; Ikari K; Kochi Y; Ohmura K; Suzuki A; Yoshida S; Graham RR; Manoharan A; Ortmann W; Bhangale T; Denny JC; Carroll RJ; Eyler AE; Greenberg JD; Kremer JM; Pappas DA; Jiang L; Yin J; Ye L; Su D-F; Yang J; Xie G; Keystone E; Westra H-J; Esko T; Metspalu A; Zhou X; Gupta N; Mirel D; Stahl EA; Diogo D; Cui J; Liao K; Guo MH; Myouzen K; Kawaguchi T; Coenen MJH; van Riel PLCM; van de Laar MAFJ; Guchelaar H-J; Huizinga TWJ; Dieudé P; Mariette X; Bridges SL; Zhernakova A; Toes REM; Tak PP; Miceli-Richard C; Bang S-Y; Lee H-S; Martin J; Gonzalez-Gay MA; Rodriguez-Rodriguez L; Rantapää-Dahlqvist S; Arlestig L; Choi HK; Kamatani Y; Galan P; Lathrop M; RACI consortium; GARNET consortium; Eyre S; Bowes J; Barton A; de Vries N; Moreland LW; Criswell LA; Karlson EW; Taniguchi A; Yamada R; Kubo M; Liu JS; Bae S-C; Worthington J; Padyukov L; Klareskog L; Gregersen PK; Raychaudhuri S; Stranger BE; De Jager PL; Franke L; Visscher PM; Brown MA; Yamanaka H; Mimori T; Takahashi A; Xu H; Behrens TW; Siminovitch KA; Momohara S; Matsuda F; Yamamoto K; Plenge RM
Article: HUMAN MUTATION. 2014;35(2):248-256

A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3.

Veal CD; Reekie KE; Lorentzen JC; Gregersen PK; Padyukov L; Brookes AJ
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(1):47-61

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.

Mayes MD; Bossini-Castillo L; Gorlova O; Martin JE; Zhou X; Chen WV; Assassi S; Ying J; Tan FK; Arnett FC; Reveille JD; Guerra S; Teruel M; Carmona FD; Gregersen PK; Lee AT; López-Isac E; Ochoa E; Carreira P; Simeón CP; Castellví I; González-Gay MÁ; Spanish Scleroderma Group; Zhernakova A; Padyukov L; Alarcón-Riquelme M; Wijmenga C; Brown M; Beretta L; Riemekasten G; Witte T; Hunzelmann N; Kreuter A; Distler JHW; Voskuyl AE; Schuerwegh AJ; Hesselstrand R; Nordin A; Airó P; Lunardi C; Shiels P; van Laar JM; Herrick A; Worthington J; Denton C; Wigley FM; Hummers LK; Varga J; Hinchcliff ME; Baron M; Hudson M; Pope JE; Furst DE; Khanna D; Phillips K; Schiopu E; Segal BM; Molitor JA; Silver RM; Steen VD; Simms RW; Lafyatis RA; Fessler BJ; Frech TM; Alkassab F; Docherty P; Kaminska E; Khalidi N; Jones HN; Markland J; Robinson D; Broen J; Radstake TRDJ; Fonseca C; Koeleman BP; Martin J
Article: PLOS ONE. 2014;9(2):e87645

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

Okada Y; Diogo D; Greenberg JD; Mouassess F; Achkar WAL; Fulton RS; Denny JC; Gupta N; Mirel D; Gabriel S; Li G; Kremer JM; Pappas DA; Carroll RJ; Eyler AE; Trynka G; Stahl EA; Cui J; Saxena R; Coenen MJH; Guchelaar H-J; Huizinga TWJ; Dieudé P; Mariette X; Barton A; Canhão H; Fonseca JE; de Vries N; Tak PP; Moreland LW; Bridges SL; Miceli-Richard C; Choi HK; Kamatani Y; Galan P; Lathrop M; Raj T; De Jager PL; Raychaudhuri S; Worthington J; Padyukov L; Klareskog L; Siminovitch KA; Gregersen PK; Mardis ER; Arayssi T; Kazkaz LA; Plenge RM
Article: ARTHRITIS & RHEUMATOLOGY. 2013;65(12):3239-3247

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.

Miller FW; Cooper RG; Vencovský J; Rider LG; Danko K; Wedderburn LR; Lundberg IE; Pachman LM; Reed AM; Ytterberg SR; Padyukov L; Selva-O'Callaghan A; Radstake TRDJ; Isenberg DA; Chinoy H; Ollier WER; O'Hanlon TP; Peng B; Lee A; Lamb JA; Chen W; Amos CI; Gregersen PK; Myositis Genetics Consortium
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2013;21(9):994-999

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations.

Wang C; Ahlford A; Järvinen TM; Nordmark G; Eloranta M-L; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jönsen A; Bengtsson AA; Truedsson L; Eriksson C; Rantapää-Dahlqvist S; Sjöwall C; Julkunen H; Criswell LA; Graham RR; Behrens TW; Kere J; Rönnblom L; Syvänen A-C; Sandling JK
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(8):1375-1381

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.

Umiċeviċ Mirkov M; Cui J; Vermeulen SH; Stahl EA; Toonen EJM; Makkinje RR; Lee AT; Huizinga TWJ; Allaart R; Barton A; Mariette X; Miceli CR; Criswell LA; Tak PP; de Vries N; Saevarsdottir S; Padyukov L; Bridges SL; van Schaardenburg D-J; Jansen TL; Dutmer EAJ; van de Laar MAFJ; Barrera P; Radstake TRDJ; van Riel PLCM; Scheffer H; Franke B; Brunner HG; Plenge RM; Gregersen PK; Guchelaar H-J; Coenen MJH
Article: HUMAN IMMUNOLOGY. 2013;74(8):957-960

Genetic evidence for involvement of adaptive immunity in the development of IgA nephropathy: MHC class II alleles are protective in a Caucasian population.

Vuong MT; Lundberg S; Gunnarsson I; Wramner L; Lundström E; Fernström A; Alfredsson L; Jacobson SH; Padyukov L
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;93(1):167-172

Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk.

Foo JN; Smedby KE; Akers NK; Berglund M; Irwan ID; Jia X; Li Y; Conde L; Darabi H; Bracci PM; Melbye M; Adami H-O; Glimelius B; Khor CC; Hjalgrim H; Padyukov L; Humphreys K; Enblad G; Skibola CF; de Bakker PIW; Liu J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(7):1233-1238

Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.

Diaz-Gallo L-M; Simeon CP; Broen JC; Ortego-Centeno N; Beretta L; Vonk MC; Carreira PE; Vargas S; Román-Ivorra JA; González-Gay MA; Tolosa C; López-Longo FJ; Espinosa G; Vicente EF; Hesselstrand R; Riemekasten G; Witte T; Distler JHW; Voskuyl AE; Schuerwegh AJ; Shiels PG; Nordin A; Padyukov L; Hoffmann-Vold A-M; Scorza R; Lunardi C; Airo P; van Laar JM; Hunzelmann N; Gathof BS; Kreuter A; Herrick A; Worthington J; Denton CP; Zhou X; Arnett FC; Fonseca C; Koeleman BPC; Assasi S; Radstake TRDJ; Mayes MD; Martín J; Spanish Scleroderma Group
Article: GENES AND IMMUNITY. 2013;14(4):217-222

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility.

Wang C; Ahlford A; Laxman N; Nordmark G; Eloranta M-L; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jönsen A; Bengtsson AA; Truedsson L; Rantapää-Dahlqvist S; Sjöwall C; Sandling JK; Rönnblom L; Syvänen A-C
Article: NATURE GENETICS. 2013;45(6):670-675

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Liu JZ; Hov JR; Folseraas T; Ellinghaus E; Rushbrook SM; Doncheva NT; Andreassen OA; Weersma RK; Weismüller TJ; Eksteen B; Invernizzi P; Hirschfield GM; Gotthardt DN; Pares A; Ellinghaus D; Shah T; Juran BD; Milkiewicz P; Rust C; Schramm C; Müller T; Srivastava B; Dalekos G; Nöthen MM; Herms S; Winkelmann J; Mitrovic M; Braun F; Ponsioen CY; Croucher PJP; Sterneck M; Teufel A; Mason AL; Saarela J; Leppa V; Dorfman R; Alvaro D; Floreani A; Onengut-Gumuscu S; Rich SS; Thompson WK; Schork AJ; Næss S; Thomsen I; Mayr G; König IR; Hveem K; Cleynen I; Gutierrez-Achury J; Ricaño-Ponce I; van Heel D; Björnsson E; Sandford RN; Durie PR; Melum E; Vatn MH; Silverberg MS; Duerr RH; Padyukov L; Brand S; Sans M; Annese V; Achkar J-P; Boberg KM; Marschall H-U; Chazouillères O; Bowlus CL; Wijmenga C; Schrumpf E; Vermeire S; Albrecht M; UK-PSCSC Consortium; Rioux JD; Alexander G; Bergquist A; Cho J; Schreiber S; Manns MP; Färkkilä M; Dale AM; Chapman RW; Lazaridis KN; International PSC Study Group; Franke A; Anderson CA; Karlsen TH; International IBD Genetics Consortium
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(6):1018-1025

HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus.

Lundström E; Gustafsson JT; Jönsen A; Leonard D; Zickert A; Elvin K; Sturfelt G; Nordmark G; Bengtsson AA; Sundin U; Källberg H; Sandling JK; Syvänen A-C; Klareskog L; Gunnarsson I; Rönnblom L; Padyukov L; Svenungsson E
Article: PLOS GENETICS. 2013;9(5):e1003487

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

Li G; Diogo D; Wu D; Spoonamore J; Dancik V; Franke L; Kurreeman F; Rossin EJ; Duclos G; Hartland C; Zhou X; Li K; Liu J; De Jager PL; Siminovitch KA; Zhernakova A; Raychaudhuri S; Bowes J; Eyre S; Padyukov L; Gregersen PK; Worthington J; Rheumatoid Arthritis Consortium International (RAC; Gupta N; Clemons PA; Stahl E; Tolliday N; Plenge RM
Article: ARTHRITIS & RHEUMATOLOGY. 2013;65(5):1224-1231

Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis.

Apel M; Uebe S; Bowes J; Giardina E; Korendowych E; Juneblad K; Pasutto F; Ekici AB; McManus R; Ho P; Bruce IN; Ryan AW; Behrens F; Böhm B; Traupe H; Lohmann J; Gieger C; Wichmann H-E; Padyukov L; Fitzgerald O; Alenius G-M; McHugh NJ; Novelli G; Burkhardt H; Barton A; Reis A; Hüffmeier U
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(5):652-658

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile.

Lundberg K; Bengtsson C; Kharlamova N; Reed E; Jiang X; Kallberg H; Pollak-Dorocic I; Israelsson L; Kessel C; Padyukov L; Holmdahl R; Alfredsson L; Klareskog L
Article: PLOS GENETICS. 2013;9(3):e1003394

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.

Cui J; Stahl EA; Saevarsdottir S; Miceli C; Diogo D; Trynka G; Raj T; Mirkov MU; Canhao H; Ikari K; Terao C; Okada Y; Wedrén S; Askling J; Yamanaka H; Momohara S; Taniguchi A; Ohmura K; Matsuda F; Mimori T; Gupta N; Kuchroo M; Morgan AW; Isaacs JD; Wilson AG; Hyrich KL; Herenius M; Doorenspleet ME; Tak P-P; Crusius JBA; van der Horst-Bruinsma IE; Wolbink GJ; van Riel PLCM; van de Laar M; Guchelaar H-J; Shadick NA; Allaart CF; Huizinga TWJ; Toes REM; Kimberly RP; Bridges SL; Criswell LA; Moreland LW; Fonseca JE; de Vries N; Stranger BE; De Jager PL; Raychaudhuri S; Weinblatt ME; Gregersen PK; Mariette X; Barton A; Padyukov L; Coenen MJH; Karlson EW; Plenge RM
Article: GENES AND IMMUNITY. 2013;14(2):83-89

Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis.

Snir O; Hesselberg E; Amoudruz P; Klareskog L; Zarea-Ganji I; Catrina AI; Padyukov L; Malmström V; Seddighzadeh M
Article: NATURE BIOTECHNOLOGY. 2013;31(2):142-147

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.

Liu Y; Aryee MJ; Padyukov L; Fallin MD; Hesselberg E; Runarsson A; Reinius L; Acevedo N; Taub M; Ronninger M; Shchetynsky K; Scheynius A; Kere J; Alfredsson L; Klareskog L; Ekström TJ; Feinberg AP
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2013;133(2):411-417

Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.

Lysell J; Padyukov L; Kockum I; Nikamo P; Ståhle M
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;92(1):15-27

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

Diogo D; Kurreeman F; Stahl EA; Liao KP; Gupta N; Greenberg JD; Rivas MA; Hickey B; Flannick J; Thomson B; Guiducci C; Ripke S; Adzhubey I; Barton A; Kremer JM; Alfredsson L; Consortium of Rheumatology Researchers of North Am; Rheumatoid Arthritis Consortium International; Sunyaev S; Martin J; Zhernakova A; Bowes J; Eyre S; Siminovitch KA; Gregersen PK; Worthington J; Klareskog L; Padyukov L; Raychaudhuri S; Plenge RM
Article: PLOS ONE. 2013;8(9):e74534

A research study of the association between maternal microchimerism and systemic lupus erythematosus in adults: a comparison between patients and healthy controls based on single-nucleotide polymorphism using quantitative real-time PCR.

Kanold AMJ; Svenungsson E; Gunnarsson I; Götherström C; Padyukov L; Papadogiannakis N; Uzunel M; Westgren M
Article: NATURE GENETICS. 2012;44(12):1336-1340

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

Eyre S; Bowes J; Diogo D; Lee A; Barton A; Martin P; Zhernakova A; Stahl E; Viatte S; McAllister K; Amos CI; Padyukov L; Toes REM; Huizinga TWJ; Wijmenga C; Trynka G; Franke L; Westra H-J; Alfredsson L; Hu X; Sandor C; de Bakker PIW; Davila S; Khor CC; Heng KK; Andrews R; Edkins S; Hunt SE; Langford C; Symmons D; Biologics in Rheumatoid Arthritis Genetics and Gen; Wellcome Trust Case Control Consortium; Concannon P; Onengut-Gumuscu S; Rich SS; Deloukas P; Gonzalez-Gay MA; Rodriguez-Rodriguez L; Ärlsetig L; Martin J; Rantapää-Dahlqvist S; Plenge RM; Raychaudhuri S; Klareskog L; Gregersen PK; Worthington J
Article: GENES AND IMMUNITY. 2012;13(8):632-640

Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.

Gyllenberg A; Asad S; Piehl F; Swanberg M; Padyukov L; Van Yserloo B; Rutledge EA; McNeney B; Graham J; Orho-Melander M; Lindholm E; Graff C; Forsell C; Akesson K; Landin-Olsson M; Carlsson A; Forsander G; Ivarsson SA; Larsson H; Lindblad B; Ludvigsson J; Marcus C; Lernmark A; Alfredsson L; Akesson K; Olsson T; Kockum I; Swedish Childhood Diabetes Study Group; Diabetes Incidence in Sweden Study Group; Better Diabetes Diagnosis Study group
Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(6):R250

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.

Too CL; Murad S; Dhaliwal JS; Larsson P; Jiang X; Ding B; Alfredsson L; Klareskog L; Padyukov L
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2012;186(9):877-885

A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.

Fischer A; Schmid B; Ellinghaus D; Nothnagel M; Gaede KI; Schürmann M; Lipinski S; Rosenstiel P; Zissel G; Höhne K; Petrek M; Kolek V; Pabst S; Grohé C; Grunewald J; Ronninger M; Eklund A; Padyukov L; Gieger C; Wichmann H-E; Nebel A; Franke A; Müller-Quernheim J; Hofmann S; Schreiber S
Article: JOURNAL OF VIROLOGY. 2012;86(17):9409-9415

STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.

Svensson A; Tunbäck P; Nordström I; Shestakov A; Padyukov L; Eriksson K
Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 8):1717-1724

Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection.

Svensson A; Tunbäck P; Nordström I; Padyukov L; Eriksson K
Article: JOURNAL OF RHEUMATOLOGY. 2012;39(8):1509-1516

Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.

Seddighzadeh M; Gonzalez A; Ding B; Ferreiro-Iglesias A; Gomez-Reino JJ; Rheumatoid Arthritis Network and Coordinated Proje; Klareskog L; Alfredsson L; Dunussi-Joannopoulos K; Clark JD; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(7):2078-2084

Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis.

Laki J; Lundström E; Snir O; Rönnelid J; Ganji I; Catrina AI; Bengtsson C; Saevarsdottir S; Wick MC; Alfredsson L; Klareskog L; Padyukov L
Article: GENES AND IMMUNITY. 2012;13(5):431-436

CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations.

Eike MC; Skinningsrud B; Ronninger M; Stormyr A; Kvien TK; Joner G; Njølstad PR; Førre O; Flatø B; Alfredsson L; Padyukov L; Undlien DE; Lie BA
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(6):961-965

Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study.

Chinoy H; Adimulam S; Marriage F; New P; Vincze M; Zilahi E; Kapitány A; Gyetvai A; Ekholm L; Novota P; Remakova M; Charles P; McHugh NJ; Padyukov L; Alfredsson L; Vencovsky J; Lundberg IE; Danko K; Ollier WE; Cooper RG
Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(2):R89

Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA).

Too CL; Yahya A; Murad S; Dhaliwal JS; Larsson PT; Muhamad NA; Abdullah NA; Mustafa AN; Klareskog L; Alfredsson L; Padyukov L; Bengtsson C; MyEIRA study group
Article: JOURNAL OF ALLERGY. 2012;2012:163089-6

The heterogeneity of asthma phenotypes in children and young adults.

Hesselmar B; Enelund A-C; Eriksson B; Padyukov L; Hanson LÅ; Aberg N
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(4):567-571

Novel genetic association of the VTCN1 region with rheumatoid arthritis.

Daha NA; Lie BA; Trouw LA; Stoeken G; Schonkeren JJM; Ding B; Kvien TK; Schilham MW; Padyukov L; Huizinga TWJ; Toes R
Article: NATURE GENETICS. 2012;44(5):511-516

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.

Okada Y; Terao C; Ikari K; Kochi Y; Ohmura K; Suzuki A; Kawaguchi T; Stahl EA; Kurreeman FAS; Nishida N; Ohmiya H; Myouzen K; Takahashi M; Sawada T; Nishioka Y; Yukioka M; Matsubara T; Wakitani S; Teshima R; Tohma S; Takasugi K; Shimada K; Murasawa A; Honjo S; Matsuo K; Tanaka H; Tajima K; Suzuki T; Iwamoto T; Kawamura Y; Tanii H; Okazaki Y; Sasaki T; Gregersen PK; Padyukov L; Worthington J; Siminovitch KA; Lathrop M; Taniguchi A; Takahashi A; Tokunaga K; Kubo M; Nakamura Y; Kamatani N; Mimori T; Plenge RM; Yamanaka H; Momohara S; Yamada R; Matsuda F; Yamamoto K
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;90(3):524-532

Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.

Kurreeman FAS; Stahl EA; Okada Y; Liao K; Diogo D; Raychaudhuri S; Freudenberg J; Kochi Y; Patsopoulos NA; Gupta N; CLEAR investigators; Sandor C; Bang S-Y; Lee H-S; Padyukov L; Suzuki A; Siminovitch K; Worthington J; Gregersen PK; Hughes LB; Reynolds RJ; Bridges SL; Bae S-C; Yamamoto K; Plenge RM
Article: NATURE GENETICS. 2012;44(3):291-296

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

Raychaudhuri S; Sandor C; Stahl EA; Freudenberg J; Lee H-S; Jia X; Alfredsson L; Padyukov L; Klareskog L; Worthington J; Siminovitch KA; Bae S-C; Plenge RM; Gregersen PK; de Bakker PIW
Article: GENOME MEDICINE. 2012;4(1):2

The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.

Ronninger M; Guo Y; Shchetynsky K; Hill A; Khademi M; Olsson T; Reddy PS; Seddighzadeh M; Clark JD; Lin L-L; O'Toole M; Padyukov L
Article: PLOS GENETICS. 2012;8(1):e1002476

High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.

Ferreira RC; Pan-Hammarström Q; Graham RR; Fontán G; Lee AT; Ortmann W; Wang N; Urcelay E; Fernández-Arquero M; Núñez C; Jorgensen G; Ludviksson BR; Koskinen S; Haimila K; Padyukov L; Gregersen PK; Hammarström L; Behrens TW
Article: BMJ OPEN. 2012;2(5):e001524

Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritis: an observational cohort study.

Kastbom A; Cöster L; Arlestig L; Chatzidionysiou A; van Vollenhoven RF; Padyukov L; Rantapää-Dahlqvist S; Saevarsdottir S
Article: PLOS ONE. 2012;7(7):e41228

A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort.

Guo J; Wu X; Too CL; Yin F; Lu X; He J; Li R; Liu X; Murad S; Padyukov L; Li Z
Article: PHARMACOGENETICS AND GENOMICS. 2012;22(1):1-9

Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.

Dervieux T; Wessels JAM; Kremer JM; Padyukov L; Seddighzadeh M; Saevarsdottir S; van Vollenhoven RF; Klareskog L; Huizinga TW; Guchelaar H-J
Article: PLOS ONE. 2012;7(3):e32861

Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.

Ronninger M; Seddighzadeh M; Eike MC; Plant D; Daha NA; Skinningsrud B; Worthington J; Kvien TK; Toes REM; Lie BA; Alfredsson L; Padyukov L
Article: EUROPEAN RESPIRATORY JOURNAL. 2011;38(5):1151-1157

HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis.

Darlington P; Tallstedt L; Padyukov L; Kockum I; Cederlund K; Eklund A; Grunewald J
Article: JOURNAL OF RHEUMATOLOGY. 2011;38(10):2130-2132

Preferential association of interferon regulatory factor 5 gene variants with seronegative rheumatoid arthritis in 2 Swedish case-control studies.

Wang C; Kokkonen H; Sandling JK; Johansson M; Seddighzadeh M; Padyukov L; Rantapää-Dahlqvist S; Syvänen A-C
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(8):908-914

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.

Korotkova M; Daha NA; Seddighzadeh M; Ding B; Catrina AI; Lindblad S; Huizinga TWJ; Toes REM; Alfredsson L; Klareskog L; Jakobsson P-J; Padyukov L
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2011;26(7):557-561

GEIRA: gene-environment and gene-gene interaction research application.

Ding B; Källberg H; Klareskog L; Padyukov L; Alfredsson L
Article: PLOS GENETICS. 2011;7(7):e1002178

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.

Gorlova O; Martin J-E; Rueda B; Koeleman BPC; Ying J; Teruel M; Diaz-Gallo L-M; Broen JC; Vonk MC; Simeon CP; Alizadeh BZ; Coenen MJH; Voskuyl AE; Schuerwegh AJ; van Riel PLCM; Vanthuyne M; van 't Slot R; Italiaander A; Ophoff RA; Hunzelmann N; Fonollosa V; Ortego-Centeno N; González-Gay MA; García-Hernández FJ; González-Escribano MF; Airo P; van Laar J; Worthington J; Hesselstrand R; Smith V; de Keyser F; Houssiau F; Chee MM; Madhok R; Shiels PG; Westhovens R; Kreuter A; de Baere E; Witte T; Padyukov L; Nordin A; Scorza R; Lunardi C; Lie BA; Hoffmann-Vold A-M; Palm O; García de la Peña P; Carreira P; Spanish Scleroderma Group; Varga J; Hinchcliff M; Lee AT; Gourh P; Amos CI; Wigley FM; Hummers LK; Nelson JL; Riemekasten G; Herrick A; Beretta L; Fonseca C; Denton CP; Gregersen PK; Agarwal S; Assassi S; Tan FK; Arnett FC; Radstake TRDJ; Mayes MD; Martin J
Article: GENES AND IMMUNITY. 2011;12(4):314-318

Fine mapping the TAGAP risk locus in rheumatoid arthritis.

Chen R; Stahl EA; Kurreeman FAS; Gregersen PK; Siminovitch KA; Worthington J; Padyukov L; Raychaudhuri S; Plenge RM
Article: BIOLOGY DIRECT. 2011;6:25

Causal graph-based analysis of genome-wide association data in rheumatoid arthritis.

Alekseyenko AV; Lytkin NI; Ai J; Ding B; Padyukov L; Aliferis CF; Statnikov A
Article: ARTHRITIS RESEARCH & THERAPY. 2011;13(2):R65

Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers.

Saevarsdottir S; Ding B; Steinsson K; Grondal G; Valdimarsson H; Alfredsson L; Klareskog L; Padyukov L
Article: PLOS GENETICS. 2011;7(4):e1001378

GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.

Smedby KE; Foo JN; Skibola CF; Darabi H; Conde L; Hjalgrim H; Kumar V; Chang ET; Rothman N; Cerhan JR; Brooks-Wilson AR; Rehnberg E; Irwan ID; Ryder LP; Brown PN; Bracci PM; Agana L; Riby J; Cozen W; Davis S; Hartge P; Morton LM; Severson RK; Wang SS; Slager SL; Fredericksen ZS; Novak AJ; Kay NE; Habermann TM; Armstrong B; Kricker A; Milliken S; Purdue MP; Vajdic CM; Boyle P; Lan Q; Zahm SH; Zhang Y; Zheng T; Leach S; Spinelli JJ; Smith MT; Chanock SJ; Padyukov L; Alfredsson L; Klareskog L; Glimelius B; Melbye M; Liu ET; Adami H-O; Humphreys K; Liu J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(4):638-641

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.

Bossini-Castillo L; Broen JCA; Simeon CP; Beretta L; Vonk MC; Ortego-Centeno N; Espinosa G; Carreira P; Camps MT; Navarrete N; González-Escribano MF; Vicente-Rabaneda E; Rodríguez L; Tolosa C; Román-Ivorra JA; Gómez-Gracia I; García-Hernández FJ; Castellví I; Gallego M; Fernández-Nebro A; García-Portales R; Egurbide MV; Fonollosa V; de la Peña PG; Pros A; González-Gay MA; Hesselstrand R; Riemekasten G; Witte T; Coenen MJH; Koeleman BP; Houssiau F; Smith V; de Keyser F; Westhovens R; De Langhe E; Voskuyl AE; Schuerwegh AJ; Chee MM; Madhok R; Shiels P; Fonseca C; Denton C; Claes K; Padykov L; Nordin A; Palm O; Lie BA; Airó P; Scorza R; van Laar JM; Hunzelmann N; Kreuter A; Herrick A; Worthington J; Radstake TRDJ; Martín J; Rueda B
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(4):479-484

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

Sandling JK; Garnier S; Sigurdsson S; Wang C; Nordmark G; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jönsen A; Bengtsson AA; Truedsson L; Eriksson C; Rantapää-Dahlqvist S; Mälarstig A; Strawbridge RJ; Hamsten A; Criswell LA; Graham RR; Behrens TW; Eloranta M-L; Alm G; Rönnblom L; Syvänen A-C
Article: PLOS ONE. 2011;6(3):e17880

Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study.

Lundström E; Hartshorne T; Li K; Lindblad S; Wick MC; Bengtsson C; Alfredsson L; Klareskog L; Padyukov L
Article: JOURNAL OF RHEUMATOLOGY. 2011;38(3):446-449

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.

Broen JCA; Coenen MJH; Rueda B; Witte T; Padyukov L; Klareskog L; Hesselstrand R; Wuttge DM; Simeon C; Ortego-Centeno N; González-Gay MA; Pros A; Hunzelman N; Riemekasten G; Kreuter A; Vonk M; Scorza R; Beretta L; Airò P; van Riel PLCM; Kimberly R; Martin J; Edberg J; Radstake TRDJ
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(3):508-511

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke.

Källberg H; Ding B; Padyukov L; Bengtsson C; Rönnelid J; Klareskog L; Alfredsson L; EIRA Study Group
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(2):259-265

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

Padyukov L; Seielstad M; Ong RTH; Ding B; Rönnelid J; Seddighzadeh M; Alfredsson L; Klareskog L; Epidemiological Investigation of Rheumatoid Arthri
Article: PLOS ONE. 2011;6(6):e21069

Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups.

Chun-Lai T; Padyukov L; Dhaliwal JS; Lundström E; Yahya A; Muhamad NA; Klareskog L; Alfredsson L; Larsson PT; Murad S; Malaysian Epidemiological Investigation of Rheumat
Article: PLOS ONE. 2010;5(12):e14326

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome.

Coenen MJH; Enevold C; Barrera P; Schijvenaars MMVAP; Toonen EJM; Scheffer H; Padyukov L; Kastbom A; Klareskog L; Barton A; Kievit W; Rood MJ; Jansen TL; Swinkels D; van Riel PLCM; Franke B; Bendtzen K; Radstake TRDJ
Article: PLOS ONE. 2010;5(12):e14212

Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus.

Järvinen TM; Hellquist A; Koskenmies S; Einarsdottir E; Panelius J; Hasan T; Julkunen H; Padyukov L; Kvarnström M; Wahren-Herlenius M; Nyberg F; D'Amato M; Kere J; Saarialho-Kere U
Article: KIDNEY INTERNATIONAL. 2010;78(12):1281-1287

Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.

Vuong MT; Hahn-Zoric M; Lundberg S; Gunnarsson I; van Kooten C; Wramner L; Seddighzadeh M; Fernström A; Hanson LÅ; Do LT; Jacobson SH; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(11):3196-3210

Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.

Keenan BT; Chibnik LB; Cui J; Ding B; Padyukov L; Kallberg H; Bengtsson C; Klareskog L; Alfredsson L; Karlson EW
Article: HUMAN MOLECULAR GENETICS. 2010;19(16):3282-3294

Copy number, linkage disequilibrium and disease association in the FCGR locus.

Niederer HA; Willcocks LC; Rayner TF; Yang W; Lau YL; Williams TN; Scott JAG; Urban BC; Peshu N; Dunstan SJ; Hien TT; Phu NH; Padyukov L; Gunnarsson I; Svenungsson E; Savage CO; Watts RA; Lyons PA; Clayton DG; Smith KGC
Article: HLA. 2010;76(2):96-101

Major histocompatibility complex class II transactivator gene polymorphism: associations with Löfgren's syndrome.

Grunewald J; Idali F; Kockum I; Seddighzadeh M; Nisell M; Eklund A; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(7):1849-1861

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

Cui J; Saevarsdottir S; Thomson B; Padyukov L; van der Helm-van Mil AHM; Nititham J; Hughes LB; de Vries N; Raychaudhuri S; Alfredsson L; Askling J; Wedrén S; Ding B; Guiducci C; Wolbink GJ; Crusius JBA; van der Horst-Bruinsma IE; Herenius M; Weinblatt ME; Shadick NA; Worthington J; Batliwalla F; Kern M; Morgan AW; Wilson AG; Isaacs JD; Hyrich K; Seldin MF; Moreland LW; Behrens TW; Allaart CF; Criswell LA; Huizinga TWJ; Tak PP; Bridges SL; Toes REM; Barton A; Klareskog L; Gregersen PK; Karlson EW; Plenge RM
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2010;18(7):821-826

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.

Seddighzadeh M; Korotkova M; Källberg H; Ding B; Daha N; Kurreeman FAS; Toes REM; Huizinga TW; Catrina AI; Alfredsson L; Klareskog L; Padyukov L
Article: NATURE GENETICS. 2010;42(6):508-U56

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Stahl EA; Raychaudhuri S; Remmers EF; Xie G; Eyre S; Thomson BP; Li Y; Kurreeman FAS; Zhernakova A; Hinks A; Guiducci C; Chen R; Alfredsson L; Amos CI; Ardlie KG; BIRAC Consortium; Barton A; Bowes J; Brouwer E; Burtt NP; Catanese JJ; Coblyn J; Coenen MJH; Costenbader KH; Criswell LA; Crusius JBA; Cui J; de Bakker PIW; De Jager PL; Ding B; Emery P; Flynn E; Harrison P; Hocking LJ; Huizinga TWJ; Kastner DL; Ke X; Lee AT; Liu X; Martin P; Morgan AW; Padyukov L; Posthumus MD; Radstake TRDJ; Reid DM; Seielstad M; Seldin MF; Shadick NA; Steer S; Tak PP; Thomson W; van der Helm-van Mil AHM; van der Horst-Bruinsma IE; van der Schoot CE; van Riel PLCM; Weinblatt ME; Wilson AG; Wolbink GJ; Wordsworth BP; YEAR Consortium; Wijmenga C; Karlson EW; Toes REM; de Vries N; Begovich AB; Worthington J; Siminovitch KA; Gregersen PK; Klareskog L; Plenge RM
Article: PLOS ONE. 2010;5(5):e10559

Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

Vuong MT; Gunnarsson I; Lundberg S; Svenungsson E; Wramner L; Fernström A; Syvänen A-C; Do LT; Jacobson SH; Padyukov L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(5):834-840

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus.

Svenungsson E; Gustafsson J; Leonard D; Sandling J; Gunnarsson I; Nordmark G; Jönsen A; Bengtsson AA; Sturfelt G; Rantapää-Dahlqvist S; Elvin K; Sundin U; Garnier S; Simard JF; Sigurdsson S; Padyukov L; Syvänen A-C; Rönnblom L
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(5):1236-1245

Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations.

van der Woude D; Lie BA; Lundström E; Balsa A; Feitsma AL; Houwing-Duistermaat JJ; Verduijn W; Nordang GBN; Alfredsson L; Klareskog L; Pascual-Salcedo D; Gonzalez-Gay MA; Lopez-Nevot MA; Valero F; Roep BO; Huizinga TWJ; Kvien TK; Martín J; Padyukov L; de Vries RRP; Toes REM
Article: NATURE GENETICS. 2010;42(5):426-U71

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.

Radstake TRDJ; Gorlova O; Rueda B; Martin J-E; Alizadeh BZ; Palomino-Morales R; Coenen MJ; Vonk MC; Voskuyl AE; Schuerwegh AJ; Broen JC; van Riel PLCM; van 't Slot R; Italiaander A; Ophoff RA; Riemekasten G; Hunzelmann N; Simeon CP; Ortego-Centeno N; González-Gay MA; González-Escribano MF; Spanish Scleroderma Group; Airo P; van Laar J; Herrick A; Worthington J; Hesselstrand R; Smith V; de Keyser F; Houssiau F; Chee MM; Madhok R; Shiels P; Westhovens R; Kreuter A; Kiener H; de Baere E; Witte T; Padykov L; Klareskog L; Beretta L; Scorza R; Lie BA; Hoffmann-Vold A-M; Carreira P; Varga J; Hinchcliff M; Gregersen PK; Lee AT; Ying J; Han Y; Weng S-F; Amos CI; Wigley FM; Hummers L; Nelson JL; Agarwal SK; Assassi S; Gourh P; Tan FK; Koeleman BPC; Arnett FC; Martin J; Mayes MD
Article: NATURE GENETICS. 2010;42(4):332-U88

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

McGovern DPB; Gardet A; Törkvist L; Goyette P; Essers J; Taylor KD; Neale BM; Ong RTH; Lagacé C; Li C; Green T; Stevens CR; Beauchamp C; Fleshner PR; Carlson M; D'Amato M; Halfvarson J; Hibberd ML; Lördal M; Padyukov L; Andriulli A; Colombo E; Latiano A; Palmieri O; Bernard E-J; Deslandres C; Hommes DW; de Jong DJ; Stokkers PC; Weersma RK; NIDDK IBD Genetics Consortium; Sharma Y; Silverberg MS; Cho JH; Wu J; Roeder K; Brant SR; Schumm LP; Duerr RH; Dubinsky MC; Glazer NL; Haritunians T; Ippoliti A; Melmed GY; Siscovick DS; Vasiliauskas EA; Targan SR; Annese V; Wijmenga C; Pettersson S; Rotter JI; Xavier RJ; Daly MJ; Rioux JD; Seielstad M
Article: NATURE. 2010;464(7289):653

Journal club. A human geneticist explores genetic diversity in Asia.

Padyukov L
Article: ACTA PAEDIATRICA. 2010;99(3):399-403

Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes.

Hesselmar B; Bergin A-M; Park H; Hahn-Zoric M; Eriksson B; Hanson L-A; Padyukov L
Article: GENES AND IMMUNITY. 2010;11(2):142-154

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.

Ockinger J; Stridh P; Beyeen AD; Lundmark F; Seddighzadeh M; Oturai A; Sørensen PS; Lorentzen AR; Celius EG; Leppä V; Koivisto K; Tienari PJ; Alfredsson L; Padyukov L; Hillert J; Kockum I; Jagodic M; Olsson T
Article: PLOS ONE. 2010;5(2):e9315

Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis.

D'Amato M; Zucchelli M; Seddighzadeh M; Anedda F; Lindblad S; Kere J; Alfredsson L; Klareskog L; Padyukov L
Article: NEUROLOGY. 2009;73(24):2107-2111

HLA-DRB1 and month of birth in multiple sclerosis.

Ramagopalan SV; Link J; Byrnes JK; Dyment DA; Giovannoni G; Hintzen RQ; Sundqvist E; Kockum I; Smestad C; Lie BA; Harbo HF; Padyukov L; Alfredsson L; Olsson T; Sadovnick AD; Hillert J; Ebers GC
Article: SCIENCE TRANSLATIONAL MEDICINE. 2009;1(10):10ra21

A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis.

Jagodic M; Colacios C; Nohra R; Dejean AS; Beyeen AD; Khademi M; Casemayou A; Lamouroux L; Duthoit C; Papapietro O; Sjöholm L; Bernard I; Lagrange D; Dahlman I; Lundmark F; Oturai AB; Soendergaard HB; Kemppinen A; Saarela J; Tienari PJ; Harbo HF; Spurkland A; Ramagopalan SV; Sadovnick DA; Ebers GC; Seddighzadeh M; Klareskog L; Alfredsson L; Padyukov L; Hillert J; Clanet M; Edan G; Fontaine B; Fournié GJ; Kockum I; Saoudi A; Olsson T
Article: PLOS ONE. 2009;4(12):e8037

Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

Hellquist A; Zucchelli M; Lindgren CM; Saarialho-Kere U; Järvinen TM; Koskenmies S; Julkunen H; Onkamo P; Skoog T; Panelius J; Räisänen-Sokolowski A; Hasan T; Widen E; Gunnarson I; Svenungsson E; Padyukov L; Assadi G; Berglind L; Mäkelä V-V; Kivinen K; Wong A; Cunningham Graham DS; Vyse TJ; D'Amato M; Kere J
Article: NATURE GENETICS. 2009;41(12):1319-1324

Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.

Mahdi H; Fisher BA; Källberg H; Plant D; Malmström V; Rönnelid J; Charles P; Ding B; Alfredsson L; Padyukov L; Symmons DPM; Venables PJ; Klareskog L; Lundberg K
Article: NATURE GENETICS. 2009;41(12):1313-1U76

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Raychaudhuri S; Thomson BP; Remmers EF; Eyre S; Hinks A; Guiducci C; Catanese JJ; Xie G; Stahl EA; Chen R; Alfredsson L; Amos CI; Ardlie KG; BIRAC Consortium; Barton A; Bowes J; Burtt NP; Chang M; Coblyn J; Costenbader KH; Criswell LA; Crusius JBA; Cui J; De Jager PL; Ding B; Emery P; Flynn E; Harrison P; Hocking LJ; Huizinga TWJ; Kastner DL; Ke X; Kurreeman FAS; Lee AT; Liu X; Li Y; Martin P; Morgan AW; Padyukov L; Reid DM; Seielstad M; Seldin MF; Shadick NA; Steer S; Tak PP; Thomson W; van der Helm-van Mil AHM; van der Horst-Bruinsma IE; Weinblatt ME; Wilson AG; Wolbink GJ; Wordsworth P; YEAR Consortium; Altshuler D; Karlson EW; Toes REM; de Vries N; Begovich AB; Siminovitch KA; Worthington J; Klareskog L; Gregersen PK; Daly MJ; Plenge RM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18680-18685

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

International MHC and Autoimmunity Genetics Networ; Rioux JD; Goyette P; Vyse TJ; Hammarström L; Fernando MMA; Green T; De Jager PL; Foisy S; Wang J; de Bakker PIW; Leslie S; McVean G; Padyukov L; Alfredsson L; Annese V; Hafler DA; Pan-Hammarström Q; Matell R; Sawcer SJ; Compston AD; Cree BAC; Mirel DB; Daly MJ; Behrens TW; Klareskog L; Gregersen PK; Oksenberg JR; Hauser SL
Article: NATURE GENETICS. 2009;41(11):1228-1U93

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

Gateva V; Sandling JK; Hom G; Taylor KE; Chung SA; Sun X; Ortmann W; Kosoy R; Ferreira RC; Nordmark G; Gunnarsson I; Svenungsson E; Padyukov L; Sturfelt G; Jönsen A; Bengtsson AA; Rantapää-Dahlqvist S; Baechler EC; Brown EE; Alarcón GS; Edberg JC; Ramsey-Goldman R; McGwin G; Reveille JD; Vilá LM; Kimberly RP; Manzi S; Petri MA; Lee A; Gregersen PK; Seldin MF; Rönnblom L; Criswell LA; Syvänen A-C; Behrens TW; Graham RR
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(10):3061-3067

Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy.

Vuong MT; Lundberg S; Gunnarsson I; Wramner L; Seddighzadeh M; Hahn-Zoric M; Fernström A; Hanson LA; Do LT; Jacobson SH; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(6):1597-1603

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important.

Lundström E; Källberg H; Alfredsson L; Klareskog L; Padyukov L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(5):736-743

Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles.

Snir O; Widhe M; von Spee C; Lindberg J; Padyukov L; Lundberg K; Engström A; Venables PJ; Lundeberg J; Holmdahl R; Klareskog L; Malmström V
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(5):1250-1254

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.

Lee YC; Raychaudhuri S; Cui J; De Vivo I; Ding B; Alfredsson L; Padyukov L; Costenbader KH; Seielstad M; Graham RR; Klareskog L; Gregersen PK; Plenge RM; Karlson EW
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(4):924-930

Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.

Lundström E; Källberg H; Smolnikova M; Ding B; Rönnelid J; Alfredsson L; Klareskog L; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(3):653-660

Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.

Liao KP; Gunnarsson M; Källberg H; Ding B; Plenge RM; Padyukov L; Karlson EW; Klareskog L; Askling J; Alfredsson L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(2):222-227

Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies.

Källberg H; Jacobsen S; Bengtsson C; Pedersen M; Padyukov L; Garred P; Frisch M; Karlson EW; Klareskog L; Alfredsson L
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(1):30-38

Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.

Ding B; Padyukov L; Lundström E; Seielstad M; Plenge RM; Oksenberg JR; Gregersen PK; Alfredsson L; Klareskog L
Article: GENES AND IMMUNITY. 2009;10(1):68-76

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome.

Nordmark G; Kristjansdottir G; Theander E; Eriksson P; Brun JG; Wang C; Padyukov L; Truedsson L; Alm G; Eloranta M-L; Jonsson R; Rönnblom L; Syvänen A-C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(12):1742-1749

Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells.

Eklöw C; Makrygiannakis D; Bäckdahl L; Padyukov L; Ulfgren A-K; Lorentzen JC; Malmström V
Article: NATURE GENETICS. 2008;40(10):1216-1223

Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

Raychaudhuri S; Remmers EF; Lee AT; Hackett R; Guiducci C; Burtt NP; Gianniny L; Korman BD; Padyukov L; Kurreeman FAS; Chang M; Catanese JJ; Ding B; Wong S; van der Helm-van Mil AHM; Neale BM; Coblyn J; Cui J; Tak PP; Wolbink GJ; Crusius JBA; van der Horst-Bruinsma IE; Criswell LA; Amos CI; Seldin MF; Kastner DL; Ardlie KG; Alfredsson L; Costenbader KH; Altshuler D; Huizinga TWJ; Shadick NA; Weinblatt ME; de Vries N; Worthington J; Seielstad M; Toes REM; Karlson EW; Begovich AB; Klareskog L; Gregersen PK; Daly MJ; Plenge RM
Article: JOURNAL OF GENERAL VIROLOGY. 2008;89(Pt 9):2262-2268

A 3'-untranslated region polymorphism in the TBX21 gene encoding T-bet is a risk factor for genital herpes simplex virus type 2 infection in humans.

Svensson A; Bergin A-MH; Löwhagen G-B; Tunbäck P; Bellner L; Padyukov L; Eriksson K
Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(8):1111-1115

Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis.

Kling A; Seddighzadeh M; Arlestig L; Alfredsson L; Rantapää-Dahlqvist S; Padyukov L
Article: GENES AND IMMUNITY. 2008;9(5):412-418

Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor.

Ronninger M; Eklöw C; Lorentzen JC; Klareskog L; Padyukov L
Article: JOURNAL OF PERIODONTOLOGY. 2008;79(3):517-524

Local expression of interleukin-10 and mCD14 in relation to the -1087 IL-10 and -159 CD14 gene polymorphisms in chronic periodontitis.

Donati M; Liljenberg B; Padyukov L; Berglundh T
Article: NATURE GENETICS. 2007;39(12):1477-1482

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Plenge RM; Cotsapas C; Davies L; Price AL; de Bakker PIW; Maller J; Pe'er I; Burtt NP; Blumenstiel B; DeFelice M; Parkin M; Barry R; Winslow W; Healy C; Graham RR; Neale BM; Izmailova E; Roubenoff R; Parker AN; Glass R; Karlson EW; Maher N; Hafler DA; Lee DM; Seldin MF; Remmers EF; Lee AT; Padyukov L; Alfredsson L; Coblyn J; Weinblatt ME; Gabriel SB; Purcell S; Klareskog L; Gregersen PK; Shadick NA; Daly MJ; Altshuler D
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2007;357(12):1199-1209

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

Plenge RM; Seielstad M; Padyukov L; Lee AT; Remmers EF; Ding B; Liew A; Khalili H; Chandrasekaran A; Davies LRL; Li W; Tan AKS; Bonnard C; Ong RTH; Thalamuthu A; Pettersson S; Liu C; Tian C; Chen WV; Carulli JP; Beckman EM; Altshuler D; Alfredsson L; Criswell LA; Amos CI; Seldin MF; Kastner DL; Klareskog L; Gregersen PK
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2007;357(10):977-986

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Remmers EF; Plenge RM; Lee AT; Graham RR; Hom G; Behrens TW; de Bakker PIW; Le JM; Lee H-S; Batliwalla F; Li W; Masters SL; Booty MG; Carulli JP; Padyukov L; Alfredsson L; Klareskog L; Chen WV; Amos CI; Criswell LA; Seldin MF; Kastner DL; Gregersen PK
Article: PLOS MEDICINE. 2007;4(9):1515-1524

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.

Kurreeman FAS; Padyukov L; Marques RB; Schrodi SJ; Seddighzadeh M; Stoeken-Rijsbergen G; van der Helm-van Mil AHM; Allaart CF; Verduyn W; Houwing-Duistermaat J; Alfredsson L; Begovich AB; Klareskog L; Huizinga TWJ; Toes REM
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(8):2620-2632

Association of arthritis with a gene complex encoding C-type lectin-like receptors.

Lorentzen JC; Flornes L; Eklöw C; Bäckdahl L; Ribbhammar U; Guo JP; Smolnikova M; Dissen E; Seddighzadeh M; Brookes AJ; Alfredsson L; Klareskog L; Padyukov L; Fossum S
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(7):2202-2210

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.

Sigurdsson S; Padyukov L; Kurreeman FAS; Liljedahl U; Wiman A-C; Alfredsson L; Toes R; Rönnelid J; Klareskog L; Huizinga TWJ; Alm G; Syvänen A-C; Rönnblom L
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2007;80(5):867-875

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.

Kallberg H; Padyukov L; Plenge RM; Ronnelid J; Gregersen PK; van der Helm-van Mil AHM; Toes REM; Huizinga TW; Klareskog L; Alfredsson L; Epidemiological Investigation of Rheumatoid Arthri
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(2):448-452

Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis.

Kastbom A; Bratt J; Ernestam S; Lampa J; Padyukov L; Söderkvist P; Skogh T
Article: ARTHRITIS RESEARCH & THERAPY. 2007;9(5):r98

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.

Olsson LM; Lindqvist A-K; Källberg H; Padyukov L; Burkhardt H; Alfredsson L; Klareskog L; Holmdahl R
Article: HUMAN MUTATION. 2006;27(10):990-998

Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform.

Bergin A-M; Balder B; Kishore S; Swärd K; Hahn-Zoric M; Löwhagen O; Hanson LA; Padyukov L
Article: JOURNAL OF AUTOIMMUNITY. 2006;27(1):62-68

Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis.

Hassan AB; Fathi M; Dastmalchi M; Lundberg IE; Padyukov L
Article: PEDIATRIC RESEARCH. 2006;59(2):254-258

Cytokines in the placenta of Pakistani newborns with and without intrauterine growth retardation.

Amu S; Hahn-Zoric M; Malik A; Ashraf R; Zaman S; Kjellmer I; Hagberg H; Padyukov L; Hanson LA
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(1):38-46

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

Klareskog L; Stolt P; Lundberg K; Källberg H; Bengtsson C; Grunewald J; Rönnelid J; Harris HE; Ulfgren A-K; Rantapää-Dahlqvist S; Eklund A; Padyukov L; Alfredsson L
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2005;77(6):1044-1060

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

Plenge RM; Padyukov L; Remmers EF; Purcell S; Lee AT; Karlson EW; Wolfe F; Kastner DL; Alfredsson L; Altshuler D; Gregersen PK; Klareskog L; Rioux JD
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3639-3645

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

Popovic K; Ek M; Espinosa A; Padyukov L; Harris HE; Wahren-Herlenius M; Nyberg F
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2005;32(5):474-479

Association of the -159 CD14 gene polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians.

Donati M; Berglundh T; Hytönen A-M; Hahn-Zoric M; Hanson L-A; Padyukov L
Article: NATURE GENETICS. 2005;37(5):486-494

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.

Swanberg M; Lidman O; Padyukov L; Eriksson P; Akesson E; Jagodic M; Lobell A; Khademi M; Börjesson O; Lindgren CM; Lundman P; Brookes AJ; Kere J; Luthman H; Alfredsson L; Hillert J; Klareskog L; Hamsten A; Piehl F; Olsson T
Article: ARTHRITIS RESEARCH & THERAPY. 2005;7(6):R1296-R1303

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study.

Sverdrup B; Källberg H; Bengtsson C; Lundberg I; Padyukov L; Alfredsson L; Klareskog L; Epidemiological Investigation of Rheumatoid Arthri
Article: ATHEROSCLEROSIS. 2004;177(2):409-414

The A-1087IL-10 allele is associated with cardiovascular disease in SLE.

Fei G-Z; Svenungsson E; Frostegård J; Padyukov L
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(10):1570-1575

Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma.

Hytönen A-M; Löwhagen O; Arvidsson M; Balder B; Björk AL; Lindgren S; Hahn-Zoric M; Hanson LA; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(10):3085-3092

A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.

Padyukov L; Silva C; Stolt P; Alfredsson L; Klareskog L
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(6):1770-1773

Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope.

Prokunina L; Padyukov L; Bennet A; de Faire U; Wiman B; Prince J; Alfredsson L; Klareskog L; Alarcón-Riquelme M
Article: JOURNAL OF RHEUMATOLOGY. 2004;31(3):422-425

Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women.

Padyukov L; Hytönen A-M; Smolnikova M; Hahn-Zoric M; Nilsson N; Hanson L-A; Tarkowski A; Klareskog L
Article: ARTHRITIS RESEARCH & THERAPY. 2004;6(4):R303-R308

A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis.

Berglin E; Padyukov L; Sundin U; Hallmans G; Stenlund H; Van Venrooij WJ; Klareskog L; Dahlqvist SR
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2003;23(4):291-296

Association of -1087 IL10 and -308 TNFA gene polymorphisms with serological markers of coeliac disease.

Hahn-Zoric M; Hytönen AM; Hanson LA; Nilsson LA; Padyukov L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2003;62(6):526-529

Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis.

Padyukov L; Lampa J; Heimbürger M; Ernestam S; Cederholm T; Lundkvist I; Andersson P; Hermansson Y; Harju A; Klareskog L; Bratt J
Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2003;30(3):249-254

Association of the -1087 IL 10 gene polymorphism with severe chronic periodontitis in Swedish Caucasians.

Berglundh T; Donati M; Hahn-Zoric M; Hanson L-A; Padyukov L
Article: HUMAN IMMUNOLOGY. 2003;64(2):290-296

MICA4/HLA-DRB1*04/TNF1 haplotype is associated with mixed connective tissue disease in Swedish patients.

Hassan AB; Nikitina-Zake L; Padyukov L; Karlsson G; Gupta M; Lundberg IE; Sanjeevi CB
Article: LANCET. 2002;360(9349):1935-1939

Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia.

Thunberg U; Tobin G; Johnson A; Söderberg O; Padyukov L; Hultdin M; Klareskog L; Enblad G; Sundström C; Roos G; Rosenquist R
Article: GENES AND IMMUNITY. 2001;2(5):280-283

Different allelic frequencies of several cytokine genes in Hong Kong Chinese and Swedish Caucasians.

Padyukov L; Hahn-Zoric M; Lau YL; Hanson LA
Article: IMMUNOGENETICS. 2001;53(1):22-30

Distribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in Swedish Caucasians and Hong Kong Chinese.

Padyukov L; Hahn-Zoric M; Blomqvist SR; Ulanova M; Welch SG; Feeney AJ; Lau YL; Hanson LA
Article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 2000;(5):15-19

[Common epitopes of protein antigens in Neisseria and Moraxella].

Goncharenko AV; Filatova TN; Padiukov LN; Baturo AP
Article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1998;(6):98-102

[Protein antigens of Branhamella (Moraxella) catarrhalis and Neisseria meningitidis].

Goncharenko AV; Filatova TN; Padiukov LN
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 1997;8(3):127-133

Variable increases of IgG and IgM antibodies in milk of IgA deficient women.

Hahn-Zoric M; Carlsson B; Björkander J; Mellander L; Friman V; Padyukov L; Hanson LA
Article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1995;(2):26-30

[The protein antigens of Streptococcus pneumoniae].

Padiukov LN; Pugacheva NL
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1990;(8):88-93

[The indices of antipneumococcal immunity in children with chronic pneumonia].

Ulanova MA; Padiukov LN; Volkov IK; Katosova LK; Sidorina TM; Sapargel'dyev A
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1990;(7):65-71

[Antibodies to Streptococcus pneumoniae antigens in newborn infants].

Ulanova MA; Sharapova MK; Mikhaĭlova ZM; Afonina LG; Padiukov LN
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1990;(2):55-62

[The characteristics of the humoral immune response to Streptococcus pneumoniae in children: The determination of antibodies in the blood serum, pleural fluid and saliva].

Ulanova MA; Padiukov LN; Tatochenko VK; Kulak IV; Katosova LK; Pugacheva NL; Aseeva VG
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1989;(3):89-92

[Use of isoelectric focusing in studying the composition of allergens from mites].

Emel'ianova OI; Berzhets VM; Padiukov LN; Sipitsyna NE; Taranov VA
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1987;(9):112-115

[Determination of pneumococcus antibodies in secretions in acute pneumonia in children].

Ulanova MA; Padiukov LN; Katosova LK; Tolkachev AM
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1987;(1):8-12

[Comparative analysis of antigenic preparations made from noncapsular strains of Pneumococcus].

Nisilevich VF; Pugacheva NL; Padiukov LN; Gruber IM; Reshilov LN
Journal article: CARBOHYDRATE RESEARCH. 1985;141(2):199-212

Two synthetic antigens related to Streptococcus pneumoniae type 3 capsular polysaccharide.

Chernyak AYa; Antonov KV; Kochetkov NK; Padyukov LN; Tsvetkova NV
Journal article: ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII. 1985;(3):23-28

[High-molecular antigenic complex of the pneumococcus: its properties].

Rodionychev EA; Krasnoproshina LI; Padiukov LN; Tsvetkova NV
Journal article: BIOORGANICHESKAYA KHIMIYA. 1984;10(10):1376-1384

[A carbohydrate-containing copolymer with the specificity of a capsular polysaccharide of type 3 Streptococcus pneumoniae].

Cherniak AI; Antonov KV; Dmitriev BA; Kochetkov NK; Padiukov LN
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Xiong Y; Kullberg S; Garman L; Pezant N; Ellinghaus D; Vasila V; Eklund A; Rybicki BA; Iannuzzi MC; Schreiber S; Müller-Quernheim J; Montgomery CG; Grunewald J; Padyukov L; Rivera NV
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Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH; Stacey D; Eriksson N; Macdonald-Dunlop E; Hedman ÅK; Kalnapenkis A; Enroth S; Cozzetto D; Digby-Bell J; Marten J; Folkersen L; Herder C; Jonsson L; Bergen SE; Gieger C; Needham EJ; Surendran P; Estonian Biobank Research Team; Paul DS; Polasek O; Thorand B; Grallert H; Roden M; Võsa U; Esko T; Hayward C; Johansson Å; Gyllensten U; Powell N; Hansson O; Mattsson-Carlgren N; Joshi PK; Danesh J; Padyukov L; Klareskog L; Landén M; Wilson JF; Siegbahn A; Wallentin L; Mälarstig A; Butterworth AS; Peters JE
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Correction to: Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis.
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Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality.

Oddsson A; Sulem P; Sveinbjornsson G; Arnadottir GA; Steinthorsdottir V; Halldorsson GH; Atlason BA; Oskarsson GR; Helgason H; Nielsen HS; Westergaard D; Karjalainen JM; Katrinardottir H; Fridriksdottir R; Jensson BO; Tragante V; Ferkingstad E; Jonsson H; Gudjonsson SA; Beyter D; Moore KHS; Thordardottir HB; Kristmundsdottir S; Stefansson OA; Rantapää-Dahlqvist S; Sonderby IE; Didriksen M; Stridh P; Haavik J; Tryggvadottir L; Frei O; Walters GB; Kockum I; Hjalgrim H; Olafsdottir TA; Selbaek G; Nyegaard M; Erikstrup C; Brodersen T; Saevarsdottir S; Olsson T; Nielsen KR; Haraldsson A; Bruun MT; Hansen TF; DBDS Genomic Consortium; Steingrimsdottir T; Jacobsen RL; Lie RT; Djurovic S; Alfredsson L; Lopez de Lapuente Portilla A; Brunak S; Melsted P; Halldorsson BV; Saemundsdottir J; Magnusson OT; Padyukov L; Banasik K; Rafnar T; Askling J; Klareskog L; Pedersen OB; Masson G; Havdahl A; Nilsson B; Andreassen OA; Daly M; Ostrowski SR; Jonsdottir I; Stefansson H; Holm H; Helgason A; Thorsteinsdottir U; Stefansson K; Gudbjartsson DF
Preprint: MEDRXIV. 2023

Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-related disease risk and novel therapeutic targets

consortium TS; Zhao JH; Stacey D; Eriksson N; Macdonald-Dunlop E; Hedman ÅK; Kalnapenkis A; Enroth S; Cozzetto D; Digby-Bell J; Marten J; Folkersen L; Herder C; Jonsson L; Bergen SE; Geiger C; Needham EJ; Surendran P; Team EBR; Paul DS; Polasek O; Thorand B; Grallert H; Roden M; Võsa U; Esko T; Hayward C; Johansson Å; Gyllensten U; Powell N; Hansson O; Mattsson-Carlgren N; Joshi PK; Danesh J; Padyukov L; Klareskog L; Landén M; Wilson JF; Siegbahn A; Wallentin L; Mälarstig A; Butterworth AS; Peters JE
Conference publication: 2023;:a16.2-a1a17

O-184 Occupational inhaled agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking

Alfredsson L; Tang B; Liu Q; Ilar A; Wiebert P; Padyukov L; Klareskog L
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):416

LOW GENE COPY NUMBERS OF COMPLEMENT C4 AND COMPLEMENT C4A DEFICIENCY ARE STRONG AND HIGHLY SIGNIFICANT GENETIC RISK FACTORS FOR IDIOPATHIC INFLAMMATORY MYOPATHY AND ITS MAJOR SUBGROUPS

Zhou D; King EH; Rothwell S; Krystufkova O; Notarnicola A; Aziz RA; Lundstrom E; Blanka S; Pachman LM; Mamyrova G; de Paepe B; de Bleecker J; O'Hanlon TP; Coss S; Miller KL; Dang A; Yu GR; Drew J; Sivaraman V; Oberle E; Akoghlanian S; Driest K; Spencer CH; Wu YL; Ardoin SP; Rider LG; Chinoy H; Miller FW; Lundberg IE; Padyukov L; Vencovsky J; Lamb JA; Yu C-Y
Letter: ARTHRITIS RESEARCH & THERAPY. 2022;24(1):239

Response to Comment "Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference" on "Age at menarche, age at natural menopause, and risk of rheumatoid arthritis-a Mendelian randomization study".

Zhu J; Niu Z; Alfredsson L; Klareskog L; Padyukov L; Jiang X
Review: SEMINARS IN IMMUNOPATHOLOGY. 2022;44(1):47-62

Genetics of rheumatoid arthritis.

Padyukov L
Letter: ARTHRITIS & RHEUMATOLOGY. 2021;73(10):1944-1945

Reply.

Tang B; Alfredsson L; Klareskog L; Padyukov L; Shi H; Jiang X
Preprint: MEDRXIV. 2021;MEDRXIV

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.

Klaric L; Gisby JS; Papadaki A; Muckian MD; Macdonald-Dunlop E; Zhao JH; Tokolyi A; Persyn E; Pairo-Castineira E; Morris AP; Kalnapenkis A; Richmond A; Landini A; Hedman ÅK; Prins B; Zanetti D; Wheeler E; Kooperberg C; Yao C; Petrie JR; Fu J; Folkersen L; Walker M; Magnusson M; Eriksson N; Mattsson-Carlgren N; Timmers PRHJ; Hwang S-J; Enroth S; Gustafsson S; Vosa U; Chen Y; Siegbahn A; Reiner A; Johansson Å; Thorand B; Gigante B; Hayward C; Herder C; Gieger C; Langenberg C; Levy D; Zhernakova DV; Smith JG; Campbell H; Sundstrom J; Danesh J; Michaëlsson K; Suhre K; Lind L; Wallentin L; Padyukov L; Landén M; Wareham NJ; Göteson A; Hansson O; Eriksson P; Strawbridge RJ; Assimes TL; Esko T; Gyllensten U; Baillie JK; Paul DS; Joshi PK; Butterworth AS; Mälarstig A; Pirastu N; Wilson JF; Peters JE
Review: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):514-533

The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis.

Klareskog L; Rönnelid J; Saevarsdottir S; Padyukov L; Alfredsson L
Corrigendum: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;105(4):880

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype.

Terao C; Brynedal B; Chen Z; Jiang X; Westerlind H; Hansson M; Jakobsson P-J; Lundberg K; Skriner K; Serre G; Rönnelid J; Mathsson-Alm L; Brink M; Dahlqvist SR; Padyukov L; Gregersen PK; Barton A; Alfredsson L; Klareskog L; Raychaudhuri S
Letter: RHEUMATOLOGY. 2019;58(2):361-363

Clinical phenotype, autoantibody profile and HLA-DR-type in Vietnamese patients with idiopathic inflammatory myopathies.

Nguyen Thi Phuong T; Nguyen Thi Ngoc L; Nguyen Xuan H; Rönnelid J; Padyukov L; Lundberg IE
Corrigendum: GENES AND IMMUNITY. 2017;18(2):109

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.

Guerreiro-Cacais AO; Norin U; Gyllenberg A; Berglund R; Beyeen AD; Rheumatoid Arthritis Consortium International (RAC; Petit-Teixeira E; Cornélis F; Saoudi A; Fournié GJ; Holmdahl R; Alfredsson L; Klareskog L; Jagodic M; Olsson T; Kockum I; Padyukov L
Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(42):E6323-E6324

Reply to Liu et al.: Translation of rat congenic data to humans on a conserved MHC-III haplotype associated with rheumatoid arthritis.

Yau ACY; Houtman M; Padyukov L; Holmdahl R
Letter: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2016;111(8):1211-1213

HLA Associations Distinguish Collagenous From Lymphocytic Colitis.

Westerlind H; Bonfiglio F; Mellander M-R; Hübenthal M; Brynedal B; Björk J; Törkvist L; Padyukov L; Ohlsson B; Löfberg R; Hultcrantz R; Franke A; Bresso F; D'Amato M
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2014;73(9):1750-1752

Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.

Jani M; Massey J; Wedderburn LR; Vencovský J; Danko K; Lundberg IE; Padyukov L; Selva-O'Callaghan A; Radstake T; Platt H; Warren RB; Griffiths CE; Lee A; Gregersen PK; Miller FW; Ollier WE; Cooper RG; Chinoy H; Lamb JA; EUMYONET
Letter: NATURE GENETICS. 2013;45(5):468-469

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.

Plenge RM; Greenberg JD; Mangravite LM; Derry JMJ; Stahl EA; Coenen MJH; Barton A; Padyukov L; Klareskog L; Gregersen PK; Mariette X; Moreland LW; Bridges SL; de Vries N; Huizinga TWJ; Guchelaar H-J; International Rheumatoid Arthritis Consortium (INT; Friend SH; Stolovitzky G
Corrigendum: PLOS ONE. 2012;7(10):10.1371/annotation/2ca25d

Correction: A Replication Study Confirms the Association of Dendritic Cell Immunoreceptor (DCIR) Polymorphisms with ACPA - Negative RA in a Large Asian Cohort.

Guo J; Wu X; Too CL; Yin F; Lu X; He J; Li R; Liu X; Murad S; Padyukov L; Li Z
Corrigendum: NATURE GENETICS. 2011;43(5):499

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus (vol 42, pg 426, 2010)

Radstake TRDJ; Gorlova O; Rueda B; Martin J-E; Alizadeh BZ; Palomino-Morales R; Coenen MJ; Vonk MC; Voskuyl AE; Schuerwegh AJ; Broen JC; van Riel PLCM; Van't Slot R; Italiaander A; Ophoff RA; Riemekasten G; Hunzelmann N; Simeon CP; Ortego-Centeno N; Gonzalez-Gay MA; Gonzalez-Escribano MF; Airo P; van Laar J; Herrick A; Worthington J; Hesselstrand R; Smith V; de Keyser F; Houssiau F; Chee MM; Madhok R; Shiels P; Westhovens R; Kreuter A; Kiener H; de Baere E; Witte T; Padykov L; Klareskog L; Beretta L; Scorza R; Lie BA; Hoffmann-Vold A-M; Carreira P; Varga J; Hinchcliff M; Gregersen PK; Lee AT; Ying J; Han Y; Weng S-F; Amos CI; Wigley FM; Hummers L; Nelson JL; Agarwal SK; Assassi S; Gourh P; Tan FK; Koeleman BPC; Arnett FC; Martin J; Mayes MD
Review: SEMINARS IN IMMUNOLOGY. 2011;23(2):92-98

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.

Klareskog L; Malmström V; Lundberg K; Padyukov L; Alfredsson L
Corrigendum: NATURE GENETICS. 2011;43(4):388

Genome-wide association identifies multiple ulcerative colitis susceptibility loci (vol 42, pg 332, 2010)

McGovern DPB; Gardet A; Toerkvist L; Goyette P; Essers J; Taylor KD; Neale BM; Ong RTH; Lagace C; Li C; Green T; Stevens CR; Beauchamp C; Fleshner PR; Carlson M; D'Amato M; Halfvarson J; Hibberd ML; Loerdal M; Padyukov L; Andriulli A; Colombo E; Latiano A; Palmieri O; Bernard E-J; Deslandres C; Hommes DW; de Jong DJ; Stokkers PC; Weersma RK; Sharma Y; Silverberg MS; Cho JH; Wu J; Roeder K; Brant SR; Schumm LP; Duerr RH; Dubinsky MC; Glazer NL; Haritunians T; Ippoliti A; Melmed GY; Siscovick DS; Vasiliauskas EA; Targan SR; Annese V; Wijmenga C; Pettersson S; Rotter JI; Xavier RJ; Daly MJ; Rioux JD; Seielstad M
Editorial comment: FERTILITY AND STERILITY. 2011;95(1):437-440

Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.

Sundqvist J; Falconer H; Seddighzadeh M; Vodolazkaia A; Fassbender A; Kyama C; Bokor A; Stephansson O; Padyukov L; Gemzell-Danielsson K; D'Hooghe TM
Editorial comment: GENOME MEDICINE. 2010;2(12):89

Report of the 60th annual meeting of the American Society of Human Genetics: several steps toward discoveries.

Padyukov L
Meeting abstract: MOLECULAR IMMUNOLOGY. 2010;47(13):2285

Low gene copy-number of complement C4A, the presence of HLA-DR3, and the presence of HLA-DR2 are independent and additive risk factors for human systemic lupus erythematosus

Wu YL; Lundstrom E; Liu C-C; Yang Y; Gunnarsson I; Svenungsson E; Zhou B; Jones KN; Nagaraja HN; Higgins GC; Spencer C; Brunner H; Birmingham DJ; Rovin BH; Tsao BP; Ahearn JM; Hebert LA; Padyukov L; Yu CY
Letter: INFLAMMATORY BOWEL DISEASES. 2010;16(6):907-909

Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.

Törkvist L; Halfvarson J; Ong RTH; Lördal M; Sjöqvist U; Bresso F; Björk J; Befrits R; Löfberg R; Blom J; Carlson M; Padyukov L; D'Amato M; Seielstad M; Pettersson S
Meeting abstract: CLINICAL IMMUNOLOGY. 2010;135:S114

Genetic Study of IgA Nephropathy and Lupus Nephritis: No Overlap in Genetic Risk Factors

Vuong M; Gunnarsson I; Lundberg S; Wramner L; Fernstrom A; Syvanen A-C; Do L; Jacobson S; Padyukov L
Editorial comment: ARTHRITIS & RHEUMATOLOGY. 2008;58(9):2591-2597

Genome-wide single-nucleotide polymorphism studies in rheumatology: hype or hope?

van der Helm-van Mil AHM; Padyukov L; Toes REM; Klareskog L; Huizinga TWJ
Review: ANNUAL REVIEW OF IMMUNOLOGY. 2008;26:651-675

Immunity to citrullinated proteins in rheumatoid arthritis.

Klareskog L; Rönnelid J; Lundberg K; Padyukov L; Alfredsson L
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S41

Combined analysis of three genome-wide scans reveals additional loci associated with rheumatoid arthritis

Seielstad M; Padyukov L; Ke X; Ding B; Tantoso E; Ong THR; Alfredsson L; Plenge R; Gregersen P; Worthington J; Klareskog L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2008;58(9):S516

MBL2 genotypes related to high mannan binding lectin levels may predispose to RF negative and/or ACPA negative rheumatoid arthritis among never smokers

Saevarsdottir S; Ding B; Klareskog L; Alfredsson L; Padyukov L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2008;58(9):S215

Gene-environment interaction involving HLA-DRB1 shared epitope Alleles and smoking in ACPA-positive rheumatoid arthritis

Lundstrom E; Kallberg H; Alfredsson L; Klareskog L; Padyukov L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2008;58(9):S620

A common variant at the CD40 locus confers risk of rheumatoid

Raychaudhuri S; Remmers EF; Lee AT; Korman BD; Padyukov L; Kurreeman FAS; Mil AHMVDH-V; Coblyn J; Criswell LA; Amos CI; Seldins MF; Kastner DL; Alfredsson L; Huzinga TWJ; Shadick NA; Weinblatt ME; Worthington J; Seielstad M; Toes REM; Karlson EW; Begovich AB; Klareskog L; Gregersen PK; Daly MJ; Plenge RM
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2008;67:A45

Association and linkage of the TRAF1/C5 region with specific subsets of rheumatoid arthritis

Kurreeman F; Padyukov L; Marques R; Schrodi S; Seddighzadeh M; Stoeken-Rijsbergen G; Van der Helm-Van Mil A; Allaart C; Verduyn W; Housing-Duistermaat J; Alsfredsson L; Begovich A; Petit-Texeira E; Cornelis F; Klareskog L; Huizinga T; Toes R
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S151

Evidence for genetic regulation of Fc alpha receptor (CD89) expression:: Study of soluble CD89 in plasma of IgA nephropathy patients and healthy controls

Hahn-Zoric M; Vuong M; Lundberg S; Wramner L; Ahlmen J; Hanson LA; Gunnarsson I; Jacobson S; Padyukov L
Corrigendum: PLOS MEDICINE. 2007;4(12):e358-2013

Correction: A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis
Meeting abstract: CLINICAL IMMUNOLOGY. 2007;123:S54-S55

Immunoassays for detection of soluble fc alpha receptor (CD89) in plasma of IgA nephropathy patients

Hahn-Zoric M; Tahmasebifar N; van Kooten C; Ahlmen J; Swerkersson S; Hansson S; Berg U; Hanson LA; Padyukov L; Jacobson SH
Review: CURRENT OPINION IN RHEUMATOLOGY. 2007;19(1):49-54

Smoking as a trigger for inflammatory rheumatic diseases.

Klareskog L; Padyukov L; Alfredsson L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:48

Gene-gene and gene-environment interactions: What we can learn from a study of rheumatoid arthritis?

Padyukov L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:135

A SNP in NCF4 is associated with RF negative RA supporting a role for the nox-complex in autoimmunity

Olsson L; Lindqvist A; Padyukov L; Klareskog L; Burkhardt H; Holmdahl R
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:680

A genome-wide SNP association study identifies novel risk loci for rheumatoid arthritis in Swedish eira study

Seielstad M; Padyukov L; Ding B; Plenge RM; Alfredsson L; Klareskog L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:291

Smoking is associated with anti-CCP positive RA in a dose dependent manner, results from the Swedish eira study

Kallberg H; Padyukov L; Bengtsson C; Ronnelid J; Klareskog L; Alfredsson L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:136

GSTM1 gene and a risk of rheumatoid arthritis

Lundstroem E; Alfredsson L; Klareskog L; Padyukov L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:136

Association of genetic variations in mhc2ta gene with rheumatoid arthritis

Seddighzadeh M; Kockum L; Olsson T; Klareskog L; Padyukov L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:92-93

Ethanol consumption is associated with decreased risks for developing RA results from the Swedish EIRA study

Kallberg H; Padyukov L; Ronnelid J; Klareskog L; Alfredsson L
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2007;37:30

Polymorphisms in the interferon regulatory factor 5 gene are associated with anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis

Sigurdsson S; Padyukov L; Liljedahl U; Alfredsson L; Klareskog L; Alm G; Ronnblom L; Syvanen A
Review: CURRENT OPINION IN IMMUNOLOGY. 2006;18(6):650-655

Genes, environment and immunity in the development of rheumatoid arthritis.

Klareskog L; Padyukov L; Rönnelid J; Alfredsson L
Review: NATURE CLINICAL PRACTICE RHEUMATOLOGY. 2006;2(8):425-433

Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis.

Klareskog L; Padyukov L; Lorentzen J; Alfredsson L
Review: NESTLE NUTRITION WORKSHOP SERIES: PEDIATRIC PROGRAM. 2006;57:223-233

Perinatal PUFA intake affects leptin and oral tolerance in neonatal rats and possibly immunoreactivity in intrauterine growth retardation in man.

Hanson LA; Korotkova M; Hahn-Zoric M; Zaman S; Malik A; Ashraf R; Amu S; Padyukov L; Telemo E; Strandvik B
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2006;65:131

Silica exposure is associated with increased risk of a restricted sub-group of

Stolt P; Padyukov L; K HJ; Lundberg I; Klareskog L; Alfredsson L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2006;54(9):S535-S536

A gene-gene interaction between PTPN22 and HLA-DRB1 SE alleles regarding anti-CCP positive rheumatoid arthritis.: Results from the Swedish EIRA study.

Alfredsson L; Källberg H; Plenge RM; Rönnelid J; Padyukov L; Klareskog L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2006;54(9):S129

The FCGR3A-158V/F genotype correlates to RA susceptibility in men, but does not predict therapy response to TNF blocking agents.

Kastbom A; Bratt J; Ernestam S; Lampa J; Klareskog L; Padyukov L; Söderkvist P; Skogh T
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2006;35:29-30

Polymorphisms in the Interferon Regulatory Factor 5 Gene are associated with systemic lupus erythematosus and rheumatoid arthritis

Sigurdsson S; Kristjansdottir G; Padyukov L; Lijedahl U; Alfredsson L; Ronnelid J; Klareskog L; Alm G; Syvanen A-C; Ronnblom L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2006;65:131

Is there a gene-environment interaction between smoking and PTPN22 regarding anti-CCP positive RA?: Results from the Swedish EIRA study

Kallberg HJ; Padyukov L; Plenge RM; Ronnelid J; Klareskog L; Alfredsson L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2006;65:75

A gene-gene interaction between PTPN22 and HLA-DRB1 SE genes regarding anti-CCP positive RA.: Results from the Swedish eira study

Alfredsson L; Kallberg H; Padyukov L; Plenge RM; Ronnelid J; Klareskog L
Letter: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3676-3678

The interaction of smoking and the HLA-DRB1 shared epitope in rheumatoid factor-positive rheumatoid arthritis:: comment on the article by Padyukov et al -: Reply

Padyukov L; Alfredsson L; Källberg H; Bengtsson C; Klareskog L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2005;52(9):S404

Silica exposure is associated with increased risk of a restricted sub-group of rheumatoid arthritis linked to antibodies to cyclic citrullinated peptides.

Stolt P; Padyukov L; Källberg H; Lundberg I; Klareskog L; Alfredsson L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2005;52(9):S152

Association between mineral oil exposure and Rheumatoid Arthritis.

Sverdrup B; Bengtsson C; Källberg H; Padyukov L; Lundberg I; Klareskog L; Alfredsson L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2005;64:165

A new model for an etiology of RA;: Smoking may trigger HLA-DR (SE)-restricted immune reactions to autoantigens modified by citruillination

Klareskog L; Stolt P; Lundberg K; Källberg H; Silva C; Grunewald J; Rönnelid J; Harris HE; Ulfgren A; Dahlqvist SR; Eklund A; Padyukov L; Alfredsson L
Published conference paper: ANNALS OF THE RHEUMATIC DISEASES. 2004;63 Suppl 2(Suppl 2):ii28-ii31

What precedes development of rheumatoid arthritis?

Klareskog L; Alfredsson L; Rantapää-Dahlqvist S; Berglin E; Stolt P; Padyukov L
Published conference paper: TRANSPLANTATION. 2004;78(1):117-121

Impaired kidney graft survival is associated with the TNF-alpha genotype.

Wramner LG; Norrby J; Hahn-Zoric M; Ahlmén J; Börjesson P-A; Carlström J; Hytönen A-M; Olausson M; Hanson LA; Padyukov L
Letter: ARTHRITIS & RHEUMATOLOGY. 2004;50(3):1013-1015

Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03) with polymyositis and dermatomyositis.

Hassan AB; Nikitina-Zake L; Sanjeevi CB; Lundberg IE; Padyukov L
Letter: RHEUMATOLOGY. 2004;43(1):104-105

Common NOD2 polymorphisms in Hong Kong Chinese patients with systemic lupus erythematosus.

Chong WP; Ip WK; Lau CS; Chan TM; Padyukov L; Lau YL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2004;63:164

Smoking is associated with occurrence of anti-CCP antibodies and is a risk factor only for anti-CCP antibody positive RA

Padyukov L; Ronnelid J; Stolt R; Alfredsson L; Klareskog L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S678-S679

Antibodies against cyclic citrullinated peptide (CCP) and shared epitope predict rheumatoid arthritis.

Berglin E; Padyukov L; Hallmans G; van Venrooji WJ; Klareskog L; Dahlqvist SR
Conference publication: JOURNAL OF DENTAL RESEARCH. 2003;82:B114

Association of the-159 CD14 gene polymorphism with severe chronic periodontitis in Swedish caucasians.

Donati M; Berglundh T; Hytonen A-M; Hahn-Zoric M; Hanson L; Padyukov L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S144

Interaction between smoking and shared epitope genes in HLA-DR provides a high risk for seropositive rheumatoid arthritis.

Bengtsson C; Padyukov L; Stolt P; Alfredsson L; Klareskog L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2003;62:134

Risk for rheumatoid arthritis in smokers is associated with the presence of shared epitope genes

Padyukov L; Bengtsson C; Stolt P; Diab D; Nise L; Alfredsson L; Klareskog L
Review: ARTHRITIS RESEARCH & THERAPY. 2002;4 Suppl 3(Suppl 3):S31-S36

Genes and environment in arthritis: can RA be prevented?

Klareskog L; Lorentzen J; Padyukov L; Alfredsson L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2002;46(9):S34-S35

The functional role of-1087 IL10 polymorphism in the development of atherosclerosis in female SLE patients

Fei GZ; Svenungsson E; Padyukov L; Frostegard J
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2002;46(9):S136-S137

Association between IL10 gene polymorphism and clinical response to infliximab in rheumatoid arthritis

Lampa J; van Vollenhoven RF; Klareskog L; Padyukov L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2001;44(9):S351

Increased frequency of the TNFA-308A allele in poly- and dermatomyositis.

Lundberg IE; Hassan AB; Padyukov L
Review: LAKARTIDNINGEN. 2000;97(15):1823-1826

[The immune system of the hunter-gatherer meets poverty and excess].

Hanson LA; Padyukov L; Strandvik B; Wramner L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2000;43(9):S230

Association of cytokine promoter polymorphisms with the clinical effect of soluble TNF receptor therapy in rheumatoid arthritis.

Lampa J; Berg L; Harju A; Klareskog L; Padyukov L
Conference publication: AIDS. 1996;10:P67

Prevalence of HCV among HIV-1-seropositive patients in Moscow region, Russia

Bobkova M; Sankov M; Padyukov L; Ladnaya NN; Buravtsova EV
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