Magdalini Lourda

About me
Publications
Public outreach and news

About me

I am a Team leader at CIM, MEDH. My team studies the role of the innate immune system in acute and chronic inflammatory diseases in children and adults. I completed my PhD in the National and Kapodistrian University of Athens (Greece) and then moved to Sweden to work as a post-doc at the Center for Infectious Medicine in the Department of Medicine Huddinge, in collaboration with the Department of Women’s and Children’s health in Karolinska Institute. During my post-doc, I studied the involvement of myeloid cells in the pathogenesis of granuloma diseases, such as Langerhans cell histiocytosis and Crohn’s disease. My research resulted in the identification of several disease-associated deregulated molecular and cellular processes and contributed to new tools for diagnosis, monitoring and treatment of the patients. I became Assistant Professor in 2015 and I am now leading a team connected to the groups of Anna Norrby-Teglund and Mattias Svensson, studying the role of the innate immune system in acute and chronic inflammatory diseases in children and adults, with focus on Langerhans cell histiocytosis, psoriasis, inflammatory bowel disease and COVID-19.

Articles

Article: JOURNAL OF INFECTIOUS DISEASES. 2024;:jiae036

Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19.

Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingström J; Geanon D; Parke Å; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarström Q; Lund-Johansen F; Strålin K; Björkström NK; Karolinska KI/K COVID-19 Study Group
Article: NATURE COMMUNICATIONS. 2024;15(1):1752

Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.

Kvedaraite E; Lourda M; Mouratidou N; Düking T; Padhi A; Moll K; Czarnewski P; Sinha I; Xagoraris I; Kokkinou E; Damdimopoulos A; Weigel W; Hartwig O; Santos TE; Soini T; Van Acker A; Rahkonen N; Flodström Tullberg M; Ringqvist E; Buggert M; Jorns C; Lindforss U; Nordenvall C; Stamper CT; Unnersjö-Jess D; Akber M; Nadisauskaite R; Jansson J; Vandamme N; Sorini C; Grundeken ME; Rolandsdotter H; Rassidakis G; Villablanca EJ; Ideström M; Eulitz S; Arnell H; Mjösberg J; Henter J-I; Svensson M
Article: HAEMATOLOGICA. 2023;108(9):2422-2434

Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells.

Hagey DW; Kvedaraite E; Akber M; Görgens A; Javadi J; Von Bahr Greenwood T; Björklund C; Åkefeldt SO; Hannegård-Hamrin T; Arnell H; Dobra K; Herold N; Svensson M; El Andaloussi S; Henter J-I; Lourda M
Article: AIDS. 2023;37(7):1023-1033

Role of myeloid cells in system-level immunometabolic dysregulation during prolonged successful HIV-1 treatment.

Svensson Akusjärvi S; Krishnan S; Ambikan AT; Mikaeloff F; Munusamy Ponnan S; Vesterbacka J; Lourda M; Nowak P; Sönnerborg A; Neogi U
Article: CELL REPORTS MEDICINE. 2023;4(5):101038

The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis.

Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Ideström M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjösberg J
Article: NATURE COMMUNICATIONS. 2023;14(1):1438

An integrated single cell and spatial transcriptomic map of human white adipose tissue.

Massier L; Jalkanen J; Elmastas M; Zhong J; Wang T; Nono Nankam PA; Frendo-Cumbo S; Bäckdahl J; Subramanian N; Sekine T; Kerr AG; Tseng BTP; Laurencikiene J; Buggert M; Lourda M; Kublickiene K; Bhalla N; Andersson A; Valsesia A; Astrup A; Blaak EE; Ståhl PL; Viguerie N; Langin D; Wolfrum C; Blüher M; Rydén M; Mejhert N
Article: IMMUNOBIOLOGY. 2023;228(2):152350

Immune cell landscape in symptomatic and asymptomatic SARS-CoV-2 infected adults and children in urban Dhaka, Bangladesh.

Akhtar E; Mily A; Sarker P; Chanda BC; Haque F; Kuddusi RU; Haq MA; Lourda M; Brighenti S; Raqib R
Article: RESPIRATORY RESEARCH. 2023;24(1):62

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

Palma Medina LM; Babačić H; Dzidic M; Parke Å; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgård J; Moll K; Karolinska K. I./K. COVID-19 Study Group; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Gredmark-Russ S; Rooyackers O; Svensson M; Chambers BJ; Eriksson LI; Pernemalm M; Björkström NK; Aleman S; Ljunggren H-G; Klingström J; Strålin K; Norrby-Teglund A
Journal article: REVISTA CHILENA DE LITERATURA. 2023;(108):2422-2434

Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells

Hagey DW; Kvedaraite E; Akber M; Gorgens A; Javadi J; Greenwood TVB; Bjorklund C; Akefeldt SO; Hannegard-Hamrin T; Arnell H; Dobra K; Herold N; Svensson M; El Andaloussi S; Henter J-I; Lourda M
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(6):925-940

Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.

Jädersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzén S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Östling P; Schinazi RF; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis GZ; Höglund M; Henter J-I; Herold N
Article: CELL SYSTEMS. 2022;13(8):665-681.e4

Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.

Ambikan AT; Yang H; Krishnan S; Svensson Akusjärvi S; Gupta S; Lourda M; Sperk M; Arif M; Zhang C; Nordqvist H; Ponnan SM; Sönnerborg A; Treutiger CJ; O'Mahony L; Mardinoglu A; Benfeitas R; Neogi U
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;198(4):721-728

Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma.

Sveijer M; von Bahr Greenwood T; Jädersten M; Kvedaraite E; Zetterberg H; Blennow K; Lourda M; Gavhed D; Henter J-I
Journal article: HEMASPHERE. 2022;6:442-443

P543: TARGETING SAMHD1 WITH HYDROXYUREA IN FIRST‐LINE CYTARABINE‐BASED THERAPY OF NEWLY DIAGNOSED ACUTE MYELOID LEUKAEMIA: RESULTS FROM THE HEAT‐AML TRIAL

Jädersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzén S; Bohlin A; Arnroth C; Erkers T; Seashore‐Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Östling P; Schinazi R; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis G; Höglund M; Henter J; Herold N
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Ljunggren H-G; Ask EH; Cornillet M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio A; Dzidic M; Filipovic I; Flodström-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Malmberg K-J; Strålin K; Björkström NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510

COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.

Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Strålin K; Ljunggren H-G; Björkström NK
Article: FRONTIERS IN PEDIATRICS. 2022;10:872859

Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions.

Mitchell J; Kvedaraite E; von Bahr Greenwood T; Lourda M; Henter J-I; Berzins SP; Kannourakis G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.

Lourda M; Dzidic M; Hertwig L; Bergsten H; Palma Medina LM; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki KT; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ; Karolinska KI/K COVID-19 Study Group
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(14):149523

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections.

Palma Medina LM; Rath E; Jahagirdar S; Bruun T; Madsen MB; Strålin K; Unge C; Hansen MB; Arnell P; Nekludov M; Hyldegaard O; Lourda M; Santos VAMD; Saccenti E; Skrede S; Svensson M; Norrby-Teglund A
Article: ACTA PAEDIATRICA. 2021;110(4):1315-1321

Patients with both Langerhans cell histiocytosis and Crohn's disease highlight a common role of interleukin-23.

Kvedaraite E; Lourda M; Han H; Tesi B; Mitchell J; Ideström M; Mouratidou N; Rassidakis G; von Bahr Greenwood T; Cohen-Aubart F; Jädersten M; Åkefeldt SO; Svensson M; Kannourakis G; Bryceson YT; Haroche J; Henter J-I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.

Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Hed Myrberg I; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström NK; Henter J-I; Svensson M; Karolinska KI/K COVID-19 Study Group
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306

SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.

Sandberg JT; Varnaitė R; Christ W; Chen P; Muvva JR; Maleki KT; García M; Dzidic M; Folkesson E; Skagerberg M; Ahlén G; Frelin L; Sällberg M; Eriksson LI; Rooyackers O; Sönnerborg A; Buggert M; Björkström NK; Aleman S; Strålin K; Klingström J; Ljunggren H-G; Blom K; Gredmark-Russ S; Karolinska COVID‐19 Study Group
Article: CELL. 2020;183(1):158-168.e14

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.

Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgård J; Parrot T; Folkesson E; Karolinska COVID-19 Study Group; Rooyackers O; Eriksson LI; Henter J-I; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670

MAIT cell activation and dynamics associated with COVID-19 disease severity.

Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgård J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Björkström NK; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg JK
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(163)

Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection.

Mily A; Kalsum S; Loreti MG; Rekha RS; Muvva JR; Lourda M; Brighenti S
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström NK; Karolinska COVID-19 Study Group
Article: CYTOKINE. 2020;126:154877

High levels of plasma interleukin-17A are associated with severe neurological sequelae in Langerhans cell histiocytosis.

Ismail MB; Åkefeldt SO; Lourda M; Gavhed D; Aricò M; Henter J-I; Delprat C; Valentin H
Article: METHODSX. 2020;7:100997

Comparison of three different ELISAs for the detection of recombinant, native and plasma IL-17A.

Ismail MB; Åkefeldt SO; Lourda M; Gavhed D; Gayet R; Aricò M; Henter J-I; Delprat C; Valentin H
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224

Innate lymphoid cell composition associates with COVID-19 disease severity.

García M; Kokkinou E; Carrasco García A; Parrot T; Palma Medina LM; Maleki KT; Christ W; Varnaitė R; Filipovic I; Ljunggren H-G; Björkström NK; Folkesson E; Rooyackers O; Eriksson LI; Sönnerborg A; Aleman S; Strålin K; Gredmark-Russ S; Klingström J; Mjösberg J; Karolinska KI/K COVID‐19 Study Group
Article: NATURE COMMUNICATIONS. 2019;10(1):3841

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.

Marquardt N; Kekäläinen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hård J; Mold JE; Ljunggren H-G; Michaëlsson J
Journal article: PEDIATRIC BLOOD & CANCER. 2019;66 Suppl 1:e27548

Abstracts from the 34th Annual Meeting of the Histiocyte Society Lisbon, Portugal October 22-23, 2018.
Journal article: JOURNAL OF CROHNS & COLITIS. 2018;12(supplement_1):s119-s120

P054 Innate lymphoid cells in paediatric inflammatory bowel disease

Van Acker A; Kvedaraite E; Lourda M; Ideström M; Henter J-I; Svensson M; Mjösberg J
Journal article: PEDIATRIC BLOOD & CANCER. 2017;64 Suppl 2

Abstracts From the 33rd Annual Meeting of the Histiocyte Society Singapore October 3-4, 2017.
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):249-350

SSI 2017 44th Annual Meeting of the Scandinavian Society of Immunology Stockholm, Sweden 17–20 October 2017
Journal article: PEDIATRIC BLOOD & CANCER. 2016;63 Suppl 2:S10-S65

Abstracts From the 32nd Annual Meeting of the Histiocyte Society Dublin, Ireland October 17-19, 2016.
Article: GUT. 2016;65(10):1632-1641

Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD.

Kvedaraite E; Lourda M; Ideström M; Chen P; Olsson-Åkefeldt S; Forkel M; Gavhed D; Lindforss U; Mjösberg J; Henter J-I; Svensson M
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46 Suppl 1:1-1238

Abstracts of ICI 2016 International Congress of Immunology, 21-26 August 2016, Melbourne, Australia.
Article: ONCOIMMUNOLOGY. 2016;5(3):e1084463

The presence of CXCR4+ CD1a+ cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome.

Quispel WT; Stegehuis-Kamp JA; Blijleven L; Santos SJ; Lourda M; van den Bos C; van Halteren AGS; Egeler RM
Journal article: PEDIATRIC BLOOD & CANCER. 2015;62(S3):s121-s141

ABSTRACTS FROM THE 31st ANNUAL MEETING OF THE HISTIOCYTE SOCIETY ATHENS, GREECE SEPTEMBER 28–30, 2015
Journal article: PEDIATRIC BLOOD & CANCER. 2015;62 Suppl 1:S1-S18

Abstracts from the 30(th) Annual Meeting of the Histiocyte Society Toronto, Ontario, Canada October 28-30, 2014.
Journal article: PEDIATRIC BLOOD & CANCER. 2014;61(11):2129-2143

Histiocyte society 29th annual meeting abstracts Washington, DC USA
Article: CLINICAL IMMUNOLOGY. 2014;153(1):112-122

Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients.

Lourda M; Olsson-Åkefeldt S; Gavhed D; Björnfot S; Clausen N; Hjalmars U; Sabel M; Tazi A; Aricò M; Delprat C; Henter J-I; Svensson M
Journal article: PEDIATRIC BLOOD & CANCER. 2013;60(9):E70-E84

Abstract
Article: PLOS ONE. 2013;8(3):e58122

Human herpesvirus 6A partially suppresses functional properties of DC without viral replication.

Gustafsson RKL; Engdahl EE; Hammarfjord O; Adikari SB; Lourda M; Klingström J; Svensson M; Fogdell-Hahn A
Article: CLINICAL CANCER RESEARCH. 2009;15(1):48-59

Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex.

Trougakos IP; Lourda M; Antonelou MH; Kletsas D; Gorgoulis VG; Papassideri IS; Zou Y; Margaritis LH; Boothman DA; Gonos ES
Article: BIOINORGANIC CHEMISTRY AND APPLICATIONS. 2008;2008:420578-6

Biological monitoring of hexavalent chromium and serum levels of the senescence biomarker apolipoprotein J/Clusterin in welders.

Alexopoulos EC; Cominos X; Trougakos IP; Lourda M; Gonos ES; Makropoulos V
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(3):611-622

Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J.

Lourda M; Trougakos IP; Gonos ES
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2005;38(4):436-449

Differential effects of clusterin/apolipoprotein J on cellular growth and survival.

Trougakos IP; Lourda M; Agiostratidou G; Kletsas D; Gonos ES
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All other publications

Preprint: 2023;bioRxiv

Alpha-toxin elicited CX3CL1-release via ADAM10 in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes

Shambat SM; Chen P; Barilla RM; Huemer M; Snäll J; Welin A; Cohen TS; Takahashi V; Berry SB; Gómez-Mejia A; Schweizer TA; Cunoosamy DM; Cajander S; Lourda M; Özenci V; Maggio EM; Schüpbach RA; Strålin K; Zinkernagel AS; Norrby-Teglund A; Svensson M
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(7):1306-1309.e4

Baricitinib Blocks Cytokine-Mediated Downregulation of PAD1 in Human Keratinocytes: A Possible Molecular Link to the Effects of JAK Inhibitors in Atopic Dermatitis.

Padhi A; Rekha RS; Benrejdal L; Grundeken ME; Lourda M; Ehrström M; Eyerich K; Páez IT; Johansson EK; Bradley M; Bergman P; Lysell J
Conference publication: PEDIATRIC BLOOD & CANCER. 2023;70:S20-S21

SCREENING FOR NEURODEGENERATION IN LCH WITH NEUROFILAMENT LIGHT IN PLASMA

Henter J-I; Sveijer M; Jadersten M; Kvedaraite E; Zetterberg H; Blennow K; Lourda M; Gavhed D; Greenwood TVB
Letter: AMERICAN JOURNAL OF HEMATOLOGY. 2022;97(6):E207-E210

Mutation in the TACI gene and autoimmune neutropenia: A case report.

Bergman P; Broliden P-A; Ratcliffe P; Lourda M; Flesch B; Höglund P; Palmblad J
Preprint: 2022;Research Square

Monocyte driven system-level inflammatory and immunometabolic dysregulation during prolonged successful HIV-1 treatment

Akusjärvi SS; Krishnan S; Ambikan A; Mikaeloff F; Ponnan S; Vesterbacka J; Lourda M; Nowak P; Sönnerborg A; Neogi U
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2022;196(1):248-254

Response to mitogen-activated protein kinase inhibition of neurodegeneration in Langerhans cell histiocytosis monitored by cerebrospinal fluid neurofilament light as a biomarker: a pilot study.

Henter J-I; Kvedaraite E; Martín Muñoz D; Cheng Munthe-Kaas M; Zeller B; Nystad TA; Björklund C; Donnér I; Lourda M; Zetterberg H; Blennow K; Herold N; Gavhed D; von Bahr Greenwood T
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S10

Response to Mapk Inhibition of Neurodegeneration in Lch Monitored by Csf Neurofilament Light as a Biomarker

Henter J-I; Kvedaraite E; Munoz DM; Munthe-Kaas MC; Zeller B; Nystad T; Bjorklund C; Donner I; Lourda M; Zetterberg H; Blennow K; Herold N; Gavhed D; Greenwood TVB
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S17

Plasma Signalling Factors in patients with Langerhans Cell Histiocytosis (Lch) Correlate with Relative Frequencies of Lch cells and T cells within Lesions

Mitchell J; Kvedaraite E; Greenwood TVB; Lourda M; Henter J-I; Berzins S; Kannourakis G
Preprint: 2021;medRxiv

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LP; Kvedaraite E; Chen P; Muvva J; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki K; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg J; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson L; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström N; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers B; the Karolinska KI/K COVID-19 Study Group
Preprint: 2021;SSRN Electronic Journal

Multiomics Personalized Network Analyses Highlight Progressive Immune Disruption of Central Metabolism Associated with COVID-19 Severity

Ambikan AT; Yang H; Krishnan S; Svensson-Akusjärvi S; Gupta S; Lourda M; Sperk M; Arif M; Zhang C; Nordqvist H; Ponnan SM; Sönnerborg A; Treutiger CJ; O’Mahony L; Mardinoglu A; Benfeitas R; Neogi U
Corrigendum: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(164)

Erratum: Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection.
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2020;191(1):115-119

High prevalence of peripheral lymphopenia in Langerhans cell histiocytosis.

Lourda M; Widesköld S; Kvedaraite E; Gavhed D; Akber M; von Bahr Greenwood T; Svensson M; Olsson-Åkefeldt S; Henter J-I
Preprint: 2020;medRxiv

Perturbations in the mononuclear phagocyte landscape associated with COVID-19 disease severity

Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Brighenti S; Norrby-Teglund A; Eriksson L; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström N; Henter J-I; Svensson M; Karolinska COVID-19 Study Group
Conference publication: PEDIATRIC BLOOD & CANCER. 2020;67:S17-S18

PERSISTENT LYMPHOPENIA IN LCH PATIENTS LIKELY RELATED TO CONSTANTLY HIGH LEVELS OF IL-7 AND IL-21

Lourda M; Wideskold S; Kvedaraite E; Gavhed D; Greenwood TVB; Svensson M; Olsson-Akefeldt S; Henter J-I
Conference publication: PEDIATRIC BLOOD & CANCER. 2019;66:S25-S26

ACTIVATION OF THE IL-23 SIGNALING PATHWAY IN LCH LESIONS

Lourda M; Kvedaraite E; Olsson-Akefeldt S; Holmstrom SB; Greenwood TVB; Svensson M; Henter J-I
Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12:S119-S120

Innate lymphoid cells in paediatric inflammatory bowel disease

Van Acker A; Kvedaraite E; Lourda M; Idestrom M; Henter J-I; Svensson M; Mjosberg J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):316

Increased prevalence of lymphopenia in patients with Langerhans cell histiocytosis

Lourda M; Olsson-Akefeldt S; Gavhed S; Kvedaraite E; Gavhed D; Svensson M; Henter J-I
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):253

Stromal cell - innate immune cell interactions in inflammatory bowel disease patients

Kvedaraite E; Lourda M; Van Acker A; Jess DU; Gavhed D; Mjosberg J; Idestrom M; Henter J-I; Svensson M
Conference publication: PEDIATRIC BLOOD & CANCER. 2017;64:S21-S22

High Prevalence of Lymphopenia in Langerhans Cell Histiocytosis: Correlation with Early Onset and More Severe Disease

Lourda M; Olsson-Akefeldt S; Gavhed S; Kvedaraite E; Gavhed D; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD & CANCER. 2017;64:S20

When Langerhans Met Crohn: A Clinical Case Report and a First Three-Dimentional Reconstruction of Human Gut

Kvedaraite E; Jess DU; Gavhed D; Idestrom M; Svensson M; Lourda M; Henter J-I
Letter: BLOOD. 2016;128(9):1302-1305

Adsorptive depletion of blood monocytes reduces the levels of circulating interleukin-17A in Langerhans cell histiocytosis.

Lourda M; Olsson-Åkefeldt S; Gavhed D; Axdorph Nygell U; Berlin G; Laurencikas E; von Bahr Greenwood T; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD & CANCER. 2016;63:S24-S25

Adsorptive Depletion of Blood Monocytes Reduces the Levels of Circulating Interleukin-17A in Langerhans Cell Histiocytosis

Lourda M; Olsson-Akefeldt S; Gavhed D; Nygell UA; Berlin G; Laurencikas E; Greenwood TVB; Svensson M; Henter J-I
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:1007-1008

In vitro neutralization of IL-17A sensitizes dendritic cells to vinblastine in Langerhans cell histiocytosis

Akefeldt OS; Ismail MB; Belot A; Lourda M; Valentin H; Maisse C; Salvatore G; Bissay N; Svensson M; Arico M; Henter J-I; Delprat C
Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S131-S132

INTERLEUKIN-17A AS A BIOMARKER IN NEURODEGENERATIVE LANGERHANS CELL HISTIOCYTOSIS

Lourda M; Olsson-Akefeldt S; Gavhed D; Greenwood TVB; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S10

EXPLORATION OF THE IL-23/IL-17A AXIS IN LANGERHANS CELL HISTIOCYTOSIS

Kvedaraite E; Lourda M; Chen P; Gavhed D; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD & CANCER. 2014;61(11):2135

PRODUCTION BY BLOOD MONOCYTES IS TIGHTLY RELATED TO THE DEGREE OF ACTIVITY OF LANGERHANS CELL HISTIOCYTOSIS

Lourda M; Akefeldt SO; Gavhed D; Clausen N; Hjalmars U; Sabel M; Tazi A; Arico M; Delprat C; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD & CANCER. 2013;60(9):E79-E80

CIRCULATING CYTOKINE-PRODUCING CELLS IN LANGERHANS CELL HISTIOCYTOSIS

Lourda M; Akefeldt SO; Gavhed D; Svensson M; Henter J-I
Conference publication: FEBS JOURNAL. 2008;275:346

Clusterin binds to the cytoplasmic Ku70-Bax nexus and suppresses Bax activation and relocation to mitochondria

Trougakos IP; Lourda M; Antonelou MM; Kletsas D; Gorgoulis VG; Papassideri IS; Zou Y; Margaritis LH; Boothman DA; Gonos ES
Conference publication: FEBS JOURNAL. 2006;273:313

Implication of clusterin/apolipoprotein J in resistance acquisition of cancer cells to chemotherapy

Lourda M; Trougakos IP; Gonos ES
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