Associate Professor and Senior Lecturer at Karolinska Institutet. Director of Doctoral Studies and Head of International Affairs at Department of Dental Medicine.
Margaret Sällberg Chen received her D.D.S. and Ph.D. degrees from Karolinska Institutet. Following postdoctoral training at The Scripps Research Institute, La Jolla, USA, where she developed T cell receptor transgene models for immunological studies of chronic viral infection, she was recruited to the former Swedish Institute for Infectious Disease Control to continue with immunology and vaccinology studies. In 2004 she was appointed as associate professor at Karolinska Institutet, and senior lecturer at Department of Dental Medicine in 2009. She has published over 60 scientific articles and cited > 2500 times, she has active commitments on numerous scientific and editorial board.
The lab is broadly interested in immunological mechanisms effective in eliminating microbial pathogens associated with chronic diseases and tumors. The research pursues several lines investigating cellular functions capable of sensing and killing intracellular pathogens and tumors, and the target identification. The models are exclusively human infectious diseases and the methodologies employed include synthetic genetics, genetically modified cells and animals, viral and non-viral vectors, and next generation sequencing.
Major research area: infection and cancer immunity, redirection of lymphocytes, T cell receptors, viral and neo-antigens, human microbiome and immune cell interactions, therapeutic targets in oral diseases including tumors and endodontic infections.
Dr. Haleh Davanian, Postdoc, Dr. Davanian holds a PhD degree in RNA sequencing.
Dr. Giorgio Gabarrini, Postdoc, Dr Gabarrini holds a PhD degree in oral microbiology.
Dr. Michal Sobkowiak, Postdoc, Dr Sobkowiak holds a PhD degree in mucosal immunology
PhD students: Hassan Alkharaan (DDS), Katie Healy (MSc), Liyan Lu (DDS), Rahul Harshad Nagadia (DDS, MD, Specialist in Oral and Maxillofacial Surgery)
Co-supervisor to PhD students Asif Halimi (MD, Specialist in Surgery), Zeeshan Ateeb (MD), and Yanhong Su (MD)
Tanja Näslund PhD degree 2009, Anna Pasetto PhD degree 2012, Haleh Davanian PhD degree 2014, Michal Sobkowiak PhD degree 2019.
Dr. Anila Yasmeen, Postdoc. Dr. Balasiddaiah Anangi, Postdoc.
Cancerfonden, KI KID faculty funds, Johnson & Johnson Innovation Award, KI/SLL SOF, ALF Stockholm