I have been working in the “Nuclear receptors in health and disease” group leads by Jan-Åke Gustafsson since 8 years now. When I arrived I had the goal to develop in-vivo models/studies for the investigation of LXRs pathways in the field of metabolic diseases. It was a real challenge since nothing was organized to run in-vivo studies in the department. Eight years later, the goal is reached with 8 publications on my own work in high impact peer-review journals. Since 2007, I have been appointed with a permanent position and since Jan-Åke is only part time associated to KI, I am the leader of all the research concerning nuclear receptor effects on metabolism in-vivo and I have been in charge of this line of research for the past 5 years.
From 2007, Senior Researcher 100 % permanent (sv tillsvidare), Research assistant, Dept of biosciences and Nutrition, Karolinska Institute, Sweden.
I am an independent senior researcher in physiology and basic molecular biology. Using animal models, I work for a better understanding of metabolic dysfunctions during obesity and diabetes and study the role of nuclear receptors in these regulations. My research focus essentially on the role of liver X receptors (LXR) and estrogen receptors beta in the regulation of metabolism.
2000 Research assistant, Department of Kinesiology, University of Montreal, Canada
Development of stable isotope studies for the investigation of carbohydrate and protein metabolism in man at rest and during moderate exercise.
1998-99 Research assistant, Laboratory of exercise physiopathology, France
Higher education qualification
2001 M.Sc. in Biochemistry and Physiolopathology, University of Medicine, Paris V, France
Research project: Cardiac variability with posture, in healthy and handicapped subjects.
Degree of Doctor
1997-2001 PhD in Biology and Physiology, University Joseph Fourier and University of Montreal France & Canada
Title: Metabolic fate of food labeled with stable isotope (13C and 15N) in healthy human and HIV patients, at rest or during exercise. Supervised by Pr Xavier Leverve (France) and Pr François Péronnet (Canada).
2005-2007 Post-doctoral fellow, Dept of biosciences and Nutrition, Karolinska Institute, Sweden
Title: Liver X receptors pathways in obesity, type 2 diabetes and metabolic disorders in mice.
2002-2004 Post-doctoral fellow, Novartis Institutes for Biomedical Research - Core
Technology – In vivo NMR Laboratory, New Jersey, USA
Title: Mechanisms for anti-diabetic action of drugs and metabolic pathways in rats and mice, investigated in vivo by MRS (magnetic resonance spectroscopy) and MRI (magnetic resonance imaging).
Docenture: in process, should be finalized in 2014
2006 Lab Animal Sciences certificate – Karolinska Institute, Sweden
Academic honours, awards and prizes
2014 travel grant (10 600 SEK) from KI fonden for Keystone meeting in Taos, NM.
2011 KI foundation: 32 300 SEK Project award: Fibroblast Growth Factor 21 (FGF21): a new LXR target that could regulate glucose and fat homeostasis.
2010-11 Cornellstiftelsen 200 000 SEK/year for 2 years. Project award: Liver-X Receptors regulate de novo lipogenesis in a tissue specific manner in C57Bl/6 female mice.
2008-09 Cornellstiftelsen 200 000 SEK/year for 2 years. Project award: Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity.
2003-05 Postdoctoral Grant (100 000 USD) from Novartis Pharmaceuticals, USA (Salary for 2 years). Project award: Mechanisms for anti-diabetic action of drugs and metabolic pathways in rats and mice.
2001 Research Grant, Canada 10 000 CAD for 6 months. Project award: Development of stable isotope studies for the investigation of carbohydrate and protein metabolism in man at rest and during moderate exercise.
1998-2000 Garches Foundation Grant, France. 12 000 €/year. Project award: Cardiac variability with posture, in healthy and handicapped subjects.