Linus Wiklund

Linus Wiklund

Phd Student
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Beronius, 171 77 Stockholm
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About me

  • Hello!

    I am a doctoral student in Anna Beronius research group, at the Institute of Environmental Medicine (IMM). My journey in this field began with a master’s degree in Toxicology from KI in 2020, and then I started at my current position as a PhD student in the unit of Biochemical Toxicology in 2021.

    My research project is titled “A Novel Mechanism-Based Approach for Assessment of Developmental Toxicity of Endocrine Disruptors, ”. The project’s objective is to develop risk assessment methodology that utilizes mechanistic data from New Approach Methods (NAMs) to facilitate the animal-free assessment of Endocrine Disruptors (EDs).

Research

  • My work is primarily focused on integrating mechanistic data from non-animal methods in the assessment of EDs. These methods include computational approaches, cell-based methods, and experiments in zebrafish embryos. I perform case studies on chemicals suspected to be EDs (like PFOS, Cadmium, PCB126, and others) to identify challenges and opportunities with my mechanistic approach to ED assessment.

    In my research, I employ a variety of methodologies including Systematic Review methodology, Weight-of-Evidence assessments, and Adverse Outcome Pathways (AOPs). I also frequently use the R programming language for various tasks, for example to generate AOP networks, and to analyze transcriptomics and metabolomics data.


    More details about the project can be found here:
    https://ki.se/en/imm/a-novel-mechanism-based-approach-for-assessment-of-developmental-toxicity-of-endocrine

Articles

All other publications

Employments

  • Phd Student, Institute of Environmental Medicine, Karolinska Institutet, 2021-2024

Degrees and Education

  • Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2020
  • Bachelor's degree, Molecular Biology, Department of Biology Education, Stockholm University, 2017

Conference/event participation

  • Poster presenter of own accepted abstract, NorthTox 2023, Is it possible to identify endocrine disruptors without animal tests? A case study on PFOS, 2023
  • Event administrator, NorthTox 2023 Early Career Researcher activities, Part of the organizing committee for early career researcher activities at NorthTox 2023. We organized presentations, group activities, and a panel discussion for master students, PhD students, and post-docs., 2023
  • Event administrator, SWACCS Junior Academy Workshop (JAWS) 2022, I was part of the organizing committee of JAWS 2022. We organized lectures from different stakeholders, a poster viewing session, a course on science communication, and a dinner for participants., https://www.swaccs.se/jaws2022, 2022
  • Poster presenter of own accepted abstract, XVIth International Congress of Toxicology (ICT 2022), Towards AOP-driven next generation assessment of endocrine disruptors, https://doi.org/10.1016/j.toxlet.2022.07.709, 2022

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Events from KI