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Lucas Morin

Lucas Morin

Affiliated to research

Department and organisational affiliation:

About me

Lucas Morin obtained his PhD from the Aging Research Center at Karolinska Institutet in 2019. He is now working as a researcher in the clinical investigation unit (Inserm CIC 1431) of a large University Hospital in Besançon, France. His main responsibility is to be the PI of a 3-year study entitled "Treating Wisely in Geriatric Oncology", funded by the French National Cancer Institute.

In addition, Lucas works at the Department of Medical Epidemiology and Biostatistics as an affiliated postdoctoral researcher. His research interests are focused on geriatric pharmacoepidemiology and causal inference methods.

Research description

Areas of research

  • Pharmacoepidemiology with real-world data
  • End-of-life and palliative care
  • Benefits and harms of drug treatments among frail or seriously ill patients 
  • Impact of bereavement on health and mortality in old age

PhD Thesis: "Too much, too late? Drug prescribing for older people near the end of life"  

  • Thesis supervisor: Prof Kristina Johnell
  • Co-supervisors: Prof Johan Fastbom, Prof Marie-Laure Laroche
  • Public Defence: 20 September 2019

Recent publications (selected):

Use of artificial nutrition near the end of life. Results from a French national population-based study of hospitalized cancer patients. Baumstarck K, Boyer L, Pauly V, Orleans V, Marin A, Fond G, Morin L, Auquier P, Salas S. Cancer Medicine. 2019 (doi: 10.1002/cam4.2731)

How many older adults receive drugs of questionable clinical benefit near the end of life? A cohort study Morin L, Wastesson J, Laroche ML, Fastbom J, Johnell K. Palliative Medicine. 2019;33(8):1080-1090

Polypharmacy and injurious falls in older adults: a nationwide nested case-control study. Morin L, Calderon-Larrañaga A, Welmer AK, Rizzuto D, Wastesson J, Johnell K. Clinical Epidemiology. 2019;11:483-493

Preventive drugs in the last year of life of older adults with cancer: is there room for deprescribing? Morin L, Todd A, Barclay S, Wastesson J, Fastbom J, Johnell K. Cancer. 2019;125(13):2309-2317

How chronic is polypharmacy in old age? A longitudinal nationwide cohort study. Wastesson J, Morin L, Laroche ML, Johnell K. J Am Geriatr Soc 2019; 67(3):455-462

Adequate, questionable, and inadequate drug prescribing for older adults at the end of life: a European expert consensus. Morin L, Laroche ML, Vetrano DL, Fastbom J, Johnell K Eur. J. Clin. Pharmacol. 2018 Oct;74(10):1333-1342

The epidemiology of polypharmacy in older adults: register-based prospective cohort study. Morin L, Johnell K, Laroche ML, Fastbom J, Wastesson JW Clin Epidemiol 2018 ;10():289-298

Timing of palliative care needs reporting and aggressiveness of care near the end of life in metastatic lung cancer: A national registry-based study. Goldwasser F, Vinant P, Aubry R, Rochigneux P, Beaussant Y, Huillard O, et al Cancer 2018 07;124(14):3044-3051

Hospital end-of-life care in haematological malignancies. Beaussant Y, Daguindau E, Chauchet A, Rochigneux P, Tournigand C, Aubry R, et al BMJ Support Palliat Care 2018 Sep;8(3):314-324

Is the level of education associated with transitions between care settings in older adults near the end of life? A nationwide, retrospective cohort study. Kelfve S, Wastesson J, Fors S, Johnell K, Morin L Palliat Med 2018 02;32(2):366-375

Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study. Morin L, Vetrano DL, Rizzuto D, Calderón-Larrañaga A, Fastbom J, Johnell K Am. J. Med. 2017 08;130(8):927-936.e9

Discrepancies in the use of chemotherapy and artificial nutrition near the end of life for hospitalised patients with metastatic gastric or oesophageal cancer. A countrywide, register-based study. Kempf E, Tournigand C, Rochigneux P, Aubry R, Morin L Eur. J. Cancer 2017 07;79():31-40

Drug Use in Older Adults with Amyotrophic Lateral Sclerosis Near the End of Life. Grande G, Morin L, Vetrano DL, Fastbom J, Johnell K Drugs Aging 2017 07;34(7):529-533

Use of Medications of Questionable Benefit During the Last Year of Life of Older Adults With Dementia. Morin L, Vetrano DL, Grande G, Fratiglioni L, Fastbom J, Johnell K J Am Med Dir Assoc 2017 Jun;18(6):551.e1-551.e7

Use of chemotherapy near the end of life: what factors matter? Rochigneux P, Raoul JL, Beaussant Y, Aubry R, Goldwasser F, Tournigand C, et al Ann. Oncol. 2017 04;28(4):809-817

Estimating the need for palliative care at the population level: A cross-national study in 12 countries. Morin L, Aubry R, Frova L, MacLeod R, Wilson DM, Loucka M, et al Palliat Med 2017 06;31(6):526-536

Prevalence of Potentially Inappropriate Medication Use in Older Adults Living in Nursing Homes: A Systematic Review. Morin L, Laroche ML, Texier G, Johnell K J Am Med Dir Assoc 2016 09;17(9):862.e1-9

Aggressiveness of End-of-Life Care for Hospitalized Individuals with Cancer with and without Dementia: A Nationwide Matched-Cohort Study in France. Morin L, Beaussant Y, Aubry R, Fastbom J, Johnell K J Am Geriatr Soc 2016 09;64(9):1851-7

End-of-life care for hospitalized patients with metastatic melanoma in France: a nationwide, register-based study. Gallais Sérézal I, Beaussant Y, Rochigneux P, Tournigand C, Aubry R, Lindelöf B, et al Br. J. Dermatol. 2016 Sep;175(3):583-92

Discussing end-of-life issues in nursing homes: a nationwide study in France. Morin L, Johnell K, Van den Block L, Aubry R Age Ageing 2016 05;45(3):395-402

Place of death in the population dying from diseases indicative of palliative care need: a cross-national population-level study in 14 countries. Pivodic L, Pardon K, Morin L, Addington-Hall J, Miccinesi G, Cardenas-Turanzas M, et al J Epidemiol Community Health 2016 Jan;70(1):17-24

 

Other scientific activities

  • Co-chair of the “Big data in End-of-Life Care Research” Task Force of the European Association for Palliative Care (EAPC). Read more
  • Member of the executive committee of the European Drug Utilisation Research Group (EuroDURG) Read more
  • Member of the “Geriatric Pharmacoepidemiology” special interest group of the International Society for Pharmacoepidemiology (ISPE). Read more
  • Guest editor of a special issue of Palliative Medicine (IF 4.95): “Big data in palliative and end-of-life care research”, for publication in late 2020. In collaboration with Prof Bregje Onwuteaka Philipsen, UMC Amsterdam. Read more

Academic honours, awards and prizes

Early Researcher Award of the European Association of Palliative Care (EAPC), 2020

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