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Lindsay Davies

Affiliated to research

About me

Publications

Original articles

1. The Potential of IGF-1 for Promoting Adult Articular Cartilage Repair: an in Vitro Study. LC Davies, Blain EJ, Gilbert SJ, Caterson B, Duance VC. Tissue Engineering Part A. 2008 Jul;14(7):1251-61PMID: 18399732 

2. Chondroitin Sulphate Impedes the Migration of a Sub-Population of Articular Cartilage Chondrocytes. LC Davies, Blain EJ, Caterson B, Duance VC. Osteoarthritis and Cartilage, 2008 Aug;16(8):855-64 PMID: 18222711

3. Increased Oral Fibroblast Lifespan is Telomerase-Independent. S Enoch, Wall I, Peake M, Davies L, Farrier J, Giles P, Baird D, Kipling D, Price PMoseley R, Thomas D, Stephens P. Journal of Dental Research, 2009 Oct; 88(10):916-21 

4. A Multipotent Neural Crest Derived Progenitor Cell Population is Resident within the Oral Mucosa Lamina Propria. LC Davies, Locke M, Webb RJ, Roberts JT, Langley M, Thomas DW, Archer C, Stephens P. Stem Cells and Development, 2010 June; 19(6):819-30 PMID: 20132052 

5. ‘Young’ Oral Fibroblasts are Geno/phenotypically Distinct. S Enoch, Wall I, Peake M, Davies L, Farrier J, Giles P, Baird D, Kipling D, Price PMoseley R, Thomas D, Stephens P. Journal of Dental Research, 2010 Dec; 89(12) 1407-13 

6. Oral Mucosal Progenitor Cells are Potently Immunosuppressive in a Dose Independent Manner. LC Davies, Lönnies H, Locke M, Sundberg B, Rosendahl K, Götherström C, Le Blanc K, Stephens P. Stem Cells and Development. 2012 June 10;21(9):1478-87 PMID: 21988324

7. Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties? G Moll, Alm JA*,Davies LC*, von Bahr L, Heldring N, Stenbeck-Funke L, Hamad OA, Hinsch R, Ignatowicz L, Locke M, Lönnies H, Lambris JD, Teramura Y, Nilsson-Ekdahl K, Nilsson B, Le Blanc K * Equal contribution Stem Cells 2014 Sep;32(9):2430-42 PMID: 24805247

8. Identification of a transcriptional signature for the wound healing continuum. MA Peake, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW, Stephens P Wound Repair and Regeneration 2014 May-Jun;22(3):399-405 PMID:  24844339 

9. Oral Mucosal Lamina Propria-Progenitor Cells Exert Antibacterial Properties via the Secretion of Osteoprotegerin and Haptoglobin. Board-Davies E,Moses R, Sloan A, Stephens P, Davies LC Stem Cells Translational Medicine 2015 Nov;4(11):1283-93 PMID: 26378260 

10.Enhanced oral healing following local mesenchymal stromal cell therapy. Garming-Legert K, Tour G, Sugars R, von BahrL, Davies LC, Le Blanc K Oral Oncology 2015Dec;51(12):e97-9 PMID:26428076 

11. Oral mucosal progenitor cell clones resist in vitro myogenic differentiation. Locke M, Davies L, Stephens PArch. Oral Biol. 2016 Jun;70():100-110 PMID:27343692

12.Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro. Davies LC, Alm JJ, Heldring N, Moll G, Gavin C, Batsis I, Qian H, Sigvardsson M, Nilsson B, Kyllonen LE, Salmela KT, Carlsson PO, Korsgren O, Le Blanc K. Stem Cells Transl Med. 2016 Nov;5(11):1485-1495 PMID: 27412884 

13.Mesenchymal Stromal Cell Secretion of PD-1 Ligands Regulates T Cell Mediated Immunosuppression. Davies LC, Heldring N, Kadri N, Le Blanc K. Stem Cells. 2017 Mar;35(3):766-776 PMID: 27671847

14. Stromal Progenitor Cell Modulation by Thalidomide in the Treatment of Oral Chronic Graft versus Host Disease. Davies LC, Board-Davies E, Shamlou B, Boberg, E, Garming-Legert K, Le Blanc K. Cytotherapy. 2018 May;20(5):755-758.PMID: 29580863

15. Phenotypic and functional alterations of myeloid derived suppressor cells during multiple sclerosis disease course. Iacobaeus E, Douagi I, Jitschin R, Marcusson-Ståhl M, Törnqvist Andrén A, Gavin C, Lefsihane K, Davies LC, Mougiakakos D, Kadri N, Le Blanc K. Immunology & Cell Biology. 2018 Sep;96(8):820-830 PMID:29569304 

16. Nagubothu SR, Sugars RV, Davies LC, Tudzarowski N, Törnqvist Andrén A, Bottai M, Hertegård S, Le Blanc K. Mesenchymal stromal cells modulate tissue repair responses within the injured vocal fold. 2019. Mar 5. doi: 10.1002/lary.27885The Laryngoscope.

17. Nagubothu SR, Hertegård S, Malmström E, Ström C, Tolf A, Davies LC*, Le Blanc K*. Human Mesenchymal Stromal Cells injection of injured rabbit vocal folds with or without Hyaluronan carrier gel. *Joint senior author. 2019. Jun 27. doi: 10.1089/scd.2019.0102. [Epub ahead of print]

18. Gavin C, Boberg E, Von Bahr L, Bottai M, Törnqvist Andrén A, Wernerson A, Davies LC, Sugars RV, Le Blanc K. Tissue immune profiles supporting response to mesenchymal stromal cell therapy in acute graft versus host disease – a gut feeling. Stem Cells Research and Therapy 2019 Nov 20;10(1):334 PMID: 31747938

19. Grinnemo KH, Löfling M, Nathanson L, Baumgartner R, Ketelhuth, Beljanski, V, Davies LC*, Österholm, C*.  Interferon-g induces programmed death 1 ligand dependent immunomodulation in human fetal cardiac mesenchymal stromal cells. *Joint senior author. Stem Cells Research and Therapy 2019 Dec 4;10(1):371. doi: 10.1186/s13287-019-1489-1

20. Boberg E, Kadri N, Winterling J, Davies LC, Björklund A, Msghina M, Iacobaeus E, Le Blanc K. Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation. Haematologica 2019 Oct 24. pii: haematol.2019.225326. doi: 10.3324/haematol.2019.225326. PMID: 31649133

21. Queckbörner S, Syk Lundberg E, Gemzell-Danielsson K, Davies LC. Phenotypic and Immunomodulatory Functions of Endometrial Stromal Cells. Stem Cells Research and Therapy 2020 Jan 6;11(1):15. doi: 10.1186/s13287-019-1496-2

Review Articles and Letters 

1. Mesenchymal stromal cells and the innate immune response.Le Blanc K and Davies LC Immunology Letters 2015 Dec;168(2):140-6 

2. Commentary: the Role of MSC Mediated Crosstalk with Macrophages in GvHD and Tissue Repair. Davies LC, Boberg E, Le Blanc K. Biol Blood Marrow Transplant. 2017 Jun;23(6):861-862 

3. MSCs – cells with many sides. Le Blanc K and Davies LC.Cytotherapy 2018 20(3):273-278 

4. Author accountability in biomedical research. Caplan A, Badylak SF, Caplan AI, Davies LC, Strömblad S, Weiss DJ and Le Blanc K. Stem Cells and Development. 2018.Nov 20. doi: 10.1089/scd.2018.0214. [Epub ahead of print]

5. Cellular Therapies for the Endometrium: An Update. Queckbörner S, Davies LC, von Grothusen C, Santamaria X, Simon C, Gemzell-Danielsson K. Acta Obstetricia et Gynecologica Scandinavica. 2019 Feb 28. doi: 10.1111/aogs.13598.

Book Chapters

1. Oral Mucosal Progenitor Cells. P. Stephens and Davies LC Stem Cell Biology and Tissue Engineering in Dental Sciences. Elsevier Inc., 2015. Edited by:Ajay Vishwakarma, Paul Sharpe, Shi Songtao and Murugan Ramalingam 

2. Immunological Modulation of Stem Cells. LC Davies and Le Blanc K Tissue Engineering and Reparative Dentistry: Current Strategies. Wiley Blackwell, 2017. Edited by: Rachel J. Waddington and Alastair J. Sloan

Research description

My academic career has centred on the fields of stem cell biology and tissue engineering with respect to wound healing and the role of endogenous stem cells. My postdoctoral research focussed on stem cell immunology and the identification of a novel progenitor cell (PC) population within the oral mucosa lamina propria suitable for allogeneic tissue engineering. This work has stemmed from my interest in the preferential healing seen within the oral mucosa compared to the skin. Within the oral mucosa rapid healing is seen within no/minimal scar formation upon wounding. My recent work has focussed on characterising this newly discovered PC population, which may contribute to this preferential healing response. In particular this research has focussed on determining the neural-crest origin of this cell population, and successfully differentiating the cells down mesenchymal, neuronal and glial lineages with a view to future therapeutic applications (Davies et al., 2010). My continuing research focuses on the mechanisms by which oral mucosal PCs are able to both modulate the immune response (Davies et al., 2012) and regulate the oral microflora through the constitutive secretion of antibacterial factors. 

Teaching portfolio

Area of teaching expertise

Cell biology, oral and craniofacial development, wound healing, tissue repair and regeneration, stem cells and stromal cell biology including related immunology

Pedagogic Qualifications

Postgraduate Certificate in University Teaching and Learning, Cardiff University, 2015

Fellow of the Higher Education Academy, UK

Teaching Experience

I have extensive experiencing in teaching and leading of courses at undergraduate and postgraduate levels. I have taught both practical courses and lectured on dental education programmes, biochemistry, medicine and tissue engineering and regenerative medicine courses. 

Public Outreach for Science

I have been actively involved in promoting and conducting outreach programmes for science in primary school (ages 4-12) children since 2013.

 

Education

BSc (Hons) Applied and Human Biology,  Aston University, Birmingham UK (1998-2001)

PhD Biochemistry, Cardiff University, Cardiff UK (2002-2006)

Fellowship of The Higher Education Academy, UK (2015)                                   

                                    

Academic honours, awards and prizes

Senior Colgate Prize for research at the British Society of Dental Research/Nordisk Odontologisk Frening conference, 2007

International Association for Dental Research (IADR) Travel Award, 2008

Value in People Award, Wellcome Trust, UK 2008

Personal Fellowship from the National Institute for Social Care and Health Research, UK, 2010

 

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