Lina Marcela Diaz-Gallo

Lina Marcela Diaz-Gallo

Research Specialist
Visiting address: D2:01, Karolinska Universitetssjukhuset, 17177 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Klareskog L Padyukov L, 171 77 Stockholm
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About me

  • My research aims to uncover homogenous subgroups of patients with autoimmune
    diseases by integrating relevant data domains to contribute to developing
    prevention-precision medicine in this field.
    I'm specialized in genetics and genomics in the context of autoimmune
    diseases. I have experience in applied bioinformatics, designing, leading,
    and executing analyses of different data domains to contribute to
    translational research. I have mostly used R and Python programming
    languages and implemented diverse bioinformatic tools.
    I really enjoy interacting with people in different settings, such as our
    international and diverse workplace, the Division of Rheumatology [1], where
    I have met excellent human beings and scientists. Through teaching, I
    contribute to empowering people, which is part of my professional role. I'm
    constantly improving and broadening my research and teaching skills. I
    organize and teach the basic bioinformatic course [2].

    [1] https://ki.se/en/meds/rheumatology
    [2] https://kiwas.ki.se/katalog/kursplan/show/4477

Research

  • My research line aims to identify and characterize homogenous subgroups of
    patients with rheumatic and musculoskeletal diseases (/RMDs/) by integrating
    relevant disease data domains, such as genetics, genomics, clinical
    variables, and immunological profiles. To achieve that my research is woven
    into other study areas such as immunology and epidemiology. I have been
    studying rheumatoid arthritis (RA), systemic lupus erythematosus (SLE),
    systemic scleroderma (SSc), and idiopathic inflammatory myopathies (IIM).
    During my postdoc, I contributed to understanding how gene-gene interactions
    are important for the genetic susceptibility and heritability of RA
    (pubmed:29967194 [1]). I, together with my collaborators, have demonstrated
    that autoantibodies can be used to identify more homogeneous subgroups of
    patients with SLE (pubmed: 34658170 [2] pubmed:35315244
    [3] pubmed:35642868 [4]) or IIM (pubmed:35315244 [5] preprint [6]), which
    differ in genetic risk factors and probably in pathogenic mechanisms.
    In collaboration with Associate Professor Karine Chemin [7], we are exploring
    the role of T-cells at the site of inflammation of RMDs and aim to integrate
    the results from those projects into the subsetting of patients suffering
    from RMDs.
    [1] https://www.ncbi.nlm.nih.gov/pubmed/?term=Systematic+approach+demonstrates+enrichment+of+multiple+interactions+between+non-HLA+risk+variants+and+HLA-DRB1+risk+alleles+in+rheumatoid+arthritis
    [2] https://pubmed.ncbi.nlm.nih.gov/34658170/
    [3] https://pubmed.ncbi.nlm.nih.gov/35315244/
    [4] https://pubmed.ncbi.nlm.nih.gov/35642868/
    [5] https://pubmed.ncbi.nlm.nih.gov/35315244/
    [6] https://t.co/bcIwYEhljl
    [7] https://staff.ki.se/people/karine-chemin

Teaching

  • I am the director of the annual doctoral course in basic bioinformatics [1].
    [1] https://kiwas.ki.se/katalog/kursplan/show/4477

Articles

All other publications

Employments

  • Research Specialist, Department of Medicine, Karolinska Institutet, 2023-
  • Assistant Professor, Department of Medicine, Karolinska Institutet, 2018-2023
  • Postdoctoral Researcher, Department of Medicine, Karolinska Institutet, 2013-2018

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